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• Article

  Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction

  Li, Z., Brecher, M., Deng, Y. Q., Zhang, J., Sakamuru, S., Liu, B., Huang, R., Koetzner, C. A., Allen, C. A., Jones, S. A., Chen, H., Zhang, N. N., Tian, M., Gao, F., Lin, Q., Banavali, N., Zhou, J., Boles, N., Xia, M., Kramer, L. D. & 2 others, Qin, C. F. & Li, H., Aug 1 2017, In: Cell Research. 27, 8, p. 1046-1064 19 p.

  Research output: Contribution to journal › Article › peer-review

  • temoporfin
  • Zika Virus
  • Flavivirus
  • Polyproteins
  • Niclosamide
  70 Scopus citations

• Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists

  Ye, N., Zhu, Y., Liu, Z., Mei, F. C., Chen, H., Wang, P., Cheng, X. & Zhou, J., 2017, In: European journal of medicinal chemistry. 134, p. 62-71 10 p.

  Research output: Contribution to journal › Article › peer-review

  • erythromycin propionate-N-acetylcysteinate
  • azastene
  • Cyanides
  • 3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile
  • Chemical modification
  3 Scopus citations

• Modulation of Bax and mTOR for cancer therapeutics

  Li, R., Ding, C., Zhang, J., Xie, M., Park, D., Ding, Y., Chen, G., Zhang, G., Gilbert-Ross, M., Zhou, W., Marcus, A. I., Sun, S. Y., Chen, Z. G., Sica, G. L., Ramalingam, S. S., Magis, A. T., Fu, H., Khuri, F. R., Curran, W. J., Owonikoko, T. K. & 3 others, Shin, D. M., Zhou, J. & Deng, X., Jun 1 2017, In: Cancer Research. 77, 11, p. 3001-3012 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Lung Neoplasms
  • Everolimus
  • Neoplasms
  • Phosphorylation
  • Mitochondrial Membranes
  11 Scopus citations

• Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs)

  Liu, Z., Zhu, Y., Chen, H., Wang, P., Mei, F. C., Ye, N., Cheng, X. & Zhou, J., Dec 1 2017, In: Bioorganic and Medicinal Chemistry Letters. 27, 23, p. 5163-5166 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyanides
  • Structure-Activity Relationship
  • Proteins
  • 3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile
  • erythromycin propionate-N-acetylcysteinate
  5 Scopus citations

• Suppression of the growth and invasion of human head and neck squamous cell carcinomas via regulating STAT3 signaling and the miR-21/β-catenin axis with HJC0152

  Wang, Y., Wang, S., Wu, Y., Ren, Y., Li, Z., Yao, X., Zhang, C., Ye, N., Jing, C., Dong, J., Zhang, K., Sun, S., Zhao, M., Guo, W., Qu, X., Qiao, Y., Chen, H., Kong, L., Jin, R., Wang, X. & 4 others, Zhang, L., Zhou, J., Shen, Q. & Zhou, X., Apr 2017, In: Molecular Cancer Therapeutics. 16, 4, p. 578-590 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Catenins
  • STAT3 Transcription Factor
  • Squamous Cell Carcinoma of Head and Neck
  • Growth
  • Cell Cycle Resting Phase
  23 Scopus citations

• Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs

  Zhou, J., Yun, E. J., Chen, W., Ding, Y., Wu, K., Wang, B., Ding, C., Hernandez, E., Santoyo, J., Pong, R. C., Chen, H., He, D., Zhou, J. & Hsieh, J. T., 2017, In: Cell Death and Disease. 8, 3, e2701.

  Research output: Contribution to journal › Article › peer-review

  • oridonin
  • 3-Phosphoinositide-Dependent Protein Kinases
  • Renal Cell Carcinoma
  • Diterpenes
  • Isodon
  14 Scopus citations

• YD277 suppresses triple-negative breast cancer partially through activating the endoplasmic reticulum stress pathway

  Chen, Z., Wu, Q., Ding, Y., Zhou, W., Liu, R., Chen, H., Zhou, J., Feng, J. & Chen, C., 2017, In: Theranostics. 7, 8, p. 2339-2349 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Triple Negative Breast Neoplasms
  • Endoplasmic Reticulum Stress
  • Factor V
  • G1 Phase Cell Cycle Checkpoints
  • Cyclin D1
  7 Scopus citations
• Chapter

  Chemistry and Bioactivity of ent-Kaurene Diterpenoids

  Ding, C., Ding, Y., Chen, H. & Zhou, J., 2017, Studies in Natural Products Chemistry. Elsevier B.V., Vol. 54. p. 141-197 57 p. (Studies in Natural Products Chemistry; vol. 54).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Kaurane Diterpenes
  • Bioactivity
  • Diterpenes
  • geranylgeranyl pyrophosphate
  • Biosynthesis
  3 Scopus citations

• Fragment-based drug design: Strategic advances and lessons learned

  Chen, H., Zhou, X., Gao, Y., Chen, H. & Zhou, J., Jun 3 2017, Drug Discovery Technologies. Elsevier Inc., Vol. 2-8. p. 212-232 21 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Screening
  • Drug Discovery
  • Pharmaceutical Preparations
  • Throughput
  • Assays
  3 Scopus citations

• Small-molecule inhibitors of protein-protein interactions

  Liu, Z., Chen, H., Wold, E. A. & Zhou, J., Jun 3 2017, Drug Discovery Technologies. Elsevier Inc., Vol. 2-8. p. 329-353 25 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Molecules
  • Proteins
  • Modulators
  • Screening
  3 Scopus citations
• Review article

  Drug Discovery Targeting Bromodomain-Containing Protein 4

  Liu, Z., Wang, P., Chen, H., Wold, E. A., Tian, B., Brasier, A. R. & Zhou, J., Jun 8 2017, In: Journal of medicinal chemistry. 60, 11, p. 4533-4558 26 p.

  Research output: Contribution to journal › Review article › peer-review

  • Drug Discovery
  • Drug Delivery Systems
  • Mediator Complex
  • Histone Acetyltransferases
  • RNA Polymerase II
  110 Scopus citations

• Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets

  Wang, P., Liu, Z., Chen, H., Ye, N., Cheng, X. & Zhou, J., 2017, In: Bioorganic and Medicinal Chemistry Letters. 27, 8, p. 1633-1639 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Proteins
  • Medical problems
  • Modulators
  • Molecules
  • Nervous System Diseases
  23 Scopus citations