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• Article

  A rodent model of mild traumatic brain blast injury

  Perez-Polo, J. R., Rea, H. C., Johnson, K. M., Parsley, M. A., Unabia, G. C., Xu, G. Y., Prough, D., Dewitt, D. S., Spratt, H. & Hulsebosch, C. E., Apr 1 2015, In: Journal of Neuroscience Research. 93, 4, p. 549-561 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Blast Injuries
  • Brain Concussion
  • Rodentia
  • Brain Injuries
  • Righting Reflex
  33 Scopus citations

• Cerebral Blood Flow and Blood Pressure: Dependent or Codependent?

  Dewitt, D. & Prough, D., Jul 1 2019, In: Critical care medicine. 47, 7, p. 1007-1009 3 p.

  Research output: Contribution to journal › Article › peer-review

• Cerebrovascular connexin expression: Effects of traumatic brain injury

  Avila, M. A., Sell, S. L., Hawkins, B. E., Hellmich, H. L., Boone, D. R., Crookshanks, J. M., Prough, D. S. & Dewitt, D. S., Sep 1 2011, In: Journal of neurotrauma. 28, 9, p. 1803-1811 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Connexins
  • Traumatic Brain Injury
  • Gap Junctions
  • Messenger RNA
  • Connexin 43
  12 Scopus citations

• Challenges in the development of Rodent models of mild traumatic brain injury

  DeWitt, D. S., Perez-Polo, R., Hulsebosch, C. E., Dash, P. K. & Robertson, C. S., May 1 2013, In: Journal of neurotrauma. 30, 9, p. 688-701 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain Concussion
  • Rodentia
  • Theoretical Models
  • 2003-2011 Iraq War
  • Amnesia
  68 Scopus citations

• Cytoprotective effect of γ-tocopherol against tumor necrosis factor α induced cell dysfunction in L929 cells

  Oláh, G., Módis, K., Gero, D., Suzuki, K., Dewit, D., Traber, D. L. & Szabó, C., Nov 2011, In: International journal of molecular medicine. 28, 5, p. 711-720 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Tocopherols
  • Tumor Necrosis Factor-alpha
  • Dactinomycin
  • Oxidants
  • Vitamins
  5 Scopus citations

• Detection of structural and metabolic changes in traumatically injured hippocampus by quantitative differential proteomics

  Wu, P., Zhao, Y., Haidacher, S. J., Wang, E., Parsley, M. O., Gao, J., Sadygov, R. G., Starkey, J. M., Luxon, B. A., Spratt, H., Dewitt, D. S., Prough, D. S. & Denner, L., May 1 2013, In: Journal of neurotrauma. 30, 9, p. 775-788 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Traumatic Brain Injury
  • Proteomics
  • Hippocampus
  • Calcineurin
  • Knowledge Bases
  18 Scopus citations

• Development of a stretch-induced neurotrauma model for medium-throughput screening in vitro: identification of rifampicin as a neuroprotectant

  López-García, I., Gerő, D., Szczesny, B., Szoleczky, P., Olah, G., Módis, K., Zhang, K., Gao, J., Wu, P., Sowers, L. C., DeWitt, D., Prough, D. S. & Szabo, C., 2018, In: British Journal of Pharmacology. 175, 2, p. 284-300 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Rifampin
  • Neuroprotective Agents
  • Wounds and Injuries
  • In Vitro Techniques
  • Neurons
  9 Scopus citations

• Effects of blast-induced neurotrauma on pressurized rodent middle cerebral arteries

  Rodriguez, U. A., Zeng, Y., Parsley, M. A., Hawkins, B. E., Prough, D. S. & Dewitt, D. S., Apr 2019, In: Journal of Visualized Experiments. 2019, 146, e58792.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Middle Cerebral Artery
  • Traumatic Brain Injury
  • Brain
  • Rodentia
  • Pressure
  2 Scopus citations

• Effects of Mild Blast Traumatic Brain Injury on Cerebral Vascular, Histopathological, and Behavioral Outcomes in Rats

  Rodriguez, U. A., Zeng, Y., Deyo, D., Parsley, M. A., Hawkins, B. E., Prough, D. S. & DeWitt, D. S., Jan 15 2018, In: Journal of neurotrauma. 35, 2, p. 375-392 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain Concussion
  • Traumatic Brain Injury
  • penicillamine methyl ester
  • Blood Vessels
  • Perfusion
  24 Scopus citations

• Effects of trauma, hemorrhage and resuscitation in aged rats

  Hawkins, B. E., Cowart, J. C., Parsley, M. A., Capra, B. A., Eidson, K. A., Hellmich, H. L., Dewitt, D. S. & Prough, D. S., Feb 16 2013, In: Brain Research. 1496, p. 28-35 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Percussion
  • Resuscitation
  • Hemorrhage
  • Wounds and Injuries
  • fluoro jade
  15 Scopus citations

• Inflammatory consequences in a rodent model of mild traumatic brain injury

  Perez-Polo, J. R., Rea, H. C., Johnson, K. M., Parsley, M. A., Unabia, G. C., Xu, G. J., Infante, S. K., Dewitt, D. S. & Hulsebosch, C. E., May 1 2013, In: Journal of neurotrauma. 30, 9, p. 727-740 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Percussion
  • Brain Concussion
  • Blood-Brain Barrier
  • Rodentia
  • Blast Injuries
  60 Scopus citations

• Influence of stochastic gene expression on the cell survival rheostat after traumatic brain injury

  Rojo, D. R., Prough, D. S., Falduto, M. T., Boone, D. R., Micci, M. A., Kahrig, K. M., Crookshanks, J. M., Jimenez, A., Uchida, T., Cowart, J. C., Hawkins, B. E., Avila, M., DeWitt, D. S. & Hellmich, H. L., 2011, In: PloS one. 6, 8, e23111.

  Research output: Contribution to journal › Article › peer-review

  • Gene expression
  • Traumatic Brain Injury
  • Cells
  • cell viability
  • Neurons
  24 Scopus citations

• Measurement of Postreplicative DNA Metabolism and Damage in the Rodent Brain

  Patel, J. P., Sowers, M. L., Herring, J. L., Theruvathu, J. A., Emmett, M. R., Hawkins, B. E., Zhang, K., Dewitt, D. S., Prough, D. S. & Sowers, L. C., Dec 21 2015, In: Chemical Research in Toxicology. 28, 12, p. 2352-2363 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Metabolism
  • DNA Damage
  • Brain
  • Rodentia
  • DNA
  5 Scopus citations

• MicroRNA profiling identifies a novel compound with antidepressant properties

  Sell, S. L., Boone, D. R., Weisz, H. A., Cardenas, C., Willey, H. E., Bolding, I. J., Micci, M. A., Falduto, M. T., Torres, K. E. O., DeWitt, D. S., Prough, D. S. & Hellmich, H. L., Aug 1 2019, In: PloS one. 14, 8, e0221163.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • antidepressants
  • microRNA
  • Traumatic Brain Injury
  • Antidepressive Agents
  • MicroRNAs
  1 Scopus citations

• MicroRNA sequencing of rat hippocampus and human biofluids identifies acute, chronic, focal and diffuse traumatic brain injuries

  Weisz, H. A., Kennedy, D., Widen, S., Spratt, H., Sell, S. L., Bailey, C., Sheffield-Moore, M., DeWitt, D. S., Prough, D. S., Levin, H., Robertson, C. & Hellmich, H. L., Dec 1 2020, In: Scientific reports. 10, 1, 3341.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diffuse Brain Injury
  • Traumatic Brain Injury
  • MicroRNAs
  • Hippocampus
  • Circulating MicroRNA

• Modulation of Peroxynitrite Reduces Norepinephrine Requirements in Ovine MRSA Septic Shock

  Fukuda, S., Ihara, K., Andersen, C. R., Randolph, A. C., Nelson, C. L., Zeng, Y., Kim, J., Dewitt, D. S., Rojas, J. D., Koutrouvelis, A., Herndon, D. N., Prough, D. S. & Enkhbaatar, P., Nov 1 2019, In: Shock. 52, 5, p. E92-E99

  Research output: Contribution to journal › Article › peer-review

  • Peroxynitrous Acid
  • Septic Shock
  • Methicillin-Resistant Staphylococcus aureus
  • Sheep
  • Norepinephrine
  3 Scopus citations

• Nano-Pulsed Laser Therapy Is Neuroprotective in a Rat Model of Blast-Induced Neurotrauma

  Esenaliev, R. O., Petrov, I. Y., Petrov, Y., Guptarak, J., Boone, D. R., Mocciaro, E., Weisz, H., Parsley, M. A., Sell, S. L., Hellmich, H., Ford, J. M., Pogue, C., Dewitt, D., Prough, D. S. & Micci, M. A., Jul 2018, In: Journal of neurotrauma. 35, 13, p. 1510-1522 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Laser Therapy
  • Lasers
  • Caspase 3
  • Brain-Derived Neurotrophic Factor
  • Microglia
  13 Scopus citations

• Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133+ ABCG2+CXCR4+ mesenchymal stem cells: Development of autologous cell-based therapeutics for traumatic brain injury

  Nichols, J. E., Niles, J. A., Dewitt, D., Prough, D., Parsley, M., Vega, S., Cantu, A., Lee, E. & Cortiella, J., 2013, In: Stem Cell Research and Therapy. 4, 1, 3.

  Research output: Contribution to journal › Article › peer-review

  • Stem cells
  • CXC Chemokines
  • Chemokine Receptors
  • Traumatic Brain Injury
  • Blood
  54 Scopus citations

• Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury

  Hellmich, H. L., Rojo, D. R., Micci, M. A., Sell, S. L., Boone, D. R., Crookshanks, J. M., DeWitt, D. S., Masel, B. E. & Prough, D. S., Jan 9 2013, In: PloS one. 8, 1, e53230.

  Research output: Contribution to journal › Article › peer-review

  • Carbenoxolone
  • metyrapone
  • Metyrapone
  • Traumatic Brain Injury
  • Genes
  17 Scopus citations

• Pathway-Focused PCR Array Profiling of Enriched Populations of Laser Capture Microdissected Hippocampal Cells after Traumatic Brain Injury

  Boone, D. R., Micci, M. A., Taglialatela, I. G., Hellmich, J. L., Weisz, H. A., Bi, M., Prough, D. S., DeWitt, D. S. & Hellmich, H. L., May 2015, In: PloS one. 10, 5, e0127287.

  Research output: Contribution to journal › Article › peer-review

  • Traumatic Brain Injury
  • Neurons
  • Brain
  • neurons
  • Lasers
  21 Scopus citations

• Pre-clinical testing of therapies for traumatic brain injury

  DeWitt, D. S., Hawkins, B. E., Dixon, C. E., Kochanek, P. M., Armstead, W., Bass, C. R., Bramlett, H. M., Buki, A., Dietrich, W. D., Ferguson, A. R., Hall, E. D., Hayes, R. L., Hinds, S. R., Laplaca, M. C., Long, J. B., Meaney, D. F., Mondello, S., Noble-Haeusslein, L. J., Poloyac, S. M., Prough, D. S. & 8 others, Robertson, C. S., Saatman, K. E., Shultz, S. R., Shear, D. A., Smith, D. H., Valadka, A. B., Vandevord, P. & Zhang, L., Dec 1 2018, In: Journal of neurotrauma. 35, 23, p. 2737-2754 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Traumatic Brain Injury
  • Consensus
  • Research Personnel
  • Guidelines
  • Investigational Therapies
  33 Scopus citations

• Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies

  Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In: Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligomers
  • Tauopathies
  • Rats
  • Traumatic Brain Injury
  • Brain
  90 Scopus citations

• Traumatic brain injury induces long-lasting changes in immune and regenerative signaling

  Boone, D. R., Weisz, H. A., Willey, H. E., Torres, K. E. O., Falduto, M. T., Sinha, M., Spratt, H., Bolding, I. J., Johnson, K. M., Parsley, M. A., DeWitt, D. S., Prough, D. S. & Hellmich, H. L., Apr 2019, In: PloS one. 14, 4, e0214741.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Traumatic Brain Injury
  • Brain
  • brain
  • Genes
  • Cell signaling
  8 Scopus citations
• Comment/debate

  Erratum to: Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury (Scientific Reports, (2017), 7, 1, (6645), 10.1038/s41598-017-06341-6)

  Boone, D. K., Weisz, H. A., Bi, M., Falduto, M. T., Torres, K. E. O., Willey, H. E., Volsko, C. M., Kumar, A. M., Micci, M. A., Dewitt, D. S., Prough, D. S. & Hellmich, H. L., Dec 1 2018, In: Scientific reports. 8, 1, 14994.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Essential Genes
  • Traumatic Brain Injury
  • MicroRNAs
  • Cell Death
• Editorial

  Introduction to the Special Issue on Translation

  Dewitt, D. & Prough, D. S., Nov 15 2020, In: Journal of neurotrauma. 37, 22, p. 2351-2352 2 p.

  Research output: Contribution to journal › Editorial › peer-review
• Review article

  Impact & blast traumatic brain injury: Implications for therapy

  Yamamoto, S., DeWitt, D. S. & Prough, D. S., 2018, In: Molecules. 23, 2, 245.

  Research output: Contribution to journal › Review article › peer-review

  • brain damage
  • blasts
  • Traumatic Brain Injury
  • therapy
  • Brain
  13 Scopus citations

• Proteomic changes in traumatic brain injury: Experimental approaches

  Sowers, J. L., Wu, P., Zhang, K., DeWitt, D. S. & Prough, D. S., 2018, In: Current opinion in neurology. 31, 6, p. 709-717 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Traumatic Brain Injury
  • Proteomics
  • Theoretical Models
  • Proteome
  • Mass Spectrometry
  4 Scopus citations