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• Article

  Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts

  Wold, E. A., Chen, J., Cunningham, K. A. & Zhou, J., Oct 1 2019, In: Journal of medicinal chemistry. 62, 1, p. 88-127 40 p.

  Research output: Contribution to journal › Article › peer-review

  • G-Protein-Coupled Receptors
  • Drug Discovery
  • Pharmaceutical Chemistry
  • Drug Delivery Systems
  • Clinical Trials
  31 Scopus citations

• An NPY Y1 receptor antagonist unmasks latent sensitization and reveals the contribution of protein kinase A and Epac to chronic inflammatory pain

  Fu, W., Nelson, T. S., Santos, D. F., Doolen, S., Gutierrez, J. J. P., Ye, N., Zhou, J. & Taylor, B. K., Aug 1 2019, In: Pain. 160, 8, p. 1754-1765 12 p.

  Research output: Contribution to journal › Article › peer-review

  • neuropeptide Y-Y1 receptor
  • Cyclic AMP-Dependent Protein Kinases
  • adenylyl cyclase 1
  • Chronic Pain
  • BIBO 3304
  9 Scopus citations

• Applications of bioorthogonal chemistry in tumor-targeted drug discovery

  Liu, G., Wold, E. A. & Zhou, J., Jan 1 2019, In: Current topics in medicinal chemistry. 19, 11, p. 892-897 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cycloaddition Reaction
  • Drug Discovery
  • Alkynes
  • nitrones
  • Catalysis
  2 Scopus citations

• Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5- b]pyridine-7,3′-indoline]-2′,5(3 H)-dione Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection

  Xu, J., Xie, X., Ye, N., Zou, J., Chen, H., White, M. A., Shi, P. Y. & Zhou, J., Sep 12 2019, In: Journal of medicinal chemistry. 62, 17, p. 7941-7960 20 p.

  Research output: Contribution to journal › Article › peer-review

  • indoline-2,3-dione
  • pyridine
  • Dengue Virus
  • indoline
  • Virus Diseases
  9 Scopus citations

• Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT _2C Receptor

  Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M. A., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Oct 1 2019, In: Journal of medicinal chemistry. 62, 1, p. 288-305 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor, Serotonin, 5-HT2C
  • Serotonin
  • 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole
  • Cocaine
  • Allosteric Site
  13 Scopus citations

• Discovery of niclosamide and its O-alkylamino-tethered derivatives as potent antibacterial agents against carbapenemase-producing and/or colistin resistant Enterobacteriaceae isolates

  Xu, J., Pachón-Ibáñez, M. E., Cebrero-Cangueiro, T., Chen, H., Sánchez-Céspedes, J. & Zhou, J., Jun 1 2019, In: Bioorganic and Medicinal Chemistry Letters. 29, 11, p. 1399-1402 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Niclosamide
  • carbapenemase
  • Colistin
  • Enterobacteriaceae
  • Derivatives
  7 Scopus citations

• Dual activity of niclosamide to suppress replication of integrated HIV-1 and Mycobacterium tuberculosis (Beijing)

  Fan, X. Z., Xu, J., Files, M., Cirillo, J. D., Endsley, J. J., Zhou, J. & Endsley, M. A., May 2019, In: Tuberculosis. 116, p. S28-S33

  Research output: Contribution to journal › Article › peer-review

  • Niclosamide
  • Beijing
  • Mycobacterium tuberculosis
  • HIV-1
  • HIV
  7 Scopus citations

• Effect of N-(2-aminoethyl) ethanolamine on hypertrophic scarring changes in vitro: Finding novel anti-fibrotic therapies

  Chen, Z., Gu, J., El Ayadi, A., Oberhauser, A. F., Zhou, J., Sousse, L. E., Finnerty, C. C., Herndon, D. N. & Boor, P. J., Jan 1 2019, In: Toxicology and Applied Pharmacology. 362, p. 9-19 11 p.

  Research output: Contribution to journal › Article › peer-review

  • N-(2-hydroxyethyl)ethylenediamine
  • Ethanolamine
  • Hypertrophic Cicatrix
  • Cicatrix
  • Fibroblasts
  2 Scopus citations

• Efficacy of novel highly specific bromodomain-containing protein 4 inhibitors in innate inflammation–driven airway remodeling

  Tian, B., Liu, Z., Litvinov, J., Maroto, R., Jamaluddin, M., Rytting, E., Patrikeev, I., Ochoa, L., Vargas, G., Motamedi, M., Ameredes, B. T., Zhou, J. & Brasier, A. R., Jan 2019, In: American journal of respiratory cell and molecular biology. 60, 1, p. 68-83 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Airway Remodeling
  • Toll-Like Receptor 3
  • Histone Acetyltransferases
  • Myofibroblasts
  • Proteins
  15 Scopus citations

• Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis

  He, X., Drelich, A., Yu, S., Chang, Q., Gong, D., Zhou, Y., Qu, Y., Yuan, Y., Su, Z., Qiu, Y., Tang, S. J., Gaitas, A., Ksiazek, T., Xu, Z., Zhou, J., Feng, Z., Wakamiya, M., Lu, F. & Gong, B., Mar 15 2019, In: Life Sciences. 221, p. 1-12 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Annexin A2
  • Endothelial cells
  • Fibrinolysis
  • Endothelial Cells
  • Blood Vessels
  2 Scopus citations

• HFIP-promoted Michael reactions: direct para-selective C-H activation of anilines with maleimides

  Li, B., Mao, Q., Zhou, J., Liu, F. & Ye, N., 2019, In: Organic and Biomolecular Chemistry. 17, 8, p. 2242-2246 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Michael reaction
  • Maleimides
  • Aniline Compounds
  • aniline
  • Nucleophiles
  9 Scopus citations

• Identification of peptidomimetics as novel chemical probes modulating fibroblast growth factor 14 (FGF14) and voltage-gated sodium channel 1.6 (Nav1.6) protein-protein interactions

  Liu, Z., Wadsworth, P., Singh, A. K., Chen, H., Wang, P., Folorunso, O., Scaduto, P., Ali, S. R., Laezza, F. & Zhou, J., Feb 1 2019, In: Bioorganic and Medicinal Chemistry Letters. 29, 3, p. 413-419 7 p.

  Research output: Contribution to journal › Article › peer-review

  • NAV1.6 Voltage-Gated Sodium Channel
  • fibroblast growth factor 14
  • Peptidomimetics
  • Voltage-Gated Sodium Channels
  • Proteins
  5 Scopus citations

• Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes

  Griggs, R. B., Santos, D. F., Laird, D. E., Doolen, S., Donahue, R. R., Wessel, C. R., Fu, W., Sinha, G. P., Wang, P., Zhou, J., Brings, S., Fleming, T., Nawroth, P. P., Susuki, K. & Taylor, B. K., Jul 2019, In: Neurobiology of Disease. 127, p. 76-86 11 p.

  Research output: Contribution to journal › Article › peer-review

  • adenylyl cyclase 1
  • Pyruvaldehyde
  • Ankyrins
  • Type 2 Diabetes Mellitus
  • Pain
  8 Scopus citations

• Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling

  Tian, B., Hosoki, K., Liu, Z., Yang, J., Zhao, Y., Sun, H., Zhou, J., Rytting, E., Kaphalia, L., Calhoun, W. J., Sur, S. & Brasier, A. R., Apr 2019, In: Journal of Allergy and Clinical Immunology. 143, 4, p. 1380-1394.e9

  Research output: Contribution to journal › Article › peer-review

  • Dander
  • Cats
  • Myofibroblasts
  • Inflammation
  • Airway Remodeling
  14 Scopus citations

• Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling

  Zhao, Y., Tian, B., Sun, H., Zhang, J., Zhang, Y., Ivannikov, M., Motamedi, M., Liu, Z., Zhou, J., Kaphalia, L., Calhoun, W. J., Maroto, R. & Brasier, A. R., Aug 15 2019, In: Journal of Proteomics. 205, 103415.

  Research output: Contribution to journal › Article › peer-review

  • Airway Remodeling
  • Bronchoalveolar Lavage Fluid
  • Homeostasis
  • Pericytes
  • Blood Vessels
  10 Scopus citations

• Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer

  Liu, G., Yin, T., Kim, H., Ding, C., Yu, Z., Wang, H., Chen, H., Yan, R., Wold, E. A., Zou, H., Liu, X., Ding, Y., Shen, Q. & Zhou, J., Sep 15 2019, In: European journal of medicinal chemistry. 178, p. 589-605 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Triple Negative Breast Neoplasms
  • Structure-Activity Relationship
  • Tumors
  • Cells
  • fluorene
  1 Scopus citations

• Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV

  Niu, Q., Liu, Z., Alamer, E., Fan, X., Chen, H., Endsley, J., Gelman, B. B., Tian, B., Kim, J. H., Michael, N. L., Robb, M. L., Ananworanich, J., Zhou, J. & Hu, H., Aug 1 2019, In: Journal of Clinical Investigation. 129, 8, p. 3361-3373 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Drug Design
  • HIV
  • Epigenomics
  • Proviruses
  • Therapeutics
  15 Scopus citations

• Synthesis and pharmacological evaluation of non-catechol G protein biased and unbiased dopamine D1 receptor agonists

  Wang, P., Felsing, D., Chen, H., Raval, S., Allen, J. & Zhou, J., May 9 2019, In: ACS Medicinal Chemistry Letters. 10.1021/acsmedchemlett.9b00050, p. 792-799 8 p., 10.1021/acsmedchemlett.9b00050.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dopamine D1 Receptors
  • Dopamine Agonists
  • GTP-Binding Proteins
  • Arrestin
  • Dopamine
  3 Scopus citations
• Comment/debate

  Positive-allosteric modulation of the 5-HT_2C receptor: implications for neuropsychopharmacology and neurotherapeutics

  Zhou, J. & Cunningham, K. A., Jan 1 2019, In: Neuropsychopharmacology. 44, 1, p. 230-231 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  6 Scopus citations
• Editorial

  Gpcr drug discovery: Emerging targets, novel approaches and future trends

  Zhou, J. & Wild, C., 2019, In: Current topics in medicinal chemistry. 19, 16, p. 1363-1364 2 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access
  2 Scopus citations
• Review article

  Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target

  Ye, N., Li, B., Mao, Q., Wold, E. A., Tian, S., Allen, J. & Zhou, J., Jan 16 2019, In: ACS Chemical Neuroscience. 10, 1, p. 190-200 11 p., 10.1021/acschemneuro.8b00572.

  Research output: Contribution to journal › Review article › peer-review

  • G-Protein-Coupled Receptors
  • 2-(4-chlorophenyl)cyclopropylamine
  • N-phenylethanolamine
  • Ligands
  • Pharmaceutical Chemistry
  8 Scopus citations

• Recent advances in developing K-ras plasma membrane localization inhibitors

  Ye, N., Xu, Q., Li, W., Wang, P. & Zhou, J., 2019, In: Current topics in medicinal chemistry. 19, 23, p. 2114-2127 14 p.

  Research output: Contribution to journal › Review article › peer-review

  • ras Proteins
  • Cell Membrane
  • Drug Repositioning
  • Drug Design
  • Biological Products
  2 Scopus citations

• Targeting the 5-ht_2c receptor in biological context and the current state of 5-ht_2c receptor ligand development

  Wold, E. A., Wild, C. T., Cunningham, K. A. & Zhou, J., 2019, In: Current topics in medicinal chemistry. 19, 16, p. 1381-1398 18 p.

  Research output: Contribution to journal › Review article › peer-review

  • lorcaserin
  • Serotonin
  • Artificial Receptors
  • Serotonin 5-HT2 Receptor Agonists
  • Receptor, Serotonin, 5-HT2C
  12 Scopus citations