Find Research outputs

Search results

• Review article

  Neuroinflammation associated with scrub typhus and spotted fever group rickettsioses

  Fisher, J., Card, G. & Soong, L., Oct 2020, In: PLoS neglected tropical diseases. 14, 10, p. 1-15 15 p., e0008675.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Spotted Fever Group Rickettsiosis
  • Scrub Typhus
  • Endemic Flea-Borne Typhus
  • Disease Vectors
  • Animal Disease Models

• Scrub Typhus Pathogenesis: Innate Immune Response and Lung Injury During Orientia tsutsugamushi Infection

  Trent, B., Fisher, J. & Soong, L., Sep 6 2019, In: Frontiers in Microbiology. 10, 2065.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Scrub Typhus
  • Lung Injury
  • Innate Immunity
  • Adult Respiratory Distress Syndrome
  • Lung
  3 Scopus citations
• Article

  A Hematogenously Disseminated Orientia tsutsugamsushi-Infected Murine Model of Scrub Typhus

  Shelite, T. R., Saito, T. B., Mendell, N. L., Gong, B., Xu, G., Soong, L., Valbuena, G., Bouyer, D. H. & Walker, D. H., Jul 2014, In: PLoS neglected tropical diseases. 8, 7, e2966.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Orientia tsutsugamushi
  • Infection
  • Inbred C57BL Mouse
  • Trombiculidae
  25 Scopus citations

• An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection

  Soong, L., Mendell, N. L., Olano, J. P., Rockx-Brouwer, D., Xu, G., Goez-Rivillas, Y., Drom, C., Shelite, T. R., Valbuena, G., Walker, D. H. & Bouyer, D. H., Aug 1 2016, In: PLoS neglected tropical diseases. 10, 8, e0004884.

  Research output: Contribution to journal › Article › peer-review

  • Immunological Models
  • Scrub Typhus
  • Infection
  • Orientia tsutsugamushi
  • Interleukin-9
  15 Scopus citations

• Annexin a2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and ebola virus infections

  Su, Z., Chang, Q., Drelich, A., Shelite, T., Judy, B., Liu, Y., Xiao, J., Zhou, C., He, X., Jin, Y., Saito, T., Tang, S., Soong, L., Wakamiya, M., Fang, X., Bukreyev, A., Ksiazek, T., Russell, W. K. & Gong, B., Jul 2020, In: PLoS neglected tropical diseases. 14, 7, p. 1-30 30 p., e0007960.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Annexin A2
  • Rickettsia
  • Ebola Hemorrhagic Fever
  • Annexins
  • Knockout Mice

• CD4⁺ T cell-dependent macrophage activation modulates sustained ps exposure on intracellular amastigotes of leishmania amazonensis

  Wanderley, J. L. M., Deolindo, P., Carlsen, E., Portugal, A. B., DaMatta, R. A., Barcinski, M. A. & Soong, L., 2019, In: Frontiers in Cellular and Infection Microbiology. 9, APR, 105.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leishmania
  • Phosphatidylserines
  • Macrophage Activation
  • T-Lymphocytes
  • Parasites
  5 Scopus citations

• CD8⁺T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection

  Xu, G., Mendell, N. L., Liang, Y., Shelite, T. R., Goez-Rivillas, Y., Soong, L., Bouyer, D. H. & Walker, D. H., Jul 19 2017, In: PLoS neglected tropical diseases. 11, 7, e0005763.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Orientia tsutsugamushi
  • T-Lymphocytes
  • Bacterial Load
  • Immunity
  15 Scopus citations

• Downregulation of microRNA-107 in intestinal CD11c⁺ myeloid cells in response to microbiota and proinflammatory cytokines increases IL-23p19 expression

  Xue, X., Cao, A. T., Cao, X., Yao, S., Carlsen, E. D., Soong, L., Liu, C. G., Liu, X., Liu, Z., Duck, L. W., Elson, C. O. & Cong, Y., Mar 2014, In: European Journal of Immunology. 44, 3, p. 673-682 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-23 Subunit p19
  • Myeloid Cells
  • Microbiota
  • MicroRNAs
  • Down-Regulation
  42 Scopus citations

• Epigenetic suppression of HIV in myeloid cells by the BRD4-selective small molecule modulator ZL0580

  Alamer, E., Zhong, C., Liu, Z., Niu, Q., Long, F., Guo, L., Gelman, B. B., Soong, L., Zhou, J. & Hu, H., Jun 1 2020, In: Journal of virology. 94, 11, e01880-19.

  Research output: Contribution to journal › Article › peer-review

  • neuroglia
  • Myeloid Cells
  • epigenetics
  • Epigenomics
  • therapeutics
  3 Scopus citations

• Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression

  Almahariq, M., Mei, F. C., Wang, H., Cao, A. T., Yao, S., Soong, L., Sun, J., Cong, Y., Chen, J. & Cheng, X., Jan 15 2015, In: Biochemical Journal. 465, p. 295-303 9 p.

  Research output: Contribution to journal › Article › peer-review

  • T-cells
  • Regulatory T-Lymphocytes
  • erythromycin propionate-N-acetylcysteinate
  • Immunosuppression
  • Pharmacology
  26 Scopus citations

• Hepatocyte growth factor in dampening liver immune-mediated pathology in acute viral hepatitis without compromising antiviral activity

  Aguilar-Valenzuela, R., Carlsen, E. D., Liang, Y., Soong, L. & Sun, J., Apr 2014, In: Journal of Gastroenterology and Hepatology (Australia). 29, 4, p. 878-886 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Hepatocyte Growth Factor
  • Hepatitis
  • Antiviral Agents
  • Pathology
  • Liver
  6 Scopus citations

• Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway

  Lu, Y., Li, C. F., Ping, N. N., Sun, Y. Y., Wang, Z., Zhao, G. X., Yuan, S. H., Zibrila, A. I., Soong, L. & Liu, J. J., May 1 2020, In: Journal of Biochemical and Molecular Toxicology. 34, 5, e22467.

  Research output: Contribution to journal › Article › peer-review

  • Kelch-Like ECH-Associated Protein 1
  • Hydrogen
  • Cyclosporine
  • Oxidative stress
  • Water
  2 Scopus citations

• IL-22 hinders antiviral T cell responses and exacerbates ZIKV encephalitis in immunocompetent neonatal mice

  Liang, Y., Yi, P., Ru, W., Jie, Z., Wang, H., Ghanayem, T., Wang, X., Alamer, E., Liu, J., Hu, H., Soong, L., Cai, J. & Sun, J., Aug 25 2020, In: Journal of neuroinflammation. 17, 1, 249.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • interleukin-22
  • Zika Virus
  • Encephalitis
  • Antiviral Agents
  • T-Lymphocytes

• IL-33-Dependent Endothelial Activation Contributes to Apoptosis and Renal Injury in Orientia tsutsugamushi-Infected Mice

  Shelite, T. R., Liang, Y., Wang, H., Mendell, N. L., Trent, B. J., Sun, J., Gong, B., Xu, G., Hu, H., Bouyer, D. H. & Soong, L., Mar 4 2016, In: PLoS neglected tropical diseases. 10, 3, e0004467.

  Research output: Contribution to journal › Article › peer-review

  • Orientia tsutsugamushi
  • Interleukin-33
  • Apoptosis
  • Endothelial Cells
  • Kidney
  19 Scopus citations

• IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis

  Liang, Y., Yi, P., Yuan, D. M. K., Jie, Z., Kwota, Z., Soong, L., Cong, Y. & Sun, J., Feb 1 2019, In: Cellular and Molecular Immunology. 16, 2, p. 126-137 12 p.

  Research output: Contribution to journal › Article › peer-review

  • STAT6 Transcription Factor
  • Interleukin-33
  • Lymphocytic choriomeningitis virus
  • Interleukin-13
  • Hepatitis
  10 Scopus citations

• IL-33 promotes innate IFN-γ production and modulates dendritic cell response in LCMV-induced hepatitis in mice

  Liang, Y., Jie, Z., Hou, L., Yi, P., Wang, W., Kwota, Z., Salvato, M., de Waal Malefyt, R., Soong, L. & Sun, J., 2015, (Accepted/In press) In: European Journal of Immunology.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-33
  • Lymphocytic choriomeningitis virus
  • Hepatitis
  • Dendritic Cells
  • T-Lymphocytes
  21 Scopus citations

• Immunotherapy using anti-PD-1 and anti-PD-L1 in Leishmania amazonensis-infected BALB/c mice reduce parasite load

  da Fonseca-Martins, A. M., Ramos, T. D., Pratti, J. E. S., Firmino-Cruz, L., Gomes, D. C. O., Soong, L., Saraiva, E. M. & de Matos Guedes, H. L., Dec 1 2019, In: Scientific reports. 9, 1, 20275.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Parasite Load
  • Leishmania
  • Immunotherapy
  • T-Lymphocytes
  • Diffuse Cutaneous Leishmaniasis
  3 Scopus citations

• Interactions between Neutrophils and Leishmania braziliensis Amastigotes Facilitate Cell Activation and Parasite Clearance

  Carlsen, E. D., Jie, Z., Liang, Y., Henard, C. A., Hay, C., Sun, J., De Matos Guedes, H. & Soong, L., Jul 22 2015, In: Journal of Innate Immunity. 7, 4, p. 354-363 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmania braziliensis
  • Parasites
  • Neutrophils
  • Neutrophil Activation
  • Leishmaniasis
  22 Scopus citations

• Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection

  Jie, Z., Liang, Y., Hou, L., Dong, C., Iwakura, Y., Soong, L., Cong, Y. & Sun, J., Apr 1 2014, In: Journal of Immunology. 192, 7, p. 3289-3300 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-17
  • Virus Diseases
  • Lymphocytes
  • T-Lymphocytes
  • Adenoviridae Infections
  28 Scopus citations

• Leishmania amazonensis Amastigotes Highly Express a Tryparedoxin Peroxidase Isoform That Increases Parasite Resistance to Macrophage Antimicrobial Defenses and Fosters Parasite Virulence

  Henard, C. A., Carlsen, E. D., Hay, C., Kima, P. E. & Soong, L., Jul 2014, In: PLoS neglected tropical diseases. 8, 7, e3000.

  Research output: Contribution to journal › Article › peer-review

  • tryparedoxin peroxidase
  • Leishmania
  • Nitric Oxide Synthase Type II
  • Virulence
  • Parasites
  17 Scopus citations

• MTOR mediates IL-23 induction of neutrophil IL-17 and IL-22 production

  Chen, F., Cao, A., Yao, S., Evans-Marin, H. L., Liu, H., Wu, W., Carlsen, E. D., Dann, S. M., Soong, L., Sun, J., Zhao, Q. & Cong, Y., May 15 2016, In: Journal of Immunology. 196, 10, p. 4390-4399 10 p.

  Research output: Contribution to journal › Article › peer-review

  • interleukin-22
  • Interleukin-23
  • Interleukin-17
  • Neutrophils
  • Colitis
  45 Scopus citations

• Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action

  Chen, J., Liang, Y., Yi, P., Xu, L., Hawkins, H. K., Rossi, S. L., Soong, L., Cai, J., Menon, R. & Sun, J., Nov 7 2017, In: Cell Reports. 21, 6, p. 1588-1599 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Viruses
  • Interferons
  • Mothers
  • Infection
  46 Scopus citations

• Permissive and protective roles for neutrophils in leishmaniasis

  Carlsen, E. D., Liang, Y., Shelite, T. R., Walker, D. H., Melby, P. C. & Soong, L., Nov 2015, In: Clinical and Experimental Immunology. 182, 2, p. 109-18 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Leishmaniasis
  • Parasites
  • Neutrophils
  • Leishmania
  • Infection
  32 Scopus citations

• Polarized lung inflammation and Tie2/angiopoietin-mediated endothelial dysfunction during severe Orientia tsutsugamushi infection

  Trent, B., Liang, Y., Xing, Y., Esqueda, M., Wei, Y., Cho, N. H., Kim, H. I., Kim, Y. S., Shelite, T. R., Cai, J., Sun, J., Bouyer, D. H., Liu, J. & Soong, L., Mar 1 2020, In: PLoS neglected tropical diseases. 14, 3, p. e0007675

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Scrub Typhus
  • Angiopoietins
  • Pneumonia
  • Angiopoietin-2
  • Lung
  2 Scopus citations

• Priming and activation of inflammasome by canarypox virus vector alvac via the CGAS/IFI16-sting-type I IFN pathway and AIM2 sensor

  Liu, F., Niu, Q., Fan, X., Liu, C., Zhang, J., Wei, Z., Hou, W., Kanneganti, T. D., Robb, M. L., Kim, J. H., Michael, N. L., Sun, J., Soong, L. & Hu, H., Nov 1 2017, In: Journal of Immunology. 199, 9, p. 3293-3305 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Inflammasomes
  • Bites and Stings
  • ALVAC vaccine
  • Vaccines
  • Poxviridae
  16 Scopus citations

• Retinoic acid modulates hyperactive T cell responses and protects Vitamin A deficient mice against persistent lymphocytic choriomeningitis virus infection

  Liang, Y., Yi, P., Wang, X., Zhang, B., Jie, Z., Soong, L. & Sun, J., Jun 1 2020, In: Journal of Immunology. 204, 11, p. 2984-2994 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphocytic choriomeningitis virus
  • Vitamin A Deficiency
  • Vitamin A
  • Tretinoin
  • Virus Diseases
  2 Scopus citations

• Retinoic acid regulates immune responses by promoting IL-22 and modulating S100 proteins in viral hepatitis

  Jie, Z., Liang, Y., Yi, P., Tang, H., Soong, L., Cong, Y., Zhang, K. & Sun, J., May 1 2017, In: Journal of Immunology. 198, 9, p. 3448-3460 13 p.

  Research output: Contribution to journal › Article › peer-review

  • interleukin-22
  • S100 Proteins
  • Tretinoin
  • Hepatitis
  • T-Lymphocytes
  16 Scopus citations

• Sequential Dysfunction and Progressive Depletion of Candida albicans-Specific CD4 T Cell Response in HIV-1 Infection

  Liu, F., Fan, X., Auclair, S., Ferguson, M., Sun, J., Soong, L., Hou, W., Redfield, R. R., Birx, D. L., Ratto-Kim, S., Robb, M. L., Kim, J. H., Michael, N. L. & Hu, H., Jun 2016, In: PLoS pathogens. 12, 6, e1005663.

  Research output: Contribution to journal › Article › peer-review

  • Candida albicans
  • HIV Infections
  • HIV-1
  • HIV
  • T-Lymphocytes
  14 Scopus citations

• Splenic CD4⁺ T cells in progressive visceral leishmaniasis show a mixed effector-regulatory phenotype and impair macrophage effector function through inhibitory receptor expression

  Medina-Colorado, A. A., Osorio, E. Y., Saldarriaga, O. A., Travi, B. L., Kong, F., Spratt, H., Soong, L. & Melby, P. C., Jan 2017, In: PloS one. 12, 1, e0169496.

  Research output: Contribution to journal › Article › peer-review

  • Macrophages
  • T-cells
  • visceral leishmaniasis
  • Visceral Leishmaniasis
  • T-lymphocytes
  19 Scopus citations

• Strong Type 1, but Impaired Type 2, Immune Responses Contribute to Orientia tsutsugamushi-Induced Pathology in Mice

  Soong, L., Wang, H., Shelite, T. R., Liang, Y., Mendell, N. L., Sun, J., Gong, B., Valbuena, G. A., Bouyer, D. H. & Walker, D. H., Sep 1 2014, In: PLoS neglected tropical diseases. 8, 9

  Research output: Contribution to journal › Article › peer-review

  • Orientia tsutsugamushi
  • Scrub Typhus
  • Angiopoietin-2
  • Pathology
  • Angiopoietin-1
  22 Scopus citations

• The burden of leishmaniasis in Iran, acquired from the global burden of disease during 1990-2010

  Badirzadeh, A., Mohebali, M., Asadgol, Z., Soong, L., Zeinali, M., Mokhayeri, Y., Shirzadi, M. R. & Spotin, A., Sep 1 2017, In: Asian Pacific Journal of Tropical Disease. 7, 9, p. 513-518 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Global Burden of Disease
  • Leishmaniasis
  • Iran
  • Visceral Leishmaniasis
  • Quality-Adjusted Life Years
  13 Scopus citations

• The co-stimulatory effects of MyD88-dependent toll-like receptor signaling on activation of murine γδ T Cells

  Zhang, J., Wang, J., Pang, L., Xie, G., Welte, T., Saxena, V., Wicker, J., Mann, B., Soong, L., Barrett, A., Born, W., O'Brien, R. & Wang, T., Sep 18 2014, In: PloS one. 9, 9, A1350.

  Research output: Contribution to journal › Article › peer-review

  • T-cells
  • Toll-like receptors
  • Toll-Like Receptors
  • T-lymphocytes
  • Chemical activation
  12 Scopus citations

• The MET Receptor Tyrosine Kinase Confers Repair of Murine Pancreatic Acinar Cells following Acute and Chronic Injury

  Gaziova, I., Jackson, D., Boor, P. J., Carter, D., Cruz-Monserrate, Z., Elferink, C. J., Joshi, A. D., Kaphalia, B., Logsdon, C. D., De Castro, K. P., Soong, L., Tao, X., Qiu, S. & Elferink, L. A., Oct 2016, In: PloS one. 11, 10, 0165485.

  Research output: Contribution to journal › Article › peer-review

  • Proto-Oncogene Proteins c-met
  • acinar cells
  • Acinar Cells
  • tyrosine
  • phosphotransferases (kinases)
  1 Scopus citations

• Type 1 interferon-induced IL-7 maintains CD8 ⁺ T-cell responses and homeostasis by suppressing PD-1 expression in viral hepatitis

  Hou, L., Jie, Z., Liang, Y., Desai, M., Soong, L. & Sun, J., Mar 1 2015, In: Cellular and Molecular Immunology. 12, 2, p. 213-221 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-7
  • Interferon Type I
  • Hepatitis
  • Homeostasis
  • T-Lymphocytes
  20 Scopus citations

• Type 1-skewed neuroinflammation and vascular damage associated with Orientia tsutsugamushi infection in mice

  Soong, L., Shelite, H. T. R., Xing, Y., Kodakandla, H., Liang, Y., Trent, B. J., Horton, P., Smith, K. C., Zhao, Z., Sun, J., Bouyer, D. H. & Cai, J., Jul 24 2017, In: PLoS neglected tropical diseases. 11, 7, e0005765.

  Research output: Contribution to journal › Article › peer-review

  • Scrub Typhus
  • Orientia tsutsugamushi
  • Phagocytes
  • Blood Vessels
  • Brain
  5 Scopus citations

• Viral retinopathy in experimental models of zika infection

  Zhao, Z., Yang, M., Azar, S. R., Soong, L., Weaver, S. C., Sun, J., Chen, Y., Rossi, S. L. & Cai, J., Aug 2017, In: Investigative Ophthalmology and Visual Science. 58, 10, p. 4075-4085 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus
  • Theoretical Models
  • Infection
  • Retinal Pigments
  • Eye
  31 Scopus citations

• γδ T cells as a major source of IL-17 production during age-dependent RPE degeneration

  Zhao, Z., Xu, P., Jie, Z., Zuo, Y., Yu, B., Soong, L., Sun, J., Chen, Y. & Cai, J., 2014, In: Investigative ophthalmology & visual science. 55, 10, p. 6580-6589 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Pigment Epithelium
  • Interleukin-17
  • Macular Degeneration
  • T-Lymphocytes
  • Retina
  21 Scopus citations