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• Article

  Alveolar macrophages contribute to the pathogenesis of human metapneumovirus infection while protecting against respiratory syncytial virus infection

  Kolli, D., Gupta, M. R., Sbrana, E., Velayutham, T. S., Chao, H., Casola, A. & Garofalo, R. P., Oct 1 2014, In: American journal of respiratory cell and molecular biology. 51, 4, p. 502-515 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Alveolar Macrophages
  • Metapneumovirus
  • Respiratory Syncytial Virus Infections
  • Viruses
  • Infection
  51 Scopus citations

• Antioxidant mimetics modulate oxidative stress and cellular signaling in airway epithelial cells infected with respiratory syncytial virus

  Hosakote, Y. M., Komaravelli, N., Mautemps, N., Liu, T., Garofalo, R. P. & Casola, A., 2012, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 303, 11, p. L991-L1000

  Research output: Contribution to journal › Article › peer-review

  • Respiratory Syncytial Viruses
  • N,N'-bis(salicylideneamino)ethane-manganese(II)
  • Antioxidants
  • Oxidative Stress
  • Epithelial Cells
  35 Scopus citations

• Antiviral and immunomodulatory activity of silver nanoparticles in experimental rsv infection

  Morris, D., Ansar, M., Speshock, J., Ivanciuc, T., Qu, Y., Casola, A. & Garofalo, R., Aug 2019, In: Viruses. 11, 8, 732.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Respiratory Syncytial Viruses
  • Silver
  • Nanoparticles
  • Antiviral Agents
  • Respiratory Syncytial Virus Infections
  18 Scopus citations

• A polymorphism in the catalase gene promoter confers protection against severe RSV bronchiolitis

  Chambliss, J. M., Ansar, M., Kelley, J. P., Spratt, H., Garofalo, R. P. & Casola, A., Jan 3 2020, In: Viruses. 12, 1, , 57.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bronchiolitis
  • Respiratory Syncytial Viruses
  • Catalase
  • NF-E2-Related Factor 2
  • Antioxidants
  3 Scopus citations

• BRD4 couples NF-κB/RelA with airway inflammation and the IRF-RIG-I amplification loop in respiratory syncytial virus infection

  Tian, B., Yang, J., Zhao, Y., Ivanciuc, T., Sun, H., Garofalo, R. P. & Brasier, A. R., 2017, In: Journal of virology. 91, 6, e00007-17.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory syncytial virus
  • Respiratory Syncytial Virus Infections
  • Interferons
  • inflammation
  • Respiratory Syncytial Viruses
  31 Scopus citations

• Broad-Range Antiviral Activity of Hydrogen Sulfide Against Highly Pathogenic RNA Viruses

  Bazhanov, N., Escaffre, O., Freiberg, A. N., Garofalo, R. P. & Casola, A., Jan 20 2017, In: Scientific reports. 7, 41029.

  Research output: Contribution to journal › Article › peer-review

  • GYY 4137
  • Hydrogen Sulfide
  • RNA Viruses
  • Antiviral Agents
  • Human Influenza
  18 Scopus citations

• CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells

  Tian, B., Zhao, Y., Kalita, M., Edeh, C. B., Paessler, S., Casola, A., Teng, M. N., Garofalo, R. P. & Brasier, A. R., Jun 2013, In: Journal of virology. 87, 12, p. 7075-7092 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclin-Dependent Kinase 9
  • Respiratory syncytial virus
  • Interferon Regulatory Factor-3
  • Respiratory Syncytial Virus Infections
  • cyclin-dependent kinase
  41 Scopus citations

• Cigarette Smoke Condensate Exposure Changes RNA Content of Extracellular Vesicles Released from Small Airway Epithelial Cells

  Corsello, T., Kudlicki, A. S., Garofalo, R. P. & Casola, A., Dec 17 2019, In: Cells. 8, 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Extracellular Vesicles
  • Smoke
  • Tobacco Products
  • Epithelial Cells
  • RNA

• Critical role of TLR4 in human metapneumovirus mediated innate immune responses and disease pathogenesis.

  Velayutham, T. S., Kolli, D., Ivanciuc, T., Garofalo, R. P. & Casola, A., 2013, In: PloS one. 8, 10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Human metapneumovirus
  • Metapneumovirus
  • Immune System Diseases
  • innate immunity
  • Innate Immunity
  11 Scopus citations

• Cystathionine γ-lyase deficiency enhances airway reactivity and viral-induced disease in mice exposed to side-stream tobacco smoke

  Ivanciuc, T., Sbrana, E., Casola, A. & Garofalo, R. P., Jul 1 2019, In: Pediatric Research. 86, 1, p. 39-46 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystathionine
  • Lyases
  • Smoke
  • Tobacco
  • Virus Diseases
  3 Scopus citations

• Differential response of BDCA-1⁺ and BDCA-3⁺ myeloid dendritic cells to respiratory syncytial virus infection

  Gupta, M. R., Kolli, D. & Garofalo, R. P., Jul 5 2013, In: Respiratory Research. 14, 1, 71.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory Syncytial Virus Infections
  • Myeloid Cells
  • Respiratory Syncytial Viruses
  • Dendritic Cells
  • Cytokines
  15 Scopus citations

• Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

  Joseph, P. R. B., Sawant, K. V., Isley, A., Pedroza, M., Garofalo, R. P., Richardson, R. M. & Rajarathnam, K., Dec 1 2013, In: Biochemical Journal. 456, 2, p. 241-251 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Proline
  • Glycine
  • G-Protein-Coupled Receptors
  • Chemokines
  • Chemical activation
  20 Scopus citations

• Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition

  Yang, J., Tian, B., Sun, H., Garofalo, R. P. & Brasier, A. R., Jun 5 2017, In: Nature Microbiology. 2, 17086.

  Research output: Contribution to journal › Article › peer-review

  • interferon type III
  • Interferon Regulatory Factor-1
  • Zinc Finger E-box-Binding Homeobox 1
  • Epithelial-Mesenchymal Transition
  • Respiratory Tract Infections
  18 Scopus citations

• Gestational Exposure to Cigarette Smoke Suppresses the Gasotransmitter H₂S Biogenesis and the Effects Are Transmitted Transgenerationally

  Singh, S. P., Devadoss, D., Manevski, M., Sheybani, A., Ivanciuc, T., Exil, V., Agarwal, H., Raizada, V., Garofalo, R. P., Chand, H. S. & Sopori, M. L., Jul 28 2020, In: Frontiers in immunology. 11, 1628.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gasotransmitters
  • Cystathionine
  • Smoke
  • Tobacco Products
  • Lyases
  2 Scopus citations

• HIF-1α modulates core metabolism and virus replication in primary airway epithelial cells infected with respiratory syncytial virus

  Morris, D. R., Qu, Y., Agrawal, A., Garofalo, R. P. & Casola, A., Oct 2020, In: Viruses. 12, 10, 1088.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hypoxia-Inducible Factor 1
  • Respiratory Syncytial Viruses
  • Virus Replication
  • Respiratory Syncytial Virus Infections
  • endothelial PAS domain-containing protein 1

• Human Metapneumovirus Glycoprotein G Disrupts Mitochondrial Signaling in Airway Epithelial Cells

  Bao, X., Kolli, D., Ren, J., Liu, T., Garofalo, R. P. & Casola, A., Apr 23 2013, In: PloS one. 8, 4, e62568.

  Research output: Contribution to journal › Article › peer-review

  • human metapneumovirus G glycoprotein
  • Human metapneumovirus
  • Epithelial Cells
  • Metapneumovirus
  • Genes
  21 Scopus citations

• Increased Lung Catalase Activity Confers Protection Against Experimental RSV Infection

  Ansar, M., Ivanciuc, T., Garofalo, R. P. & Casola, A., Dec 1 2020, In: Scientific reports. 10, 1, 3653.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • catalase-polyethylene glycol
  • Respiratory Syncytial Virus Infections
  • Respiratory Syncytial Viruses
  • Catalase
  • Lung
  4 Scopus citations

• Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity

  Mehta, R., Scheffler, M., Tapia, L., Aideyan, L., Patel, K. D., Jewell, A. M., Avadhanula, V., Mei, M., Garofalo, R. P. & Piedra, P. A., Nov 1 2014, In: Influenza and other respiratory viruses. 8, 6, p. 617-625 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bronchiolitis
  • Caspases
  • L-Lactate Dehydrogenase
  • Caspase 3
  • Child
  11 Scopus citations

• Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions

  Sawant, K. V., Sepuru, K. M., Lowry, E., Penaranda, B., Frevert, C. W., Garofalo, R. P. & Rajarathnam, K., 2020, (Accepted/In press) In: Journal of Leukocyte Biology.

  Research output: Contribution to journal › Article › peer-review

  • Neutrophil Infiltration
  • Glycosaminoglycans
  • Chemokines
  • Personnel Selection
  • Neutrophil Activation

• Pancreatitis activates pancreatic apelin-APJ axis in mice

  Han, S., Englander, E. W., Gomez, G. A., Aronson, J. F., Rastellini, C., Garofalo, R. P., Kolli, D., Quertermous, T., Kundu, R. & Greeley, G. H., Jul 15 2013, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 2, p. G139-G150

  Research output: Contribution to journal › Article › peer-review

  • Apelin
  • Pancreatitis
  • Pancreatic Stellate Cells
  • Chronic Pancreatitis
  • Fibrosis
  11 Scopus citations

• Paramyxovirus infection regulates T cell responses by BDCA-1⁺and BDCA-3⁺ myeloid dendritic cells

  Gupta, M. R., Kolli, D., Molteni, C., Casola, A. & Garofalo, R. P., Jun 11 2014, In: PloS one. 9, 6, e99227.

  Research output: Contribution to journal › Article › peer-review

  • Human metapneumovirus
  • Dendritic Cells
  • Respiratory syncytial virus
  • T-cells
  • Metapneumovirus
  5 Scopus citations

• Proline substitution of dimer interface β-strand residues as a strategy for the design of functional monomeric proteins

  Joseph, P. R. B., Poluri, K. M., Gangavarapu, P., Rajagopalan, L., Raghuwanshi, S., Richardson, R. M., Garofalo, R. P. & Rajarathnam, K., Sep 17 2013, In: Biophysical journal. 105, 6, p. 1491-1501 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Proline
  • Proteins
  • Catalysis
  • Amides
  • Static Electricity
  19 Scopus citations

• Respiratory syncytial virus induces NRF2 degradation through a promyelocytic leukemia protein ‐ ring finger protein 4 dependent pathway

  Komaravelli, N., Ansar, M., Garofalo, R. P. & Casola, A., Dec 2017, In: Free Radical Biology and Medicine. 113, p. 494-504 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Promyelocytic Leukemia Protein
  • NF-E2-Related Factor 2
  • Respiratory Syncytial Viruses
  • Viruses
  • Fingers
  14 Scopus citations

• Respiratory syncytial virus infection induces chromatin remodeling to activate growth factor and extracellular matrix secretion pathways

  Xu, X., Qiao, D., Mann, M., Garofalo, R. P. & Brasier, A. R., Aug 2020, In: Viruses. 12, 8, 804.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Respiratory Syncytial Virus Infections
  • Chromatin Assembly and Disassembly
  • Secretory Pathway
  • Chromatin
  • Extracellular Matrix
  1 Scopus citations

• Selective blockade of TNFR1 improves clinical disease and bronchoconstriction in experimental RSV infection

  Morris, D. R., Ansar, M., Ivanciuc, T., Qu, Y., Casola, A. & Garofalo, R. P., Oct 17 2020, In: Viruses. 12, 10, 1176.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Receptors, Tumor Necrosis Factor, Type I
  • Respiratory Syncytial Virus Infections
  • Bronchoconstriction
  • Respiratory Syncytial Viruses
  • Receptors, Tumor Necrosis Factor, Type II

• Systematic analysis of cell-type differences in the epithelial secretome reveals insights into the pathogenesis of respiratory syncytial virus-induced lower respiratory tract infections

  Zhao, Y., Jamaluddin, M., Zhang, Y., Sun, H., Ivanciuc, T., Garofalo, R. P. & Brasier, A. R., Apr 15 2017, In: Journal of Immunology. 198, 8, p. 3345-3364 20 p.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory Syncytial Viruses
  • Respiratory Tract Infections
  • Trachea
  • Proteins
  • Human respiratory syncytial virus
  25 Scopus citations

• The interdependencies of viral load, the innate immune response, and clinical outcome in children presenting to the emergency department with respiratory syncytial virus-Associated bronchiolitis

  Piedra, F. A., Mei, M., Avadhanula, V., Mehta, R., Aideyan, L., Garofalo, R. P. & Piedra, P. A., Mar 2017, In: PloS one. 12, 3, e0172953.

  Research output: Contribution to journal › Article › peer-review

  • bronchiolitis
  • Respiratory syncytial virus
  • Bronchiolitis
  • Respiratory Syncytial Viruses
  • Viruses
  21 Scopus citations

• The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

  Gangavarapu, P., Rajagopalan, L., Kolli, D., Guerrero-Plata, A., Garofalo, R. P. & Rajarathnam, K., Feb 2012, In: Journal of Leukocyte Biology. 91, 2, p. 259-265 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Neutrophil Infiltration
  • Glycosaminoglycans
  • Interleukin-8
  • Chemokines
  • Peritoneum
  62 Scopus citations
• Comment/debate

  Corrigendum to "MyD88 controls human metapneumovirus-induced pulmonary immune responses and disease pathogenesis" [Virus Res. 176 (1-2) (2013) 241-250]

  Ren, J., Kolli, D., Deng, J., Fang, R., Gong, B., Xue, M., Casola, A., Garofalo, R. P., Wang, T. & Bao, X., Nov 6 2013, In: Virus Research. 177, 2, 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review
• Review article

  Hydrogen sulfide: A novel player in airway development, pathophysiology of respiratory diseases, and antiviral defenses

  Bazhanov, N., Ansar, M., Ivanciuc, T., Garofalo, R. P. & Casola, A., Oct 2017, In: American journal of respiratory cell and molecular biology. 57, 4, p. 403-410 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cystathionine
  • Pulmonary diseases
  • Hydrogen Sulfide
  • Antiviral Agents
  • Lung Diseases
  34 Scopus citations

• Respiratory syncytial virus infection: Mechanisms of redox control and novel therapeutic opportunities

  Garofalo, R. P., Kolli, D. & Casola, A., Jan 10 2013, In: Antioxidants and Redox Signaling. 18, 2, p. 186-217 32 p.

  Research output: Contribution to journal › Review article › peer-review

  • Oxidation-Reduction
  • Respiratory Syncytial Virus Infections
  • Respiratory Syncytial Viruses
  • Viruses
  • Oxidative stress
  47 Scopus citations