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• Article

  3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics

  Abdollahi Govar, A., Törő, G., Szaniszlo, P., Pavlidou, A., Bibli, S. I., Thanki, K., Resto, V. A., Chao, C., Hellmich, M. R., Szabo, C., Papapetropoulos, A. & Módis, K., Feb 1 2020, In: British Journal of Pharmacology. 177, 4, p. 866-883 18 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-mercaptopyruvic acid
  • Energy Metabolism
  • Endothelial Cells
  • Hydrogen Sulfide
  • Small Interfering RNA
  10 Scopus citations

• Apigenin Decreases Acinar Cell Damage in Pancreatitis

  Mrazek, A. A., Bhatia, V., Falzon, M., Spratt, H., Chao, C. & Hellmich, M. R., May 1 2019, In: Pancreas. 48, 5, p. 711-718 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Apigenin
  • Acinar Cells
  • Pancreatitis
  • Parathyroid Hormone-Related Protein
  • Transforming Growth Factors
  2 Scopus citations

• Apigenin inhibits pancreatic stellate cell activity in pancreatitis

  Mrazek, A. A., Porro, L. J., Bhatia, V., Falzon, M., Spratt, H., Zhou, J., Chao, C. & Hellmich, M. R., Jun 1 2015, In: Journal of Surgical Research. 196, 1, p. 8-16 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Stellate Cells
  • Apigenin
  • Pancreatitis
  • Chronic Pancreatitis
  • Fibrosis
  23 Scopus citations

• Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis

  Gao, X., Cao, Y., Staloch, D. A., Gonzales, M. A., Aronson, J. F., Chao, C., Hellmich, M. R. & Ko, T. C., Feb 21 2014, In: PloS one. 9, 2, e89114.

  Research output: Contribution to journal › Article › peer-review

  • bone morphogenetic proteins
  • Ceruletide
  • fibrosis
  • Bone Morphogenetic Proteins
  • Pancreatic Stellate Cells
  18 Scopus citations

• CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133-cells

  Chao, C., Carmical, J. R., Ives, K. L., Wood, T. G., Aronson, J. F., Gomez, G. A., Djukom, C. D. & Hellmich, M. R., Mar 2012, In: Laboratory Investigation. 92, 3, p. 420-436 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumor Microenvironment
  • Colonic Neoplasms
  • Fibroblasts
  • Carcinoma
  • Genes
  33 Scopus citations

• Colorectal cancer-associated fibroblasts are genotypically distinct

  Mrazek, A. A., Carmical, J. R., Wood, T. G., Hellmich, M. R., Eltorky, M. & Chao, C., Jan 1 2014, In: Current Cancer Therapy Reviews. 10, 3, p. 97-218 122 p.

  Research output: Contribution to journal › Article › peer-review

  • Cancer-Associated Fibroblasts
  • Colorectal Neoplasms
  • Fibroblasts
  • Carcinoma
  • Methylation
  12 Scopus citations

• Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo

  Chen, H., Mrazek, A. A., Wang, X., Ding, C., Ding, Y., Porro, L. J., Liu, H., Chao, C., Hellmich, M. R. & Zhou, J., Jul 1 2014, In: Bioorganic and Medicinal Chemistry. 22, 13, p. 3393-3404 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Stellate Cells
  • Cell proliferation
  • Apigenin
  • Chronic Pancreatitis
  • Fibrosis
  25 Scopus citations

• Dual inhibition of PI3K and mTOR signaling pathways decreases human pancreatic neuroendocrine tumor metastatic progression

  Djukom, C., Porro, L. J., Mrazek, A., Townsend, C. M., Hellmich, M. R. & Chao, C., Jan 2014, In: Pancreas. 43, 1, p. 88-92 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Everolimus
  • Neuroendocrine Tumors
  • TOR Serine-Threonine Kinases
  • Phosphatidylinositol 3-Kinase
  • 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
  16 Scopus citations

• Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-β-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro

  Módis, K., Coletta, C., Asimakopoulou, A., Szczesny, B., Chao, C., Papapetropoulos, A., Hellmich, M. R. & Szabo, C., Sep 15 2014, In: Nitric Oxide - Biology and Chemistry. 41, p. 146-156 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystathionine
  • Cell proliferation
  • S-Adenosylmethionine
  • Energy Metabolism
  • Colorectal Neoplasms
  53 Scopus citations

• Gremlin is a key pro-fibrogenic factor in chronic pancreatitis

  Staloch, D., Gao, X., Liu, K., Xu, M., Feng, X., Aronson, J. F., Falzon, M., Greeley, G. H., Rastellini, C., Chao, C., Hellmich, M. R., Cao, Y. & Ko, T. C., Oct 3 2015, In: Journal of Molecular Medicine. 93, 10, p. 1085-1093 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Chronic Pancreatitis
  • Bone Morphogenetic Proteins
  • Transforming Growth Factors
  • Pancreatic Stellate Cells
  • Mouse Grem1 protein
  22 Scopus citations

• Hydrogen sulfide and cancer

  Hellmich, M. R. & Szabo, C., 2015, In: Handbook of Experimental Pharmacology. 230, p. 233-241 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Hydrogen Sulfide
  • Tumors
  • Energy Metabolism
  • Cells
  • Tissue
  91 Scopus citations

• Pharmacological inhibition and genetic knockdown of exchange protein directly activated by cAMP 1 reduce pancreatic cancer metastasis in vivos

  Almahariq, M., Chao, C., Mei, F. C., Hellmich, M. R., Patrikeev, I., Motamedi, M. & Cheng, X., Feb 1 2015, In: Molecular pharmacology. 87, 2, p. 142-149 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Pancreatic Neoplasms
  • Adenocarcinoma
  • Pharmacology
  • Neoplasm Metastasis
  • Proteins
  28 Scopus citations

• Raf-1 kinase inhibitory protein (RKIP) mediates ethanol-induced sensitization of secretagogue signaling in pancreatic acinar cells

  Kim, S. O., Ives, K. L., Wang, X., Davey, R. A., Chao, C. & Hellmich, M. R., Sep 28 2012, In: Journal of Biological Chemistry. 287, 40, p. 33377-33388 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Proto-Oncogene Proteins c-raf
  • Secretagogues
  • Acinar Cells
  • Cholecystokinin
  • Ethanol
  8 Scopus citations

• Regulation of bombesin-stimulated cyclooxygenase-2 expression in prostate cancer cells

  Wen, X., Chao, C., Ives, K. & Hellmich, M. R., Jul 11 2011, In: BMC Molecular Biology. 12, 29.

  Research output: Contribution to journal › Article › peer-review

  • Bombesin
  • Cyclooxygenase 2
  • Prostatic Neoplasms
  • Phosphatidylinositol 3-Kinases
  • NF-kappa B
  8 Scopus citations

• Role of parathyroid hormone-related protein in the pro-inflammatory and pro-fibrogenic response associated with acute pancreatitis

  Bhatia, V., Kim, S. O. K., Aronson, J. F., Chao, C., Hellmich, M. R. & Falzon, M., Apr 10 2012, In: Regulatory Peptides. 175, 1-3, p. 49-60 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Parathyroid Hormone-Related Protein
  • Pancreatitis
  • Ceruletide
  • Acinar Cells
  • Procollagen
  16 Scopus citations

• The Multidisciplinary Translational Team (MTT) Model for Training and Development of Translational Research Investigators

  Ameredes, B. T., Hellmich, M. R., Cestone, C. M., Wooten, K. C., Ottenbacher, K. J., Chonmaitree, T., Anderson, K. E. & Brasier, A. R., Oct 2015, In: Clinical and translational science. 8, 5, p. 533-541 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Translational Medical Research
  • Research Personnel
  • Interdisciplinary Research
  • Mentoring
  • Health
  12 Scopus citations

• Translational Research Track for Medical Students: Developing Interprofessional Collaborative Competencies for Translational Research

  Aronson, J. F., Valbuena, G. A., Hellmich, M. R. & Asimakis, G., Apr 1 2011, In: Medical Science Educator. 21, 1, p. 63-66 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Translational Medical Research
  • Medical Students
  • medical student
  • Education
  • research project
  1 Scopus citations
• Chapter

  Gastrointestinal Peptides: Gastrin, Cholecystokinin, Somatostatin, and Ghrelin

  Chao, C. & Hellmich, M. R., 2012, Physiology of the Gastrointestinal Tract. Elsevier Inc., Vol. 1. p. 115-154 40 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  2 Scopus citations
• Comment/debate

  Corrigendum to "Role of parathyroid hormone-related protein in the pro-inflammatory and pro-fibrogenic response associated with acute pancreatitis" [Regul Pept 175 (2012) 49-60]

  Bhatia, V., Kim, S. O. K., Aronson, J., Chao, C., Hellmich, M. & Falzon, M., Jun 1 2014, In: Regulatory Peptides. 192, p. 59 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  2 Scopus citations
• Review article

  Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II Pathophysiological and therapeutic aspects

  Módis, K., Bos, E. M., Calzia, E., Van Goor, H., Coletta, C., Papapetropoulos, A., Hellmich, M. R., Radermacher, P., Bouillaud, F. & Szabo, C., Apr 2014, In: British Journal of Pharmacology. 171, 8, p. 2123-2146 24 p.

  Research output: Contribution to journal › Review article › peer-review

  • Hydrogen Sulfide
  • Energy Metabolism
  • Cystathionine
  • Pharmacology
  • Cell Hypoxia
  85 Scopus citations

• The therapeutic potential of cystathionine β-Synthetase/hydrogen sulfide inhibition in cancer

  Hellmich, M. R., Coletta, C., Chao, C. & Szabo, C., Feb 10 2015, In: Antioxidants and Redox Signaling. 22, 5, p. 424-448 25 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cystathionine beta-Synthase
  • Hydrogen Sulfide
  • Cells
  • Tumors
  • Energy Metabolism
  115 Scopus citations