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• Article

  Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress

  Módis, K., Gerö, D., Erdélyi, K., Szoleczky, P., Dewitt, D. & Szabo, C., Mar 1 2012, In: Biochemical Pharmacology. 83, 5, p. 633-643 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • Endothelial cells
  • Energy Metabolism
  • Epithelial Cells
  • Oxidative Phosphorylation
  55 Scopus citations

• Cerebral Blood Flow and Blood Pressure: Dependent or Codependent?

  Dewitt, D. & Prough, D., Jul 1 2019, In: Critical care medicine. 47, 7, p. 1007-1009 3 p.

  Research output: Contribution to journal › Article › peer-review

• Cerebrovascular connexin expression: Effects of traumatic brain injury

  Avila, M. A., Sell, S. L., Hawkins, B. E., Hellmich, H. L., Boone, D. R., Crookshanks, J. M., Prough, D. S. & Dewitt, D. S., Sep 1 2011, In: Journal of neurotrauma. 28, 9, p. 1803-1811 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Connexins
  • Traumatic Brain Injury
  • Gap Junctions
  • Messenger RNA
  • Connexin 43
  12 Scopus citations

• Challenges in the development of Rodent models of mild traumatic brain injury

  DeWitt, D. S., Perez-Polo, R., Hulsebosch, C. E., Dash, P. K. & Robertson, C. S., May 1 2013, In: Journal of neurotrauma. 30, 9, p. 688-701 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain Concussion
  • Rodentia
  • Theoretical Models
  • 2003-2011 Iraq War
  • Amnesia
  68 Scopus citations

• Cytoprotective effect of γ-tocopherol against tumor necrosis factor α induced cell dysfunction in L929 cells

  Oláh, G., Módis, K., Gero, D., Suzuki, K., Dewit, D., Traber, D. L. & Szabó, C., Nov 2011, In: International journal of molecular medicine. 28, 5, p. 711-720 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Tocopherols
  • Tumor Necrosis Factor-alpha
  • Dactinomycin
  • Oxidants
  • Vitamins
  5 Scopus citations

• Detection of structural and metabolic changes in traumatically injured hippocampus by quantitative differential proteomics

  Wu, P., Zhao, Y., Haidacher, S. J., Wang, E., Parsley, M. O., Gao, J., Sadygov, R. G., Starkey, J. M., Luxon, B. A., Spratt, H., Dewitt, D. S., Prough, D. S. & Denner, L., May 1 2013, In: Journal of neurotrauma. 30, 9, p. 775-788 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Traumatic Brain Injury
  • Proteomics
  • Hippocampus
  • Calcineurin
  • Knowledge Bases
  17 Scopus citations

• Effects of AAV-mediated knockdown of nNOS and GPx-1 gene expression in rat hippocampus after traumatic brain injury

  Boone, D. R., Leek, J. M., Falduto, M. T., Torres, K. E. O., Sell, S. L., Parsley, M. A., Cowart, J. C., Uchida, T., Micci, M. A., DeWitt, D. S., Prough, D. S. & Hellmich, H. L., Oct 2017, In: PloS one. 12, 10, e0185943.

  Research output: Contribution to journal › Article › peer-review

  • Dependoparvovirus
  • glutathione peroxidase GPX1
  • neuronal nitric oxide synthase
  • Nitric Oxide Synthase Type I
  • Dependovirus
  3 Scopus citations

• Effects of blast-induced neurotrauma on pressurized rodent middle cerebral arteries

  Rodriguez, U. A., Zeng, Y., Parsley, M. A., Hawkins, B. E., Prough, D. S. & Dewitt, D. S., Apr 2019, In: Journal of Visualized Experiments. 2019, 146, e58792.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Middle Cerebral Artery
  • Traumatic Brain Injury
  • Brain
  • Rodentia
  • Pressure
  2 Scopus citations

• Effects of trauma, hemorrhage and resuscitation in aged rats

  Hawkins, B. E., Cowart, J. C., Parsley, M. A., Capra, B. A., Eidson, K. A., Hellmich, H. L., Dewitt, D. S. & Prough, D. S., Feb 16 2013, In: Brain Research. 1496, p. 28-35 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Percussion
  • Resuscitation
  • Hemorrhage
  • Wounds and Injuries
  • fluoro jade
  15 Scopus citations

• Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury

  Boone, D. K., Weisz, H. A., Bi, M., Falduto, M. T., Torres, K. E. O., Willey, H. E., Volsko, C. M., Kumar, A. M., Micci, M. A., Dewitt, D. S., Prough, D. S. & Hellmich, H. L., Dec 1 2017, In: Scientific reports. 7, 1, 6645.

  Research output: Contribution to journal › Article › peer-review

  • Essential Genes
  • Traumatic Brain Injury
  • MicroRNAs
  • Cell Death
  • Genes
  12 Scopus citations

• Fluorophilia: Fluorophore-containing compounds adhere non-specifically to injured neurons

  Hawkins, B. E., Frederickson, C. J., Dewitt, D. S. & Prough, D. S., Jan 13 2012, In: Brain Research. 1432, p. 28-35 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Fluorescein
  • Coloring Agents
  • Neurons
  • Staining and Labeling
  • Brain
  6 Scopus citations

• Galveston brain injury conference 2010: Clinical and experimental aspects of blast injury

  Masel, B. E., Bell, R. S., Brossart, S., Grill, R. J., Hayes, R. L., Levin, H. S., Rasband, M. N., Ritzel, D. V., Wade, C. E. & Dewitt, D. S., Aug 10 2012, In: Journal of neurotrauma. 29, 12, p. 2143-2171 29 p.

  Research output: Contribution to journal › Article › peer-review

  • Blast Injuries
  • Congresses
  • Brain Injuries
  • Theoretical Models
  • Afghan Campaign 2001-
  25 Scopus citations

• Human neural stem cell transplantation-mediated alteration of microglial/macrophage phenotypes after traumatic brain injury

  Gao, J., Grill, R. J., Dunn, T. J., Bedi, S., Labastida, J. A., Hetz, R. A., Xue, H., Thonhoff, J. R., Dewitt, D. S., Prough, D. S., Cox, C. S. & Wu, P., 2016, In: Cell Transplantation. 25, 10, p. 1863-1877 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Macrophages
  • Stem cells
  • Microglia
  • Neural Stem Cells
  • Stem Cell Transplantation
  21 Scopus citations

• Identification of agents that reduce renal hypoxia-reoxygenation injury using cell-based screening: Purine nucleosides are alternative energy sources in LLC-PK1 cells during hypoxia

  Szoleczky, P., Módis, K., Nagy, N., Dóri Tóth, Z., Dewitt, D., Szabó, C. & Gero, D., Jan 1 2012, In: Archives of Biochemistry and Biophysics. 517, 1, p. 53-70 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Renal Agents
  • LLC-PK1 Cells
  • Purine Nucleosides
  • Cell Hypoxia
  • Cell death
  18 Scopus citations

• Inflammatory consequences in a rodent model of mild traumatic brain injury

  Perez-Polo, J. R., Rea, H. C., Johnson, K. M., Parsley, M. A., Unabia, G. C., Xu, G. J., Infante, S. K., Dewitt, D. S. & Hulsebosch, C. E., May 1 2013, In: Journal of neurotrauma. 30, 9, p. 727-740 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Percussion
  • Brain Concussion
  • Blood-Brain Barrier
  • Rodentia
  • Blast Injuries
  60 Scopus citations

• Inflammatory cytokine receptor blockade in a rodent model of mild traumatic brain injury

  Perez-Polo, J. R., Rea, H. C., Johnson, K. M., Parsley, M. A., Unabia, G. C., Xu, G. Y., Prough, D., Dewitt, D. S., Paulucci-Holthauzen, A. A., Werrbach-Perez, K. & Hulsebosch, C. E., Jan 2016, In: Journal of Neuroscience Research. 94, 1, p. 27-38 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain Concussion
  • Cytokine Receptors
  • Interleukin 1 Receptor Antagonist Protein
  • Rodentia
  • Tumor Necrosis Factor-alpha
  10 Scopus citations

• Influence of stochastic gene expression on the cell survival rheostat after traumatic brain injury

  Rojo, D. R., Prough, D. S., Falduto, M. T., Boone, D. R., Micci, M. A., Kahrig, K. M., Crookshanks, J. M., Jimenez, A., Uchida, T., Cowart, J. C., Hawkins, B. E., Avila, M., DeWitt, D. S. & Hellmich, H. L., 2011, In: PloS one. 6, 8, e23111.

  Research output: Contribution to journal › Article › peer-review

  • Gene expression
  • Traumatic Brain Injury
  • Cells
  • cell viability
  • Neurons
  24 Scopus citations

• MicroRNA profiling identifies a novel compound with antidepressant properties

  Sell, S. L., Boone, D. R., Weisz, H. A., Cardenas, C., Willey, H. E., Bolding, I. J., Micci, M. A., Falduto, M. T., Torres, K. E. O., DeWitt, D. S., Prough, D. S. & Hellmich, H. L., Aug 1 2019, In: PloS one. 14, 8, e0221163.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • antidepressants
  • microRNA
  • Traumatic Brain Injury
  • Antidepressive Agents
  • MicroRNAs

• MicroRNA sequencing of rat hippocampus and human biofluids identifies acute, chronic, focal and diffuse traumatic brain injuries

  Weisz, H. A., Kennedy, D., Widen, S., Spratt, H., Sell, S. L., Bailey, C., Sheffield-Moore, M., DeWitt, D. S., Prough, D. S., Levin, H., Robertson, C. & Hellmich, H. L., Dec 1 2020, In: Scientific reports. 10, 1, 3341.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diffuse Brain Injury
  • Traumatic Brain Injury
  • MicroRNAs
  • Hippocampus
  • Circulating MicroRNA

• Military Blast Exposure and Chronic Neurodegeneration: Summary of Working Groups and Expert Panel Findings and Recommendations

  Brix, K. A., Brody, D. L., Grimes, J. B., Yitzhak, A., Agoston, D., Aldag, M., Armstrong, R., Arun, P., Audette, M., Babcock, D., Balaban, C., Banton, R., Bellgowan, P., Borkholder, D., Broglio, S., Brokaw, E., Cantu, R., Carr, W., Chapman, S., Cmarik, J. & 96 others, Colder, B., Colombe, J., Cook, D., Cozzarelli, T., Da Silva, U. O., Daphalapurkar, N., Dardzinski, B., DeGraba, T., DeMar, J., DeWitt, D., Dickstein, D., Duckworth, J., Elder, G., Fazel-Rezai, R., Fine, M., Fiskum, G., Fournier, A., Ganpule, S., Gill, J., Glenn, J. F., Greene, C., Greig, N., Haering, C., Harrington, J., Hein, A., Helmick, K., Hicks, R., Hinds, S., Hoffman, S., Horkayne-Szakaly, I., Iacono, D., Ishii, E., Jones, R. V., Karami, G., Krawczyk, D., Labutta, R., Latta, R., Lattimore, T., Leggieri, M., Leonessa, F., Lin, A., Ling, G., Long, M., Lu, K. P., Panker, S. M., McCabe, J., Merkle, A., Montenigro, P., Mueller, G. P., Ng, L., Nigam, S., O'Donnell, J., Okonkwo, D., Pauli, I., Perl, D., Peskind, E., Pfister, B., Philippens, M., Piehler, T., Proctor, J., Przekwas, A., Qashu, F., Raskind, M., Razumovsky, A., Reifman, J., Reyes, P., Rigby, P., Risling, M., Robinson, M., Rooks, T., Rosen, C., Rosseau, G., Sammons-Jackson, W., Santago, A., Shoge, R., Sours, C., Stone, J., Templin, M., Tepe, V., Thielen, P., Thomas, M., Timmes, T., Tortella, F., Tucker, L., Tweedie, D., Hamm, D. V., Christie Vu, B., Wang, Y., West, T., Wilde, E., Willis, A., Wu, J., Zai, L., Zander, N., Zheng, J. & Ziejewski, M., Sep 2017, In: Journal of neurotrauma. 34, S1, p. S18-S25

  Research output: Contribution to journal › Article › peer-review

  • Chronic Traumatic Encephalopathy
  • Traumatic Brain Injury
  • Sports
  • Blast Injuries
  • Neuropathology
  5 Scopus citations

• Modulation of Peroxynitrite Reduces Norepinephrine Requirements in Ovine MRSA Septic Shock

  Fukuda, S., Ihara, K., Andersen, C. R., Randolph, A. C., Nelson, C. L., Zeng, Y., Kim, J., Dewitt, D. S., Rojas, J. D., Koutrouvelis, A., Herndon, D. N., Prough, D. S. & Enkhbaatar, P., Nov 1 2019, In: Shock. 52, 5, p. E92-E99

  Research output: Contribution to journal › Article › peer-review

  • Peroxynitrous Acid
  • Septic Shock
  • Methicillin-Resistant Staphylococcus aureus
  • Sheep
  • Norepinephrine
  3 Scopus citations

• Molecular mechanisms underlying effects of neural stem cells against traumatic axonal injury

  Wang, E., Gao, J., Yang, Q., Parsley, M. O., Dunn, T. J., Zhang, L., Dewitt, D. S., Denner, L., Prough, D. S. & Wu, P., Jan 20 2012, In: Journal of neurotrauma. 29, 2, p. 295-312 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Glial Cell Line-Derived Neurotrophic Factor
  • Neural Stem Cells
  • Traumatic Brain Injury
  • Wounds and Injuries
  • Actins
  22 Scopus citations

• Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133+ ABCG2+CXCR4+ mesenchymal stem cells: Development of autologous cell-based therapeutics for traumatic brain injury

  Nichols, J. E., Niles, J. A., Dewitt, D., Prough, D., Parsley, M., Vega, S., Cantu, A., Lee, E. & Cortiella, J., 2013, In: Stem Cell Research and Therapy. 4, 1, 3.

  Research output: Contribution to journal › Article › peer-review

  • Stem cells
  • CXC Chemokines
  • Chemokine Receptors
  • Traumatic Brain Injury
  • Blood
  54 Scopus citations

• Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury

  Hellmich, H. L., Rojo, D. R., Micci, M. A., Sell, S. L., Boone, D. R., Crookshanks, J. M., DeWitt, D. S., Masel, B. E. & Prough, D. S., Jan 9 2013, In: PloS one. 8, 1, e53230.

  Research output: Contribution to journal › Article › peer-review

  • Carbenoxolone
  • metyrapone
  • Metyrapone
  • Traumatic Brain Injury
  • Genes
  16 Scopus citations

• Persistent Behavioral Deficits in Rats after Parasagittal Fluid Percussion Injury

  Sell, S., Johnson, K., Dewitt, D. & Prough, D., Mar 1 2017, In: Journal of Neurotrauma. 34, 5, p. 1086-1096 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Percussion
  • Traumatic Brain Injury
  • Wounds and Injuries
  • Memory Disorders
  • Short-Term Memory
  17 Scopus citations

• Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies

  Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In: Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Tauopathies
  • Rats
  • Traumatic Brain Injury
  • Brain
  90 Scopus citations

• Stochastic fluctuations in gene expression in aging hippocampal neurons could be exacerbated by traumatic brain injury

  Shearer, J., Boone, D., Weisz, H., Jennings, K., Uchida, T., Parsley, M., DeWitt, D., Prough, D. & Hellmich, H., Apr 1 2016, In: Aging Clinical and Experimental Research. 28, 2, p. 363-367 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Traumatic Brain Injury
  • Neurons
  • Gene Expression
  • Cognitive Dysfunction
  • Cell Survival
  1 Scopus citations

• Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice

  Gerson, J., Castillo-Carranza, D. L., Sengupta, U., Bodani, R., Prough, D. S., DeWitt, D. S., Hawkins, B. E. & Kayed, R., Nov 15 2016, In: Journal of neurotrauma. 33, 22, p. 2034-2043 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Traumatic Brain Injury
  • Cognitive Dysfunction
  • Pathology
  • Brain
  • Neurodegenerative Diseases
  39 Scopus citations

• Traumatic Brain Injury-Induced Dysregulation of the Circadian Clock

  Boone, D. R., Sell, S. L., Micci, M. A., Crookshanks, J. M., Parsley, M., Uchida, T., Prough, D. S., DeWitt, D. S. & Hellmich, H. L., Oct 3 2012, In: PloS one. 7, 10, e46204.

  Research output: Contribution to journal › Article › peer-review

  • Circadian Clocks
  • circadian clocks
  • Traumatic Brain Injury
  • Clocks
  • Brain
  45 Scopus citations

• Traumatic brain injury induces long-lasting changes in immune and regenerative signaling

  Boone, D. R., Weisz, H. A., Willey, H. E., Torres, K. E. O., Falduto, M. T., Sinha, M., Spratt, H., Bolding, I. J., Johnson, K. M., Parsley, M. A., DeWitt, D. S., Prough, D. S. & Hellmich, H. L., Apr 2019, In: PloS one. 14, 4, e0214741.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Traumatic Brain Injury
  • Brain
  • brain
  • Genes
  • Cell signaling
  8 Scopus citations
• Editorial

  Introduction to the Special Issue on Translation

  Dewitt, D. & Prough, D. S., Nov 15 2020, In: Journal of neurotrauma. 37, 22, p. 2351-2352 2 p.

  Research output: Contribution to journal › Editorial › peer-review