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  High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells

  Gong, D., Zhang, T. H., Zhao, D., Du, Y., Chapa, T. J., Shi, Y., Wang, L., Contreras, D., Zeng, G., Shi, P. Y., Wu, T. T., Arumugaswami, V. & Sun, R., Mar 23 2018, In: iScience. 1, p. 97-111 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Culicidae
  • Glycosylation
  • Zika Virus Infection
  • Infection
  16 Scopus citations

• Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability

  Johnson, B., VanBlargan, L. A., Xu, W., White, J. P., Shan, C., Shi, P. Y., Zhang, R., Adhikari, J., Gross, M. L., Leung, D. W., Diamond, M. S. & Amarasinghe, G. K., Mar 20 2018, In: Immunity. 48, 3, p. 487-499.e5

  Research output: Contribution to journal › Article › peer-review

  • Protein Stability
  • RNA-Binding Proteins
  • RNA Caps
  • RNA
  • Methylation
  31 Scopus citations

• Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign

  Smith, T. M., Lim, S. P., Yue, K., Busby, S. A., Arora, R., Seh, C. C., Kirk Wright, S., Nutiu, R., Niyomrattanakit, P., Wan, K. F., Beer, D., Shi, P. Y. & Benson, T. E., Jan 30 2015, In: Journal of Biomolecular Screening. 20, 1, p. 153-163 11 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • Dengue Virus
  • Viruses
  • Assays
  • DNA-Directed RNA Polymerases
  20 Scopus citations

• Identifying optimal capsid duplication length for the stability of reporter flaviviruses

  Baker, C., Liu, Y., Zou, J., Muruato, A., Xie, X. & Shi, P. Y., Jan 1 2020, In: Emerging Microbes and Infections. 9, 1, p. 2256-2265 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Flavivirus
  • Capsid
  • Zika Virus
  • Culicidae
  • Viruses

• Inhibition of coronavirus entry in vitro and ex vivo by a lipid-conjugated peptide derived from the sars-cov-2 spike glycoprotein hrc domain

  Outlaw, V. K., Bovier, F. T., Mears, M. C., Cajimat, M. N., Zhu, Y., Lin, M. J., Addetia, A., Lieberman, N. A. P., Peddu, V., Xie, X., Shi, P. Y., Greninger, A. L., Gellman, S. H., Bente, D. A., Moscona, A. & Porotto, M., Sep 1 2020, In: mBio. 11, 5, p. 1-14 14 p., e01935-20.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • Glycoproteins
  • Lipopeptides
  • Lipids
  1 Scopus citations

• Inhibition of dengue virus by targeting viral NS4B protein

  Xie, X., Wang, Q. Y., Xu, H. Y., Qing, M., Kramer, L., Yuan, Z. & Shi, P. Y., Nov 2011, In: Journal of virology. 85, 21, p. 11183-11195 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • viral proteins
  • Viral Proteins
  • Replicon
  93 Scopus citations

• Inhibition of dengue virus through suppression of host pyrimidine biosynthesis

  Wang, Q. Y., Bushell, S., Qing, M., Xu, H. Y., Bonavia, A., Nunes, S., Zhou, J., Poh, M. K., de Sessions, P. F., Niyomrattanakit, P., Dong, H., Hoffmaster, K., Goh, A., Nilar, S., Schul, W., Jones, S., Kramer, L., Compton, T. & Shi, P. Y., Jul 2011, In: Journal of virology. 85, 13, p. 6548-6556 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • pyrimidine
  • Dengue Virus
  • dihydroorotate dehydrogenase
  • pyrimidines
  105 Scopus citations

• Inhibition of enterovirus 71 by adenosine analog NITD008

  Deng, C. L., Yeo, H., Ye, H. Q., Liu, S. Q., Shang, B. D., Gong, P., Alonso, S., Shi, P. Y. & Zhang, B., 2014, In: Journal of virology. 88, 20, p. 11915-11923 9 p.

  Research output: Contribution to journal › Article › peer-review

  • NITD008
  • Enterovirus
  • adenosine
  • Adenosine
  • Inhibition (Psychology)
  46 Scopus citations

• Inhibitors of HIV-1 attachment. Part 7: Indole-7-carboxamides as potent and orally bioavailable antiviral agents

  Yeung, K. S., Qiu, Z., Xue, Q., Fang, H., Yang, Z., Zadjura, L., D'Arienzo, C. J., Eggers, B. J., Riccardi, K., Shi, P. Y., Gong, Y. F., Browning, M. R., Gao, Q., Hansel, S., Santone, K., Lin, P. F., Meanwell, N. A. & Kadow, J. F., Jan 1 2013, In: Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 198-202 5 p.

  Research output: Contribution to journal › Article › peer-review

  • indole
  • HIV-1
  • Antiviral Agents
  • Pharmacokinetics
  • Amides
  37 Scopus citations

• Inhibitors of HIV-1 attachment. Part 8: The effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors

  Yeung, K. S., Qiu, Z., Yin, Z., Trehan, A., Fang, H., Pearce, B., Yang, Z., Zadjura, L., D'Arienzo, C. J., Riccardi, K., Shi, P. Y., Spicer, T. P., Gong, Y. F., Browning, M. R., Hansel, S., Santone, K., Barker, J., Coulter, T., Lin, P. F., Meanwell, N. A. & 1 others, Kadow, J. F., Jan 1 2013, In: Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 203-208 6 p.

  Research output: Contribution to journal › Article › peer-review

  • indole
  • Rats
  • Assays
  • Substitution reactions
  • HIV-1
  29 Scopus citations

• Internally deleted WNV genomes isolated from exotic birds in New Mexico: Function in cells, mosquitoes, and mice

  Pesko, K. N., Fitzpatrick, K. A., Ryan, E. M., Shi, P. Y., Zhang, B., Lennon, N. J., Newman, R. M., Henn, M. R. & Ebel, G. D., May 25 2012, In: Virology. 427, 1, p. 10-17 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Culicidae
  • Birds
  • Genome
  • 4-(2-(4-isopropylbenzamido)ethoxy)benzoic acid
  • Population
  24 Scopus citations

• In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age

  Lieberman, N. A. P., Peddu, V., Xie, H., Shrestha, L., Huang, M. L., Mears, M. C., Cajimat, M. N., Bente, D. A., Shi, P. Y., Bovier, F., Roychoudhury, P., Jerome, K. R., Moscona, A., Porotto, M. & Greninger, A. L., Sep 2020, In: PLoS Biology. 18, 9, e3000849.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe acute respiratory syndrome coronavirus
  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • viral load
  • Viral Load
  12 Scopus citations

• K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B

  Giraldo, M. I., Vargas-Cuartas, O., Gallego-Gomez, J. C., Shi, P. Y., Padilla-Sanabria, L., Castaño-Osorio, J. C. & Rajsbaum, R., Feb 15 2018, In: Virus Research. 246, p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Dengue
  • Proteins
  • Ubiquitination
  • Viral Proteins
  9 Scopus citations

• Keratinocytes are cell targets of west nile virus in vivo

  Lim, P. Y., Behr, M. J., Chadwick, C. M., Shi, P. Y. & Bernard, K. A., May 2011, In: Journal of virology. 85, 10, p. 5197-5201 5 p.

  Research output: Contribution to journal › Article › peer-review

  • West Nile virus
  • keratinocytes
  • Keratinocytes
  • Skin
  • cells
  75 Scopus citations

• Lead optimization of spiropyrazolopyridones: A new and potent class of dengue virus inhibitors

  Zou, B., Chan, W. L., Ding, M., Leong, S. Y., Nilar, S., Seah, P. G., Liu, W., Karuna, R., Blasco, F., Yip, A., Chao, A., Susila, A., Dong, H., Wang, Q. Y., Xu, H. Y., Chan, K., Wan, K. F., Gu, F., Diagana, T. T., Wagner, T. & 3 others, Dix, I., Shi, P. Y. & Smith, P. W., Mar 12 2015, In: ACS Medicinal Chemistry Letters. 6, 3, p. 344-348 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Viruses
  • Lead
  • Enantiomers
  • Pharmacokinetics
  35 Scopus citations

• Ligand-bound structures of the dengue virus protease reveal the active conformation

  Noble, C. G., Seh, C. C., Chao, A. T. & Shi, P. Y., Jan 2012, In: Journal of virology. 86, 1, p. 438-446 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus
  • Dengue Virus
  • ligands
  • Peptide Hydrolases
  • proteinases
  166 Scopus citations

• Mapping the interactions between the NS4B and NS3 proteins of dengue virus

  Zou, J., Lee, L. T., Wang, Q. Y., Xie, X., Lu, S., Yau, Y. H., Yuan, Z., Shochat, S. G., Kang, C., Lescar, J. & Shi, P. Y., Jan 1 2015, In: Journal of virology. 89, 7, p. 3471-3483 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue virus NS4B protein
  • flavivirus NS3 protein
  • Dengue virus
  • Flavivirus
  • Dengue Virus
  49 Scopus citations

• Membrane topology and function of dengue virus NS2A protein

  Xie, X., Gayen, S., Kang, C. B., Yuan, Z. & Shi, P. Y., Apr 2013, In: Journal of virology. 87, 8, p. 4609-4622 14 p.

  Research output: Contribution to journal › Article › peer-review

  • virus protein 2A
  • Dengue virus
  • Dengue Virus
  • topology
  • Flavivirus
  118 Scopus citations

• Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

  Zhao, Y., Soh, T. S., Lim, S. P., Chung, K. Y., Swaminathan, K., Vasudevan, S. G., Shi, P. Y., Lescar, J. & Luo, D., Dec 1 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 48, p. 14834-14839 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Ribose
  • Dengue Virus
  • Viral RNA
  • Methylation
  • Flavivirus
  39 Scopus citations

• NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex

  Kim, Y. M., Gayen, S., Kang, C. B., Joy, J., Huang, Q., Chen, A. S., Wee, J. L. K., Ang, M. J. Y., Lim, H. A., Hung, A. W., Li, R., Noble, C. G., Lee, L. T., Yip, A., Wang, Q. Y., Chia, C. S. B., Hill, J., Shi, P. Y. & Keller, T. H., May 3 2013, In: Journal of Biological Chemistry. 288, 18, p. 12891-12900 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Nuclear magnetic resonance
  • Dengue
  • Peptide Hydrolases
  • Dengue Virus
  • Viruses
  69 Scopus citations

• Nonconsensus west nile virus genomes arising during mosquito infection suppress pathogenesis and modulate virus fitness in vivo

  Ebel, G. D., Fitzpatrick, K. A., Lim, P. Y., Bennett, C. J., Deardorff, E. R., Kramer, G. V. S. J., Zhou, Y., Shi, P. Y. & Bernard, K. A., Dec 2011, In: Journal of virology. 85, 23, p. 12605-12613 9 p.

  Research output: Contribution to journal › Article › peer-review

  • West Nile virus
  • Culicidae
  • pathogenesis
  • RNA helicases
  • RNA Helicases
  19 Scopus citations

• Noninvasive bioluminescence imaging of dengue virus infection in the brain of A129 mice

  Li, X. F., Deng, Y. Q., Zhao, H., Ye, Q., Wang, H. J., Li, S. H., Zhu, S. Y., Shi, P. Y., Qin, E. D., Zhang, B. & Qin, C. F., May 1 2013, In: Applied Microbiology and Biotechnology. 97, 10, p. 4589-4596 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Virus Diseases
  • Brain
  • Antiviral Agents
  • Renilla Luciferases
  9 Scopus citations

• NS5 from dengue virus serotype 2 can adopt a conformation analogous to that of its zika virus and Japanese encephalitis virus homologues

  El Sahili, A., Soh, T. S., Schiltz, J., Gharbi-Ayachi, A., Seh, C. C., Shi, P. Y., Lim, S. P. & Lescar, J., Jan 1 2020, In: Journal of virology. 94, 1, e01294-19.

  Research output: Contribution to journal › Article › peer-review

  • Zika virus
  • Japanese encephalitis virus
  • Japanese Encephalitis Virus
  • Zika Virus
  • Dengue virus
  5 Scopus citations

• Overlapping and distinct molecular determinants dictating the antiviral activities of TRIM56 against flaviviruses and coronavirus

  Liu, B., Li, N. L., Wang, J., Shi, P. Y., Wang, T., Miller, M. A. & Li, K., 2014, In: Journal of virology. 88, 23, p. 13821-13835 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Flaviviridae
  • Coronavirinae
  • Flavivirus
  • Coronavirus
  • Human Coronavirus OC43
  40 Scopus citations

• Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection

  Luo, H., Winkelmann, E. R., Zhu, S., Ru, W., Mays, E., Silvas, J. A., Vollmer, L. L., Gao, J., Peng, B. H., Bopp, N. E., Cromer, C., Shan, C., Xie, G., Li, G., Tesh, R., Popov, V. L., Shi, P. Y., Sun, S. C., Wu, P., Klein, R. S. & 4 others, Tang, S. J., Zhang, W., Aguilar, P. V. & Wang, T., Nov 1 2018, In: Journal of Clinical Investigation. 128, 11, p. 4980-4991 12 p.

  Research output: Contribution to journal › Article › peer-review

  • West Nile Fever
  • West Nile virus
  • Microglia
  • Virus Replication
  • Encephalitis
  11 Scopus citations

• Peli1 signaling blockade attenuates congenital zika syndrome

  Luo, H., Li, G., Wang, B., Tian, B., Gao, J., Zou, J., Shi, S., Zhu, S., Peng, B. H., Adam, A., Martinez, A., Hein, K., Winkelmann, E. R., Mahmoud, Y., Zhou, X., Shan, C., Rossi, S., Weaver, S., Barrett, A. D. T., Sun, S. C. & 4 others, Zhang, W., Shi, P. Y., Wu, P. & Wang, T., Jun 2020, In: PLoS pathogens. 16, 6, e1008538.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Trophoblasts
  • Flavivirus
  • Cell Death
  • Zika Virus Infection
  1 Scopus citations

• Point mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivo

  Van Slyke, G. A., Ciota, A. T., Willsey, G. G., Jaeger, J., Shi, P. Y. & Kramer, L. D., May 25 2012, In: Virology. 427, 1, p. 18-24 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Flaviviridae
  • RNA Replicase
  • West Nile virus
  • Flavivirus
  • Point Mutation
  21 Scopus citations

• Quantitative SARS-CoV-2 Serology in Children With Multisystem Inflammatory Syndrome (MIS-C)

  Rostad, C. A., Chahroudi, A., Mantus, G., Lapp, S. A., Teherani, M., Macoy, L., Tarquinio, K. M., Basu, R. K., Kao, C., Linam, W. M., Zimmerman, M. G., Shi, P-Y., Menachery, V. D., Oster, M. E., Edupuganti, S., Anderson, E. J., Suthar, M. S., Wrammert, J. & Jaggi, P., Dec 1 2020, In: Pediatrics. 146, 6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • Serology
  • Child
  • Immunoglobulin G

• Rational design of a flavivirus vaccine by abolishing viral RNA 2′-O methylation

  Li, S. H., Dong, H., Li, X. F., Xie, X., Zhao, H., Deng, Y. Q., Wang, X. Y., Ye, Q., Zhu, S. Y., Wang, H. J., Zhang, B., Leng, Q. B., Zuest, R., Qin, E. D., Qin, C. F. & Shi, P. Y., May 2013, In: Journal of virology. 87, 10, p. 5812-5819 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Flavivirus
  • Viral RNA
  • methylation
  • Methylation
  • vaccines
  67 Scopus citations

• Rational Design of a Live Attenuated Dengue Vaccine: 2′-O-Methyltransferase Mutants Are Highly Attenuated and Immunogenic in Mice and Macaques

  Züst, R., Dong, H., Li, X. F., Chang, D. C., Zhang, B., Balakrishnan, T., Toh, Y. X., Jiang, T., Li, S. H., Deng, Y. Q., Ellis, B. R., Ellis, E. M., Poidinger, M., Zolezzi, F., Qin, C. F., Shi, P. Y. & Fink, K., Aug 2013, In: PLoS pathogens. 9, 8, e1003521.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Vaccines
  • Attenuated Vaccines
  • Methyltransferases
  • Macaca
  • Viruses
  79 Scopus citations

• Recovery of a chemically synthesized Japanese encephalitis virus reveals two critical adaptive mutations in NS2B and NS4A

  Li, X. D., Li, X. F., Ye, H. Q., Deng, C. L., Ye, Q., Shan, C., Shang, B. D., Xu, L. L., Li, S. H., Cao, S. B., Yuan, Z. M., Shi, P. Y., Qin, C. F. & Zhang, B., 2014, In: Journal of General Virology. 95, PART 4, p. 806-815 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Japanese Encephalitis Virus
  • Mutation
  • Viruses
  • Clone Cells
  • Nucleic Acid Databases
  27 Scopus citations

• Resistance analysis of an antibody that selectively inhibits dengue virus serotype-1

  Zou, G., Kukkaro, P., Lok, S. M., Ng, J. K. W., Tan, G. K., Hanson, B. J., Alonso, S., MacAry, P. A. & Shi, P. Y., Sep 1 2012, In: Antiviral research. 95, 3, p. 216-223 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Serogroup
  • Antibodies
  • Viral Envelope Proteins
  • Viruses
  11 Scopus citations

• Role of microglia in the dissemination of zika virus from mother to fetal brain

  Xu, P., Shan, C., Dunn, T. J., Xie, X., Xia, H., Gao, J., Labastida, J. A., Zou, J., Villarreal, P. P., Schlagal, C. R., Yu, Y., Vargas, G., Rossi, S. L., Vasilakis, N., Shi, P. Y., Weaver, S. C. & Wu, P., Jul 2020, In: PLoS neglected tropical diseases. 14, 7, p. 1-21 21 p., e0008413.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus
  • Yolk Sac
  • Microglia
  • Zika Virus Infection
  • Microcephaly
  2 Scopus citations

• RPLP1 and RPLP2 are essential flavivirus host factors that promote early viral protein accumulation

  Campos, R. K., Wong, B., Xie, X., Lu, Y. F., Shi, P. Y., Pompon, J., Garcia-Blanco, M. A. & Bradrick, S. S., 2017, In: Journal of virology. 91, 4, e01706-16.

  Research output: Contribution to journal › Article › peer-review

  • Flavivirus
  • Dengue virus
  • Dengue Virus
  • viral proteins
  • Viral Proteins
  29 Scopus citations

• Safety and immunogenicity of two RNA-based covid-19 vaccine candidates

  Walsh, E. E., Frenck, R. W., Falsey, A. R., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Neuzil, K., Mulligan, M. J., Bailey, R., Swanson, K. A., Li, P., Koury, K., Kalina, W., Cooper, D., Fontes-Garfias, C., Shi, P. Y., Türeci, Ö., Tompkins, K. R., Lyke, K. E. & 5 others, Raabe, V., Dormitzer, P. R., Jansen, K. U., Şahin, U. & Gruber, W. C., Dec 17 2020, In: New England Journal of Medicine. 383, 25, p. 2439-2450 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Vaccines
  • Severe Acute Respiratory Syndrome
  • RNA
  • Safety
  • Coronavirus
  73 Scopus citations

• Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids

  Li, Y., Kim, Y. M., Zou, J., Wang, Q. Y., Gayen, S., Wong, Y. L., Lee, L. T., Xie, X., Huang, Q., Lescar, J., Shi, P. Y. & Kang, C., Dec 1 2015, In: Biochimica et Biophysica Acta - Biomembranes. 1848, 12, p. 3150-3157 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Viruses
  • Membranes
  • Micelles
  • Dengue virus NS4B protein
  21 Scopus citations

• Short Direct Repeats in the 3' Untranslated Region Are Involved in Subgenomic Flaviviral RNA Production

  Zhang, Q. Y., Li, X. F., Niu, X., Li, N., Wang, H. J., Deng, C. L., Ye, H. Q., Huang, X. Y., Chen, Q., Xu, Y. P., Dong, H. L., Li, X. D., Zhao, H., Shi, P. Y., Yuan, Z. M., Gong, P., Fang, X., Qin, C. F. & Zhang, B., Feb 28 2020, In: Journal of virology. 94, 6

  Research output: Contribution to journal › Article › peer-review

  • Nucleic Acid Repetitive Sequences
  • 3' untranslated regions
  • 3' Untranslated Regions
  • RNA
  • Flavivirus
  3 Scopus citations

• Small molecule inhibitors that selectively block dengue virus methyltransferase

  Lim, S. P., Sonntag, L. S., Noble, C., Nilar, S. H., Ng, R. H., Zou, G., Monaghan, P., Chung, K. Y., Dong, H., Liu, B., Bodenreider, C., Lee, G., Ding, M., Chan, W. L., Wang, G., Jian, Y. L., Chao, A. T., Lescar, J., Yin, Z., Vedananda, T. R. & 2 others, Keller, T. H. & Shi, P. Y., Feb 25 2011, In: Journal of Biological Chemistry. 286, 8, p. 6233-6240 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • Viruses
  • Methyltransferases
  • Molecules
  • Flavivirus
  108 Scopus citations
• • SARS Virus
  • Viral Vaccines
  • Mutation
  • Cricetinae
  • Viruses
  35 Scopus citations

• Spike mutation D614G alters SARS-CoV-2 fitness

  Plante, J. A., Liu, Y., Liu, J., Xia, H., Johnson, B. A., Lokugamage, K. G., Zhang, X., Muruato, A. E., Zou, J., Fontes-Garfias, C. R., Mirchandani, D., Scharton, D., Bilello, J. P., Ku, Z., An, Z., Kalveram, B., Freiberg, A. N., Menachery, V. D., Xie, X., Plante, K. S. & 2 others, Weaver, S. C. & Shi, P. Y., 2020, (Accepted/In press) In: Nature.

  Research output: Contribution to journal › Article › peer-review

  • SARS Virus
  • Viral Vaccines
  • Mutation
  • Cricetinae
  • Viruses
  35 Scopus citations

• Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening

  Niyomrattanakit, P., Wan, K. F., Chung, K. Y., Abas, S. N., Seh, C. C., Dong, H., Lim, C. C., Chao, A. T., Lee, C. B., Nilar, S., Lescar, J., Shi, P. Y., Beer, D. & Lim, S. P., Jul 1 2015, In: Antiviral research. 119, p. 36-46 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • RNA Replicase
  • Enzymes
  • dengue virus NS5 protein
  • Heavy Ions
  13 Scopus citations

• Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase

  Wang, G., Lim, S. P., Chen, Y. L., Hunziker, J., Rao, R., Gu, F., Seh, C. C., Ghafar, N. A., Xu, H., Chan, K., Lin, X., Saunders, O. L., Fenaux, M., Zhong, W., Shi, P. Y. & Yokokawa, F., Jul 15 2018, In: Bioorganic and Medicinal Chemistry Letters. 28, 13, p. 2324-2327 4 p.

  Research output: Contribution to journal › Article › peer-review

  • phosphoramidic acid
  • RNA Replicase
  • Uridine
  • Dengue Virus
  • Structure-Activity Relationship
  8 Scopus citations

• Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors

  Yeo, K. L., Chen, Y. L., Xu, H. Y., Dong, H., Wang, Q. Y., Yokokawa, F. & Shi, P. Y., Apr 1 2015, In: Antimicrobial agents and chemotherapy. 59, 4, p. 2086-2093 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dengue Virus
  • brequinar
  • Nucleosides
  • Virus Replication
  • Ribavirin
  39 Scopus citations

• Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides

  Tichý, M., Pohl, R., Xu, H. Y., Chen, Y. L., Yokokawa, F., Shi, P. Y. & Hocek, M., Oct 15 2012, In: Bioorganic and Medicinal Chemistry. 20, 20, p. 6123-6133 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Ribonucleosides
  • indole
  • Antiviral Agents
  • stannane
  • Cross Reactions
  37 Scopus citations

• The 5′ and 3′ downstream AUG region elements are required for mosquito-borne flavivirus RNA replication

  Friebe, P., Shi, P. Y. & Harris, E., Feb 2011, In: Journal of virology. 85, 4, p. 1900-1905 6 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA replication
  • Flavivirus
  • Flaviviridae
  • Culicidae
  • Viral RNA
  54 Scopus citations

• The C-terminal helical domain of dengue virus precursor membrane protein is involved in virus assembly and entry

  Hsieh, S. C., Zou, G., Tsai, W. Y., Qing, M., Chang, G. J., Shi, P. Y. & Wang, W. K., Feb 5 2011, In: Virology. 410, 1, p. 170-180 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Virus Assembly
  • Virus Internalization
  • Dengue Virus
  • Membrane Proteins
  • Mutation
  26 Scopus citations

• The dengue virus NS5 protein as a target for drug discovery

  Lim, S. P., Noble, C. G. & Shi, P-Y., Jul 1 2015, In: Antiviral Research. 119, p. 57-67 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Viral Structural Proteins
  • RNA Replicase
  • Flavivirus
  • Dengue Virus
  • Methyltransferases
  101 Scopus citations

• The helical domains of the stem region of dengue virus envelope protein are involved in both virus assembly and entry

  Lin, S. R., Zou, G., Hsieh, S. C., Qing, M., Tsai, W. Y., Shi, P. Y. & Wang, W. K., May 2011, In: Journal of virology. 85, 10, p. 5159-5171 13 p.

  Research output: Contribution to journal › Article › peer-review

  • virus assembly
  • Viral Envelope Proteins
  • Dengue virus
  • Virus Assembly
  • Virus Internalization
  34 Scopus citations

• The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

  Li, X. D., Shan, C., Deng, C. L., Ye, H. Q., Shi, P. Y., Yuan, Z. M., Gong, P. & Zhang, B., May 2014, In: PLoS neglected tropical diseases. 8, 5, e2891.

  Research output: Contribution to journal › Article › peer-review

  • RNA Replicase
  • Flavivirus
  • Methyltransferases
  • Japanese Encephalitis Virus
  • Reverse Genetics
  28 Scopus citations

• Therapeutics for Dengue: Recommendations for Design and Conduct of Early-Phase Clinical Trials

  Simmons, C. P., Wolbers, M., Nguyen, M. N., Whitehorn, J., Shi, P. Y., Young, P., Petric, R., Nguyen, V. V. C., Farrar, J. & Wills, B., Sep 2012, In: PLoS neglected tropical diseases. 6, 9, e1752.

  Research output: Contribution to journal › Article › peer-review
  25 Scopus citations