Find Research outputs

Search results

• Article

  A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

  Johnson, R. E., Klassen, R., Prakash, L. & Prakash, S., Jul 16 2015, In: Molecular cell. 59, 2, p. 163-175 13 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA-Directed DNA Polymerase
  • Alleles
  • DNA
  • DNA Replication
  • Saccharomyces cerevisiae
  122 Scopus citations

• Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme

  Jain, R., Rice, W. J., Malik, R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Oct 1 2019, In: Nature Structural and Molecular Biology. 26, 10, p. 955-962 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Holoenzymes
  • DNA-Directed DNA Polymerase
  • DNA
  • Yeasts
  • Exonucleases
  12 Scopus citations

• DNA polymerase θ accomplishes translesion synthesis opposite 1, N ⁶ -ethenodeoxyadenosine with a remarkably high fidelity in human cells

  Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., Mar 1 2019, In: Genes and Development. 33, 5-6, p. 282-287 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 1,N(6)-ethenodeoxyadenosine
  • DNA-Directed DNA Polymerase
  • Base Pairing
  • Catalytic Domain
  • Nucleotides
  3 Scopus citations

• Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers

  Yoon, J. H., McArthur, M. J., Park, J., Basu, D., Wakamiya, M., Prakash, L. & Prakash, S., Mar 7 2019, In: Cell. 176, 6, p. 1295-1309.e15

  Research output: Contribution to journal › Article › peer-review

  • DNA-Directed DNA Polymerase
  • Skin Neoplasms
  • Skin
  • Mutation
  • Carcinogenesis
  23 Scopus citations

• Genetic control of replication through N1-methyladenine in human cells

  Conde, J., Yoon, J. H., Choudhury, J. R., Prakash, L. & Prakash, S., Dec 11 2015, In: Journal of Biological Chemistry. 290, 50, p. 29794-29800 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Cells
  • Nucleotides
  • Base Pairing
  • Hydrogen Bonding
  • Adenine
  13 Scopus citations

• Genetic control of translesion synthesis on leading and lagging DNA strands in plasmids derived from epstein-barr virus in human cells

  Yoon, J. H., Prakash, S. & Prakash, L., 2012, In: mBio. 3, 5, e00271-12.

  Research output: Contribution to journal › Article › peer-review

  • Human Herpesvirus 4
  • Plasmids
  • DNA
  • Replicon
  • Replication Origin
  5 Scopus citations

• Genetic evidence for reconfiguration of DNA polymerase θ active site for error-free translesion synthesis in human cells

  Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., May 1 2020, In: Journal of Biological Chemistry. 295, 18, p. 5918-5927 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA-Directed DNA Polymerase
  • Cells
  • Catalytic Domain
  • Conformations
  • Base Pairing
  1 Scopus citations

• Human DNA polymerase α in binary complex with a DNA:DNA template-primer

  Coloma, J., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Apr 1 2016, In: Scientific reports. 6, 23784.

  Research output: Contribution to journal › Article › peer-review

  • DNA Primers
  • DNA-Directed DNA Polymerase
  • DNA
  • RNA primers
  • Eukaryota
  14 Scopus citations

• Human DNA polymerase η is pre-aligned for dNTP binding and catalysis

  Ummat, A., Silverstein, T. D., Jain, R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Jan 27 2012, In: Journal of Molecular Biology. 415, 4, p. 627-634 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Catalysis
  • DNA-Directed DNA Polymerase
  • Catalytic Domain
  • Metals
  • DNA
  26 Scopus citations

• Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-l

  Jain, R., Choudhury, J. R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Mar 8 2017, In: Scientific reports. 7, 43904.

  Research output: Contribution to journal › Article › peer-review

  • 2'-deoxycytidine 5'-triphosphate
  • thymidine 5'-triphosphate
  • 2'-deoxyadenosine
  • DNA-Directed DNA Polymerase
  • Nucleotides
  8 Scopus citations

• Pol31 and Pol32 subunits of yeast DNA polymerase δ are also essential subunits of DNA polymerase ζ

  Johnson, R. E., Prakash, L. & Prakash, S., Jul 31 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 31, p. 12455-12460 6 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA-Directed DNA Polymerase
  • Yeasts
  • pol Gene Products
  • Nucleotides
  • Enzymes
  116 Scopus citations

• Requirement of Rad18 protein for replication through DNA lesions in mouse and human cells

  Yoon, J. H., Prakash, S. & Prakash, L., May 15 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 20, p. 7799-7804 6 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Replication
  • Chickens
  • Proteins
  • Ubiquitin-Conjugating Enzymes
  • Pyrimidine Dimers
  19 Scopus citations

• Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ

  Yoon, J. H., Park, J., Conde, J., Wakamiya, M., Prakash, L. & Prakash, S., Dec 15 2015, In: Genes and Development. 29, 24, p. 2588-2602 15 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA-Directed DNA Polymerase
  • Yeasts
  • Genomic Instability
  • Oligonucleotide Array Sequence Analysis
  • DNA Replication
  23 Scopus citations

• Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy

  Ummat, A., Rechkoblit, O., Jain, R., Roy Choudhury, J., Johnson, R. E., Silverstein, T. D., Buku, A., Lone, S., Prakash, L., Prakash, S. & Aggarwal, A. K., Jun 1 2012, In: Nature Structural and Molecular Biology. 19, 6, p. 628-632 5 p.

  Research output: Contribution to journal › Article › peer-review

  • 2'-deoxycytidine 5'-triphosphate
  • Cisplatin
  • DNA Damage
  • Drug Therapy
  • Neoplasms
  59 Scopus citations

• Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η

  Rechkoblit, O., Johnson, R. E., Buku, A., Prakash, L., Prakash, S. & Aggarwal, A. K., Dec 1 2019, In: Scientific reports. 9, 1, 16400.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cytarabine
  • DNA-Directed DNA Polymerase
  • Nucleosides
  • Acute Myeloid Leukemia
  • Mutagenesis
  1 Scopus citations

• Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis

  Malik, R., Kopylov, M., Gomez-Llorente, Y., Jain, R., Johnson, R. E., Prakash, L., Prakash, S., Ubarretxena-Belandia, I. & Aggarwal, A. K., Oct 1 2020, In: Nature Structural and Molecular Biology. 27, 10, p. 913-924 12 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA-Directed DNA Polymerase
  • DNA
  • Holoenzymes
  • Nucleotides
  • Neoplasms
  6 Scopus citations

• Structure and mechanism of human PrimPol, a DNA polymerase with primase activity

  Rechkoblit, O., Gupta, Y. K., Malik, R., Rajashankar, K. R., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K., Oct 2016, In: Science Advances. 2, 10, e1601317.

  Research output: Contribution to journal › Article › peer-review

  • DNA Primase
  • DNA-Directed DNA Polymerase
  • DNA Primers
  • Enzymes
  • DNA
  33 Scopus citations

• Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine

  Yoon, J. H., Choudhury, J. R., Park, J., Prakash, S. & Prakash, L., Nov 10 2017, In: Journal of Biological Chemistry. 292, 45, p. 18682-18688 7 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-deaza-3-methyladenine
  • DNA Adducts
  • DNA-Directed DNA Polymerase
  • Nucleotides
  • Cells
  11 Scopus citations

• Translesion synthesis DNA polymerases η, ι, and ν promote mutagenic replication through the anticancer nucleoside cytarabine

  Yoon, J. H., Choudhury, J. R., Prakash, L. & Prakash, S., Dec 13 2019, In: Journal of Biological Chemistry. 294, 50, p. 19048-19054 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytarabine
  • DNA-Directed DNA Polymerase
  • Nucleosides
  • DNA
  • Acute Myeloid Leukemia
  2 Scopus citations
• Comment/debate

  Corrigendum: DNA polymerase θ accomplishes translesion synthesis opposite 1,N⁶-ethenodeoxyadenosine with a remarkably high fidelity in human cells

  Yoon, J. H., Johnson, R. E., Prakash, L. & Prakash, S., Jan 1 2020, In: Genes & development. 34, 1-2, p. 146 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
• Letter

  Response to Burgers et al.

  Johnson, R. E., Klassen, R., Prakash, L. & Prakash, S., Feb 18 2016, In: Molecular cell. 61, 4, p. 494-495 2 p.

  Research output: Contribution to journal › Letter › peer-review
  6 Scopus citations