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• Article

  Pathological Interface between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies

  Sengupta, U., Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Lasagna-Reeves, C. A., Gerson, J. E., Paulucci-Holthauzen, A. A., Krishnamurthy, S., Farhed, M., Jackson, G. R. & Kayed, R., Nov 15 2015, In: Biological Psychiatry. 78, 10, p. 672-683 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • alpha-Synuclein
  • Antibodies
  • Brain
  • Lewy Body Disease
  86 Scopus citations

• Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein

  Sengupta, U., Puangmalai, N., Bhatt, N., Garcia, S., Zhao, Y. & Kayed, R., Jun 1 2020, In: Molecular Neurobiology. 57, 6, p. 2741-2765 25 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synucleins
  • tau Proteins
  • Docosahexaenoic Acids
  • Parkinson Disease
  • Dopamine
  2 Scopus citations

• Pre-amyloid oligomers budding: A metastatic mechanism of proteotoxicity

  Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Oct 24 2016, In: Scientific reports. 6, 35865.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Proteostasis Deficiencies
  • Immunoglobulin Fragments
  • Atomic Force Microscopy
  • Immunotherapy
  8 Scopus citations

• Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

  Violet, M., Chauderlier, A., Delattre, L., Tardivel, M., Chouala, M. S., Sultan, A., Marciniak, E., Humez, S., Binder, L., Kayed, R., Lefebvre, B., Bonnefoy, E., Buée, L. & Galas, M. C., Oct 1 2015, In: Neurobiology of Disease. 82, p. 540-551 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Nucleic Acids
  • Neurons
  • Induced Hyperthermia
  • Alzheimer Disease
  • Pathology
  34 Scopus citations

• Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies

  Bittar, A., Sengupta, U. & Kayed, R., Dec 1 2018, In: npj Vaccines. 3, 1, 9.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Passive Immunization
  • Immunotherapy
  • Alzheimer Disease
  • Poisons
  24 Scopus citations

• Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies

  Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In: Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Tauopathies
  • Rats
  • Traumatic Brain Injury
  • Brain
  90 Scopus citations

• RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction

  Montalbano, M., McAllen, S., Puangmalai, N., Sengupta, U., Bhatt, N., Johnson, O. D., Kharas, M. G. & Kayed, R., Dec 1 2020, In: Nature communications. 11, 1, 4305.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA-Binding Proteins
  • proteins
  • Alzheimer Disease
  • Frontotemporal Dementia With Motor Neuron Disease
  • Neurodegenerative diseases
  2 Scopus citations

• Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

  Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., Benfenati, F., Lee, M. K., Bennett, D. A. & Lesné, S. E., Jun 6 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4648-E4657

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Synapsins
  • Memory Disorders
  • Amyloidogenic Proteins
  • Response Elements
  24 Scopus citations

• Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

  Wu, J. W., Herman, M., Liu, L., Simoes, S., Acker, C. M., Figueroa, H., Steinberg, J. I., Margittai, M., Kayed, R., Zurzolo, C., Di Paolo, G. & Duff, K. E., Jan 18 2013, In: Journal of Biological Chemistry. 288, 3, p. 1856-1870 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Endocytosis
  • Neurons
  • Tauopathies
  • Conformations
  • Molecular weight
  273 Scopus citations

• Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

  Ghag, G., Bhatt, N., Cantu, D. V., Guerrero-Munoz, M. J., Ellsworth, A., Sengupta, U. & Kayed, R., Nov 2018, In: Protein Science. 27, 11, p. 1901-1909 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sonication
  • Poisons
  • Oligomers
  • Amyloidogenic Proteins
  • Prions
  21 Scopus citations

• Tau aggregates as immunotherapeutic targets

  Castillo-Carranza, D. L., Lasagna-Reeves, C. A. & Kayed, R., Jan 1 2013, In: Frontiers in Bioscience - Scholar. 5 S, 2, p. 426-438 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Neurofibrillary Tangles
  • Toxicity
  • Tauopathies
  • Neurodegenerative diseases
  30 Scopus citations

• Tau Immunotherapy for Alpha-Synucleinopathy

  Aguilar, C., Al Lahham, R., Sengupta, U., Carretero Murillo, M., Kayed, R. & Dineley, K., Jul 2018, In: Alzheimer's and Dementia. 14, 7, p. 1412

  Research output: Contribution to journal › Article › peer-review

• Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an alzheimer’s disease mouse model

  Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Hernandez, C., Barrett, A. D. T., Dineley, K. & Kayed, R., 2015, In: Journal of Neuroscience. 35, 12, p. 4857-4868 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Immunotherapy
  • Alzheimer Disease
  • Memory Disorders
  • Pathology
  82 Scopus citations

• Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

  Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In: Biochemistry. 58, 25, p. 2814-2821 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Conformation
  • Synucleins
  • Conformations
  • Poisons
  • Agglomeration
  6 Scopus citations

• Tau oligomers associate with inflammation in the brain and retina of tauopathy mice and in neurodegenerative diseases

  Nilson, A. N., English, K. C., Gerson, J. E., Barton Whittle, T., Nicolas Crain, C., Xue, J., Sengupta, U., Castillo-Carranza, D. L., Zhang, W., Gupta, P. & Kayed, R., 2017, In: Journal of Alzheimer's Disease. 55, 3, p. 1083-1099 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Tauopathies
  • Encephalitis
  • Neurodegenerative Diseases
  • Retina
  • Inflammation
  45 Scopus citations

• Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice

  Gerson, J., Castillo-Carranza, D. L., Sengupta, U., Bodani, R., Prough, D. S., DeWitt, D. S., Hawkins, B. E. & Kayed, R., Nov 15 2016, In: Journal of neurotrauma. 33, 22, p. 2034-2043 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Traumatic Brain Injury
  • Cognitive Dysfunction
  • Pathology
  • Brain
  • Neurodegenerative Diseases
  39 Scopus citations

• Tau Oligomers in Sera of Patients with Alzheimer's Disease and Aged Controls

  Kolarova, M., Sengupta, U., Bartos, A., Ricny, J. & Kayed, R., 2017, In: Journal of Alzheimer's Disease. 58, 2, p. 471-478 8 p.

  Research output: Contribution to journal › Article › peer-review

  • tau Proteins
  • Cognitive Dysfunction
  • Alzheimer Disease
  • Serum
  • Extracellular Space
  11 Scopus citations

• Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration

  Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In: Aging cell. 18, 6, e13035.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lamins
  • Tauopathies
  • RNA-Binding Proteins
  • Alzheimer Disease
  • Poisons
  7 Scopus citations

• Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

  Gerson, J. E., Farmer, K. M., Henson, N., Castillo-Carranza, D. L., Carretero Murillo, M., Sengupta, U., Barrett, A. & Kayed, R., Mar 15 2018, In: Molecular Neurodegeneration. 13, 1, 13.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Immunotherapy
  • Poisons
  • Monoclonal Antibodies
  • Lewy Bodies
  21 Scopus citations

• TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia

  Montalbano, M., McAllen, S., Cascio, F. L., Sengupta, U., Garcia, S., Bhatt, N., Ellsworth, A., Heidelman, E. A., Johnson, O. D., Doskocil, S. & Kayed, R., Dec 2020, In: Neurobiology of Disease. 146, 105130.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Frontotemporal Dementia With Motor Neuron Disease
  • DNA-Binding Proteins
  • Alzheimer Disease
  • Inclusion Bodies
  • Neurodegenerative Diseases

• Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

  Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In: Scientific reports. 9, 1, 19011.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Curcumin
  • Neurodegenerative Diseases
  • Poisons
  • Tauopathies
  • Microtubule-Associated Proteins
  12 Scopus citations

• Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

  Rasool, S., Albay, R., Martinez-Coria, H., Breydo, L., Wu, J., Milton, S., Misra, S., Tran, A., Pensalfini, A., Laferla, F., Kayed, R. & Glabe, C. G., 2012, In: Molecular Neurodegeneration. 7, 1, 37.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid
  • Vaccination
  • Cognition
  • Hemorrhage
  • Vaccines
  29 Scopus citations

• α-Synuclein Oligomers Induce a Unique Toxic Tau Strain

  Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Gerson, J. E. & Kayed, R., Oct 1 2018, In: Biological Psychiatry. 84, 7, p. 499-508 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Poisons
  • Parkinson Disease
  • Brain
  • Disease Progression
  28 Scopus citations

• α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: Relevance to human synucleopathic diseases

  Martin, Z. S., Neugebauer, V., Dineley, K. T., Kayed, R., Zhang, W., Reese, L. C. & Taglialatela, G., Feb 2012, In: Journal of neurochemistry. 120, 3, p. 440-452 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Synucleins
  • Oligomers
  • Calcineurin
  • Long-Term Potentiation
  • Memory
  63 Scopus citations
• Abstract

  Immunotherapy Targeting Tau Oligomeric Strains in Aged Transgenic Animals of Tauopathy

  Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Oct 2018, p. S64.

  Research output: Contribution to conference › Abstract › peer-review

  • Tauopathies
  • Genetically Modified Animals
  • Passive Immunization
  • Immunotherapy
  • Clone Cells