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• Article

  Comparison of the structural and dynamic effects of 5-methylcytosine and 5-chlorocytosine in a CpG dinucleotide sequence

  Theruvathu, J. A., Yin, Y. W., Pettitt, B. M. & Sowers, L. C., Nov 26 2013, In: Biochemistry. 52, 47, p. 8590-8598 9 p.

  Research output: Contribution to journal › Article › peer-review

  • 5-chlorocytosine
  • 5-Methylcytosine
  • Cytosine
  • Oligonucleotides
  • Protons
  7 Scopus citations

• Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles

  Singh, A., Pandey, M., Nandakumar, D., Raney, K. D., Yin, Y. W. & Patel, S. S., Mar 16 2020, In: EMBO Journal. 39, 6, e103367.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Exonucleases
  • DNA-Directed DNA Polymerase
  • Nucleotides
  • DNA
  • Catalytic Domain
  2 Scopus citations

• Exonuclease of human DNA polymerase gamma disengages its strand displacement function

  He, Q., Shumate, C. K., White, M. A., Molineux, I. J. & Yin, Y. W., Nov 2013, In: Mitochondrion. 13, 6, p. 592-601 10 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Polymerase gamma
  • Exonucleases
  • Mitochondrial DNA
  • DNA
  • Holoenzymes
  15 Scopus citations

• Networked Communication between Polymerase and Exonuclease Active Sites in Human Mitochondrial DNA Polymerase

  Sowers, M. L., Anderson, A. P. P., Wrabl, J. O. & Yin, Y. W., Jul 10 2019, In: Journal of the American Chemical Society. 141, 27, p. 10821-10829 9 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Polymerase gamma
  • Exonucleases
  • Nucleotides
  • DNA
  • Catalytic Domain

• Oxidative damage diminishes mitochondrial DNA polymerase replication fidelity

  Anderson, A. P., Luo, X., Russell, W. & Yin, Y. W., Jan 24 2020, In: Nucleic acids research. 48, 2, p. 817-829 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Polymerase gamma
  • Exonucleases
  • DNA Replication
  • Mitochondrial DNA
  • Mutation
  7 Scopus citations

• PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance

  Wen, J. J., Yin, Y. W. & Garg, N. J., May 2018, In: PLoS pathogens. 14, 5, e1007065.

  Research output: Contribution to journal › Article › peer-review

  • Poly (ADP-Ribose) Polymerase-1
  • Chagas Disease
  • Mitochondrial DNA
  • Maintenance
  • Heart
  15 Scopus citations

• Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ

  Sohl, C. D., Szymanski, M. R., Mislak, A. C., Shumate, C. K., Amiralaei, S., Schinazi, R. F., Anderson, K. S. & Yin, Y. W., Jul 14 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 28, p. 8596-8601 6 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Polymerase gamma
  • Reverse Transcriptase Inhibitors
  • Nucleosides
  • Nucleotides
  • HIV Reverse Transcriptase
  15 Scopus citations

• Selective inhibition of bacterial tryptophanyl-tRNA synthetases by indolmycin is mechanism-based

  Williams, T. L., Yin, Y. W. & Carter, C. W., Jan 1 2016, In: Journal of Biological Chemistry. 291, 1, p. 255-265 11 p.

  Research output: Contribution to journal › Article › peer-review

  • indolmycin
  • Tryptophan-tRNA Ligase
  • Tryptophan
  • Adenosine Triphosphate
  • Stabilization
  20 Scopus citations

• Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase

  Szymanski, M. R., Kuznetsov, V. B., Shumate, C., Meng, Q., Lee, Y. S., Patel, G., Patel, S. & Yin, Y. W., 2015, In: EMBO Journal. 34, 14, p. 1959-1970 12 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA replicase
  • Zalcitabine
  • DNA Polymerase gamma
  • Toxicity
  • Mitochondrial DNA
  29 Scopus citations

• Structural Energy Landscapes and Plasticity of the Microstates of Apo Escherichia coli cAMP Receptor Protein

  Chkheidze, R., Evangelista, W., White, M. A., Yin, Y. W. & Lee, J. C., Feb 4 2020, In: Biochemistry. 59, 4, p. 460-470 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclic AMP Receptor Protein
  • Escherichia coli
  • Escherichia coli Proteins
  • Plasticity
  • X ray scattering
  1 Scopus citations

• Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine

  Bertoletti, N., Chan, A. H., Schinazi, R. F., Yin, Y. W. & Anderson, K. S., 2019, In: Protein Science. 28, 9, p. 1664-1675 12 p.

  Research output: Contribution to journal › Article › peer-review

  • lamivudine triphosphate
  • Emtricitabine
  • Human immunodeficiency virus 1 reverse transcriptase
  • Crystal structure
  • Reverse Transcriptase Inhibitors
  5 Scopus citations

• The DNA polymerase gamma R953C mutant is associated with antiretroviral therapy-induced mitochondrial toxicity

  Li, M., Mislak, A. C., Foli, Y., Agbosu, E., Bose, V., Bhandari, S., Szymanski, M. R., Shumate, C. K., Yin, Y. W., Anderson, K. S. & Paintsil, E., Sep 1 2016, In: Antimicrobial agents and chemotherapy. 60, 9, p. 5608-5611 4 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Polymerase gamma
  • 2'-deoxycytidine 5'-triphosphate
  • triphosphoric acid
  • Nucleotides
  • Binding Sites
  3 Scopus citations

• The yeast mitochondrial RNA polymerase and transcription factor complex catalyzes efficient priming of DNA synthesis on single-stranded DNA

  Ramachandran, A., Nandakumar, D., Deshpande, A. P., Lucas, T. P., R-Bhojappa, R., Tang, G. Q., Raney, K., Yin, Y. W. & Patel, S. S., Aug 5 2016, In: Journal of Biological Chemistry. 291, 32, p. 16828-16839 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondrial RNA
  • Single-Stranded DNA
  • Yeast
  • DNA-Directed RNA Polymerases
  • Yeasts
  8 Scopus citations

• Transcription polymerase-catalyzed emergence of novel RNA replicons

  Jain, N., Blauch, L. R., Szymanski, M. R., Das, R., Tang, S. K. Y., Yin, Y. W. & Fire, A. Z., Apr 10 2020, In: Science. 368, 6487, eaay0688.

  Research output: Contribution to journal › Article › peer-review

  • Replicon
  • RNA
  • Viroids
  • Bacteriophage T7
  • Hepatitis Delta Virus
  3 Scopus citations

• Transcription yield of fully 2'-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants

  Meyer, A. J., Garry, D. J., Hall, B., Byrom, M. M., McDonald, H. G., Yang, X., Yin, Y. W. & Ellington, A. D., Jul 7 2015, In: Nucleic acids research. 43, 15, p. 7480-7488 9 p.

  Research output: Contribution to journal › Article › peer-review

  • bacteriophage T7 RNA polymerase
  • RNA
  • Mutation
  • Thermotolerance
  • Ribose
  30 Scopus citations

• Yeast mitochondrial transcription factor Mtf1 determines the precision of promoter-directed initiation of RNA polymerase Rpo41

  Yang, X., Chang, H. R. & Yin, Y. W., Sep 2 2015, In: PloS one. 10, 9, e0136879.

  Research output: Contribution to journal › Article › peer-review

  • Yeast
  • DNA-Directed RNA Polymerases
  • Bacteriophages
  • DNA-directed RNA polymerase
  • Mitochondrial RNA
  5 Scopus citations
• Chapter

  Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase

  Yin, Y. W. & Steitz, T. A., Jan 1 2020, Structural Insights into Gene Expression and Protein Synthesis. World Scientific Publishing Co., p. 333-341 9 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • bacteriophage T7 RNA polymerase
  • Transcription
  • Elongation
  • RNA
  • Base Pairing

• The structural mechanism of translocation and Helicase activity in t7 RNA polymerase

  Yin, Y. W. & Steitz, T. A., Jan 1 2020, Structural Insights into Gene Expression and Protein Synthesis. World Scientific Publishing Co., p. 342-353 12 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • bacteriophage T7 RNA polymerase
  • Nucleotides
  • Bacteriophage T7
  • diphosphoric acid
  • Elongation

• Working with Tom

  Yin, W., Jan 1 2020, Structural Insights into Gene Expression and Protein Synthesis. World Scientific Publishing Co., p. 223-224 2 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Tryptophan-tRNA Ligase
  • Maximum entropy methods
  • Cryoelectron Microscopy
  • Molecular biology
  • Entropy
• Comment/debate

  Erratum: Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ (Proceedings of the National Academy of Sciences of the United States of America (2015) 112 (8596-8601) DOI: 10.1073/pnas.1421733112)

  Sohl, C. D., Szymanski, M. R., Mislak, A. C., Shumate, C. K., Amiralaei, S., Schinazi, R. F., Anderson, K. S. & Yin, Y. W., Feb 2 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 5, p. E662

  Research output: Contribution to journal › Comment/debate › peer-review
• Review article

  Structural insight on processivity, human disease and antiviral drug toxicity

  Yin, Y. W., Feb 2011, In: Current Opinion in Structural Biology. 21, 1, p. 83-91 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • DNA Polymerase gamma
  • HIV Reverse Transcriptase
  • Bacteriophage T7
  • DNA-Directed DNA Polymerase
  • DNA-Directed RNA Polymerases
  2 Scopus citations