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• Article

  Allosteric discrimination at the NADH/ADP regulatory site of glutamate dehydrogenase

  Nassar, O. M., Wong, K. Y., Lynch, G. C., Smith, T. J. & Pettitt, B. M., Dec 1 2019, In: Protein Science. 28, 12, p. 2080-2088 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Glutamate Dehydrogenase
  • Diphosphates
  • Niacinamide
  • Hydrides
  • Adenine

• Atomic structure of cucumber necrosis virus and the role of the capsid in vector transmission

  Li, M., Kakani, K., Katpally, U., Johnson, S., Rochon, DA. & Smith, T. J., 2013, In: Journal of virology. 87, 22, p. 12166-12175 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Cucumber necrosis virus
  • Tombusvirus
  • capsid
  • Capsid
  • zoospores
  16 Scopus citations

• Bile Salts Alter the Mouse Norovirus Capsid Conformation: Possible Implications for Cell Attachment and Immune Evasion

  Sherman, M. B., Williams, A. N., Smith, H. Q., Nelson, C., Wilen, C. B., Fremont, D. H., Virgin, H. W. & Smith, T. J., Oct 1 2019, In: Journal of virology. 93, 19

  Research output: Contribution to journal › Article › peer-review

  • immune evasion
  • Norovirus
  • Immune Evasion
  • bile salts
  • capsid
  11 Scopus citations

• Cellular production of a counterfeit viral protein confers immunity to infection by a related virus

  Warner, B. E., Ballinger, M. J., Yerramsetty, P., Reed, J., Taylor, D. J., Smith, T. J. & Bruenn, J. A., 2018, In: PeerJ. 2018, 9, e5679.

  Research output: Contribution to journal › Article › peer-review

  • Viruses
  • viral proteins
  • Viral Proteins
  • immunity
  • Immunity
  3 Scopus citations

• Dissecting the Antenna in Human Glutamate Dehydrogenase: Understanding Its Role in Subunit Communication and Allosteric Regulation

  Hoffpauir, Z. A., Sherman, E. & Smith, T. J., Oct 15 2019, In: Biochemistry. 58, 41, p. 4195-4206 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Allosteric Regulation
  • Glutamate Dehydrogenase
  • Communication
  • Antennas
  • Purine Nucleotides

• Evolution on the biophysical fitness landscape of an RNA virus

  Rotem, A., Serohijos, A. W. R., Chang, C. B., Wolfe, J. T., Fischer, A. E., Mehoke, T. S., Zhang, H., Tao, Y., Lloyd Ung, W., Choi, J. M., Rodrigues, J. V., Kolawole, A. O., Koehler, S. A., Wu, S., Thielen, P. M., Cui, N., Demirev, P. A., Giacobbi, N. S., Julian, T. R., Schwab, K. & 7 others, Lin, J. S., Smith, T. J., Pipas, J. M., Wobus, C. E., Feldman, A. B., Weitz, D. A. & Shakhnovich, E. I., 2018, In: Molecular biology and evolution. 35, 10, p. 2390-2400 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • Antibody Affinity
  • Microfluidics
  • RNA viruses
  • Population Density
  3 Scopus citations

• Explorative study on isolation and characterization of a microviridae G4 bacteriophage, EMCL318, against multi-drug-resistant Escherichia coli 15-318

  Ghosh, S., Persad, E., Shiue, T. Y., Lam, C., Islam, A., Mascibroda, L. G., Sherman, M. B., Smith, T. & Cheeptham, N., Dec 2018, In: Antibiotics. 7, 4, 92.

  Research output: Contribution to journal › Article › peer-review

  • Microviridae
  • Microvirus
  • Bacteriophages
  • Escherichia coli
  • Pharmaceutical Preparations
  1 Scopus citations

• Fungal Secretome Analysis via PepSAVI-MS: Identification of the Bioactive Peptide KP4 from Ustilago maydis

  Kirkpatrick, C. L., Parsley, N. C., Bartges, T. E., Cooke, M. E., Evans, W. S., Heil, L. R., Smith, T. J. & Hicks, L. M., May 1 2018, In: Journal of the American Society for Mass Spectrometry. 29, 5, p. 859-865 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Ustilago
  • Fungal Genome
  • Food safety
  • Metabolites
  • Peptides
  4 Scopus citations

• Glutamate dehydrogenase: Structure of a hyperinsulinism mutant, corrections to the atomic model, and insights into a regulatory site

  Nassar, O. M., Li, C., Stanley, C. A., Pettitt, B. M. & Smith, T. J., Jan 2019, In: Proteins: Structure, Function and Bioinformatics. 87, 1, p. 41-50 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Hyperinsulinemic hypoglycemia, familial, 6
  • Glutamate Dehydrogenase
  • Hyperinsulinism
  • Crystal structure
  • Free energy
  4 Scopus citations

• Glutamate Dehydrogenase, a Complex Enzyme at a Crucial Metabolic Branch Point

  Smith, H. Q., Li, C., Stanley, C. A. & Smith, T. J., Jan 15 2019, In: Neurochemical Research. 44, 1, p. 117-132 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Glutamate Dehydrogenase
  • Animals
  • Enzymes
  • Naphazoline
  • Metabolites
  12 Scopus citations

• Identification of a Novel Activator of Mammalian Glutamate Dehydrogenase

  Smith, H. Q. & Smith, T., Nov 29 2016, In: Biochemistry. 55, 47, p. 6568-6576 9 p.

  Research output: Contribution to journal › Article › peer-review

  • N1-(4-(2-aminopyrimidin-4-yl)phenyl)-3-(trifluoromethyl)benzene-1-sulfonamide
  • Glutamate Dehydrogenase
  • Adenosine Diphosphate
  • Guanosine Triphosphate
  • Hyperinsulinemic hypoglycemia, familial, 6
  8 Scopus citations

• Multidomain carbohydrate-binding proteins involved in Bacteroides thetaiotaomicron starch metabolism

  Cameron, E. A., Maynard, M. A., Smith, C. J., Smith, T. J., Koropatkin, N. M. & Martens, E. C., Oct 5 2012, In: Journal of Biological Chemistry. 287, 41, p. 34614-34625 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Bacteroides thetaiotaomicron
  • saccharide-binding proteins
  • Metabolism
  • Starch
  • Carbohydrates
  58 Scopus citations

• Protruding domain of capsid protein is necessary and sufficient to determine murine norovirus replication and pathogenesis in vivo

  Strong, D. W., Thackray, L. B., Smith, T. J. & Virgin, H. W., Mar 2012, In: Journal of virology. 86, 6, p. 2950-2958 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • Capsid Proteins
  • coat proteins
  • pathogenesis
  • mice
  54 Scopus citations

• Structural and functional studies of a phosphatidic acid-binding antifungal plant defensin MtDef4: Identification of an RGFRRR motif governing fungal cell entry

  Sagaram, U. S., El-Mounadi, K., Buchko, G. W., Berg, H. R., Kaur, J., Pandurangi, R. S., Smith, T. J. & Shah, D. M., Dec 4 2013, In: PloS one. 8, 12, e82485.

  Research output: Contribution to journal › Article › peer-review

  • Defensins
  • Phosphatidic Acids
  • Membranes
  • acids
  • Biosynthesis
  78 Scopus citations

• Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle

  Hansman, G. S., Taylor, D. W., McLellan, J. S., Smith, T. J., Georgiev, I., Tame, J. R. H., Park, S. Y., Yamazaki, M., Gondaira, F., Miki, M., Katayama, K., Murata, K. & Kwong, P. D., Apr 2012, In: Journal of virology. 86, 7, p. 3635-3646 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • virus-like particles
  • virion
  • Virion
  • monoclonal antibodies
  50 Scopus citations

• Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor

  Nelson, C. A., Wilen, C. B., Dai, Y. N., Orchard, R. C., Kim, A. S., Stegeman, R. A., Hsieh, L. L., Smith, T. J., Virgin, H. W. & Fremont, D. H., Sep 25 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 39, p. E9201-E9210

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • Bile Acids and Salts
  • Glycochenodeoxycholic Acid
  • Lithocholic Acid
  • Binding Sites
  30 Scopus citations

• The atomic structure of the virally encoded antifungal protein, KP6

  Allen, A., Chatt, E. & Smith, T. J., Feb 8 2013, In: Journal of Molecular Biology. 425, 3, p. 609-621 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Ustilago
  • Double-Stranded RNA
  • Meiosis
  • RNA Viruses
  • Proteins
  3 Scopus citations
• Chapter

  Glutamate dehydrogenase: Structure, regulation, and its role in insulin homeostasis

  Smith, T. J., Apr 4 2012, Monogenic Hyperinsulinemic Hypoglycemia Disorders. Charles, S. & Diva, D. L. (eds.). p. 87-99 13 p. (Frontiers in Diabetes; vol. 21).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Glutamate Dehydrogenase
  • Allosteric Regulation
  • Homeostasis
  • Insulin
  • Naphazoline

• Green Tea and Control of Glutamate Dehydrogenase Activity

  Smith, T. J., Aug 29 2013, Tea in Health and Disease Prevention. Elsevier Inc., p. 1029-1038 10 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• Comment/debate

  Correction to: Fungal Secretome Analysis Via PepSAVI-MS: Identification of the Bioactive Peptide KP4 from Ustilago maydis (Journal of The American Society for Mass Spectrometry, (2018), 29, 5, (859-865), 10.1007/s13361-017-1880-z)

  Kirkpatrick, C. L., Parsley, N. C., Bartges, T. E., Cooke, M. E., Evans, W. S., Heil, L. R., Smith, T. J. & Hicks, L. M., Sep 1 2018, In: Journal of the American Society for Mass Spectrometry. 29, 9, p. 1940 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Ustilago
  • Financial Support
  • Mass spectrometry
  • Mass Spectrometry
  • Peptides
• Review article

  The dynamic capsid structures of the noroviruses

  Smith, H. Q. & Smith, T. J., Mar 2019, In: Viruses. 11, 3, 235.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Norovirus
  • Capsid
  • Herd Immunity
  • Capsid Proteins
  • Viral Genome
  6 Scopus citations

• The dynamic life of virus capsids

  Sherman, M. B., Smith, H. Q. & Smith, T. J., Jun 2020, In: Viruses. 12, 6, 618.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Capsid
  • Viruses
  • Rhinovirus
  • Norovirus
  • Immune System

• The structure and allosteric regulation of mammalian glutamate dehydrogenase

  Li, M., Li, C., Allen, A., Stanley, C. A. & Smith, T. J., Mar 15 2012, In: Archives of Biochemistry and Biophysics. 519, 2, p. 69-80 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Allosteric Regulation
  • Glutamate Dehydrogenase
  • Guanosine Triphosphate
  • Hyperinsulinemic hypoglycemia, familial, 6
  • Animals
  77 Scopus citations

• The virally encoded killer proteins from Ustilago maydis

  Allen, A., Islamovic, E., Kaur, J., Gold, S., Shah, D. & Smith, T. J., Jan 1 2013, In: Fungal Biology Reviews. 26, 4, p. 166-173 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Ustilago
  • Ustilago zeae
  • antifungal proteins
  • viruses
  • mechanism of action
  5 Scopus citations