Find Research outputs

Search results

• Article

  A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri atlantic rainforest strain

  Londoño, A. F., Mendell, N. L., Walker, D. H. & Bouyer, D. H., Jun 2019, In: PLoS neglected tropical diseases. 13, 6, e0007054.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Rainforest
  • Spotted Fever Group Rickettsiosis
  • Rickettsia
  • Containment of Biohazards
  • Infection
  2 Scopus citations

• A cluster of cases of rocky mountain spotted fever in an area of Colombia not known to be endemic for this disease

  Londoño, A. F., Arango-Ferreira, C., Acevedo-Gutiérrez, L. Y., Paternina, L. E., Montes, C., Ruiz, I., Labruna, M. B., Díaz, F. J., Walker, D. H. & Rodas, J. D., 2019, In: American Journal of Tropical Medicine and Hygiene. 101, 2, p. 336-342 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Rocky Mountain Spotted Fever
  • Endemic Diseases
  • Colombia
  • Rickettsia rickettsii
  • Molecular Diagnostic Techniques
  2 Scopus citations

• Analysis of health-Care charges in murine typhus: Need for improved clinical recognition and diagnostics for acute disease

  Vohra, R. F., Walker, D. H. & Blanton, L. S., 2018, In: American Journal of Tropical Medicine and Hygiene. 98, 6, p. 1594-1598 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Endemic Flea-Borne Typhus
  • Acute Disease
  • Delivery of Health Care
  • Human Influenza
  • Rickettsia typhi
  5 Scopus citations

• An animal model of a newly emerging human ehrlichiosis

  Saito, T. B., Thirumalapura, N. R., Shelite, T. R., Rockx-Brouwer, D., Popov, V. L. & Walker, D. H., Feb 1 2015, In: Journal of Infectious Diseases. 211, 3, p. 452-461 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia
  • Ehrlichiosis
  • Animal Models
  • Infection
  • Clinical Chemistry
  14 Scopus citations

• Approaches to vaccines against Orientia tsutsugamushi

  Valbuena, G. & Walker, D. H., 2013, In: Frontiers in cellular and infection microbiology. 4, JAN, Article 170.

  Research output: Contribution to journal › Article › peer-review

  • Orientia tsutsugamushi
  • Scrub Typhus
  • Vaccines
  • Pacific Ocean
  • Northern Asia

• A review of the global epidemiology of scrub typhus

  Xu, G., Walker, D. H., Jupiter, D., Melby, P. C. & Arcari, C. M., Nov 3 2017, In: PLoS neglected tropical diseases. 11, 11, e0006062.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Epidemiology
  • Orientia tsutsugamushi
  • Public Health
  • Neglected Diseases
  74 Scopus citations

• Atg5 supports Rickettsia australis infection in macrophages in vitro and in vivo

  Bechelli, J., Vergara, L., Smalley, C., Buzhdygan, T. P., Bender, S., Zhang, W., Liu, Y., Popov, V. L., Wang, J., Garg, N., Hwang, S., Walker, D. H. & Fang, R., Jan 1 2019, In: Infection and immunity. 87, 1, e00651.

  Research output: Contribution to journal › Article › peer-review

  • Spotted Fever Group Rickettsiosis
  • Macrophages
  • In Vitro Techniques
  • Rickettsia
  • Interleukin-1
  9 Scopus citations

• A Tick Vector Transmission Model of Monocytotropic Ehrlichiosis

  Saito, T. B. & Walker, D. H., Sep 15 2015, In: Journal of Infectious Diseases. 212, 6, p. 968-977 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichiosis
  • Ticks
  • Ehrlichia
  • Nymph
  • Larva
  14 Scopus citations

• Burkholderia pseudomallei ΔtonB Δhcp1 live attenuated vaccine strain elicits full protective immunity against aerosolized melioidosis infection

  Khakhum, N., Bharaj, P., Myers, J. N., Tapia, D., Kilgore, P. B., Ross, B. N., Walker, D. H., Endsley, J. J. & Torresa, A. G., Jan 1 2019, In: mSphere. 4, 1, e00570-18.

  Research output: Contribution to journal › Article › peer-review

  • Melioidosis
  • Burkholderia pseudomallei
  • Attenuated Vaccines
  • Burkholderia mallei
  • Immunity
  11 Scopus citations

• Case-Fatality ratio and effectiveness of ribavirin therapy among hospitalized patients in china who had severe fever with thrombocytopenia syndrome

  Liu, W., Lu, Q. B., Cui, N., Li, H., Wang, L. Y., Liu, K., Yang, Z. D., Wang, B. J., Wang, H. Y., Zhang, Y. Y., Zhuang, L., Hu, C. Y., Yuan, C., Fan, X. J., Wang, Z., Zhang, L., Zhang, X. A., Walker, D. H. & Cao, W. C., Nov 1 2013, In: Clinical Infectious Diseases. 57, 9, p. 1292-1299 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Ribavirin
  • Thrombocytopenia
  • China
  • Fever
  • Fatal Outcome
  97 Scopus citations

• Case report: An unusual cutaneous manifestation in a patient with murine typhus

  Blanton, L. S., Lea, A. S., Kelly, B. C. & Walker, D. H., Dec 2015, In: American Journal of Tropical Medicine and Hygiene. 93, 6, p. 1164-1167 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Endemic Flea-Borne Typhus
  • Skin Manifestations
  • Rickettsia typhi
  • Siphonaptera
  • Mites
  9 Scopus citations

• CD8⁺T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection

  Xu, G., Mendell, N. L., Liang, Y., Shelite, T. R., Goez-Rivillas, Y., Soong, L., Bouyer, D. H. & Walker, D. H., Jul 19 2017, In: PLoS neglected tropical diseases. 11, 7, e0005763.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Orientia tsutsugamushi
  • T-Lymphocytes
  • Bacterial Load
  • Immunity
  15 Scopus citations

• Compartmentalized, functional role of angiogenin during spotted fever group rickettsia-induced endothelial barrier dysfunction: Evidence of possible mediation by host tRNA-derived small noncoding RNAs

  Gong, B., Lee, Y. S., Lee, I., Shelite, T. R., Kunkeaw, N., Xu, G., Lee, K., Jeon, S. H., Johnson, B. H., Chang, Q., Ha, T., Mendell, N. L., Cheng, X., Bouyer, D. H., Boor, P. J., Ksiazek, T. G. & Walker, D. H., Jun 23 2013, In: BMC Infectious Diseases. 13, 1, 285.

  Research output: Contribution to journal › Article › peer-review

  • angiogenin
  • Spotted Fever Group Rickettsiosis
  • Rickettsia
  • Small Untranslated RNA
  • Transfer RNA
  27 Scopus citations

• Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium

  Fang, R., Ismail, N. & Walker, D. H., Jul 2012, In: American Journal of Pathology. 181, 1, p. 185-195 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Natural Killer Cells
  • Endothelium
  • Bacteria
  • Rickettsia
  • Interferons
  21 Scopus citations

• Ehrlichia chaffeensis outer membrane protein 1-specific human antibody-mediated immunity is defined by intracellular TRIM21-dependent innate immune activation and extracellular neutralization

  Velayutham, T. S., Kumar, S., Zhang, X., Kose, N., Walker, D. H., Winslow, G., Crowe, J. E. & McBride, J. W., Dec 1 2019, In: Infection and immunity. 87, 12, e00383-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ehrlichia chaffeensis
  • Ehrlichia
  • Membrane Proteins
  • Immunity
  • Autophagy
  3 Scopus citations

• Evaluation of Burkholderia mallei ΔtonB Δhcp1 (CLH001) as a live attenuated vaccine in murine models of glanders and melioidosis

  Khakhum, N., Bharaj, P., Myers, J. N., Tapia, D., Walker, D. H., Endsley, J. J. & Torres, A. G., Jul 2019, In: PLoS neglected tropical diseases. 13, 7, e0007578.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Burkholderia mallei
  • Glanders
  • Melioidosis
  • Attenuated Vaccines
  • Humoral Immunity
  5 Scopus citations

• Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses

  Gong, B., Shelite, T., Mei, F. C., Ha, T., Hu, Y., Xu, G., Chang, Q., Wakamiya, M., Ksiazek, T. G., Boor, P. J., Bouyer, D. H., Popov, V. L., Chen, J., Walker, D. H. & Cheng, X., Nov 26 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 48, p. 19615-19620 6 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile
  • Spotted Fever Group Rickettsiosis
  • Bioterrorism
  • Bacterial Adhesion
  • Host-Pathogen Interactions
  48 Scopus citations

• Fever and rash after a safari

  Damavandy, A. A., Rojek, N. W., Dugan, E. M., Walker, D. & Norton, S. A., Jan 1 2015, In: Journal of the American Academy of Dermatology. 72, 1, p. e5-e6

  Research output: Contribution to journal › Article › peer-review

• Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium

  Sahni, A., Patel, J., Narra, H. P., Schroeder, C. L. C., Walker, D. H. & Sahni, S. K., Aug 2017, In: PloS one. 12, 8, e0183181.

  Research output: Contribution to journal › Article › peer-review

  • fibroblast growth factor receptor 1
  • Spotted Fever Group Rickettsiosis
  • Endothelial cells
  • Receptor, Fibroblast Growth Factor, Type 1
  • fibroblast growth factor receptors
  10 Scopus citations

• Genotypic characterization of Orientia tsutsugamushi from patients in two geographical locations in Sri Lanka

  Premaratna, R., Blanton, L. S., Samaraweera, D. N., de Silva, G. N. N., Chandrasena, N. T. G. A., Walker, D. H. & de Silva, H. J., Jan 13 2017, In: BMC Infectious Diseases. 17, 1, 67.

  Research output: Contribution to journal › Article › peer-review

  • Orientia tsutsugamushi
  • Sri Lanka
  • Genotype
  • Real-Time Polymerase Chain Reaction
  • Fever
  9 Scopus citations

• Immune Mediators of protective and pathogenic immune responses in patients with mild and fatal human monocytotropic ehrlichiosis

  Ismail, N., Walker, D. H., Ghose, P. & Tang, Y. W., May 21 2012, In: BMC Immunology. 13, 26.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichiosis
  • Chemokines
  • Septic Shock
  • Interleukin-1
  • Interleukin-10
  11 Scopus citations

• Mechanisms of immunity to rickettsia and implications for vaccine development

  Walker, D., Jan 1 2017, In: Revista Colombiana de Ciencias Pecuarias. 30, p. 262-263 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Spotted Fever Group Rickettsiosis
  • Rickettsia
  • vaccine development
  • fever
  • immunity

• Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus

  Yun, N. E., Seregin, A. V., Walker, D. H., Popov, V. L., Walker, A. G., Smith, J. N., Miller, M., de la Torre, J. C., Smith, J. K., Borisevich, V., Fair, J. N., Wauquier, N., Grant, D. S., Bockarie, B., Bente, D. & Paessler, S., 2013, In: Journal of virology. 87, 19, p. 10908-10911 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Lassa virus fever
  • Lassa virus
  • Lassa Fever
  • Arenavirus
  • Western Africa
  33 Scopus citations

• Murine models of scrub typhus associated with host control of Orientia tsutsugamushi infection

  Mendell, N. L., Bouyer, D. H. & Walker, D. H., Mar 10 2017, In: PLoS neglected tropical diseases. 11, 3, e0005453.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Orientia tsutsugamushi
  • Infection
  • Trombiculidae
  • Heterologous Immunity
  11 Scopus citations

• Pathogenesis of Rickettsial Diseases: Pathogenic and Immune Mechanisms of an Endotheliotropic Infection

  Sahni, A., Fang, R., Sahni, S. K. & Walker, D. H., 2019, In: Annual Review of Pathology: Mechanisms of Disease. 14, p. 127-152 26 p.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia Infections
  • Actins
  • Endothelial Cells
  • Infection
  • Rickettsia
  12 Scopus citations

• Permissive and protective roles for neutrophils in leishmaniasis

  Carlsen, E. D., Liang, Y., Shelite, T. R., Walker, D. H., Melby, P. C. & Soong, L., Nov 2015, In: Clinical and Experimental Immunology. 182, 2, p. 109-18 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmaniasis
  • Parasites
  • Neutrophils
  • Leishmania
  • Infection
  32 Scopus citations

• Person-to-person transmission of severe fever with thrombocytopenia syndrome virus

  Liu, Y., Li, Q., Hu, W., Wu, J., Weng, Y., Mei, L., Walker, D. H., Ren, J., Wang, Y. & Yu, X. J., Feb 1 2012, In: Vector-Borne and Zoonotic Diseases. 12, 2, p. 156-160 5 p.

  Research output: Contribution to journal › Article › peer-review

  • SFTS phlebovirus
  • Thrombocytopenia
  • Fever
  • Viruses
  • Phlebovirus
  154 Scopus citations

• Recombinant Ehrlichia P29 protein induces a protective immune response in a mouse model of ehrlichiosis

  Thirumalapura, N. R., Crocquet-Valdes, P. A., Saito, T. B., Thomas, S., McBride, J. W. & Walker, D. H., Dec 5 2013, In: Vaccine. 31, 50, p. 5960-5967 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia
  • ehrlichiosis
  • Ehrlichiosis
  • Tandem Repeat Sequences
  • Ehrlichia chaffeensis
  4 Scopus citations

• Reemergence of murine typhus in galveston, texas, usa, 2013

  Blanton, L. S., Vohra, R. F., Bouyer, D. H. & Walker, D. H., 2015, In: Emerging infectious diseases. 21, 3, p. 484-486 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Endemic Flea-Borne Typhus
  • Rickettsia typhi
  • Public Health
  • Physicians
  24 Scopus citations

• Rickettsiae Within the Fleas of Feral Cats in Galveston, Texas

  Blanton, L. S., Vohra, R. F., Fistein, L., Quade, B., Walker, D. H. & Bouyer, D. H., Sep 2019, In: Vector-Borne and Zoonotic Diseases. 19, 9, p. 647-651 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Ctenocephalides
  • feral
  • Siphonaptera
  • Rickettsia typhi
  • Endemic Flea-Borne Typhus
  7 Scopus citations

• Rickettsia massiliae and rickettsia conorii israeli spotted fever strain differentially regulate endothelial cell responses

  Bechelli, J., Smalley, C., Milhano, N., Walker, D. H. & Fang, R., Sep 22 2015, In: PloS one. 10, 9, e0138830.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia massiliae
  • Rickettsia conorii
  • Spotted Fever Group Rickettsiosis
  • Endothelial cells
  • Rickettsia
  5 Scopus citations

• Simple method to differentiate among Rickettsia species

  Peniche-Lara, G., Zavala-Velazquez, J., Dzul-Rosado, K., Walker, D. H. & Zavala-Castro, J., Apr 2013, In: Journal of Molecular Microbiology and Biotechnology. 23, 3, p. 203-208 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia
  • Polymerase Chain Reaction
  • Ecosystem
  • Enzymes
  • Restriction Fragment Length Polymorphisms
  8 Scopus citations

• Spotted fever group Rickettsia in small rodents from areas of low endemicity for Brazilian spotted fever in the Eastern Region of Minas Gerais State, Brazil

  Milagres, B. S., Padilha, A. F., Montandon, C. E., Freitas, R. N., Pacheco, R., Walker, D. H., Labruna, M. B., Mafra, C. L. & Galvão, M. A. M., May 2013, In: American Journal of Tropical Medicine and Hygiene. 88, 5, p. 937-939 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Rocky Mountain Spotted Fever
  • Spotted Fever Group Rickettsiosis
  • Rickettsia
  • Brazil
  • Rodentia
  7 Scopus citations

• Susceptibility of Rickettsia rickettsii to Tigecycline in a Cell Culture Assay and Animal Model for Rocky Mountain Spotted Fever

  Blanton, L. S., Wilson, N. M., Quade, B. R. & Walker, D. H., 2019, In: American Journal of Tropical Medicine and Hygiene. 101, 5, p. 1091-1095 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia rickettsii
  • Rocky Mountain Spotted Fever
  • Tigecycline
  • Cell Culture Techniques
  • Animal Models
  2 Scopus citations

• Systemic treatment with cpg-b after sublethal rickettsial infection induces mouse death through indoleamine 2,3-dioxygenase (ido)

  Xin, L., Shelite, T. R., Gong, B., Mendell, N. L., Soong, L., Fang, R. & Walker, D. H., Mar 28 2012, In: PloS one. 7, 3, e34062.

  Research output: Contribution to journal › Article › peer-review

  • indoleamine 2,3-dioxygenase
  • rickettsial diseases
  • T-cells
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Dendritic Cells
  16 Scopus citations

• The role of Rhipicephalus sanguineus sensu lato saliva in the dissemination of Rickettsia conorii in C3H/HeJ mice

  Milhano, N., Saito, T. B., Bechelli, J., Fang, R., Vilhena, M., De Sousa, R. & Walker, D. H., Sep 1 2015, In: Medical and Veterinary Entomology. 29, 3, p. 225-229 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia conorii
  • Rhipicephalus sanguineus
  • tick
  • saliva
  • Ticks
  9 Scopus citations

• Time to Worry about Anthrax Again

  Keim, P. S., Walker, D. H. & Zilinskas, R. A., Mar 14 2017, In: Scientific American. 316, 4, p. 70-75 6 p.

  Research output: Contribution to journal › Article › peer-review
  1 Scopus citations

• Vector Tick Transmission Model of Spotted Fever Rickettsiosis

  Saito, T. B., Bechelli, J., Smalley, C., Karim, S. & Walker, D. H., Jan 2019, In: American Journal of Pathology. 189, 1, p. 115-123 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Spotted Fever Group Rickettsiosis
  • Ticks
  • Infection
  • Rickettsia Infections
  • Bacterial Load
  4 Scopus citations

• Whole-genome sequence of rickettsia parkeri strain atlantic rainforest, isolated from a colombian tick

  Londoño, A. F., Mendell, N. L., Valbuena, G. A., Routh, A. L., Wood, T. G., Widen, S. G., Rodas, J. D., Walker, D. H. & Bouyer, D. H., Sep 26 2019, In: Microbiology Resource Announcements. 8, 39, e00684-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Rainforest
  • Rickettsia
  • Ticks
  • Genome
  • Colombia
• Chapter

  Chlamydial, Mycoplasmal, Rickettsial, and Ehrlichial Diseases

  Walker, D. H., 2018, Pulmonary Pathology: A Volume in the Series: Foundations in Diagnostic Pathology. Elsevier Inc., p. 315-326 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Human ehrlichioses and rickettsioses in Cameroon

  Ndip, LN., Ndip, R., Walker, D. H. & McBride, J. W., 2012, Current Topics in Tropical Medicine. p. 25-42

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Rickettsia, orientia, ehrlichia, anaplasma and coxiella: Typhus; spotted fevers; scrub typhus; ehrlichioses; Q fever

  Walker, D. & Yu, X. J., Jul 23 2012, Medical Microbiology: Eighteenth Edition. Elsevier Inc., p. 390-399 10 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  1 Scopus citations

• Rocky mountain spotted fever and other rickettsioses

  Walker, D., May 15 2012, Schaechter's Mechanisms of Microbial Disease: Fifth Edition. Wolters Kluwer Health Adis (ESP), p. 301-307 7 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Rocky mountain spotted fever and other rickettsioses

  Walker, D., Jul 8 2013, Schaechter's Mechanisms of Microbial Disease: Fifth Edition. Wolters Kluwer Health Adis (ESP), p. 301-307 7 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• Comment/debate

  Seek and you shall find — Unknown pathogens?

  Vasilakis, N. & Walker, D. H., May 30 2019, In: New England Journal of Medicine. 380, 22, p. 2174-2175 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
• Letter

  Letters to the editor

  Walker, D., Mar 2012, In: Archives of Pathology and Laboratory Medicine. 136, 3, p. 235-236 2 p.

  Research output: Contribution to journal › Letter › peer-review
• Review article

  Approaches to vaccines against Orientia tsutsugamushi

  Valbuena, G. & Walker, D. H., 2013, In: Frontiers in Cellular and Infection Microbiology. 4, JAN, Article 170.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Orientia tsutsugamushi
  • Scrub Typhus
  • Vaccines
  • Pacific Ocean
  • Northern Asia
  43 Scopus citations

• Flea-Borne Rickettsioses and Rickettsiae

  Blanton, L. S. & Walker, D. H., Jan 2017, In: American Journal of Tropical Medicine and Hygiene. 96, 1, p. 53-56 4 p.

  Research output: Contribution to journal › Review article › peer-review

  • Siphonaptera
  • Rickettsia felis
  • Rickettsia typhi
  • Ecology
  • Uncertainty
  33 Scopus citations

• New insight into immunity and immunopathology of Rickettsial diseases

  Mansueto, P., Vitale, G., Cascio, A., Seidita, A., Pepe, I., Carroccio, A., Di Rosa, S., Rini, G. B., Cillari, E. & Walker, D. H., 2012, In: Clinical and Developmental Immunology. 2012, 967852.

  Research output: Contribution to journal › Review article › peer-review

  • Rickettsia Infections
  • Rickettsia
  • Virulence
  • Immunity
  • Anaplasma
  83 Scopus citations

• Pathogenesis of lassa fever

  Yun, N. E. & Walker, D. H., Oct 2012, In: Viruses. 4, 10, p. 2031-2048 18 p.

  Research output: Contribution to journal › Review article › peer-review

  • Lassa Fever
  • Lassa virus
  • Old World Arenaviruses
  • Arenaviridae
  • Vaccines
  89 Scopus citations