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  • Rakez Kayed
2014

The formation of tau pore-like structures is prevalent and cell specific: Possible implications for the disease phenotypes

Lasagna-Reeves, C. A., Sengupta, U., Castillo-Carranza, D., Gerson, J. E., Guerrero-Munoz, M., Troncoso, J. C., Jackson, G. R. & Kayed, R., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 56.

Research output: Contribution to journalArticle

32 Scopus citations
2018

AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and Tau oligomer formation

Ha, Y., Liu, W., Liu, H., Zhu, S., Xia, F., Gerson, J. E., Azhar, N. A., Tilton, R., Motamedi, M., Kayed, R. & Zhang, W., Sep 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 11, p. 4670-4682 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Azure C Targets and Modulates Toxic Tau Oligomers

Lo Cascio, F. & Kayed, R., Jun 20 2018, In : ACS Chemical Neuroscience. 9, 6, p. 1317-1326 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

Molecular mechanisms of amyloid oligomers toxicity

Kayed, R. & Lasagna-Reeves, C. A., Dec 1 2012, Alzheimer'S Disease: Advances For A New Century. Perry, G., Zhu, X., Smith, M., Sorensen, A. & Avila, J. (eds.). p. 67-78 12 p. (Advances in Alzheimer's Disease; vol. 3).

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Scopus citations
2017
15 Scopus citations
2012

Differential activation of the ER stress factor XBP1 by oligomeric assemblies

Castillo-Carranza, D. L., Zhang, Y., Guerrero-Muñoz, M. J., Kayed, R., Rincon-Limas, D. E. & Fernandez-Funez, P., Aug 1 2012, In : Neurochemical Research. 37, 8, p. 1707-1717 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2019

Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration

Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In : Aging Cell. 18, 6, e13035.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

α-Synuclein Oligomers Induce a Unique Toxic Tau Strain

Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Gerson, J. E. & Kayed, R., Jan 1 2018, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

17 Scopus citations
2016

Pre-amyloid oligomers budding: A metastatic mechanism of proteotoxicity

Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Oct 24 2016, In : Scientific reports. 6, 35865.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Tau Oligomers in Sera of Patients with Alzheimer's Disease and Aged Controls

Kolarova, M., Sengupta, U., Bartos, A., Ricny, J. & Kayed, R., 2017, In : Journal of Alzheimer's Disease. 58, 2, p. 471-478 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
2018

Immunotherapy Targeting Tau Oligomeric Strains in Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Oct 2018, p. S64.

Research output: Contribution to conferenceAbstract

2019

Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau

Sengupta, U. & Kayed, R., Jan 1 2019, In : Neuropsychopharmacology. 44, 1, p. 222-223 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
2018

Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Jul 2018, In : Alzheimer's and Dementia. 14, 7, p. 1657

Research output: Contribution to journalMeeting Abstract

Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies

Bittar, A., Sengupta, U. & Kayed, R., Dec 1 2018, In : npj Vaccines. 3, 1, 9.

Research output: Contribution to journalArticle

21 Scopus citations

Preparation and characterization of tau oligomer strains

Sengupta, U., Carretero-Murillo, M. & Kayed, R., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 113-146 34 p. (Methods in Molecular Biology; vol. 1779).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations
2013

Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies

Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In : Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.

Research output: Contribution to journalArticle

85 Scopus citations
2015

Pathological Interface between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies

Sengupta, U., Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Lasagna-Reeves, C. A., Gerson, J. E., Paulucci-Holthauzen, A. A., Krishnamurthy, S., Farhed, M., Jackson, G. R. & Kayed, R., Nov 15 2015, In : Biological Psychiatry. 78, 10, p. 672-683 12 p.

Research output: Contribution to journalArticle

81 Scopus citations

The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration

Deger, J. M., Gerson, J. E. & Kayed, R., Oct 1 2015, In : Aging Cell. 14, 5, p. 715-724 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2013

Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity

Lasagna-Reeves, C. A., Clos, A. L., Castillo-Carranza, D., Sengupta, U., Guerrero-Muñoz, M., Kelly, B., Wagner, R. & Kayed, R., Jan 18 2013, In : Biochemical and Biophysical Research Communications. 430, 3, p. 963-968 6 p.

Research output: Contribution to journalArticle

45 Scopus citations
2015

Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows spinocerebellar ataxia type 1 phenotypes

Lasagna-Reeves, C. A., Rousseaux, M. W. C., Guerrero-Munoz, M. J., Vilanova-Velez, L., Park, J., See, L., Jafar-Nejad, P., Richman, R., Orr, H. T., Kayed, R. & Zoghbi, H. Y., Dec 17 2015, In : eLife. 4, DECEMBER2015, e10891.

Research output: Contribution to journalArticle

9 Scopus citations
2011

Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain

Lasagna-Reeves, C. A., Glabe, C. G. & Kayed, R., Jun 24 2011, In : Journal of Biological Chemistry. 286, 25, p. 22122-22130 9 p.

Research output: Contribution to journalArticle

98 Scopus citations
2017

Evaluating Tau Oligomers Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 2017, (Unpublished).

Research output: Contribution to conferencePoster

2014

Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds

Castillo-Carranza, D. L., Gerson, J. E., Sengupta, U., Guerrero-Muñoz, M. J., Lasagna-Reeves, C. A. & Kayed, R., 2014, In : Journal of Alzheimer's Disease. 40, S1, p. S97-S111

Research output: Contribution to journalArticle

85 Scopus citations
2011

Formation of immunoglobulin light chain amyloid oligomers in primary cutaneous nodular amyloidosis

Clos, A. L., Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Jackson, G. R., Kelly, B., Beachkofsky, T. M. & Kayed, R., Dec 1 2011, In : British Journal of Dermatology. 165, 6, p. 1349-1354 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Characterization of tau oligomeric seeds in progressive supranuclear palsy

Gerson, J. E., Sengupta, U., Lasagna-Reeves, C. A., Guerrero-Muñoz, M. J., Troncoso, J. & Kayed, R., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 73.

Research output: Contribution to journalArticle

42 Scopus citations
2019

Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In : Biochemistry. 58, 25, p. 2814-2821 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2020

Advances and considerations in AD tau-targeted immunotherapy

Bittar, A., Bhatt, N. & Kayed, R., Feb 2020, In : Neurobiology of Disease. 134, 104707.

Research output: Contribution to journalReview article

Open Access
5 Scopus citations
2018

Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease

Sengupta, U., Montalbano, M., McAllen, S., Minuesa, G., Kharas, M. & Kayed, R., Oct 26 2018, In : Acta Neuropathologica Communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

4 Scopus citations
10 Scopus citations
2016

Advances in tau immunotherapy

Gerson, J. & Kayed, R., Jan 1 2016, Research Progress in Alzheimer’s Disease and Dementia. Volume 6. Nova Science Publishers, Inc., p. 99-114 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Clos, A. L., Jackson, G. R. & Kayed, R., Jun 8 2011, In : Molecular Neurodegeneration. 6, 1, 39.

Research output: Contribution to journalArticle

245 Scopus citations
2018

Evaluating Passive Immunotherapy using Aged Transgenic Animals of Tauopathy

Al Lahham, R., Bittar, A., Montalbano, M., Carretero Murillo, M., McAllen, S., Bhatt, N., Ellsworth, A. & Kayed, R., Apr 2018, (Unpublished).

Research output: Contribution to conferencePoster