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• Review article

  Glutamate dehydrogenase: Structure, allosteric regulation, and role in insulin homeostasis

  Li, M., Li, C., Allen, A., Stanley, C. A. & Smith, T. J., Mar 2014, In: Neurochemical Research. 39, 3, p. 433-445 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Allosteric Regulation
  • Glutamate Dehydrogenase
  • Homeostasis
  • Insulin
  • Guanosine Triphosphate
  28 Scopus citations

• Green tea polyphenols in drug discovery: A success or failure?

  Smith, T. J., Jun 2011, In: Expert Opinion on Drug Discovery. 6, 6, p. 589-595 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Polyphenols
  • Tea
  • Drug Discovery
  • Camellia sinensis
  • Food Supply
  24 Scopus citations

• Structural studies on antibody recognition and neutralization of viruses

  Smith, T. J., Aug 2011, In: Current Opinion in Virology. 1, 2, p. 150-156 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Viruses
  • Antibodies
  • Cucumovirus
  • Ross River virus
  • Aphids
  6 Scopus citations

• The dynamic capsid structures of the noroviruses

  Smith, H. Q. & Smith, T. J., Mar 2019, In: Viruses. 11, 3, 235.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Norovirus
  • Capsid
  • Herd Immunity
  • Capsid Proteins
  • Viral Genome
  6 Scopus citations

• The dynamic life of virus capsids

  Sherman, M. B., Smith, H. Q. & Smith, T. J., Jun 2020, In: Viruses. 12, 6, 618.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Capsid
  • Viruses
  • Rhinovirus
  • Norovirus
  • Immune System

• The structure and allosteric regulation of glutamate dehydrogenase

  Li, M., Li, C., Allen, A., Stanley, C. A. & Smith, T. J., Sep 2011, In: Neurochemistry International. 59, 4, p. 445-455 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Allosteric Regulation
  • Glutamate Dehydrogenase
  • Insulin
  • Animals
  • Housekeeping
  30 Scopus citations

• The structure and allosteric regulation of mammalian glutamate dehydrogenase

  Li, M., Li, C., Allen, A., Stanley, C. A. & Smith, T. J., Mar 15 2012, In: Archives of Biochemistry and Biophysics. 519, 2, p. 69-80 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Allosteric Regulation
  • Glutamate Dehydrogenase
  • Guanosine Triphosphate
  • Hyperinsulinemic hypoglycemia, familial, 6
  • Animals
  77 Scopus citations

• The virally encoded killer proteins from Ustilago maydis

  Allen, A., Islamovic, E., Kaur, J., Gold, S., Shah, D. & Smith, T. J., Jan 1 2013, In: Fungal Biology Reviews. 26, 4, p. 166-173 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Ustilago
  • Ustilago zeae
  • antifungal proteins
  • viruses
  • mechanism of action
  5 Scopus citations
• Editorial

  Editorial overview: Theory and simulation: Macromolecular machines

  Hopfner, K. P. & Smith, T. J., Apr 2014, In: Current Opinion in Structural Biology. 25, p. 6-8 3 p.

  Research output: Contribution to journal › Editorial › peer-review
• Chapter

  Glutamate dehydrogenase

  Smith, T. J. & Stanley, C. A., Nov 24 2011, Amino Acids in Human Nutrition and Health. CABI Publishing, p. 1-23 23 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Glutamate Dehydrogenase
  • glutamate dehydrogenase
  • Animals
  • Enzymes
  • enzymes

• Glutamate dehydrogenase: Structure, regulation, and its role in insulin homeostasis

  Smith, T. J., Apr 4 2012, Monogenic Hyperinsulinemic Hypoglycemia Disorders. Charles, S. & Diva, D. L. (eds.). p. 87-99 13 p. (Frontiers in Diabetes; vol. 21).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Glutamate Dehydrogenase
  • Allosteric Regulation
  • Homeostasis
  • Insulin
  • Naphazoline

• Green Tea and Control of Glutamate Dehydrogenase Activity

  Smith, T. J., Aug 29 2013, Tea in Health and Disease Prevention. Elsevier Inc., p. 1029-1038 10 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• Article

  Allosteric discrimination at the NADH/ADP regulatory site of glutamate dehydrogenase

  Nassar, O. M., Wong, K. Y., Lynch, G. C., Smith, T. J. & Pettitt, B. M., Dec 1 2019, In: Protein Science. 28, 12, p. 2080-2088 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Glutamate Dehydrogenase
  • Diphosphates
  • Niacinamide
  • Hydrides
  • Adenine

• A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis

  Bailey, J., Powell, L., Sinanan, L., Neal, J., Li, M., Smith, T. & Bell, E., Sep 2011, In: FEBS Journal. 278, 17, p. 3140-3151 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Glutamate Dehydrogenase
  • Catalysis
  • Zinc
  • Inhibition (Psychology)
  • Europium
  7 Scopus citations

• Antibody-induced uncoating of human rhinovirus B14

  Dong, Y., Liu, Y., Jiang, W., Smith, T. J., Xu, Z. & Rossmann, M. G., Jul 25 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. 8017-8022 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Rhinovirus
  • Capsid
  • Antibodies
  • Virus Uncoating
  • Cryoelectron Microscopy
  27 Scopus citations

• A severe case of hyperinsulinism due to hemizygous activating mutation of glutamate dehydrogenase

  Barrosse-Antle, M., Su, C., Chen, P., Boodhansingh, K. E., Smith, T. J., Stanley, C. A., De León, D. D. & Li, C., Dec 2017, In: Pediatric Diabetes. 18, 8, p. 911-916 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Glutamate Dehydrogenase
  • Hyperinsulinism
  • Guanosine Triphosphate
  • Mutation
  • Heterozygote
  9 Scopus citations

• Atomic structure of cucumber necrosis virus and the role of the capsid in vector transmission

  Li, M., Kakani, K., Katpally, U., Johnson, S., Rochon, DA. & Smith, T. J., 2013, In: Journal of virology. 87, 22, p. 12166-12175 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Cucumber necrosis virus
  • Tombusvirus
  • capsid
  • Capsid
  • zoospores
  16 Scopus citations

• Atomic structure of salutaridine reductase from the opium poppy (Papaver somniferum)

  Higashi, Y., Kutchan, T. M. & Smith, T. J., Feb 25 2011, In: Journal of Biological Chemistry. 286, 8, p. 6532-6541 10 p.

  Research output: Contribution to journal › Article › peer-review

  • salutaridine
  • Papaver
  • Short Chain Dehydrogenase-Reductases
  • Opium
  • Oxidoreductases
  10 Scopus citations

• Bile Salts Alter the Mouse Norovirus Capsid Conformation: Possible Implications for Cell Attachment and Immune Evasion

  Sherman, M. B., Williams, A. N., Smith, H. Q., Nelson, C., Wilen, C. B., Fremont, D. H., Virgin, H. W. & Smith, T. J., Oct 1 2019, In: Journal of virology. 93, 19

  Research output: Contribution to journal › Article › peer-review

  • immune evasion
  • Norovirus
  • Immune Evasion
  • bile salts
  • capsid
  11 Scopus citations

• Dissecting the Antenna in Human Glutamate Dehydrogenase: Understanding Its Role in Subunit Communication and Allosteric Regulation

  Hoffpauir, Z. A., Sherman, E. & Smith, T. J., Oct 15 2019, In: Biochemistry. 58, 41, p. 4195-4206 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Allosteric Regulation
  • Glutamate Dehydrogenase
  • Communication
  • Antennas
  • Purine Nucleotides

• Flexibility in surface-exposed loops in a virus capsid mediates escape from antibody neutralization

  Kolawole, A. O., Li, M., Xia, C., Fischer, A. E., Giacobbi, N. S., Rippinger, C. M., Proescher, J. B. G., Wu, S. K., Bessling, S. L., Gamez, M., Yu, C., Zhang, R., Mehoke, T. S., Pipas, J. M., Wolfe, J. T., Lin, J. S., Feldman, A. B., Smith, T. J. & Wobus, C. E., Apr 2014, In: Journal of virology. 88, 8, p. 4543-4557 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • capsid
  • Capsid
  • neutralization
  • Viruses
  23 Scopus citations

• Glutamate dehydrogenase: Structure of a hyperinsulinism mutant, corrections to the atomic model, and insights into a regulatory site

  Nassar, O. M., Li, C., Stanley, C. A., Pettitt, B. M. & Smith, T. J., Jan 2019, In: Proteins: Structure, Function and Bioinformatics. 87, 1, p. 41-50 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Hyperinsulinemic hypoglycemia, familial, 6
  • Glutamate Dehydrogenase
  • Hyperinsulinism
  • Crystal structure
  • Free energy
  4 Scopus citations

• Glutamate Dehydrogenase, a Complex Enzyme at a Crucial Metabolic Branch Point

  Smith, H. Q., Li, C., Stanley, C. A. & Smith, T. J., Jan 15 2019, In: Neurochemical Research. 44, 1, p. 117-132 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Glutamate Dehydrogenase
  • Animals
  • Enzymes
  • Naphazoline
  • Metabolites
  12 Scopus citations

• Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site

  Li, C., Li, M., Chen, P., Narayan, S., Matschinsky, F. M., Bennett, M. J., Stanley, C. A. & Smith, T. J., Oct 30 2011, In: Journal of Biological Chemistry. 286, 39, p. 34164-34174 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Tea
  • Glutamate Dehydrogenase
  • Hyperinsulinemic hypoglycemia, familial, 6
  • Polyphenols
  • epigallocatechin gallate
  48 Scopus citations

• Multidomain carbohydrate-binding proteins involved in Bacteroides thetaiotaomicron starch metabolism

  Cameron, E. A., Maynard, M. A., Smith, C. J., Smith, T. J., Koropatkin, N. M. & Martens, E. C., Oct 5 2012, In: Journal of Biological Chemistry. 287, 41, p. 34614-34625 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Bacteroides thetaiotaomicron
  • saccharide-binding proteins
  • Metabolism
  • Starch
  • Carbohydrates
  58 Scopus citations

• Newly isolated mAbs broaden the neutralizing epitope in murine norovirus

  Kolawole, A. O., Xia, C., Li, M., Gamez, M., Yu, C., Rippinger, C. M., Yucha, R. E., Smith, T. J. & Wobus, C. E., Sep 2014, In: Journal of General Virology. 95, PART 9, p. 1958-1968 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • Epitopes
  • Antibodies
  • Immunoglobulin A
  • Viruses
  9 Scopus citations

• Norovirus escape from broadly neutralizing antibodies is limited to allostery-like mechanisms

  Kolawole, A. O., Smith, H. Q., Svoboda, S. A., Lewis, M. S., Sherman, M. B., Lynch, G. C., Pettitt, B. M., Smith, T. J. & Wobus, C. E., Sep 1 2017, In: mSphere. 2, 5, e00334-17.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • Neutralizing Antibodies
  • Antibodies
  • Mutation
  • Vaccines
  18 Scopus citations

• Protruding domain of capsid protein is necessary and sufficient to determine murine norovirus replication and pathogenesis in vivo

  Strong, D. W., Thackray, L. B., Smith, T. J. & Virgin, H. W., Mar 2012, In: Journal of virology. 86, 6, p. 2950-2958 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • Capsid Proteins
  • coat proteins
  • pathogenesis
  • mice
  54 Scopus citations

• Stability of cucumber necrosis virus at the quasi-6-fold axis affects zoospore transmission

  Sherman, M. B., Kakani, K., Rochon, DA., Jiang, W., Voss, N. R. & Smith, T. J., Oct 1 2017, In: Journal of virology. 91, 19, e01030-17.

  Research output: Contribution to journal › Article › peer-review

  • Cucumber necrosis virus
  • zoospores
  • Zinc
  • Tombusvirus
  • capsid
  2 Scopus citations

• Structural and functional studies of a phosphatidic acid-binding antifungal plant defensin MtDef4: Identification of an RGFRRR motif governing fungal cell entry

  Sagaram, U. S., El-Mounadi, K., Buchko, G. W., Berg, H. R., Kaur, J., Pandurangi, R. S., Smith, T. J. & Shah, D. M., Dec 4 2013, In: PloS one. 8, 12, e82485.

  Research output: Contribution to journal › Article › peer-review

  • Defensins
  • Phosphatidic Acids
  • Membranes
  • acids
  • Biosynthesis
  78 Scopus citations

• Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle

  Hansman, G. S., Taylor, D. W., McLellan, J. S., Smith, T. J., Georgiev, I., Tame, J. R. H., Park, S. Y., Yamazaki, M., Gondaira, F., Miki, M., Katayama, K., Murata, K. & Kwong, P. D., Apr 2012, In: Journal of virology. 86, 7, p. 3635-3646 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Norovirus
  • virus-like particles
  • virion
  • Virion
  • monoclonal antibodies
  50 Scopus citations

• Structure-activity determinants in antifungal plant defensins msdef1 and mtdef4 with different modes of action against fusarium graminearum

  Sagaram, U. S., Pandurangi, R., Kaur, J., Smith, T. J. & Shah, D. M., 2011, In: PloS one. 6, 4, e18550.

  Research output: Contribution to journal › Article › peer-review

  • Defensins
  • Fusarium
  • Fusarium graminearum
  • mechanism of action
  • antifungal properties
  101 Scopus citations

• The atomic structure of the virally encoded antifungal protein, KP6

  Allen, A., Chatt, E. & Smith, T. J., Feb 8 2013, In: Journal of Molecular Biology. 425, 3, p. 609-621 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Ustilago
  • Double-Stranded RNA
  • Meiosis
  • RNA Viruses
  • Proteins
  3 Scopus citations

• Transgenic maize plants expressing the Totivirus antifungal protein, KP4, are highly resistant to corn smut

  Allen, A., Islamovic, E., Kaur, J., Gold, S., Shah, D. & Smith, T. J., Oct 2011, In: Plant Biotechnology Journal. 9, 8, p. 857-864 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Totivirus
  • Genetically Modified Plants
  • antifungal proteins
  • Zea mays
  • Ustilago zeae
  23 Scopus citations