Find Research outputs

Search results

• Article

  2′-O methylation of internal adenosine by flavivirus NS5 methyltransferase

  Dong, H., Chang, D. C., Hua, M. H. C., Lim, S. P., Chionh, Y. H., Hia, F., Lee, Y. H., Kukkaro, P., Lok, S. M., Dedon, P. C. & Shi, P. Y., Apr 2012, In: PLoS pathogens. 8, 4, e1002642.

  Research output: Contribution to journal › Article › peer-review

  • Flavivirus
  • Methyltransferases
  • Adenosine
  • Methylation
  • 2'-O-methyladenosine
  85 Scopus citations

• A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine

  Yang, Y., Shan, C., Zou, J., Muruato, A. E., Bruno, D. N., de Almeida Medeiros Daniele, B., Vasconcelos, P. F. C., Rossi, S. L., Weaver, S. C., Xie, X. & Shi, P. Y., Mar 1 2017, In: EBioMedicine. 17, p. 145-156 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Inactivated Vaccines
  • Viruses
  • Zika Virus
  • Complementary DNA
  • Clone Cells
  28 Scopus citations

• A chimeric dengue virus vaccine using japanese encephalitis virus vaccine strain SA14-14-2 as backbone is immunogenic and protective against either parental virus in mice and nonhuman primates

  Li, X. F., Deng, Y. Q., Yang, H. Q., Zhao, H., Jiang, T., Yu, X. D., Li, S. H., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, Y., Ma, J., Yu, Y. X., Liu, Z. Y., Li, Y. H., Qin, E. D., Shi, P. Y. & Qin, C. F., Dec 2013, In: Journal of virology. 87, 24, p. 13694-13705 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Vaccines
  • Japanese encephalitis virus
  • Japanese Encephalitis Virus
  • Dengue virus
  • Dengue Virus
  43 Scopus citations

• A conserved pocket in the dengue virus polymerase identified through fragment-based screening

  Noble, C. G., Lim, S. P., Arora, R., Yokokawa, F., Nilar, S., Seh, C. C., Wright, S. K., Benson, T. E., Smith, P. W. & Shi, P. Y., Apr 15 2016, In: Journal of Biological Chemistry. 291, 16, p. 8541-8548 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Viruses
  • Screening
  • Serogroup
  • Enzyme inhibition
  31 Scopus citations

• A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities

  Lim, S. P., Koh, J. H. K., Seh, C. C., Liew, C. W., Davidson, A. D., Chua, L. S., Chandrasekaran, R., Cornvik, T. C., Shi, P. Y. & Lescar, J., Oct 25 2013, In: Journal of Biological Chemistry. 288, 43, p. 31105-31114 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Viral Structural Proteins
  • RNA Replicase
  • Crystal structure
  • Dengue Virus
  • Viruses
  55 Scopus citations

• Adenosine analog NITD008 is a potent inhibitor of zika virus

  Deng, Y. Q., Zhang, N. N., Li, C. F., Tian, M., Hao, J. N., Xie, X. P., Shi, P. Y. & Qin, C. F., Oct 1 2016, In: Open Forum Infectious Diseases. 3, 4

  Research output: Contribution to journal › Article › peer-review

  • NITD008
  • Zika Virus
  • Adenosine
  • Antiviral Agents
  • Viremia
  82 Scopus citations

• Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments

  Du, S., Liu, Y., Liu, J., Zhao, J., Champagne, C., Tong, L., Zhang, R., Zhang, F., Qin, C. F., Ma, P., Chen, C. H., Liang, G., Liu, Q., Shi, P. Y., Cazelles, B., Wang, P., Tian, H. & Cheng, G., Dec 1 2019, In: Nature communications. 10, 1, 1324.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Aedes
  • viruses
  • Viruses
  • Breeding
  12 Scopus citations

• A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

  Shan, C., Muruato, A. E., Nunes, B. T. D., Luo, H., Xie, X., Medeiros, D. B. A., Wakamiya, M., Tesh, R. B., Barrett, A. D., Wang, T., Weaver, S. C., Vasconcelos, P. F. C., Rossi, S. L. & Shi, P. Y., Jun 1 2017, In: Nature Medicine. 23, 6, p. 763-767 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Viruses
  • Immunity
  • Vaccines
  • Epidemics
  159 Scopus citations

• A multidimensional platform for the purification of non-coding RNA species

  Chionh, Y. H., Ho, C. H., Pruksakorn, D., Ramesh Babu, I., Ng, C. S., Hia, F., McBee, M. E., Su, D., Pang, Y. L. J., Gu, C., Dong, H., Prestwich, E. G., Shi, P. Y., Preiser, P. R., Alonso, S. & Dedon, P. C., Sep 2013, In: Nucleic acids research. 41, 17, p. e168

  Research output: Contribution to journal › Article › peer-review

  • Untranslated RNA
  • Ribonucleosides
  • Viral Genome
  • RNA
  • Plasmodium
  28 Scopus citations

• A Multiplex Microsphere Immunoassay for Zika Virus Diagnosis

  Wong, S. J., Furuya, A., Zou, J., Xie, X., Dupuis, A. P., Kramer, L. D. & Shi, P. Y., Feb 1 2017, In: EBioMedicine. 16, p. 136-140 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Microspheres
  • Viruses
  • Immunoassay
  • Zika Virus Infection
  58 Scopus citations

• An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses

  Li, G., Adam, A., Luo, H., Shan, C., Cao, Z., Fontes-Garfias, C. R., Sarathy, V. V., Teleki, C., Winkelmann, E. R., Liang, Y., Sun, J., Bourne, N., Barrett, A. D. T., Shi, P. Y. & Wang, T., Dec 1 2019, In: npj Vaccines. 4, 1, 48.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Mutant Proteins
  • Antiviral Agents
  • Attenuated Vaccines
  • Flavivirus
  4 Scopus citations

• An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

  Xia, H., Luo, H., Shan, C., Muruato, A. E., Nunes, B. T. D., Medeiros, D. B. A., Zou, J., Xie, X., Giraldo, M. I., Vasconcelos, P. F. C., Weaver, S. C., Wang, T., Rajsbaum, R. & Shi, P. Y., Dec 1 2018, In: Nature communications. 9, 1, 414.

  Research output: Contribution to journal › Article › peer-review

  • interferon
  • Zika Virus
  • viruses
  • Viruses
  • mutations
  95 Scopus citations

• An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors

  Shan, C., Xie, X., Muruato, A. E., Rossi, S. L., Roundy, C. M., Azar, S. R., Yang, Y., Tesh, R. B., Bourne, N., Barrett, A. D., Vasilakis, N., Weaver, S. C. & Shi, P. Y., Jun 8 2016, In: Cell Host and Microbe. 19, 6, p. 891-900 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Culicidae
  • Virulence
  • Antiviral Agents
  • Complementary DNA
  162 Scopus citations

• Anti-Zika virus RNAi in neural progenitor cells

  Xie, X. & Shi, P. Y., Apr 1 2019, In: Cell Research. 29, 4, p. 261-262 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Scopus citations

• A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients

  Shan, C., Xie, X., Ren, P., Loeffelholz, M. J., Yang, Y., Furuya, A., Dupuis, A. P., Kramer, L. D., Wong, S. J. & Shi, P. Y., Mar 1 2017, In: EBioMedicine. 17, p. 157-162 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Viruses
  • Assays
  • Neutralizing Antibodies
  • Zika Virus Infection
  • Neutralization Tests
  45 Scopus citations

• A Single Amino Acid Substitution in the Core Protein of West Nile Virus Increases Resistance to Acidotropic Compounds

  Martín-Acebes, M. A., Blázquez, A. B., de Oya, N. J., Escribano-Romero, E., Shi, P. Y. & Saiz, J. C., Jul 18 2013, In: PloS one. 8, 7, e69479.

  Research output: Contribution to journal › Article › peer-review

  • West Nile virus
  • Viruses
  • Amino Acid Substitution
  • amino acid substitution
  • Substitution reactions
  10 Scopus citations

• A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

  Shan, C., Muruato, A. E., Jagger, B. W., Richner, J., Nunes, B. T. D., Medeiros, D. B. A., Xie, X., Nunes, J. G. C., Morabito, K. M., Kong, W. P., Pierson, T. C., Barrett, A. D., Weaver, S. C., Rossi, S. L., Vasconcelos, P. F. C., Graham, B. S., Diamond, M. S. & Shi, P. Y., Dec 1 2017, In: Nature communications. 8, 1, 676.

  Research output: Contribution to journal › Article › peer-review

  • vaccines
  • testes
  • pregnancy
  • Zika Virus
  • Attenuated Vaccines
  80 Scopus citations

• A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission

  Xie, X., Kum, D. B., Xia, H., Luo, H., Shan, C., Zou, J., Muruato, A. E., Medeiros, D. B. A., Nunes, B. T. D., Dallmeier, K., Rossi, S. L., Weaver, S. C., Neyts, J., Wang, T., Vasconcelos, P. F. C. & Shi, P. Y., Oct 10 2018, In: Cell Host and Microbe. 24, 4, p. 487-499.e5

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Vaccines
  • Infection
  • Attenuated Vaccines
  • Capsid Proteins
  23 Scopus citations

• A single-dose plasmid-launched live-attenuated Zika vaccine induces protective immunity

  Zou, J., Xie, X., Luo, H., Shan, C., Muruato, A. E., Weaver, S. C., Wang, T. & Shi, P. Y., Oct 2018, In: EBioMedicine. 36, p. 92-102 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Attenuated Vaccines
  • Immunity
  • Plasmids
  • Vaccines
  • DNA
  21 Scopus citations

• A single mutation in the prM protein of Zika virus contributes to fetal microcephaly

  Yuan, L., Huang, X. Y., Liu, Z. Y., Zhang, F., Zhu, X. L., Yu, J. Y., Ji, X., Xu, Y. P., Li, G., Li, C., Wang, H. J., Deng, Y. Q., Wu, M., Cheng, M. L., Ye, Q., Xie, D. Y., Li, X. F., Wang, X., Shi, W., Hu, B. & 3 others, Shi, P. Y., Xu, Z. & Qin, C. F., Nov 17 2017, In: Science. 358, 6365, p. 933-936 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Microcephaly
  • Mutation
  • Epidemics
  • Polynesia
  215 Scopus citations

• A survey of core replacements in indole-based HIV-1 attachment inhibitors

  Wang, T., Wallace, O. B., Zhang, Z., Fang, H., Yang, Z., Robinson, B. A., Spicer, T. P., Gong, Y. F., Blair, W. S., Shi, P. Y., Lin, P. F., Deshpande, M., Meanwell, N. A. & Kadow, J. F., Jun 1 2019, In: Bioorganic and Medicinal Chemistry Letters. 29, 11, p. 1423-1429 7 p.

  Research output: Contribution to journal › Article › peer-review

  • indole
  • HIV-1
  • Antiviral Agents
  • quinoline
  • naphthalene
  6 Scopus citations

• Axl promotes zika virus entry and modulates the antiviral state of human sertoli cells

  Strange, D. P., Jiyarom, B., Zarandi, N. P., Xie, X., Baker, C., Sadri-Ardekani, H., Shi, P. Y. & Verma, S., Jul 1 2019, In: mBio. 10, 4, e01372-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Virus Internalization
  • Sertoli Cells
  • Antiviral Agents
  • Zika Virus Infection
  20 Scopus citations

• A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein

  Li, A., Yu, J., Lu, M., Ma, Y., Attia, Z., Shan, C., Xue, M., Liang, X., Craig, K., Makadiya, N., He, J. J., Jennings, R., Shi, P. Y., Peeples, M. E., Liu, S. L., Boyaka, P. N. & Li, J., Dec 1 2018, In: Nature communications. 9, 1, 3067.

  Research output: Contribution to journal › Article › peer-review

  • vaccines
  • Zika Virus
  • Polyproteins
  • viruses
  • Viruses
  27 Scopus citations

• Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

  Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., Yoon, K. J., Jeang, W., Lin, L., Li, Y., Thakor, J., Berg, D. A., Zhang, C., Kang, E., Chickering, M., Nauen, D. & 10 others, Ho, C. Y., Wen, Z., Christian, K. M., Shi, P. Y., Maher, B. J., Wu, H., Jin, P., Tang, H., Song, H. & Ming, G. L., May 19 2016, In: Cell. 165, 5, p. 1238-1254 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Organoids
  • Bioreactors
  • Viruses
  • Brain
  783 Scopus citations

• Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Primates

  Li, X. F., Dong, H. L., Huang, X. Y., Qiu, Y. F., Wang, H. J., Deng, Y. Q., Zhang, N. N., Ye, Q., Zhao, H., Liu, Z. Y., Fan, H., An, X. P., Sun, S. H., Gao, B., Fa, Y. Z., Tong, Y. G., Zhang, F. C., Gao, G. F., Cao, W. C., Shi, P. Y. & 1 others, Qin, C. F., Oct 1 2016, In: EBioMedicine. 12, p. 170-177 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Viruses
  • Primates
  • Animals
  • Spleen
  86 Scopus citations

• Characterization of a candidate tetravalent vaccine based on 2’-O-methyltransferase mutants

  Züst, R., Li, S. H., Xie, X., Velumani, S., Chng, M., Toh, Y. X., Zou, J., Dong, H., Shan, C., Pang, J., Qin, C. F., Newell, E. W., Shi, P. Y. & Fink, K., Jan 2018, In: PloS one. 13, 1, e0189262.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • Viruses
  • Methyltransferases
  • methyltransferases
  4 Scopus citations

• Conformational flexibility of the dengue virus RNA-Dependent RNA polymerase revealed by a complex with an inhibitor

  Noble, C. G., Lim, S. P., Chen, Y. L., Liew, C. W., Yap, L., Lescar, J. & Shi, P. Y., May 2013, In: Journal of virology. 87, 9, p. 5291-5295 5 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • Dengue virus
  • RNA-directed RNA polymerase
  • Dengue Virus
  • Serogroup
  70 Scopus citations

• Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: Implication for a trans mechanism of VPg uridylylation

  Chen, C., Wang, Y., Shan, C., Sun, Y., Xu, P., Zhou, H., Yang, C., Shi, P. Y., Rao, Z., Zhang, B. & Lou, Z., May 1 2013, In: Journal of virology. 87, 10, p. 5755-5768 14 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • RNA-directed RNA polymerase
  • Enterovirus
  • crystal structure
  • Picornaviridae
  45 Scopus citations

• Dengue NS2A Protein Orchestrates Virus Assembly

  Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In: Cell Host and Microbe. 26, 5, p. 606-622.e8

  Research output: Contribution to journal › Article › peer-review

  • Virus Assembly
  • Dengue
  • Virion
  • Polyproteins
  • Nucleocapsid
  17 Scopus citations

• Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission

  Pompon, J., Manuel, M., Ng, G. K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S. S., Ooi, E. E., Missé, D., Shi, P. Y. & Garcia-Blanco, M. A., Jul 2017, In: PLoS pathogens. 13, 7, e1006535.

  Research output: Contribution to journal › Article › peer-review

  • Dengue
  • Culicidae
  • Salivary Glands
  • Immunity
  • RNA
  47 Scopus citations

• Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5- b]pyridine-7,3′-indoline]-2′,5(3 H)-dione Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection

  Xu, J., Xie, X., Ye, N., Zou, J., Chen, H., White, M. A., Shi, P. Y. & Zhou, J., Sep 12 2019, In: Journal of medicinal chemistry. 62, 17, p. 7941-7960 20 p.

  Research output: Contribution to journal › Article › peer-review

  • indoline-2,3-dione
  • pyridine
  • Dengue Virus
  • indoline
  • Virus Diseases
  10 Scopus citations

• Development and characterization of a stable eGFP enterovirus 71 for antiviral screening

  Shang, B., Deng, C., Ye, H., Xu, W., Yuan, Z., Shi, P. Y. & Zhang, B., Feb 2013, In: Antiviral research. 97, 2, p. 198-205 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Enterovirus
  • Antiviral Agents
  • Viruses
  • Vero Cells
  • Complementary DNA
  33 Scopus citations

• Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

  Li, X. F., Dong, H. L., Wang, H. J., Huang, X. Y., Qiu, Y. F., Ji, X., Ye, Q., Li, C., Liu, Y., Deng, Y. Q., Jiang, T., Cheng, G., Zhang, F. C., Davidson, A. D., Song, Y. J., Shi, P. Y. & Qin, C. F., Dec 1 2018, In: Nature communications. 9, 1, 673.

  Research output: Contribution to journal › Article › peer-review

  • vaccines
  • Zika Virus
  • Flavivirus
  • Attenuated Vaccines
  • viruses
  45 Scopus citations

• Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

  Yokokawa, F., Nilar, S., Noble, C. G., Lim, S. P., Rao, R., Tania, S., Wang, G., Lee, G., Hunziker, J., Karuna, R., Manjunatha, U., Shi, P-Y. & Smith, P. W., Apr 28 2016, In: Journal of Medicinal Chemistry. 59, 8, p. 3935-3952 18 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • Drug Design
  • Dengue
  • Viral RNA
  • Serogroup
  47 Scopus citations

• Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase

  Sun, Y., Wang, Y., Shan, C., Chen, C., Xu, P., Song, M., Zhou, H., Yang, C., Xu, W., Shi, P. Y., Zhang, B. & Lou, Z., Dec 2012, In: Journal of virology. 86, 24, p. 13662-13671 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Enterovirus
  • Picornaviridae
  • RNA
  • mutation
  • Mutation
  32 Scopus citations

• Evaluation of a novel reporter virus neutralization test for serological diagnosis of Zika and Dengue virus infection

  Shan, C., Ortiz, D. A., Yang, Y., Wong, S. J., Kramer, L. D., Shi, P. Y., Loeffelholz, M. J. & Ren, P., Oct 2017, In: Journal of Clinical Microbiology. 55, 10, p. 3028-3036 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus Infection
  • Zika Virus
  • Neutralization Tests
  • Dengue Virus
  • Viruses
  24 Scopus citations

• Evasion of early innate immune response by 2′-O-methylation of dengue genomic RNA

  Chang, D. C., Hoang, L. T., Mohamed Naim, A. N., Dong, H., Schreiber, M. J., Hibberd, M. L., Tan, M. J. A. & Shi, P. Y., Dec 1 2016, In: Virology. 499, p. 259-266 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Dengue
  • Innate Immunity
  • Methylation
  • RNA
  18 Scopus citations

• Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes

  Liu, Y., Liu, J., Du, S., Shan, C., Nie, K., Zhang, R., Li, X. F., Zhang, R., Wang, T., Qin, C. F., Wang, P., Shi, P. Y. & Cheng, G., May 25 2017, In: Nature. 545, 7655, p. 482-486 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Aedes
  • Culicidae
  • Proteins
  • Epidemics
  193 Scopus citations

• Flavivirus Entry Inhibitors

  Wang, Q. Y. & Shi, P-Y., Jan 8 2016, In: ACS Infectious Diseases. 1, 9, p. 428-434 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Flavivirus
  • Flavivirus Infections
  • Yellow fever virus
  • Tick-Borne Encephalitis Viruses
  • Viral Envelope Proteins
  14 Scopus citations

• Fragile X mental retardation protein is a zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

  Soto-Acosta, R., Xie, X., Shan, C., Baker, C. K., Shi, P. Y., Rossi, S. L., Garcia-Blanco, M. A. & Bradrick, S., Dec 1 2018, In: eLife. 7, e39023.

  Research output: Contribution to journal › Article › peer-review

  • Fragile X Mental Retardation Protein
  • Zika Virus
  • Viruses
  • RNA
  • Zika Virus Infection
  17 Scopus citations

• Functional Analysis of Glycosylation of Zika Virus Envelope Protein

  Fontes-Garfias, C. R., Shan, C., Luo, H., Muruato, A. E., Medeiros, D. B. A., Mays, E., Xie, X., Zou, J., Roundy, C. M., Wakamiya, M., Rossi, S. L., Wang, T., Weaver, S. C. & Shi, P. Y., Oct 31 2017, In: Cell Reports. 21, 5, p. 1180-1190 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycosylation
  • Viral Envelope Proteins
  • Zika Virus
  • Functional analysis
  • Viruses
  62 Scopus citations

• Generation and characterization of West Nile pseudo-infectious reporter virus for antiviral screening

  Zhang, H. L., Ye, H. Q., Deng, C. L., Liu, S. Q., Shi, P. Y., Qin, C. F., Yuan, Z. M. & Zhang, B., May 1 2017, In: Antiviral research. 141, p. 38-47 10 p.

  Research output: Contribution to journal › Article › peer-review

  • West Nile virus
  • Antiviral Agents
  • Viruses
  • Containment of Biohazards
  • Luciferases
  11 Scopus citations

• Generation of a recombinant West Nile virus stably expressing the Gaussia luciferase for neutralization assay

  Zhang, P. T., Shan, C., Li, X. D., Liu, S. Q., Deng, C. L., Ye, H. Q., Shang, B. D., Shi, P. Y., Lv, M., Shen, B. F., Qin, C. F. & Zhang, B., Jan 4 2016, In: Virus Research. 211, p. 17-24 8 p.

  Research output: Contribution to journal › Article › peer-review

  • West Nile virus
  • Luciferases
  • Neutralizing Antibodies
  • West Nile Virus Vaccines
  • Antiviral Agents
  13 Scopus citations

• Genetic and biochemical characterizations of Zika virus NS2A protein

  Zhang, X., Xie, X., Zou, J., Xia, H., Shan, C., Chen, X. & Shi, P. Y., Jan 1 2019, In: Emerging Microbes and Infections. 8, 1, p. 585-602 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Virion
  • Molecular Biology
  • Viral Nonstructural Proteins
  • Proteins
  13 Scopus citations

• Genetic stability of live-attenuated Zika vaccine candidates

  Muruato, A. E., Shan, C., Fontes-Garfias, C. R., Liu, Y., Cao, Z., Gao, Q., Weaver, S. C. & Shi, P. Y., Nov 2019, In: Antiviral research. 171, 104596.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Attenuated Vaccines
  • Zika Virus Infection
  • Aedes
  • Vero Cells
  4 Scopus citations

• High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells

  Gong, D., Zhang, T. H., Zhao, D., Du, Y., Chapa, T. J., Shi, Y., Wang, L., Contreras, D., Zeng, G., Shi, P. Y., Wu, T. T., Arumugaswami, V. & Sun, R., Mar 23 2018, In: iScience. 1, p. 97-111 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Culicidae
  • Glycosylation
  • Zika Virus Infection
  • Infection
  16 Scopus citations

• Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability

  Johnson, B., VanBlargan, L. A., Xu, W., White, J. P., Shan, C., Shi, P. Y., Zhang, R., Adhikari, J., Gross, M. L., Leung, D. W., Diamond, M. S. & Amarasinghe, G. K., Mar 20 2018, In: Immunity. 48, 3, p. 487-499.e5

  Research output: Contribution to journal › Article › peer-review

  • Protein Stability
  • RNA-Binding Proteins
  • RNA Caps
  • RNA
  • Methylation
  31 Scopus citations

• Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents

  Yeung, K. S., Qiu, Z., Xue, Q., Fang, H., Yang, Z., Zadjura, L., D'Arienzo, C. J., Eggers, B. J., Riccardi, K., Shi, P. Y., Gong, Y. F., Browning, M. R., Gao, Q., Hansel, S., Santone, K., Lin, P. F., Meanwell, N. A. & Kadow, J. F., Jan 1 2013, In: Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 198-202 5 p.

  Research output: Contribution to journal › Article › peer-review

  • indole
  • HIV-1
  • Antiviral Agents
  • Pharmacokinetics
  • Amides
  37 Scopus citations

• Inhibitors of HIV-1 attachment. Part 8: The effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors

  Yeung, K. S., Qiu, Z., Yin, Z., Trehan, A., Fang, H., Pearce, B., Yang, Z., Zadjura, L., D'Arienzo, C. J., Riccardi, K., Shi, P. Y., Spicer, T. P., Gong, Y. F., Browning, M. R., Hansel, S., Santone, K., Barker, J., Coulter, T., Lin, P. F., Meanwell, N. A. & 1 others, Kadow, J. F., Jan 1 2013, In: Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 203-208 6 p.

  Research output: Contribution to journal › Article › peer-review

  • indole
  • Rats
  • Assays
  • Substitution reactions
  • HIV-1
  29 Scopus citations

• Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity

  Collins, N. D., Widen, S. G., Li, L., Swetnam, D. M., Shi, P. Y., Tesh, R. B. & Sarathy, V. V., Jan 1 2019, In: Emerging Microbes and Infections. 8, 1, p. 1126-1138 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Genetic Variation
  • Nucleotides
  • Asian Americans
  • Membranes
  4 Scopus citations