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• Article

  An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection

  Soong, L., Mendell, N. L., Olano, J. P., Rockx-Brouwer, D., Xu, G., Goez-Rivillas, Y., Drom, C., Shelite, T. R., Valbuena, G., Walker, D. H. & Bouyer, D. H., Aug 1 2016, In: PLoS neglected tropical diseases. 10, 8, e0004884.

  Research output: Contribution to journal › Article › peer-review

  • Immunological Models
  • Scrub Typhus
  • Infection
  • Orientia tsutsugamushi
  • Interleukin-9
  15 Scopus citations

• A variant in the promoter of MBL2 is associated with protection against visceral leishmaniasis in Morocco

  Hamdi, S., Ejghal, R., Idrissi, M., Ezzikouri, S., Hida, M., Soong, L., Amarouch, H. & Lemrani, M., Jan 1 2013, In: Infection, Genetics and Evolution. 13, 1, p. 162-167 6 p.

  Research output: Contribution to journal › Article › peer-review

  • leishmaniasis
  • Mannose-Binding Lectin
  • Morocco
  • visceral leishmaniasis
  • Visceral Leishmaniasis
  8 Scopus citations

• CD4⁺ T cell-dependent macrophage activation modulates sustained ps exposure on intracellular amastigotes of leishmania amazonensis

  Wanderley, J. L. M., Deolindo, P., Carlsen, E., Portugal, A. B., DaMatta, R. A., Barcinski, M. A. & Soong, L., 2019, In: Frontiers in Cellular and Infection Microbiology. 9, APR, 105.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leishmania
  • Phosphatidylserines
  • Macrophage Activation
  • T-Lymphocytes
  • Parasites
  5 Scopus citations

• Developmental Defects Associated with DNA Copy Number Gain of Chromosome 2q33.1: A Case Report and Review of Literature

  Gupta, A., Yo, J., Huang, G., Soong, L. & Dong, J., Mar 21 2018, In: Lab Medicine. 49, 2, p. 160-164 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Chromosomes
  • Genes
  • Defects
  • Caspases
  • Cells

• Differential, type i interferon-mediated autophagic trafficking of hepatitis C virus proteins in mouse liver

  Desai, M. M., Gong, B., Chan, T., Davey, R. A., Soong, L., Kolokoltsov, A. A. & Sun, J., Aug 2011, In: Gastroenterology. 141, 2, p. 674-685.e6

  Research output: Contribution to journal › Article › peer-review

  • Hepacivirus
  • Interferon-beta
  • Interferons
  • Antiviral Agents
  • Mitochondria
  27 Scopus citations

• Differential microbicidal effects of human histone proteins H2A and H2B on Leishmania promastigotes and amastigotes

  Wang, Y., Chen, Y., Xin, L., Beverley, S. M., Carlsen, E. D., Popov, V., Chang, K. P., Wang, M. & Soong, L., Mar 2011, In: Infection and immunity. 79, 3, p. 1124-1133 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmania
  • Histones
  • Proteins
  • lipophosphonoglycan
  • Recombinant Proteins
  53 Scopus citations

• Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection

  Auclair, S., Liu, F., Niu, Q., Hou, W., Churchyard, G., Morgan, C., Frahm, N., Nitayaphan, S., Pitisuthithum, P., Rerks-Ngarm, S., Kimata, J. T., Soong, L., Franchini, G., Robb, M., Kim, J., Michael, N. & Hu, H., Feb 2018, In: PLoS pathogens. 14, 2, e1006888.

  Research output: Contribution to journal › Article › peer-review

  • AIDS Vaccines
  • HIV Infections
  • T-Lymphocytes
  • Adenoviridae
  • HIV
  13 Scopus citations

• Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis

  Hou, L., Jie, Z., Desai, M., Liang, Y., Soong, L., Wang, T. & Sun, J., Jan 15 2013, In: Journal of Immunology. 190, 2, p. 621-629 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-17
  • Adaptive Immunity
  • Hepatitis
  • Interleukin-7
  • T-Lymphocytes
  37 Scopus citations

• Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression

  Almahariq, M., Mei, F. C., Wang, H., Cao, A. T., Yao, S., Soong, L., Sun, J., Cong, Y., Chen, J. & Cheng, X., Jan 15 2015, In: Biochemical Journal. 465, p. 295-303 9 p.

  Research output: Contribution to journal › Article › peer-review

  • T-cells
  • Regulatory T-Lymphocytes
  • erythromycin propionate-N-acetylcysteinate
  • Immunosuppression
  • Pharmacology
  24 Scopus citations

• Exposure of phosphatidylserine on leishmania amazonensis isolates is associated with diffuse cutaneous leishmaniasis and parasite infectivity

  França-Costa, J., Wanderley, J. L. M., Deolindo, P., Zarattini, J. B., Costa, J., Soong, L., Barcinski, M. A., Barral, A. & Borges, V. M., May 4 2012, In: PloS one. 7, 5, e36595.

  Research output: Contribution to journal › Article › peer-review

  • Diffuse Cutaneous Leishmaniasis
  • Macrophages
  • Leishmania amazonensis
  • Parasites
  • cutaneous leishmaniasis
  26 Scopus citations

• Functional interferon system is required for clearance of Lassa virus

  Yun, N. E., Poussard, A. L., Seregin, A. V., Walker, A. G., Smith, J. K., Aronson, J. F., Smith, J. N., Soong, L. & Paessler, S., Mar 2012, In: Journal of virology. 86, 6, p. 3389-3392 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Lassa virus
  • interferons
  • Interferons
  • Lassa Fever
  • endemic diseases
  34 Scopus citations

• IL-33-Dependent Endothelial Activation Contributes to Apoptosis and Renal Injury in Orientia tsutsugamushi-Infected Mice

  Shelite, T. R., Liang, Y., Wang, H., Mendell, N. L., Trent, B. J., Sun, J., Gong, B., Xu, G., Hu, H., Bouyer, D. H. & Soong, L., Mar 4 2016, In: PLoS neglected tropical diseases. 10, 3, e0004467.

  Research output: Contribution to journal › Article › peer-review

  • Orientia tsutsugamushi
  • Interleukin-33
  • Apoptosis
  • Endothelial Cells
  • Kidney
  19 Scopus citations

• IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis

  Liang, Y., Yi, P., Yuan, D. M. K., Jie, Z., Kwota, Z., Soong, L., Cong, Y. & Sun, J., Feb 1 2019, In: Cellular and Molecular Immunology. 16, 2, p. 126-137 12 p.

  Research output: Contribution to journal › Article › peer-review

  • STAT6 Transcription Factor
  • Interleukin-33
  • Lymphocytic choriomeningitis virus
  • Interleukin-13
  • Hepatitis
  8 Scopus citations

• IL-33 induces nuocytes and modulates liver injury in viral hepatitis

  Liang, Y., Jie, Z., Hou, L., Aguilar-Valenzuela, R., Vu, D., Soong, L. & Sun, J., Jun 1 2013, In: Journal of Immunology. 190, 11, p. 5666-5675 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-33
  • Hepatitis
  • Liver
  • Wounds and Injuries
  • Alarmins
  51 Scopus citations

• IL-33 promotes innate IFN-γ production and modulates dendritic cell response in LCMV-induced hepatitis in mice

  Liang, Y., Jie, Z., Hou, L., Yi, P., Wang, W., Kwota, Z., Salvato, M., de Waal Malefyt, R., Soong, L. & Sun, J., 2015, (Accepted/In press) In: European Journal of Immunology.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-33
  • Lymphocytic choriomeningitis virus
  • Hepatitis
  • Dendritic Cells
  • T-Lymphocytes
  21 Scopus citations

• Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis

  Eaves-Pyles, T., Patel, J., Arigi, E., Cong, Y., Cao, A., Garg, N., Dhiman, M., Pyles, R. B., Arulanandam, B., Miller, A. L., Popov, V. L., Soong, L., Carlsen, E. D., Coletta, C., Szabo, C. & Almeida, I. C., 2013, In: Molecular Medicine. 19, 1, p. 263-275 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystatins
  • Francisella tularensis
  • Macrophages
  • Cysteine Proteinase Inhibitors
  • Phagosomes
  7 Scopus citations

• Immunotherapy using anti-PD-1 and anti-PD-L1 in Leishmania amazonensis-infected BALB/c mice reduce parasite load

  da Fonseca-Martins, A. M., Ramos, T. D., Pratti, J. E. S., Firmino-Cruz, L., Gomes, D. C. O., Soong, L., Saraiva, E. M. & de Matos Guedes, H. L., Dec 1 2019, In: Scientific reports. 9, 1, 20275.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Parasite Load
  • Leishmania
  • Immunotherapy
  • T-Lymphocytes
  • Diffuse Cutaneous Leishmaniasis
  3 Scopus citations

• Imported leishmaniasis cases in Cuba (2006-2016): What have we learned

  Montalvo, A. M., Fraga, J., Blanco, O., González, D., Monzote, L., Soong, L. & Capó, V., Aug 7 2018, In: Tropical Diseases, Travel Medicine and Vaccines. 4, 1, 7.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cuba
  • Leishmaniasis
  • Tropical Medicine
  • Parasitology
  • Climate Change
  3 Scopus citations

• Interactions between Neutrophils and Leishmania braziliensis Amastigotes Facilitate Cell Activation and Parasite Clearance

  Carlsen, E. D., Jie, Z., Liang, Y., Henard, C. A., Hay, C., Sun, J., De Matos Guedes, H. & Soong, L., Jul 22 2015, In: Journal of Innate Immunity. 7, 4, p. 354-363 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmania braziliensis
  • Parasites
  • Neutrophils
  • Neutrophil Activation
  • Leishmaniasis
  21 Scopus citations

• Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms

  Carlsen, E. D., Hay, C., Henard, C. A., Popov, V., Garg, N. J. & Soong, L., Nov 2013, In: Infection and immunity. 81, 11, p. 3966-3974 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Neutrophil Activation
  • Leishmania
  • Neutrophils
  • Parasites
  • Axenic Culture
  24 Scopus citations

• MTOR mediates IL-23 induction of neutrophil IL-17 and IL-22 production

  Chen, F., Cao, A., Yao, S., Evans-Marin, H. L., Liu, H., Wu, W., Carlsen, E. D., Dann, S. M., Soong, L., Sun, J., Zhao, Q. & Cong, Y., May 15 2016, In: Journal of Immunology. 196, 10, p. 4390-4399 10 p.

  Research output: Contribution to journal › Article › peer-review

  • interleukin-22
  • Interleukin-23
  • Interleukin-17
  • Neutrophils
  • Colitis
  43 Scopus citations

• Multistrain influenza protection induced by a nanoparticulate mucosal immunotherapeutic

  Tai, W., Roberts, L., Seryshev, A., Gubatan, J. M., Bland, C. S., Zabriskie, R., Kulkarni, S., Soong, L., Mbawuike, I., Gilbert, B., Kheradmand, F. & Corry, D. B., Mar 2011, In: Mucosal Immunology. 4, 2, p. 197-207 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Influenza
  • Pandemics
  • Epidemics
  • Antiviral Agents
  • Viruses
  21 Scopus citations

• Parenchymal expression of CD40 exacerbates adenovirus-induced hepatitis in mice

  Yan, J., Jie, Z., Hou, L., Wanderley, J. L., Soong, L., Gupta, S., Qiu, S., Chan, T. & Sun, J., May 2011, In: Hepatology. 53, 5, p. 1455-1467 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Adenoviridae
  • Hepatitis
  • Liver
  • Cre recombinase
  • Major Histocompatibility Complex
  12 Scopus citations

• Permissive and protective roles for neutrophils in leishmaniasis

  Carlsen, E. D., Liang, Y., Shelite, T. R., Walker, D. H., Melby, P. C. & Soong, L., Nov 2015, In: Clinical and Experimental Immunology. 182, 2, p. 109-18 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmaniasis
  • Parasites
  • Neutrophils
  • Leishmania
  • Infection
  32 Scopus citations

• Phosphatidylserine exposure on the surface of Leishmania amazonensis amastigotes modulates in vivo infection and dendritic cell function

  Wanderley, J. L. M., Thorpe, P. E., Barcinski, M. A. & Soong, L., Mar 2013, In: Parasite Immunology. 35, 3-4, p. 109-119 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmania
  • Phosphatidylserines
  • Dendritic Cells
  • Parasites
  • Leishmaniasis
  15 Scopus citations

• Sequential Dysfunction and Progressive Depletion of Candida albicans-Specific CD4 T Cell Response in HIV-1 Infection

  Liu, F., Fan, X., Auclair, S., Ferguson, M., Sun, J., Soong, L., Hou, W., Redfield, R. R., Birx, D. L., Ratto-Kim, S., Robb, M. L., Kim, J. H., Michael, N. L. & Hu, H., Jun 2016, In: PLoS pathogens. 12, 6, e1005663.

  Research output: Contribution to journal › Article › peer-review

  • Candida albicans
  • HIV Infections
  • HIV-1
  • HIV
  • T-Lymphocytes
  13 Scopus citations

• Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host

  Xu, W., Xin, L., Soong, L. & Zhang, K., Aug 2011, In: Infection and immunity. 79, 8, p. 3377-3387 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmania major
  • Sphingolipids
  • Leishmania
  • Nitrosative Stress
  • Parasites
  19 Scopus citations

• Systemic treatment with cpg-b after sublethal rickettsial infection induces mouse death through indoleamine 2,3-dioxygenase (ido)

  Xin, L., Shelite, T. R., Gong, B., Mendell, N. L., Soong, L., Fang, R. & Walker, D. H., Mar 28 2012, In: PloS one. 7, 3, e34062.

  Research output: Contribution to journal › Article › peer-review

  • indoleamine 2,3-dioxygenase
  • rickettsial diseases
  • T-cells
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Dendritic Cells
  16 Scopus citations

• The magnitude of CD4⁺ T-cell activation rather than TCR diversity determines the outcome of Leishmania infection in mice

  Xin, L., Wanderley, J. L., Wang, Y., Vargas-Inchaustegui, D. A. & Soong, L., Mar 2011, In: Parasite Immunology. 33, 3, p. 170-180 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmaniasis
  • T-Cell Antigen Receptor
  • T-Lymphocytes
  • Infection
  • Cross Protection
  11 Scopus citations

• The MET Receptor Tyrosine Kinase Confers Repair of Murine Pancreatic Acinar Cells following Acute and Chronic Injury

  Gaziova, I., Jackson, D., Boor, P. J., Carter, D., Cruz-Monserrate, Z., Elferink, C. J., Joshi, A. D., Kaphalia, B., Logsdon, C. D., De Castro, K. P., Soong, L., Tao, X., Qiu, S. & Elferink, L. A., Oct 2016, In: PloS one. 11, 10, 0165485.

  Research output: Contribution to journal › Article › peer-review

  • Proto-Oncogene Proteins c-met
  • acinar cells
  • Acinar Cells
  • tyrosine
  • phosphotransferases (kinases)
  1 Scopus citations

• Type 1 interferon-induced IL-7 maintains CD8 ⁺ T-cell responses and homeostasis by suppressing PD-1 expression in viral hepatitis

  Hou, L., Jie, Z., Liang, Y., Desai, M., Soong, L. & Sun, J., Mar 1 2015, In: Cellular and Molecular Immunology. 12, 2, p. 213-221 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-7
  • Interferon Type I
  • Hepatitis
  • Homeostasis
  • T-Lymphocytes
  20 Scopus citations
• Review article

  Dysregulated Th1 immune and vascular responses in scrub typhus pathogenesis

  Soong, L., Feb 15 2018, In: Journal of Immunology. 200, 4, p. 1233-1240 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Scrub Typhus
  • Blood Vessels
  • Orientia tsutsugamushi
  • Alarmins
  • Angiopoietins
  6 Scopus citations

• Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis

  Soong, L., Henard, C. A. & Melby, P. C., Nov 2012, In: Seminars in Immunopathology. 34, 6, p. 735-751 17 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cutaneous Leishmaniasis
  • Visceral Leishmaniasis
  • Parasites
  • Th1 Cells
  • Interleukin-17
  67 Scopus citations

• Scrub Typhus Pathogenesis: Innate Immune Response and Lung Injury During Orientia tsutsugamushi Infection

  Trent, B., Fisher, J. & Soong, L., Sep 6 2019, In: Frontiers in Microbiology. 10, 2065.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Scrub Typhus
  • Lung Injury
  • Innate Immunity
  • Adult Respiratory Distress Syndrome
  • Lung
  2 Scopus citations

• Subversion and utilization of host innate defense by Leishmania amazonensis

  Soong, L., 2012, In: Frontiers in immunology. 3, MAR, Article 58.

  Research output: Contribution to journal › Review article › peer-review

  • Leishmania
  • Parasites
  • Cutaneous Leishmaniasis
  • Infection
  • Leishmaniasis
  36 Scopus citations
• Short survey

  IFNα/β and autophagy: Tug-of-war between HCV and the host

  Sun, J., Desai, M. M., Soong, L. & Ou, J. H. J., Nov 2011, In: Autophagy. 7, 11, p. 1394-1396 3 p.

  Research output: Contribution to journal › Short survey › peer-review

  • Armed Conflicts
  • Autophagy
  • Hepacivirus
  • Antiviral Agents
  • Viral Nonstructural Proteins
  14 Scopus citations

• Interferon gamma in leishmaniasis

  Kima, P. E. & Soong, L., 2013, In: Frontiers in immunology. 4, JUN, Article 156.

  Research output: Contribution to journal › Short survey › peer-review

  • Leishmaniasis
  • Leishmania
  • Interferon-gamma
  • Parasites
  • Infection
  45 Scopus citations