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  Endothelial cell proteomic response to Rickettsia conorii infection reveals activation of the Janus Kinase (JAK)-signal transducer and activator of transcription (STAT)-inferferon stimulated gene (ISG)15 pathway and reprogramming plasma membrane integrin/cadherin signaling

  Zhao, Y., Valbuena, G., Walker, D. H., Gazi, M., Hidalgo, M., DeSousa, R., Oteo, J. A., Goez, Y. & Brasier, A. R., Jan 2016, In: Molecular and Cellular Proteomics. 15, 1, p. 289-304 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Boutonneuse Fever
  • Endothelial cells
  • Cell membranes
  • Proteomics
  • Janus Kinases
  10 Scopus citations

• Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses

  Gong, B., Shelite, T., Mei, F. C., Ha, T., Hu, Y., Xu, G., Chang, Q., Wakamiya, M., Ksiazek, T. G., Boor, P. J., Bouyer, D. H., Popov, V. L., Chen, J., Walker, D. H. & Cheng, X., Nov 26 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 48, p. 19615-19620 6 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile
  • Spotted Fever Group Rickettsiosis
  • Bioterrorism
  • Bacterial Adhesion
  • Host-Pathogen Interactions
  48 Scopus citations

• Fatal monocytic ehrlichiosis in woman, Mexico, 2013

  Sosa-Gutierrez, C. G., Solorzano-Santos, F., Walker, D. H., Torres, J., Serrano, C. A. & Gordillo-Perez, G., May 2016, In: Emerging infectious diseases. 22, 5, p. 871-874 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichiosis
  • Mexico
  • Ehrlichia chaffeensis
  • Fever
  • Tick Bites
  8 Scopus citations

• Fever and rash after a safari

  Damavandy, A. A., Rojek, N. W., Dugan, E. M., Walker, D. & Norton, S. A., Jan 1 2015, In: Journal of the American Academy of Dermatology. 72, 1, p. e5-e6

  Research output: Contribution to journal › Article › peer-review

• Fever with thrombocytopenia associated with a novel bunyavirus in China

  Yu, X. J., Liang, M. F., Zhang, S. Y., Liu, Y., Li, J. D., Sun, Y. L., Zhang, L., Zhang, Q. F., Popov, V. L., Li, C., Qu, J., Li, Q., Zhang, Y. P., Hai, R., Wu, W., Wang, Q., Zhan, F. X., Wang, X. J., Kan, B., Wang, S. W. & 26 others, Wan, K. L., Jing, H. Q., Lu, J. X., Yin, W. W., Zhou, H., Guan, X. H., Liu, J. F., Bi, Z. Q., Liu, G. H., Ren, J., Wang, H., Zhao, Z., Song, J. D., He, J. R., Wan, T., Zhang, J. S., Fu, X. P., Sun, L. N., Dong, X. P., Feng, Z. J., Yang, W. Z., Hong, T., Zhang, Y., Walker, D. H., Wang, Y. & Li, D. X., Apr 21 2011, In: New England Journal of Medicine. 364, 16, p. 1523-1532 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Orthobunyavirus
  • Thrombocytopenia
  • China
  • Fever
  • Phlebovirus
  762 Scopus citations

• Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium

  Sahni, A., Patel, J., Narra, H. P., Schroeder, C. L. C., Walker, D. H. & Sahni, S. K., Aug 2017, In: PloS one. 12, 8, e0183181.

  Research output: Contribution to journal › Article › peer-review

  • fibroblast growth factor receptor 1
  • Spotted Fever Group Rickettsiosis
  • Endothelial cells
  • Receptor, Fibroblast Growth Factor, Type 1
  • fibroblast growth factor receptors
  10 Scopus citations

• Genotypic characterization of Orientia tsutsugamushi from patients in two geographical locations in Sri Lanka

  Premaratna, R., Blanton, L. S., Samaraweera, D. N., de Silva, G. N. N., Chandrasena, N. T. G. A., Walker, D. H. & de Silva, H. J., Jan 13 2017, In: BMC Infectious Diseases. 17, 1, 67.

  Research output: Contribution to journal › Article › peer-review

  • Orientia tsutsugamushi
  • Sri Lanka
  • Genotype
  • Real-Time Polymerase Chain Reaction
  • Fever
  9 Scopus citations

• Human monocytic ehrlichiosis, Mexico City, Mexico

  Alcántara-Rodríguez, V. E., Sánchez-Montes, S., Contreras, H., Colunga-Salas, P., Fierro-Flores, L., Avalos, S., Rodríguez-Rangel, F., Becker, I. & Walker, D. H., Dec 2020, In: Emerging infectious diseases. 26, 12, p. 3016-3019 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichiosis
  • Mexico
  • Ehrlichia canis
  • Ehrlichia
  • Infection

• Human rickettsiosis caused by rickettsia parkeri strain Atlantic rainforest, Urabá, Colombia

  Arboleda, M., Acevedo-Gutiérrez, L. Y., Ávila, A., Ospina, D., Díaz, F. J., Walker, D. H. & Rodas, J. D., Dec 2020, In: Emerging infectious diseases. 26, 12, p. 3048-3050 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Rainforest
  • Rickettsia
  • Colombia
  • vpr Genes
  • Gene Amplification

• Immune Mediators of protective and pathogenic immune responses in patients with mild and fatal human monocytotropic ehrlichiosis

  Ismail, N., Walker, D. H., Ghose, P. & Tang, Y. W., May 21 2012, In: BMC Immunology. 13, 26.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichiosis
  • Chemokines
  • Septic Shock
  • Interleukin-1
  • Interleukin-10
  11 Scopus citations

• Immunization with Ehrlichia P28 outer membrane proteins confers protection in a mouse model of ehrlichiosis

  Crocquet-Valdes, P. A., Thirumalapura, N. R., Ismail, N., Yu, X., Saito, T. B., Stevenson, H. L., Pietzsch, C. A., Thomas, S. & Walker, D. H., Dec 2011, In: Clinical and Vaccine Immunology. 18, 12, p. 2018-2025 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia
  • Immunization
  • Ehrlichiosis
  • T-cells
  • Membrane Proteins
  17 Scopus citations

• Mechanisms of immunity to rickettsia and implications for vaccine development

  Walker, D., Jan 1 2017, In: Revista Colombiana de Ciencias Pecuarias. 30, p. 262-263 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Spotted Fever Group Rickettsiosis
  • Rickettsia
  • vaccine development
  • fever
  • immunity

• Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus

  Yun, N. E., Seregin, A. V., Walker, D. H., Popov, V. L., Walker, A. G., Smith, J. N., Miller, M., de la Torre, J. C., Smith, J. K., Borisevich, V., Fair, J. N., Wauquier, N., Grant, D. S., Bockarie, B., Bente, D. & Paessler, S., 2013, In: Journal of virology. 87, 19, p. 10908-10911 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Lassa virus fever
  • Lassa virus
  • Lassa Fever
  • Arenavirus
  • Western Africa
  33 Scopus citations

• Molecular and cellular pathobiology of Ehrlichia infection: Targets for new therapeutics and immunomodulation strategies

  McBride, J. W. & Walker, D. H., Jan 2011, In: Expert reviews in molecular medicine. 13, e3.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichiosis
  • Immunomodulation
  • Ehrlichia
  • Host-Pathogen Interactions
  • Rickettsiales
  39 Scopus citations

• Murine models of scrub typhus associated with host control of Orientia tsutsugamushi infection

  Mendell, N. L., Bouyer, D. H. & Walker, D. H., Mar 10 2017, In: PLoS neglected tropical diseases. 11, 3, e0005453.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Orientia tsutsugamushi
  • Infection
  • Trombiculidae
  • Heterologous Immunity
  11 Scopus citations

• MyD88 mediates instructive signaling in dendritic cells and protective inflammatory response during rickettsial infection

  Bechelli, J., Smalley, C., Zhao, X., Judy, B., Valdes, P., Walker, D. H. & Fang, R., Apr 1 2016, In: Infection and immunity. 84, 4, p. 883-893 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Dendritic Cells
  • Interleukin-1
  • Infection
  • Bone Marrow
  • Rickettsia
  12 Scopus citations

• Obligate intracellular bacterium Ehrlichia inhibiting mitochondrial activity

  Liu, Y., Zhang, Z., Jiang, Y., Zhang, L., Popov, V. L., Zhang, J., Walker, D. H. & Yu, X. J., Mar 2011, In: Microbes and Infection. 13, 3, p. 232-238 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia
  • Bacteria
  • Mitochondria
  • Phagocytes
  • Ehrlichia chaffeensis
  15 Scopus citations

• Opossums and cat fleas: New insights in the ecology of murine typhus in Galveston, Texas

  Blanton, L. S., Idowu, B. M., Tatsch, T. N., Henderson, J. M., Bouyer, D. H. & Walker, D. H., Aug 2016, In: American Journal of Tropical Medicine and Hygiene. 95, 2, p. 457-461 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Ctenocephalides
  • Endemic Flea-Borne Typhus
  • Siphonaptera
  • Opossums
  • Ecology
  32 Scopus citations

• Permissive and protective roles for neutrophils in leishmaniasis

  Carlsen, E. D., Liang, Y., Shelite, T. R., Walker, D. H., Melby, P. C. & Soong, L., Nov 2015, In: Clinical and Experimental Immunology. 182, 2, p. 109-18 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmaniasis
  • Parasites
  • Neutrophils
  • Leishmania
  • Infection
  32 Scopus citations

• Person-to-person transmission of severe fever with thrombocytopenia syndrome virus

  Liu, Y., Li, Q., Hu, W., Wu, J., Weng, Y., Mei, L., Walker, D. H., Ren, J., Wang, Y. & Yu, X. J., Feb 1 2012, In: Vector-Borne and Zoonotic Diseases. 12, 2, p. 156-160 5 p.

  Research output: Contribution to journal › Article › peer-review

  • SFTS phlebovirus
  • Thrombocytopenia
  • Fever
  • Viruses
  • Phlebovirus
  154 Scopus citations

• Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections

  Zhao, Y., Fang, R., Zhang, J., Zhang, Y., Bechelli, J., Smalley, C., Valbuena, G., Walker, D. H., Oteo, J. A. & Brasier, A. R., Feb 2020, In: American Journal of Pathology. 190, 2, p. 306-322 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Spotted Fever Group Rickettsiosis
  • Rickettsia conorii
  • Proteomics
  • Boutonneuse Fever
  • Infection
  3 Scopus citations

• Recombinant Ehrlichia P29 protein induces a protective immune response in a mouse model of ehrlichiosis

  Thirumalapura, N. R., Crocquet-Valdes, P. A., Saito, T. B., Thomas, S., McBride, J. W. & Walker, D. H., Dec 5 2013, In: Vaccine. 31, 50, p. 5960-5967 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia
  • ehrlichiosis
  • Ehrlichiosis
  • Tandem Repeat Sequences
  • Ehrlichia chaffeensis
  4 Scopus citations

• Reemergence of murine typhus in galveston, texas, usa, 2013

  Blanton, L. S., Vohra, R. F., Bouyer, D. H. & Walker, D. H., 2015, In: Emerging infectious diseases. 21, 3, p. 484-486 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Endemic Flea-Borne Typhus
  • Rickettsia typhi
  • Public Health
  • Physicians
  24 Scopus citations

• Rickettsia australis activates inflammasome in human and murine macrophages

  Smalley, C., Bechelli, J., Rockx-Brouwer, D., Saito, T., Azar, S. R., Ismail, N., Walker, D. H. & Fang, R., Jun 2016, In: PloS one. 11, 6, e0157231.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia australis
  • inflammasomes
  • Macrophages
  • Rickettsia
  • Inflammasomes
  13 Scopus citations

• Rickettsia massiliae and rickettsia conorii israeli spotted fever strain differentially regulate endothelial cell responses

  Bechelli, J., Smalley, C., Milhano, N., Walker, D. H. & Fang, R., Sep 22 2015, In: PloS one. 10, 9, e0138830.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia massiliae
  • Rickettsia conorii
  • Spotted Fever Group Rickettsiosis
  • Endothelial cells
  • Rickettsia
  5 Scopus citations

• Simple method to differentiate among Rickettsia species

  Peniche-Lara, G., Zavala-Velazquez, J., Dzul-Rosado, K., Walker, D. H. & Zavala-Castro, J., Apr 2013, In: Journal of Molecular Microbiology and Biotechnology. 23, 3, p. 203-208 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia
  • Polymerase Chain Reaction
  • Ecosystem
  • Enzymes
  • Restriction Fragment Length Polymorphisms
  8 Scopus citations

• Spotted fever group Rickettsia in small rodents from areas of low endemicity for Brazilian spotted fever in the Eastern Region of Minas Gerais State, Brazil

  Milagres, B. S., Padilha, A. F., Montandon, C. E., Freitas, R. N., Pacheco, R., Walker, D. H., Labruna, M. B., Mafra, C. L. & Galvão, M. A. M., May 2013, In: American Journal of Tropical Medicine and Hygiene. 88, 5, p. 937-939 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Rocky Mountain Spotted Fever
  • Spotted Fever Group Rickettsiosis
  • Rickettsia
  • Brazil
  • Rodentia
  7 Scopus citations

• Structure-based vaccines provide protection in a mouse model of ehrlichiosis

  Thomas, S., Thirumalapura, N. R., Crocquet-Valdes, P. A., Luxon, B. A. & Walker, D. H., Nov 17 2011, In: PloS one. 6, 11, e27981.

  Research output: Contribution to journal › Article › peer-review

  • Ehrlichia
  • ehrlichiosis
  • Ehrlichiosis
  • animal models
  • vaccines
  15 Scopus citations

• Systemic treatment with cpg-b after sublethal rickettsial infection induces mouse death through indoleamine 2,3-dioxygenase (ido)

  Xin, L., Shelite, T. R., Gong, B., Mendell, N. L., Soong, L., Fang, R. & Walker, D. H., Mar 28 2012, In: PloS one. 7, 3, e34062.

  Research output: Contribution to journal › Article › peer-review

  • indoleamine 2,3-dioxygenase
  • rickettsial diseases
  • T-cells
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Dendritic Cells
  16 Scopus citations

• The role of Rhipicephalus sanguineus sensu lato saliva in the dissemination of Rickettsia conorii in C3H/HeJ mice

  Milhano, N., Saito, T. B., Bechelli, J., Fang, R., Vilhena, M., De Sousa, R. & Walker, D. H., Sep 1 2015, In: Medical and Veterinary Entomology. 29, 3, p. 225-229 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Rickettsia conorii
  • Rhipicephalus sanguineus
  • tick
  • saliva
  • Ticks
  9 Scopus citations

• Time to Worry about Anthrax Again

  Keim, P. S., Walker, D. H. & Zilinskas, R. A., Mar 14 2017, In: Scientific American. 316, 4, p. 70-75 6 p.

  Research output: Contribution to journal › Article › peer-review
  1 Scopus citations

• Value of autopsy emphasized in the case report of a single patient with middle east respiratory syndrome

  Walker, D. H., Mar 1 2016, In: American Journal of Pathology. 186, 3, p. 507-510 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Coronavirus Infections
  • Communicable Diseases
  • Autopsy
  7 Scopus citations