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  • Jia Zhou
Article

Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs

Zhou, J., Yun, E. J., Chen, W., Ding, Y., Wu, K., Wang, B., Ding, C., Hernandez, E., Santoyo, J., Pong, R. C., Chen, H., He, D., Zhou, J. & Hsieh, J. T., Mar 23 2017, In : Cell death & disease. 8, 3, p. e2701

Research output: Contribution to journalArticle

14 Scopus citations

Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis

Li, D., Wang, H., Ding, Y., Zhang, Z., Zheng, Z., Dong, J., Kim, H., Meng, X., Zhou, Q., Zhou, J., Fang, L. & Shen, Q., Jun 28 2018, In : Cancer Letters. 424, p. 97-108 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

YD277 suppresses triple-negative breast cancer partially through activating the endoplasmic reticulum stress pathway

Chen, Z., Wu, Q., Ding, Y., Zhou, W., Liu, R., Chen, H., Zhou, J., Feng, J. & Chen, C., 2017, In : Theranostics. 7, 8, p. 2339-2349 11 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
Chapter

Chemistry and Bioactivity of ent-Kaurene Diterpenoids

Ding, C., Ding, Y., Chen, H. & Zhou, J., 2017, Studies in Natural Products Chemistry. Elsevier B.V., Vol. 54. p. 141-197 57 p. (Studies in Natural Products Chemistry; vol. 54).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Fragment-based drug design: Strategic advances and lessons learned

Chen, H., Zhou, X., Gao, Y., Chen, H. & Zhou, J., Jun 3 2017, Drug Discovery Technologies. Elsevier Inc., Vol. 2-8. p. 212-232 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Small-molecule inhibitors of protein-protein interactions

Liu, Z., Chen, H., Wold, E. A. & Zhou, J., Jun 3 2017, Drug Discovery Technologies. Elsevier Inc., Vol. 2-8. p. 329-353 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
Comment/debate
5 Scopus citations
Editorial

Gpcr drug discovery: Emerging targets, novel approaches and future trends

Zhou, J. & Wild, C., 2019, In : Current topics in medicinal chemistry. 19, 16, p. 1363-1364 2 p.

Research output: Contribution to journalEditorial

Open Access
1 Scopus citations
Review article

Drug Discovery Targeting Bromodomain-Containing Protein 4

Liu, Z., Wang, P., Chen, H., Wold, E. A., Tian, B., Brasier, A. R. & Zhou, J., Jun 8 2017, In : Journal of Medicinal Chemistry. 60, 11, p. 4533-4558 26 p.

Research output: Contribution to journalReview article

92 Scopus citations

Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets

Wang, P., Liu, Z., Chen, H., Ye, N., Cheng, X. & Zhou, J., 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 8, p. 1633-1639 7 p.

Research output: Contribution to journalReview article

21 Scopus citations

Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance

Liu, X., Xu, J., Zhou, J. & Shen, Q., 2020, (Accepted/In press) In : Genes and Diseases.

Research output: Contribution to journalReview article

Open Access

Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target

Ye, N., Li, B., Mao, Q., Wold, E. A., Tian, S., Allen, J. & Zhou, J., Jan 16 2019, In : ACS Chemical Neuroscience. 10, 1, p. 190-200 11 p., 10.1021/acschemneuro.8b00572.

Research output: Contribution to journalReview article

1 Scopus citations

Proteolysis Targeting Chimera (PROTAC): A Paradigm-Shifting Approach in Small Molecule Drug Discovery

Wang, P. & Zhou, J., Jan 1 2018, In : Current Topics in Medicinal Chemistry. 18, 16, p. 1354-1356 3 p.

Research output: Contribution to journalReview article

17 Scopus citations

Recent advances in developing K-ras plasma membrane localization inhibitors

Ye, N., Xu, Q., Li, W., Wang, P. & Zhou, J., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 23, p. 2114-2127 14 p.

Research output: Contribution to journalReview article

2 Scopus citations

Targeting the 5-ht2c receptor in biological context and the current state of 5-ht2c receptor ligand development

Wold, E. A., Wild, C. T., Cunningham, K. A. & Zhou, J., 2019, In : Current topics in medicinal chemistry. 19, 16, p. 1381-1398 18 p.

Research output: Contribution to journalReview article

7 Scopus citations

Therapeutic potential of oridonin and its analogs: From anticancer and antiinflammation to neuroprotection

Xu, J., Wold, E. A., Ding, Y., Shen, Q. & Zhou, J., 2018, In : Molecules. 23, 2, 474.

Research output: Contribution to journalReview article

31 Scopus citations

Validation of the epigenetic reader bromodomain-containing protein 4 (BRD4) as a therapeutic target for treatment of airway remodeling

Brasier, A. R. & Zhou, J., Jan 2020, In : Drug Discovery Today. 25, 1, p. 126-132 7 p.

Research output: Contribution to journalReview article

3 Scopus citations