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  • Jia Zhou
Article

A Bromodomain-Containing Protein 4 (BRD4) Inhibitor Suppresses Angiogenesis by Regulating AP-1 Expression

Zhou, Z., Li, X., Liu, Z., Huang, L., Yao, Y., Li, L., Chen, J., Zhang, R., Zhou, J., Wang, L. & Zhang, Q. Q., Jul 10 2020, In : Frontiers in Pharmacology. 11, 1043.

Research output: Contribution to journalArticle

Open Access

AMPA receptor positive allosteric modulators attenuate morphine tolerance and dependence

Hu, X., Tian, X., Guo, X., He, Y., Chen, H., Zhou, J. & Wang, Z. J., Jul 15 2018, In : Neuropharmacology. 137, p. 50-58 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Antifibrosis effect of novel oridonin analog CYD0618 via suppression of the NF-κB pathway

Cummins, C. B., Wang, X., Xu, J., Hughes, B. D., Ding, Y., Chen, H., Zhou, J. & Radhakrishnan, R. S., Dec 2018, In : Journal of Surgical Research. 232, p. 283-292 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Bidirectional modulation of the voltage-gated sodium (Nav1.6) channel by rationally designed peptidomimetics

Dvorak, N. M., Wadsworth, P. A., Wang, P., Chen, H., Zhou, J. & Laezza, F., Aug 2020, In : Molecules. 25, 15, 3365.

Research output: Contribution to journalArticle

Open Access

Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2CReceptor-Positive Allosteric Modulators with Enhanced Drug-like Properties

Wold, E. A., Garcia, E. J., Wild, C. T., Miszkiel, J. M., Soto, C. A., Chen, J., Pazdrak, K., Fox, R. G., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 23 2020, In : Journal of medicinal chemistry. 63, 14, p. 7529-7544 16 p.

Research output: Contribution to journalArticle

Discovery of novel mifepristone derivatives via suppressing KLF5 expression for the treatment of triple-negative breast cancer

Lin, Y., Liu, R., Zhao, P., Ye, J., Zheng, Z., Huang, J., Zhang, Y., Gao, Y., Chen, H., Liu, S., Zhou, J., Chen, C. & Chen, H., Feb 25 2018, In : European Journal of Medicinal Chemistry. 146, p. 354-367 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation

Liu, Z., Chen, H., Wang, P., Li, Y., Wold, E. A., Leonard, P. G., Joseph, S., Brasier, A. R., Tian, B., Tian, B., Zhou, J., Zhou, J. & Zhou, J., May 28 2020, In : Journal of medicinal chemistry. 63, 10, p. 5242-5256 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation

Liu, Z., Tian, B., Chen, H., Wang, P., Brasier, A. R. & Zhou, J., May 10 2018, In : European journal of medicinal chemistry. 151, p. 450-461 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Epigenetic suppression of HIV in myeloid cells by the BRD4-selective small molecule modulator ZL0580

Alamer, E., Zhong, C., Liu, Z., Niu, Q., Long, F., Guo, L., Gelman, B. B., Soong, L., Zhou, J. & Hu, H., Jun 1 2020, In : Journal of virology. 94, 11, e01880-19.

Research output: Contribution to journalArticle

2 Scopus citations

Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease

Li, Z., Sakamuru, S., Huang, R., Brecher, M., Koetzner, C. A., Zhang, J., Chen, H., Qin, C. F., Zhang, Q. Y., Zhou, J., Kramer, L. D., Xia, M. & Li, H., Feb 1 2018, In : Antiviral Research. 150, p. 217-225 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Exchange protein directly activated by cAMP modulates ebola virus uptake into vascular endothelial cells

Drelich, A., Judy, B., He, X., Chang, Q., Yu, S., Li, X., Lu, F., Wakamiya, M., Popov, V., Zhou, J., Ksiazek, T. & Gong, B., Oct 16 2018, In : Viruses. 10, 10, 563.

Research output: Contribution to journalArticle

4 Scopus citations

Exchange proteins directly activated by cAMP and their roles in respiratory syncytial virus infection

Choi, E. J., Ren, Y., Chen, Y., Liu, S., Wu, W., Ren, J., Wang, P., Garofalo, R. P., Zhou, J. & Bao, X., Nov 1 2018, In : Journal of virology. 92, 22, e01200-18.

Research output: Contribution to journalArticle

2 Scopus citations

Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction

Li, Z., Brecher, M., Deng, Y. Q., Zhang, J., Sakamuru, S., Liu, B., Huang, R., Koetzner, C. A., Allen, C. A., Jones, S. A., Chen, H., Zhang, N. N., Tian, M., Gao, F., Lin, Q., Banavali, N., Zhou, J., Boles, N., Xia, M., Kramer, L. D. & 2 others, Qin, C. F. & Li, H., Aug 1 2017, In : Cell Research. 27, 8, p. 1046-1064 19 p.

Research output: Contribution to journalArticle

54 Scopus citations

Functional Modulation of Voltage-Gated Sodium Channels by a FGF14-Based Peptidomimetic

Ali, S. R., Liu, Z., Nenov, M. N., Folorunso, O., Singh, A., Scala, F., Chen, H., James, T. F., Alshammari, M., Panova-Elektronova, N. I., White, M. A., Zhou, J. & Laezza, F., May 16 2018, In : ACS chemical neuroscience. 9, 5, p. 976-987 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

GPCR allosteric modulators: Mechanistic advantages and therapeutic applications

Wold, E. A. & Zhou, J., 2018, In : Current topics in medicinal chemistry. 18, 23, p. 2002-2006 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

HJC0152 suppresses human non–small-cell lung cancer by inhibiting STAT3 and modulating metabolism

Lu, L., Li, H., Wu, X., Rao, J., Zhou, J., Fan, S. & Shen, Q., Mar 1 2020, In : Cell Proliferation. 53, 3, e12777.

Research output: Contribution to journalArticle

Open Access

Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists

Ye, N., Zhu, Y., Liu, Z., Mei, F. C., Chen, H., Wang, P., Cheng, X. & Zhou, J., 2017, In : European journal of medicinal chemistry. 134, p. 62-71 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Luteolin-mediated inhibition of hepatic stellate cell activation via suppression of the STAT3 pathway

Cummins, C. B., Wang, X., Nunez Lopez, O., Graham, G., Tie, H. Y., Zhou, J. & Radhakrishnan, R. S., Jun 2018, In : International journal of molecular sciences. 19, 6, 1567.

Research output: Contribution to journalArticle

9 Scopus citations

Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist

Shao, H., Mohamed, H., Boulton, S., Huang, J., Wang, P., Chen, H., Zhou, J., Luchowska-Stańska, U., Jentsch, N. G., Armstrong, A. L., Magolan, J., Yarwood, S. & Melacini, G., May 14 2020, In : Journal of medicinal chemistry. 63, 9, p. 4762-4775 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Modulation of Bax and mTOR for cancer therapeutics

Li, R., Ding, C., Zhang, J., Xie, M., Park, D., Ding, Y., Chen, G., Zhang, G., Gilbert-Ross, M., Zhou, W., Marcus, A. I., Sun, S. Y., Chen, Z. G., Sica, G. L., Ramalingam, S. S., Magis, A. T., Fu, H., Khuri, F. R., Curran, W. J., Owonikoko, T. K. & 3 others, Shin, D. M., Zhou, J. & Deng, X., Jun 1 2017, In : Cancer Research. 77, 11, p. 3001-3012 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Natural Compound Oridonin Inhibits Endotoxin-Induced Inflammatory Response of Activated Hepatic Stellate Cells

Cummins, C. B., Wang, X., Sommerhalder, C., Bohanon, F. J., Nunez Lopez, O., Tie, H. Y., Rontoyanni, V. G., Zhou, J. & Radhakrishnan, R. S., 2018, In : BioMed Research International. 2018, 6137420.

Research output: Contribution to journalArticle

6 Scopus citations

Regio- and Stereospecific Synthesis of Oridonin D-Ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads

Ding, Y., Li, D., Ding, C., Wang, P., Liu, Z., Wold, E. A., Ye, N., Chen, H., White, M. A., Shen, Q. & Zhou, J., Apr 12 2018, In : Journal of medicinal chemistry. 61, 7, p. 2737-2752 16 p.

Research output: Contribution to journalArticle

15 Scopus citations

Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation

Tian, B., Liu, Z., Yang, J., Sun, H., Zhao, Y., Wakamiya, M., Chen, H., Rytting, E., Zhou, J. & Brasier, A. R., Apr 24 2018, In : Cell Reports. 23, 4, p. 1138-1151 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Selective BCL-X L inhibition promotes apoptosis in combination with MLN8237 in medulloblastoma and pediatric glioblastoma cells

Levesley, J., Steele, L., Brüning-Richardson, A., Davison, A., Zhou, J., Ding, C., Lawler, S. & Short, S. C., Jan 22 2018, In : Neuro-Oncology. 20, 2, p. 203-214 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Small Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models.

Sampson, C. M., Kasper, J., Felsing, D., Raval, S., Ye, N., P, W., Rytting, E., Zhou, J., Allen, J. & Hommel, J., Aug 23 2018, In : Pharmacology Research and Perspectives. 6, (5):e00425. , doi: 10.1002/prp2.425.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs)

Liu, Z., Zhu, Y., Chen, H., Wang, P., Mei, F. C., Ye, N., Cheng, X. & Zhou, J., Dec 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 23, p. 5163-5166 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structure-Activity Relationship Studies on Diversified Salicylamide Derivatives as Potent Inhibitors of Human Adenovirus Infection

Xu, J., Berastegui-Cabrera, J., Chen, H., Pachón, J., Zhou, J. & Sánchez-Céspedes, J., Mar 26 2020, In : Journal of medicinal chemistry. 63, 6, p. 3142-3160 19 p.

Research output: Contribution to journalArticle

1 Scopus citations

Suppression of the growth and invasion of human head and neck squamous cell carcinomas via regulating STAT3 signaling and the miR-21/β-catenin axis with HJC0152

Wang, Y., Wang, S., Wu, Y., Ren, Y., Li, Z., Yao, X., Zhang, C., Ye, N., Jing, C., Dong, J., Zhang, K., Sun, S., Zhao, M., Guo, W., Qu, X., Qiao, Y., Chen, H., Kong, L., Jin, R., Wang, X. & 4 others, Zhang, L., Zhou, J., Shen, Q. & Zhou, X., Apr 2017, In : Molecular Cancer Therapeutics. 16, 4, p. 578-590 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators

Wang, P., Luchowska-Stańska, U., Van Basten, B., Chen, H., Liu, Z., Wiejak, J., Whelan, P., Morgan, D., Lochhead, E., Barker, G., Rehmann, H., Yarwood, S. J. & Zhou, J., May 28 2020, In : Journal of medicinal chemistry. 63, 10, p. 5159-5184 26 p.

Research output: Contribution to journalArticle

Synthesis and structure–activity relationship studies of MI-2 analogues as MALT1 inhibitors

Wu, G., Wang, H., Zhou, W., Zeng, B., Mo, W., Zhu, K., Liu, R., Zhou, J., Chen, C. & Chen, H., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

7 Scopus citations

Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs

Zhou, J., Yun, E. J., Chen, W., Ding, Y., Wu, K., Wang, B., Ding, C., Hernandez, E., Santoyo, J., Pong, R. C., Chen, H., He, D., Zhou, J. & Hsieh, J. T., 2017, In : Cell Death and Disease. 8, 3, e2701.

Research output: Contribution to journalArticle

14 Scopus citations

Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis

Li, D., Wang, H., Ding, Y., Zhang, Z., Zheng, Z., Dong, J., Kim, H., Meng, X., Zhou, Q., Zhou, J., Fang, L. & Shen, Q., Jun 28 2018, In : Cancer Letters. 424, p. 97-108 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

YD277 suppresses triple-negative breast cancer partially through activating the endoplasmic reticulum stress pathway

Chen, Z., Wu, Q., Ding, Y., Zhou, W., Liu, R., Chen, H., Zhou, J., Feng, J. & Chen, C., 2017, In : Theranostics. 7, 8, p. 2339-2349 11 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
Chapter

Chemistry and Bioactivity of ent-Kaurene Diterpenoids

Ding, C., Ding, Y., Chen, H. & Zhou, J., 2017, Studies in Natural Products Chemistry. Elsevier B.V., Vol. 54. p. 141-197 57 p. (Studies in Natural Products Chemistry; vol. 54).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Fragment-based drug design: Strategic advances and lessons learned

Chen, H., Zhou, X., Gao, Y., Chen, H. & Zhou, J., Jun 3 2017, Drug Discovery Technologies. Elsevier Inc., Vol. 2-8. p. 212-232 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Small-molecule inhibitors of protein-protein interactions

Liu, Z., Chen, H., Wold, E. A. & Zhou, J., Jun 3 2017, Drug Discovery Technologies. Elsevier Inc., Vol. 2-8. p. 329-353 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
Review article

Drug Discovery Targeting Bromodomain-Containing Protein 4

Liu, Z., Wang, P., Chen, H., Wold, E. A., Tian, B., Brasier, A. R. & Zhou, J., Jun 8 2017, In : Journal of medicinal chemistry. 60, 11, p. 4533-4558 26 p.

Research output: Contribution to journalReview article

96 Scopus citations

Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets

Wang, P., Liu, Z., Chen, H., Ye, N., Cheng, X. & Zhou, J., 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 8, p. 1633-1639 7 p.

Research output: Contribution to journalReview article

22 Scopus citations

Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance

Liu, X., Xu, J., Zhou, J. & Shen, Q., 2020, (Accepted/In press) In : Genes and Diseases.

Research output: Contribution to journalReview article

Open Access

Proteolysis Targeting Chimera (PROTAC): A Paradigm-Shifting Approach in Small Molecule Drug Discovery

Wang, P. & Zhou, J., Jan 1 2018, In : Current Topics in Medicinal Chemistry. 18, 16, p. 1354-1356 3 p.

Research output: Contribution to journalReview article

19 Scopus citations

Therapeutic potential of oridonin and its analogs: From anticancer and antiinflammation to neuroprotection

Xu, J., Wold, E. A., Ding, Y., Shen, Q. & Zhou, J., 2018, In : Molecules. 23, 2, 474.

Research output: Contribution to journalReview article

30 Scopus citations

Validation of the epigenetic reader bromodomain-containing protein 4 (BRD4) as a therapeutic target for treatment of airway remodeling

Brasier, A. R. & Zhou, J., Jan 2020, In : Drug Discovery Today. 25, 1, p. 126-132 7 p.

Research output: Contribution to journalReview article

4 Scopus citations