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• Article

  Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R. & Kayed, R., 2012, In: Scientific reports. 2, 700.

  Research output: Contribution to journal › Article › peer-review

  • Pathology
  • Brain
  • Alzheimer Disease
  • Amyloid angiopathy
  • Genetically Modified Animals
  262 Scopus citations

• A native interactor scaffolds and stabilizes toxic Ataxin-1 oligomers in SCA1

  Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Park, J., Jafar-Nejad, P., Richman, R., Lu, N., Sengupta, U., Litvinchuk, A., Orr, H. T., Kayed, R. & Zoghbi, H. Y., May 19 2015, In: eLife. 4, MAY, p. 1-46 46 p., e07558.

  Research output: Contribution to journal › Article › peer-review

  • Ataxin-1
  • Oligomers
  • Spinocerebellar Ataxias
  • Scaffolds
  • Drive
  16 Scopus citations

• Antibody against Small Aggregated Peptide Specifically Recognizes Toxic Aβ-42 Oligomers in Alzheimer's Disease

  Bodani, R. U., Sengupta, U., Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Gerson, J. E., Rudra, J. & Kayed, R., Dec 16 2015, In: ACS Chemical Neuroscience. 6, 12, p. 1981-1989 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Amyloid
  • Alzheimer Disease
  • Poisons
  • Peptides
  13 Scopus citations

• Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis

  Clos, A. L., Kayed, R. & Lasagna-Reeves, C. A., 2012, In: Frontiers in Neurology. JAN, Article 5.

  Research output: Contribution to journal › Article › peer-review

  • Amyloidosis
  • Skin
  • Brain
  • Protein Aggregates
  • Amyloid Plaques
  10 Scopus citations

• Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows spinocerebellar ataxia type 1 phenotypes

  Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Vilanova-Velez, L., Park, J., See, L., Jafar-Nejad, P., Richman, R., Orr, H. T., Kayed, R. & Zoghbi, H. Y., Dec 17 2015, In: eLife. 4, DECEMBER2015, e10891.

  Research output: Contribution to journal › Article › peer-review

  • Ataxin-1
  • Immunization
  • Oligomers
  • Spinocerebellar Ataxias
  • Passive Immunization
  9 Scopus citations

• Cerebral microvascular accumulation of tau oligomers in Alzheimer's disease and related tauopathies

  Castillo-Carranza, D. L., Nilson, A. N., Van Skike, C. E., Jahrling, J. B., Patel, K., Garach, P., Gerson, J. E., Sengupta, U., Abisambra, J., Nelson, P., Troncoso, J., Ungvari, Z., Galvan, V. & Kayed, R., 2017, In: Aging and Disease. 8, 3, p. 257-266 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Alzheimer Disease
  • Progressive Supranuclear Palsy
  • Lewy Body Disease
  • Blood Vessels
  33 Scopus citations

• Critical Role of the CXCL10/C-X-C Chemokine Receptor 3 Axis in Promoting Leukocyte Recruitment and Neuronal Injury during Traumatic Optic Neuropathy Induced by Optic Nerve Crush

  Ha, Y., Liu, H., Zhu, S., Yi, P., Liu, W., Nathanson, J., Kayed, R., Loucas, B., Sun, J., Frishman, L. J., Motamedi, M. & Zhang, W., Feb 1 2017, In: American Journal of Pathology. 187, 2, p. 352-365 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Optic Nerve Injuries
  • Nerve Crush
  • CXC Chemokines
  • Chemokine Receptors
  • Optic Nerve
  17 Scopus citations

• Differential activation of the ER stress factor XBP1 by oligomeric assemblies

  Castillo-Carranza, D. L., Zhang, Y., Guerrero-Muñoz, M. J., Kayed, R., Rincon-Limas, D. E. & Fernandez-Funez, P., Aug 2012, In: Neurochemical Research. 37, 8, p. 1707-1717 11 p.

  Research output: Contribution to journal › Article › peer-review

  • X-Box Binding Protein 1
  • Factor X
  • Oligomers
  • Amyloid
  • Chemical activation
  25 Scopus citations

• Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer's Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers

  Singh, A., Allen, D., Fracassi, A., Tumurbaatar, B., Natarajan, C., Scaduto, P., Woltjer, R., Kayed, R., Limon, A., Krishnan, B., Taglialatela, G. & Abisambra, J., 2020, In: Journal of Alzheimer's Disease. 78, 4, p. 1661-1678 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuropathology
  • Synapses
  • Alzheimer Disease
  • Central Nervous System
  • Cognitive Dysfunction

• Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

  Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R. & Kayed, R., May 2012, In: FASEB Journal. 26, 5, p. 1946-1959 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Neurofibrillary Tangles
  • Agglomeration
  • Alzheimer Disease
  • Brain
  246 Scopus citations

• Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies

  Puangmalai, N., Bhatt, N., Montalbano, M., Sengupta, U., Gaikwad, S., Ventura, F., McAllen, S., Ellsworth, A., Garcia, S. & Kayed, R., May 1 2020, In: Cell Death and Disease. 11, 5, 314.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Progressive Supranuclear Palsy
  • Lewy Body Disease
  • Heparan Sulfate Proteoglycans
  • Alzheimer Disease
  • Brain
  15 Scopus citations

• iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

  Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., Caraway, C. A., Fote, G. M., Madany, A. M., Agrawal, A., Kayed, R., Gylys, K. H., Cahalan, M. D., Cummings, B. J., Antel, J. P., Mortazavi, A. & 3 others, Carson, M. J., Poon, W. W. & Blurton-Jones, M., Apr 19 2017, In: Neuron. 94, 2, p. 278-293.e9

  Research output: Contribution to journal › Article › peer-review

  • Microglia
  • Alzheimer Disease
  • Brain
  • Organoids
  • Gene Expression Profiling
  264 Scopus citations

• Modulating disease-relevant tau oligomeric strains by small molecules

  Cascio, F. L., Garcia, S., Montalbano, M., Puangmalai, N., McAllen, S., Pace, A., Piccionello, A. P. & Kayed, R., Oct 30 2020, In: Journal of Biological Chemistry. 295, 44, p. 14807-14825 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oligomers
  • Tauopathies
  • Molecules
  • Brain
  • Agglomeration
  2 Scopus citations

• Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies

  Comerota, M. M., Tumurbaatar, B., Krishnan, B., Kayed, R. & Taglialatela, G., May 1 2019, In: Molecular Neurobiology. 56, 5, p. 3341-3355 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Transgenic Mice
  • Poisons
  • Light
  • Synaptosomes
  5 Scopus citations

• NLRP3 inflammasome activation drives tau pathology

  Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, Buée, L. & Heneka, M. T., Nov 28 2019, In: Nature. 575, 7784, p. 669-673 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Inflammasomes
  • Drive
  • Amyloid
  • Pathology
  • Neurofibrillary Tangles
  136 Scopus citations

• Oligomeric tau-targeted immunotherapy in Tg4510 mice

  Schroeder, S., Joly-Amado, A., Soliman, A., Sengupta, U., Kayed, R., Gordon, M. N. & Morgan, D., Jun 27 2017, In: Alzheimer's Research and Therapy. 9, 1, 46.

  Research output: Contribution to journal › Article › peer-review

  • Immunotherapy
  • Monoclonal Antibodies
  • Immunoglobulin G
  • Brain
  • Tauopathies
  7 Scopus citations

• P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease

  Farmer, K. M., Ghag, G., Puangmalai, N., Montalbano, M., Bhatt, N. & Kayed, R., Aug 10 2020, In: Acta Neuropathologica Communications. 8, 1, 132.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Damage
  • Alzheimer Disease
  • Brain
  • Neurodegenerative Diseases
  • Transcription Factors
  6 Scopus citations

• Pathological Interface between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies

  Sengupta, U., Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Lasagna-Reeves, C. A., Gerson, J. E., Paulucci-Holthauzen, A. A., Krishnamurthy, S., Farhed, M., Jackson, G. R. & Kayed, R., Nov 15 2015, In: Biological Psychiatry. 78, 10, p. 672-683 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • alpha-Synuclein
  • Antibodies
  • Brain
  • Lewy Body Disease
  89 Scopus citations

• Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein

  Sengupta, U., Puangmalai, N., Bhatt, N., Garcia, S., Zhao, Y. & Kayed, R., Jun 1 2020, In: Molecular Neurobiology. 57, 6, p. 2741-2765 25 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins
  • tau Proteins
  • Docosahexaenoic Acids
  • Parkinson Disease
  • Dopamine
  3 Scopus citations

• Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

  Violet, M., Chauderlier, A., Delattre, L., Tardivel, M., Chouala, M. S., Sultan, A., Marciniak, E., Humez, S., Binder, L., Kayed, R., Lefebvre, B., Bonnefoy, E., Buée, L. & Galas, M. C., Oct 1 2015, In: Neurobiology of Disease. 82, p. 540-551 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Nucleic Acids
  • Neurons
  • Induced Hyperthermia
  • Alzheimer Disease
  • Pathology
  36 Scopus citations

• RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction

  Montalbano, M., McAllen, S., Puangmalai, N., Sengupta, U., Bhatt, N., Johnson, O. D., Kharas, M. G. & Kayed, R., Dec 1 2020, In: Nature communications. 11, 1, 4305.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA-Binding Proteins
  • proteins
  • Alzheimer Disease
  • Frontotemporal Dementia With Motor Neuron Disease
  • Neurodegenerative diseases
  5 Scopus citations

• Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

  Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., Benfenati, F., Lee, M. K., Bennett, D. A. & Lesné, S. E., Jun 6 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4648-E4657

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Synapsins
  • Memory Disorders
  • Amyloidogenic Proteins
  • Response Elements
  25 Scopus citations

• Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an alzheimer’s disease mouse model

  Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Hernandez, C., Barrett, A. D. T., Dineley, K. & Kayed, R., 2015, In: Journal of Neuroscience. 35, 12, p. 4857-4868 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Immunotherapy
  • Alzheimer Disease
  • Memory Disorders
  • Pathology
  85 Scopus citations

• Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

  Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In: Biochemistry. 58, 25, p. 2814-2821 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Conformation
  • Synucleins
  • Conformations
  • Poisons
  • Agglomeration
  10 Scopus citations

• Tau oligomers associate with inflammation in the brain and retina of tauopathy mice and in neurodegenerative diseases

  Nilson, A. N., English, K. C., Gerson, J. E., Barton Whittle, T., Nicolas Crain, C., Xue, J., Sengupta, U., Castillo-Carranza, D. L., Zhang, W., Gupta, P. & Kayed, R., 2017, In: Journal of Alzheimer's Disease. 55, 3, p. 1083-1099 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Encephalitis
  • Neurodegenerative Diseases
  • Retina
  • Inflammation
  51 Scopus citations

• Tau Oligomers in Sera of Patients with Alzheimer's Disease and Aged Controls

  Kolarova, M., Sengupta, U., Bartos, A., Ricny, J. & Kayed, R., 2017, In: Journal of Alzheimer's Disease. 58, 2, p. 471-478 8 p.

  Research output: Contribution to journal › Article › peer-review

  • tau Proteins
  • Cognitive Dysfunction
  • Alzheimer Disease
  • Serum
  • Extracellular Space
  12 Scopus citations

• Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration

  Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In: Aging cell. 18, 6, e13035.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lamins
  • Tauopathies
  • RNA-Binding Proteins
  • Alzheimer Disease
  • Poisons
  8 Scopus citations

• TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia

  Montalbano, M., McAllen, S., Cascio, F. L., Sengupta, U., Garcia, S., Bhatt, N., Ellsworth, A., Heidelman, E. A., Johnson, O. D., Doskocil, S. & Kayed, R., Dec 2020, In: Neurobiology of Disease. 146, 105130.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Frontotemporal Dementia With Motor Neuron Disease
  • DNA-Binding Proteins
  • Alzheimer Disease
  • Inclusion Bodies
  • Neurodegenerative Diseases

• Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

  Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In: Scientific reports. 9, 1, 19011.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Curcumin
  • Neurodegenerative Diseases
  • Poisons
  • Tauopathies
  • Microtubule-Associated Proteins
  14 Scopus citations

• Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

  Rasool, S., Albay, R., Martinez-Coria, H., Breydo, L., Wu, J., Milton, S., Misra, S., Tran, A., Pensalfini, A., Laferla, F., Kayed, R. & Glabe, C. G., 2012, In: Molecular Neurodegeneration. 7, 1, 37.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Vaccination
  • Cognition
  • Hemorrhage
  • Vaccines
  29 Scopus citations

• α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: Relevance to human synucleopathic diseases

  Martin, Z. S., Neugebauer, V., Dineley, K. T., Kayed, R., Zhang, W., Reese, L. C. & Taglialatela, G., Feb 2012, In: Journal of neurochemistry. 120, 3, p. 440-452 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Oligomers
  • Calcineurin
  • Long-Term Potentiation
  • Memory
  66 Scopus citations
• Chapter

  Molecular mechanisms of amyloid oligomers toxicity

  Kayed, R. & Lasagna-Reeves, C. A., Dec 1 2012, Alzheimer'S Disease: Advances For A New Century. Perry, G., Zhu, X., Smith, M., Sorensen, A. & Avila, J. (eds.). p. 67-78 12 p. (Advances in Alzheimer's Disease; vol. 3).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Amyloid
  • Amyloid Plaques
  • Cell Death
  • Poisons
  • Memory
  18 Scopus citations

• Tau oligomers as pathogenic seeds: Preparation and propagation in vitro and in vivo

  Gerson, J. E., Sengupta, U. & Kayed, R., 2017, Methods in Molecular Biology. Humana Press Inc., p. 141-157 17 p. (Methods in Molecular Biology; vol. 1523).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Seeds
  • In Vitro Techniques
  • Neurodegenerative Diseases
  • Poisons
  • Antibodies
  16 Scopus citations

• The Potential of Small Molecules in Preventing Tau Oligomer Formation and Toxicity

  Gerson, J. E., Lo Cascio, F. & Kayed, R., Jan 20 2017, Neuroprotection in Alzheimer's Disease. Elsevier Inc., p. 97-121 25 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Amyloid
  • Neurodegenerative Diseases
  • Poisons
  • Tauopathies
  • Amyloidogenic Proteins
  1 Scopus citations
• Comment/debate

  Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau

  Sengupta, U. & Kayed, R., Jan 1 2019, In: Neuropsychopharmacology. 44, 1, p. 222-223 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  1 Scopus citations

• Corrigendum: Pre-amyloid oligomers budding:a metastatic mechanism of proteotoxicity

  Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Jan 19 2017, In: Scientific reports. 7, 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
• Editorial

  Tau protein: Function and pathology

  Rosenmann, H., Blum, D., Kayed, R. & Ittner, L. M., 2012, In: International Journal of Alzheimer's Disease. 707482.

  Research output: Contribution to journal › Editorial › peer-review
  6 Scopus citations
• Poster

  Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

  Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 2017, (Unpublished).

  Research output: Contribution to conference › Poster

  • Tauopathies
  • Genetically Modified Animals
  • Passive Immunization
  • Monoclonal Antibodies
  • Clone Cells
• Review article

  Advances and considerations in AD tau-targeted immunotherapy

  Bittar, A., Bhatt, N. & Kayed, R., Feb 2020, In: Neurobiology of Disease. 134, 104707.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Immunotherapy
  • Alzheimer Disease
  • tau Proteins
  • Amyloid
  • Direction compound
  15 Scopus citations

• Oligomer Formation and Cross-Seeding: The New Frontier

  Farmer, K., Gerson, J. E. & Kayed, R., Jul 2017, In: Israel Journal of Chemistry. 57, 7, p. 665-673 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Oligomers
  • Seed
  • Agglomeration
  • Protein Aggregates
  • Brain
  4 Scopus citations

• Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective

  Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Tsai, A. L. & Kent, T. A., Jan 2020, In: Progress in Neurobiology. 184, 101716.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Amyloid
  • Iron
  • Alzheimer Disease
  • Metals
  • Oxidative Stress
  14 Scopus citations

• Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk

  Kayed, R., Dettmer, U. & Lesné, S. E., 2020, In: Journal of Parkinson's Disease. 10, 3, p. 791-818 28 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Synucleins
  • Neurodegenerative Diseases
  • Amyloidogenic Proteins
  • Multiple System Atrophy
  • Lewy Body Disease
  1 Scopus citations

• The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration

  Deger, J. M., Gerson, J. E. & Kayed, R., Oct 1 2015, In: Aging cell. 14, 5, p. 715-724 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Proteasome Endopeptidase Complex
  • Neurodegenerative Diseases
  • Ubiquitin
  • Sumoylation
  • Amyloidogenic Proteins
  39 Scopus citations