Find Research outputs

Search results

• Review article

  Regulation of chemokine function: The roles of GAG-binding and post-translational nitration

  Thompson, S., Martínez-Burgo, B., Sepuru, K. M., Rajarathnam, K., Kirby, J. A., Sheerin, N. S. & Ali, S., Aug 3 2017, In: International journal of molecular sciences. 18, 8, 1692.

  Research output: Contribution to journal › Review article › peer-review

  • Glycosaminoglycans
  • nitration
  • Nitration
  • Chemokines
  • leukocytes
  12 Scopus citations

• Structural Insights Into How Proteoglycans Determine Chemokine-CXCR1/CXCR2 Interactions: Progress and Challenges

  Rajarathnam, K. & Desai, U. R., Apr 24 2020, In: Frontiers in immunology. 11, 660.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Proteoglycans
  • Glycosaminoglycans
  • Chemokines
  • Interleukin-8A Receptors
  • Interleukin-8B Receptors
  5 Scopus citations
• Article

  Characterizing protein–glycosaminoglycan interactions using solution NMR spectroscopy

  Joseph, P. R. B., Poluri, K. M., Sepuru, K. M. & Rajarathnam, K., 2015, In: Methods in Molecular Biology. 1229, p. 325-333 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Magnetic Resonance Spectroscopy
  • Macromolecular Substances
  • Data Accuracy
  • Proteins
  5 Scopus citations

• Chemokine CXCL1-Mediated Neutrophil Trafficking in the Lung: Role of CXCR2 Activation

  Sawant, K. V., Xu, R., Cox, R., Hawkins, H., Sbrana, E., Kolli, D., Garofalo, R. P. & Rajarathnam, K., Oct 16 2015, In: Journal of Innate Immunity. 7, 6, p. 647-658 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemokine CXCL1
  • Neutrophils
  • Lung
  • Neutrophil Infiltration
  • Interleukin-8B Receptors
  46 Scopus citations

• Chemokine CXCL7 heterodimers: Structural insights, CXCR2 receptor function, and glycosaminoglycan interactions

  Brown, A. J., Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., Apr 2017, In: International journal of molecular sciences. 18, 4, 748.

  Research output: Contribution to journal › Article › peer-review

  • Glycosaminoglycans
  • Interleukin-8B Receptors
  • Chemokines
  • disulfides
  • infectious diseases
  11 Scopus citations

• Diverging mechanisms of activation of chemokine receptors revealed by novel chemokine agonists

  Sarmiento, J., Shumate, C., Suetomi, K., Ravindran, A., Villegas, L., Rajarathnam, K. & Navarro, J., Dec 9 2011, In: PloS one. 6, 12, e27967.

  Research output: Contribution to journal › Article › peer-review

  • chemokine receptors
  • chemokines
  • Chemokine Receptors
  • Interleukin-8
  • Chemokines
  12 Scopus citations

• Flexible Linker Modulates Glycosaminoglycan Affinity of Decorin Binding Protein A

  Morgan, A., Sepuru, K. M., Feng, W., Rajarathnam, K. & Wang, X., Jul 30 2015, In: Biochemistry. 54, 32, p. 5113-5119 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Decorin
  • Staphylococcal Protein A
  • Glycosaminoglycans
  • Carrier Proteins
  • Borrelia burgdorferi
  4 Scopus citations

• Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: Implications for gradients and neutrophil trafficking

  Joseph, P. R. B., Sawant, K. V. & Rajarathnam, K., 2017, In: Open Biology. 7, 11, 170168.

  Research output: Contribution to journal › Article › peer-review

  • Dimers
  • Monomers
  • Glycosaminoglycans
  • Interleukin-8
  • Heparin
  17 Scopus citations

• Long-Range Coupled Motions Underlie Ligand Recognition by a Chemokine Receptor

  Sepuru, K. M., Nair, V., Prakash, P., Gorfe, A. A. & Rajarathnam, K., Dec 18 2020, In: iScience. 23, 12, 101858.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Molecular modeling
  • Biochemistry
  • Molecular dynamics
  • Chemokine Receptors
  • Ligands

• Lyophilization of human amniotic fluid is feasible without affecting biological activity

  Coon, J. I., Jain, S., Sepuru, K. M., Chung, Y., Mohankumar, K., Rajarathnam, K. & Jain, S. K., Apr 1 2020, In: Pediatric Research. 87, 5, p. 847-852 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Freeze Drying
  • Amniotic Fluid
  • Interleukin-8
  • Deglutition
  • Dialysis

• Platelet-derived chemokine CXCL₇ dimer preferentially exists in the glycosaminoglycan-bound form: Implications for neutrophil-platelet crosstalk

  Brown, A. J., Sepuru, K. M., Sawant, K. V. & Rajarathnam, K., Oct 2 2017, In: Frontiers in immunology. 8, OCT, 1248.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-8B Receptors
  • Glycosaminoglycans
  • Chemokines
  • Heparin
  • Neutrophils
  20 Scopus citations

• Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: Structural plasticity mediates differential binding interactions

  Joseph, P. R. B., Mosier, P. D., Desai, U. R. & Rajarathnam, K., Nov 15 2015, In: Biochemical Journal. 472, 1, p. 121-133 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Dimers
  • Nuclear magnetic resonance
  • Monomers
  • Glycosaminoglycans
  • Interleukin-8
  56 Scopus citations

• Solution NMR characterization of WT CXCL8 monomer and dimer binding to CXCR1 N-terminal domain

  Joseph, P. R. B. & Rajarathnam, K., Jan 1 2015, In: Protein Science. 24, 1, p. 81-92 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Dimers
  • Nuclear magnetic resonance
  • Monomers
  • Protein Domains
  • Interleukin-8A Receptors
  25 Scopus citations

• Structural basis of native CXCL7 monomer binding to CXCR2 receptor N-domain and glycosaminoglycan heparin

  Brown, A. J., Sepuru, K. M. & Rajarathnam, K., Mar 2017, In: International journal of molecular sciences. 18, 3, 508.

  Research output: Contribution to journal › Article › peer-review

  • Glycosaminoglycans
  • Heparin
  • Interleukin-8B Receptors
  • heparins
  • Monomers
  14 Scopus citations

• The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

  Gangavarapu, P., Rajagopalan, L., Kolli, D., Guerrero-Plata, A., Garofalo, R. P. & Rajarathnam, K., Feb 2012, In: Journal of Leukocyte Biology. 91, 2, p. 259-265 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neutrophil Infiltration
  • Glycosaminoglycans
  • Interleukin-8
  • Chemokines
  • Peritoneum
  65 Scopus citations

• Using isothermal titration calorimetry to determine thermodynamic parameters of protein–glycosaminoglycan interactions

  Dutta, A. K., Rösgen, J. & Rajarathnam, K., 2015, In: Methods in Molecular Biology. 1229, p. 315-324 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Calorimetry
  • Thermodynamics
  • Entropy
  • Kinetics
  27 Scopus citations