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Article

Activation of Human Peripheral Blood Eosinophils by Cytokines in a Comparative Time-Course Proteomic/Phosphoproteomic Study

Soman, K. V., Stafford, S. J., Pazdrak, K., Wu, Z., Luo, X., White, W. I., Wiktorowicz, J. E., Calhoun, W. J. & Kurosky, A., Aug 4 2017, In: Journal of Proteome Research. 16, 8, p. 2663-2679 17 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Boldogh, I., Boulares, H. A., Calhoun, W. J., Ramana, K. V. & Srivastava, S. K., Feb 27 2013, In: PloS one. 8, 2, e57442.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype

Holguin, F., Comhair, S. A. A., Hazen, S. L., Powers, R. W., Khatri, S. S., Bleecker, E. R., Busse, W. W., Calhoun, W. J., Castro, M., Fitzpatrick, A. M., Gaston, B., Israel, E., Jarjour, N. N., Moore, W. C., Peters, S. P., Teague, W. G., Chung, K. F., Erzurum, S. C. & Wenzel, S. E., Jan 15 2013, In: American Journal of Respiratory and Critical Care Medicine. 187, 2, p. 153-159 7 p.

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Anticholinergic vs long-acting β-Agonist in combination with inhaled corticosteroids in black adults with asthma: The BELT randomized clinical trial

Wechsler, M. E., Yawn, B. P., Fuhlbrigge, A. L., Pace, W. D., Pencina, M. J., Doros, G., Kazani, S., Raby, B. A., Lanzillotti, J., Madison, S., Israel, E., Ansari, A., Raum, D., Marthur, M., Avila, P., Bailey, J. E., Calhoun, W. J., Chang, K. L., Coto, M., Davis, C. & 8 others, Dawson, R., Ferguson, M. L. F., Dransfield, M. T., Ferguson, F., Greiner, A., Jingo, A., Pankey, W. & Schear, M., Oct 27 2015, In: JAMA - Journal of the American Medical Association. 314, 16, p. 1720-1730 11 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Assessing and Evaluating Multidisciplinary Translational Teams: A Mixed Methods Approach

Wooten, K. C., Rose, R. M., Ostir, G. V., Calhoun, W. J., Ameredes, B. T. & Brasier, A. R., 2014, In: Evaluation and the Health Professions. 37, 1, p. 33-49 17 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study

Silkoff, P. E., Strambu, I., Laviolette, M., Singh, D., FitzGerald, J. M., Lam, S., Kelsen, S., Eich, A., Ludwig-Sengpiel, A., hupp, G. C., Backer, V., Porsbjerg, C., Girodet, P. O., Berger, P., Leigh, R., Kline, J. N., Dransfield, M., Calhoun, W., Hussaini, A., Khatri, S. & 8 others, Chanez, P., Susulic, V. S., Barnathan, E. S., Curran, M., Das, A. M., Brodmerkel, C., Baribaud, F. & Loza, M. J., Nov 17 2015, In: Respiratory Research. 16, 1, 142.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Asthma exacerbations and lung function in patients with severe or difficult-to-treat asthma

Calhoun, W., Haselkorn, T., Miller, D. P. & Omachi, T. A., Oct 1 2015, In: Journal of Allergy and Clinical Immunology. 136, 4, p. 1125-1127e4

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Asthma is more severe in older adults

Zein, J. G., Dweik, R. A., Comhair, S. A., Bleecker, E. R., Moore, W. C., Peters, S. P., Busse, W. W., Jarjour, N. N., Calhoun, W. J., Castro, M., Chung, K. F., Fitzpatrick, A., Israel, E., Teague, W. G., Wenzel, S. E., Love, T. E., Gaston, B. M. & Erzurum, S. C., Jul 22 2015, In: PloS one. 10, 7, e0133490.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Characteristics of perimenstrual asthma and its relation to asthma severity and control: Data from the Severe Asthma Research Program

Rao, C. K., Moore, C. G., Bleecker, E., Busse, W. W., Calhoun, W., Castro, M., Chung, K. F., Erzurum, S. C., Israel, E., Curran-Everett, D. & Wenzel, S. E., Apr 2013, In: Chest. 143, 4, p. 984-992 9 p.

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Children and Adults With Frequent Hospitalizations for Asthma Exacerbation, 2012-2013: A Multicenter Observational Study

Multicenter Airway Research Collaboration-37 Investigators, Sep 1 2015, In: Journal of Allergy and Clinical Immunology: In Practice. 3, 5, p. 751-758.e1

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Chronic Respiratory Disease and Cognitive Impairment in Older Mexican Adults

Veeranki, S., Downer, B., Jupiter, D., Kuo, Y. F., Raji, M., Calhoun, W. & Wong, R., Nov 1 2019, In: Neurology India. 67, 6, p. 1539-1542 4 p.

Research output: Contribution to journal › Article › peer-review

Clinical burden and predictors of asthma exacerbations in patients on guideline-based steps 4-6 asthma therapy in the TENOR cohort

Calhoun, W. J., Haselkorn, T., Mink, D. R., Miller, D. P., Dorenbaum, A. & Zeiger, R. S., Mar 2014, In: Journal of Allergy and Clinical Immunology: In Practice. 2, 2, p. 193-200.e3

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Clinical implications of having reduced mid forced expiratory flow rates (FEF_25-75), independently of FEV1, in adult patients with asthma

Riley, C. M., Wenzel, S. E., Castro, M., Erzurum, S. C., Chung, K. F., Fitzpatrick, A. M., Gaston, B., Israel, E., Moore, W. C., Bleecker, E. R., Calhoun, W. J., Jarjour, N. N., Busse, W. W., Peters, S. P., Teague, W. G., Sorkness, R. & Holguin, F., Dec 2015, In: PloS one. 10, 12, e0145476.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: A randomized clinical trial

Smith, L. J., Kalhan, R., Wise, R. A., Sugar, E. A., Lima, J. J., Irvin, C. G., Dozor, A. J., Holbrook, J. T., Hanania, N., Sockrider, M., Bertrand, L., Atik, M. A., Lopez, B. A., Reibman, J., DiMango, E., Rogers, L., Carapetyan, K., Rivera, K., Bryce-Robinson, N., Scheuerman, M. & 180 others, Fiorino, E., Sundy, J., Green, D., Shah, A., Foss, C., Ghidorzi, J., Allen, S., Mervin-Blake, S., Pangborn, E., Robertson, V. S., Eberlein, N., Land, M., Vickery, B., Wu, E., Jaggers, D., Moy, J., Naureckas, E., Nevin, M., Hixon, J., Brees, A., Gonsalves, Z., Zagaja, V., Kustwin, J., Xu, B., Matthews, T., Robinson, L., Singh, N., Busk, M., Puntenney, P., Busk, N., Hutchins, J., Happel, K. I., Tejedor, R. S., Sandi, M. C., Romaine, C., Burzynski, C. J., Antoine, A., Cruse, J., Katial, R., Hoyte, F., Searing, D., Larson, T., Phillips, N., Currier, H., Blake, K., Lang, J., Mougey, E., Archer, N., Seymour, D., Warde, M., Cohen, R., Santiago, M., Ramdeo, R., Dreyfus, M., Dixon, A. E., Kaminsky, D. A., Lahiri, T., Burns, S. M., Mastronarde, J., Parsons, J., Drake, J., Santiago, J., Cosmar, D., Compton, R. A., Krishnan, S., Boyer, J., Banquet, A., De La Riva-Velasco, E., Lowenthal, D., Gjonaj, S., Kim, Y. C., Traeger, N., Welter, J., Scharbach, M., Siegel, S., Gherson, I., Monchil, L., Formisano, T. M., Williams, J., Castro, M., Bacharier, L., Sumino, K., Tarsi, J. J., Patterson, B., Montgomery, T., Slavin, R. G., Chassaing, D. K., Gerald, L. B., Goodwin, J. L., Brown, M. A., Knox, K. S., Carr, T. F., Berry, C. E., Martinez, F. D., Morgan, W. J., Daines, C. L., Daines, M. O., Grad, R., Ezmigna, D., Vasquez, M. M., Wences, J. A., Lopez, S. S., Priefert, J. C., Varela, M. T., Weese, R., Chee, K., Paco, A., Wanner, A., Lockey, R., Schmid, A., Campos, M., King, M., Mendes, E. S., Rebolledo, P. D., Arana, J., Cadet, L., McCrery, R., Croker, S. M., McCullough, S., Salzman, G., Abdeljalil, A., Pyszczynski, D., Bhat, A., Haney, P., Wasserman, S., Ramsdell, J., Soler, X., Kinninger, K., Ferguson, P., Martineau, A., Ung, S., Greene, T., Teague, W. G., Wavell, K. W., Wolf, D., Thompson-Batt, D., Bailey, W. C., Anthonisen, N., Yasin, R., Amend-Libercci, D., Adler, A., Casper, A. S., Daniel, M., Hart, A., Lears, A., Leatherman, G., Nowakowski, D., Prusakowski, N., Rayapudi, S., Rea, A., Saams, J., Shade, D., Thurman, A., Wei, C., Newcomer, A., Bime, C., Brown, E., Levine, C., Roettger, S., Wu, N., Shen, W., Wang, L., Ukken, J., Lazarus, S. C., Calhoun, W. J., Cloutier, M., Kahrilas, P., McWilliams, B., Rogatko, A., Sorkness, C., Sicherer, S., Weinmann, G., Freemer, M., Smith, R., Taggart, V., Webber, L., Zheng, G., Lancet, E., Edelman, N. H. & Rappaport, S., May 26 2015, In: JAMA - Journal of the American Medical Association. 313, 20, p. 2033-2043 11 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Ethanol Exposure Impairs AMPK Signaling and Phagocytosis in Human Alveolar Macrophages: Role of Ethanol Metabolism

Kaphalia, L., Srinivasan, M. P., Kakumanu, R. D., Kaphalia, B. S. & Calhoun, W. J., 2019, In: Alcoholism: Clinical and Experimental Research. 43, 8, p. 1682-1694 13 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Ethanol metabolism, oxidative stress, and endoplasmic reticulum stress responses in the lungs of hepatic alcohol dehydrogenase deficient deer mice after chronic ethanol feeding

Kaphalia, L., Boroumand, N., Hyunsu, J., Kaphalia, B. S. & Calhoun, W. J., Jun 1 2014, In: Toxicology and Applied Pharmacology. 277, 2, p. 109-117 9 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Evolution of Multidisciplinary Translational Teams (MTTs): Insights for Accelerating Translational Innovations

Wooten, K. C., Calhoun, W. J., Bhavnani, S., Rose, R. M., Ameredes, B. & Brasier, A. R., Oct 2015, In: Clinical and translational science. 8, 5, p. 542-552 11 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Genome-wide association study identifies T_H1 pathway genes associated with lung function in asthmatic patients

Li, X., Hawkins, G. A., Ampleford, E. J., Moore, W. C., Li, H., Hastie, A. T., Howard, T. D., Boushey, H. A., Busse, W. W., Calhoun, W. J., Castro, M., Erzurum, S. C., Israel, E., Lemanske, R. F., Szefler, S. J., Wasserman, S. I., Wenzel, S. E., Peters, S. P., Meyers, D. A. & Bleecker, E. R., Aug 2013, In: Journal of Allergy and Clinical Immunology. 132, 2, p. 313-320.e15

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

Zein, J., Gaston, B., Bazeley, P., DeBoer, M. D., Igo, R. P., Bleecker, E. R., Meyers, D., Comhair, S., Marozkina, N. V., Cotton, C., Patel, M., Alyamani, M., Xu, W., Busse, W. W., Calhoun, W. J., Ortega, V., Hawkins, G. A., Castro, M., Chung, K. F., Fahy, J. V. & 12 others, Fitzpatrick, A. M., Israel, E., Jarjour, N. N., Levy, B., Mauger, D. T., Moore, W. C., Noel, P., Peters, S. P., Teague, W. G., Wenzel, S. E., Erzurum, S. C. & Sharifi, N., Jan 28 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 4, p. 2187-2193 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients

Silkoff, P. E., Laviolette, M., Singh, D., FitzGerald, J. M., Kelsen, S., Backer, V., Porsbjerg, C. M., Girodet, P. O., Berger, P., Kline, J. N., Chupp, G., Susulic, V. S., Barnathan, E. S., Baribaud, F., Loza, M. J., Strambu, I., Lam, S., Eich, A., Ludwig-Sengpiel, A., Leigh, R. & 4 others, Dransfield, M., Calhoun, W., Hussaini, A. & Chanez, P., Sep 2017, In: Journal of Allergy and Clinical Immunology. 140, 3, p. 710-719 10 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling

Tian, B., Hosoki, K., Liu, Z., Yang, J., Zhao, Y., Sun, H., Zhou, J., Rytting, E., Kaphalia, L., Calhoun, W. J., Sur, S. & Brasier, A. R., Apr 2019, In: Journal of Allergy and Clinical Immunology. 143, 4, p. 1380-1394.e9

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

P2X₇-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy

Denlinger, L. C., Manthei, D. M., Seibold, M. A., Ahn, K., Bleecker, E., Boushey, H. A., Calhoun, W. J., Castro, M., Chinchili, V. M., Fahy, J. V., Hawkins, G. A., Icitovic, N., Israel, E., Jarjour, N. N., King, T., Kraft, M., Lazarus, S. C., Lehman, E., Martin, R. J., Meyers, D. A. & 8 others, Peters, S. P., Sheerar, D., Shi, L., Sutherland, E. R., Szefler, S. J., Wechsler, M. E., Sorkness, C. A. & Lemanske, R. F., Jan 1 2013, In: American Journal of Respiratory and Critical Care Medicine. 187, 1, p. 28-33 6 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling

Zhao, Y., Tian, B., Sun, H., Zhang, J., Zhang, Y., Ivannikov, M., Motamedi, M., Liu, Z., Zhou, J., Kaphalia, L., Calhoun, W. J., Maroto, R. & Brasier, A. R., Aug 15 2019, In: Journal of Proteomics. 205, 103415.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Post-transplant native pneumonectomy for interstitial fibrosis and small cell lung cancer

Li, R. T., Zahedi, S., Trieu, J., Lea, A. S., Calhoun, W. J., Duarte, A. G., Zhao, J. & Okereke, I. C., Dec 1 2017, In: Journal of Thoracic Disease. 9, 12, p. E1096-E1099

Research output: Contribution to journal › Article › peer-review

Predictors of response to tiotropium versus salmeterol in asthmatic adults

Peters, S. P., Bleecker, E. R., Kunselman, S. J., Icitovic, N., Moore, W. C., Pascual, R., Ameredes, B. T., Boushey, H. A., Calhoun, W. J., Castro, M., Cherniack, R. M., Craig, T., Denlinger, L. C., Engle, L. L., Dimango, E. A., Israel, E., Kraft, M., Lazarus, S. C., Lemanske, R. F., Lugogo, N. & 10 others, Martin, R. J., Meyers, D. A., Ramsdell, J., Sorkness, C. A., Sutherland, E. R., Wasserman, S. I., Walter, M. J., Wechsler, M. E., Chinchilli, V. M. & Szefler, S. J., Nov 2013, In: Journal of Allergy and Clinical Immunology. 132, 5, p. 1068-1074.e1

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Race is associated with differences in airway inflammation in patients with asthma

Nyenhuis, S. M., Krishnan, J. A., Berry, A., Calhoun, W. J., Chinchilli, V. M., Engle, L., Grossman, N., Holguin, F., Israel, E., Kittles, R. A., Kraft, M., Lazarus, S. C., Lehman, E. B., Mauger, D. T., Moy, J. N., Peters, S. P., Phipatanakul, W., Smith, L. J., Sumino, K., Szefler, S. J. & 4 others, Wechsler, M. E., Wenzel, S., White, S. R. & Ackerman, S. J., Jul 2017, In: Journal of Allergy and Clinical Immunology. 140, 1, p. 257-265.e11

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Sex differences in hospital length of stay in children and adults hospitalized for asthma exacerbation

Hasegawa, K., Calhoun, W. J., Pei, Y. V., Chasm, R. M., Youngquist, S. T., Bittner, J. C. & Camargo, C. A., Dec 1 2015, In: Annals of Allergy, Asthma and Immunology. 115, 6, p. 533-535.e1

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Symptom-based controller therapy: A new paradigm for asthma management

Divekar, R., Ameredes, B. T. & Calhoun, W. J., Oct 2013, In: Current Allergy and Asthma Reports. 13, 5, p. 427-433 7 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

The CTSA as an Exemplar Framework for Developing Multidisciplinary Translational Teams

Calhoun, W. J., Wooten, K., Bhavnani, S., Anderson, K. E., Freeman, J. & Brasier, A. R., Feb 2013, In: Clinical and translational science. 6, 1, p. 60-71 12 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Therapeutic potential of anti-IL-6 therapies for granulocytic airway inflammation in asthma

Chu, D. K., Al-Garawi, A., Llop-Guevara, A., Pillai, R. A., Radford, K., Shen, P., Walker, T. D., Goncharova, S., Calhoun, W. J., Nair, P. & Jordana, M., Apr 12 2015, In: Allergy, Asthma and Clinical Immunology. 11, 1, 14.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

The role of computed tomography in chronic obstructive pulmonary diseases

Sze, T. F. C., Ditzler, M. G., Walser, E. M. & Calhoun, W. J., 2015, In: Journal of Allergy and Clinical Immunology: In Practice. 3, 4, p. 594-596 3 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Underuse of guideline-recommended long-term asthma management in children hospitalized to the intensive care unit: A multicenter observational study

Hasegawa, K., Ahn, J., Brown, M. A., Press, V. G., Gabriel, S., Herrera, V., Bittner, J. C., Camargo, C. A., Aurora, T., Brenner, B., Calhoun, W., Gough, J. E., Gutta, R. C., Heidt, J., Khosravi, M., Moore, W. C., Mould-Millman, N. K., Nonas, S., Nowak, R., Pei, V. & 9 others, Probst, B. D., Ramratnam, S. K., Tallar, M., Snipes, C., Teuber, S. S., Trent, S. A., Villarreal, R., Watase, T. & Youngquist, S., Jul 1 2015, In: Annals of Allergy, Asthma and Immunology. 115, 1, p. 10-16.e1

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data

Wu, W., Bleecker, E., Moore, W., Busse, W. W., Castro, M., Chung, K. F., Calhoun, W. J., Erzurum, S., Gaston, B., Israel, E., Curran-Everett, D. & Wenzel, S. E., May 2014, In: Journal of Allergy and Clinical Immunology. 133, 5, p. 1280-1288 9 p.

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Chapter

Conclusions and future directions

Calhoun, W. & Brasier, A. R., 2014, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 795. p. 335-343 9 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Conclusions and future directions

Calhoun, W. J. & Brasier, A. R., 2014, Advances in Experimental Medicine and Biology. Vol. 795. p. 335-343 9 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Heterogeneity of asthma in society

Divekar, R. & Calhoun, W. J., 2014, Advances in Experimental Medicine and Biology. Vol. 795. p. 31-41 11 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Heterogeneity of asthma in society

Divekar, R. & Calhoun, W., 2014, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 795. p. 31-41 11 p. (Advances in Experimental Medicine and Biology; vol. 795).

Research output: Chapter in Book/Report/Conference proceeding › Chapter