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  • Slobodan Paessler
2015

Improving attrition rates in Ebola virus drug discovery

Glisic, S., Paessler, S., Veljkovic, N., Perovic, V. R., Prljic, J. & Veljkovic, V., Sep 2 2015, In : Expert Opinion on Drug Discovery. 10, 9, p. 1025-1032 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

In silico analysis suggests repurposing of ibuprofen for prevention and treatment of EBOLA virus disease

Veljkovic, V., Goeijenbier, M., Glisic, S., Veljkovic, N., Perovic, V. R., Sencanski, M., Branch, D. R. & Paessler, S., May 1 2015, In : F1000Research. 4, 104.

Research output: Contribution to journalArticle

11 Scopus citations

Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage

Manning, J. T., Forrester, N. & Paessler, S., 2015, In : Frontiers in Microbiology. 6, OCT, 1037.

Research output: Contribution to journalArticle

34 Scopus citations

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

Zhang, Y., Mao, D., Roswit, W. T., Jin, X., Patel, A. C., Patel, D. A., Agapov, E., Wang, Z., Tidwell, R. M., Atkinson, J. J., Huang, G., McCarthy, R., Yu, J., Yun, N. E., Paessler, S., Lawson, T. G., Omattage, N. S., Brett, T. J. & Holtzman, M. J., Dec 1 2015, In : Nature Immunology. 16, 12, p. 1215-1227 13 p.

Research output: Contribution to journalArticle

48 Scopus citations

The glycoprotein precursor gene of Junin virus determines the virulence of the romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever

Seregin, A. V., Yun, N. E., Miller, M., Aronson, J., Smith, J. K., Walker, A. G., Smith, J. N., Huang, C., Manning, J., de la Torre, J. C. & Paessler, S., 2015, In : Journal of Virology. 89, 11, p. 5949-5956 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
2014

A substitution in the transmembrane region of the glycoprotein leads to an unstable attenuation of machupo virus

Patterson, M., Koma, T., Seregin, A., Huang, C., Miller, M., Smith, J., Yun, N., Smith, J. & Paessler, S., 2014, In : Journal of virology. 88, 18, p. 10995-10999 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

A viral RNA structural element alters host recognition of nonself RNA

Hyde, J. L., Gardner, C. L., Kimura, T., White, J. P., Liu, G., Trobaugh, D. W., Huang, C., Tonelli, M., Paessler, S., Takeda, K., Klimstra, W. B., Amarasinghe, G. K. & Diamond, M. S., 2014, In : Science. 343, 6172, p. 783-787 5 p.

Research output: Contribution to journalArticle

82 Scopus citations

Epidemiology and pathogenesis of Bolivian hemorrhagic fever

Patterson, M., Grant, A. & Paessler, S., Apr 2014, In : Current Opinion in Virology. 5, 1, p. 82-90 9 p.

Research output: Contribution to journalReview article

24 Scopus citations

Lymphocytic Choriomeningitis, Lassa Fever, and the South American Hemorrhagic Fevers (Arenaviruses)

Seregin, A., Yun, N. & Paessler, S., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 2031-2037.e2

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Potent Inhibition of Junín Virus Infection by Interferon in Murine Cells

Huang, C., Walker, A. G., Grant, A. M., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V. & Paessler, S., Jun 2014, In : PLoS neglected tropical diseases. 8, 6, e2933.

Research output: Contribution to journalArticle

11 Scopus citations

Reactive astrogliosis in response to hemorrhagic fever virus: Microarray profile of Junin virus-infected human astrocytes

Kolokoltsova, O. A., Yun, N. E. & Paessler, S., Jul 11 2014, In : Virology journal. 11, 1, 126.

Research output: Contribution to journalArticle

4 Scopus citations

Rescue of a recombinant Machupo virus from cloned cDNAs and in vivo characterization in interferon (αβ/γ) receptor double knockout mice

Patterson, M., Seregin, A., Huang, C., Kolokoltsova, O., Smith, J., Miller, M., Smith, J., Yun, N., Poussard, A., Grant, A., Tigabu, B., Walker, A. & Paessler, S., Feb 1 2014, In : Journal of virology. 88, 4, p. 1914-1923 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

RIG-I enhanced interferon independent apoptosis upon Junin virus infection

Kolokoltsova, O. A., Grant, A. M., Huang, C., Smith, J. K., Poussard, A. L., Tian, B., Brasier, A. R., Peters, C. J., Tseng, C. T. K., De La Torre, J. C. & Paessler, S., Jun 11 2014, In : PloS one. 9, 6, e99610.

Research output: Contribution to journalArticle

15 Scopus citations
64 Scopus citations
2013

Alphavirus neurovirulence

Taylor, K. & Paessler, S., Jan 1 2013, Neuroviral Infections: RNA Viruses and Retroviruses. CRC Press, p. 3-20 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells

Tian, B., Zhao, Y., Kalita, M., Edeh, C. B., Paessler, S., Casola, A., Teng, M. N., Garofalo, R. P. & Brasier, A. R., Jun 1 2013, In : Journal of virology. 87, 12, p. 7075-7092 18 p.

Research output: Contribution to journalArticle

40 Scopus citations

Innate immune response to arenaviral infection: A focus on the highly pathogenic new world hemorrhagic arenaviruses

Koma, T., Huang, C., Kolokoltsova, O. A., Brasier, A. R. & Paessler, S., Dec 13 2013, In : Journal of Molecular Biology. 425, 24, p. 4893-4903 11 p.

Research output: Contribution to journalReview article

18 Scopus citations

Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus

Yun, N. E., Seregin, A. V., Walker, D. H., Popov, V. L., Walker, A. G., Smith, J. N., Miller, M., de la Torre, J. C., Smith, J. K., Borisevich, V., Fair, J. N., Wauquier, N., Grant, D. S., Bockarie, B., Bente, D. & Paessler, S., 2013, In : Journal of virology. 87, 19, p. 10908-10911 4 p.

Research output: Contribution to journalArticle

31 Scopus citations

Pathogenesis of the viral hemorrhagic fevers

Paessler, S. & Walker, D. H., Jan 2013, In : Annual Review of Pathology: Mechanisms of Disease. 8, p. 411-440 30 p.

Research output: Contribution to journalReview article

147 Scopus citations

Pathogenesis of Venezuelan equine encephalitis

Taylor, K. G. & Paessler, S., Nov 29 2013, In : Veterinary Microbiology. 167, 1-2, p. 145-150 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Production of IL-8, IL-17, IFN-gamma and IP-10 in human astrocytes correlates with alphavirus attenuation

Peng, B. H., Borisevich, V., Popov, V. L., Zacks, M. A., Estes, D. M., Campbell, G. A. & Paessler, S., May 3 2013, In : Veterinary Microbiology. 163, 3-4, p. 223-234 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2012

Control of SIV infection and subsequent induction of pandemic H1N1 immunity in rhesus macaques using an Ad5 [E1-, E2b-] vector platform

Gabitzsch, E. S., Balint-Junior, J. P., Xu, Y., Balcaitis, S., Sanders-Beer, B., Karl, J., Weinhold, K. J., Paessler, S. & Jones, F. R., Nov 26 2012, In : Vaccine. 30, 50, p. 7265-7270 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Effect of Ribavirin on Junin Virus Infection in Guinea Pigs

Salazar, M., Yun, N. E., Poussard, A. L., Smith, J. N., Smith, J. K., Kolokoltsova, O. A., Patterson, M. J., Linde, J. & Paessler, S., Jun 1 2012, In : Zoonoses and Public Health. 59, 4, p. 278-285 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Functional interferon system is required for clearance of Lassa virus

Yun, N. E., Poussard, A. L., Seregin, A. V., Walker, A. G., Smith, J. K., Aronson, J. F., Smith, J. N., Soong, L. & Paessler, S., Mar 2012, In : Journal of virology. 86, 6, p. 3389-3392 4 p.

Research output: Contribution to journalArticle

33 Scopus citations

In vivo imaging systems (IVIS) detection of a neuro-invasive encephalitic virus.

Poussard, A., Patterson, M., Taylor, K., Seregin, A., Smith, J., Smith, J., Salazar, M. & Paessler, S., 2012, In : Journal of visualized experiments : JoVE. 70, p. e4429

Research output: Contribution to journalArticle

9 Scopus citations

Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner

Huang, C., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V., Poussard, A. L., Walker, A. G., Brasier, A. R., Zhao, Y., Tian, B., de la Torre, J. C. & Paessler, S., May 2012, In : PLoS neglected tropical diseases. 6, 5, e1659.

Research output: Contribution to journalArticle

42 Scopus citations

Junín virus pathogenesis and virus replication

Grant, A., Seregin, A., Huang, C., Kolokoltsova, O., Brasier, A., Peters, C. & Paessler, S., Oct 2012, In : Viruses. 4, 10, p. 2317-2339 23 p.

Research output: Contribution to journalReview article

40 Scopus citations

Natural killer cell mediated pathogenesis determines outcome of central nervous system infection with Venezuelan equine encephalitis virus in C3H/HeN mice

Taylor, K., Kolokoltsova, O., Patterson, M., Poussard, A., Smith, J., Estes, D. M. & Paessler, S., Jun 8 2012, In : Vaccine. 30, 27, p. 4095-4105 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Neuropathology of H5N1 virus infection in ferrets

Peng, B. H., Yun, N. E., Chumakova, O., Zacks, M., Campbell, G., Smith, J., Smith, J., Linde, S., Linde, J. & Paessler, S., May 4 2012, In : Veterinary Microbiology. 156, 3-4, p. 294-304 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Resequencing of the puumala virus strain sotkamo from the WHO arbovirus collection

Kurolt, I. C., Paessler, S. & Markotić, A., Oct 1 2012, In : Virus Genes. 45, 2, p. 389-392 4 p.

Research output: Contribution to journalArticle

Viral Hemorrhagic Fevers: South American Hemorrhagic Fevers

Paessler, S., Nov 1 2012, Hunter's Tropical Medicine and Emerging Infectious Disease: Ninth Edition. Elsevier Inc., p. 328-330 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease

Urata, S., Yun, N., Pasquato, A., Paessler, S., Kunz, S. & De La Torre, J. C., Jan 1 2011, In : Journal of virology. 85, 2, p. 795-803 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Prevention of influenza virus shedding and protection from lethal H1N1 challenge using a consensus 2009 H1N1 HA and NA adenovirus vector vaccine

Jones, F. R., Gabitzsch, E. S., Xu, Y., Balint, J. P., Borisevich, V., Smith, J., Smith, J., Peng, B. H., Walker, A., Salazar, M. & Paessler, S., Sep 16 2011, In : Vaccine. 29, 40, p. 7020-7026 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Rapid, non-invasive imaging of alphaviral brain infection: Reducing animal numbers and morbidity to identify efficacy of potential vaccines and antivirals

Patterson, M., Poussard, A., Taylor, K., Seregin, A., Smith, J., Peng, B. H., Walker, A., Linde, J., Smith, J., Salazar, M. & Paessler, S., Nov 21 2011, In : Vaccine. 29, 50, p. 9345-9351 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Rescue from cloned cDNAs and in vivo characterization of recombinant pathogenic romero and live-attenuated candid #1 strains of Junin virus, the causative agent of argentine hemorrhagic fever disease

Emonet, S. F., Seregin, A. V., Yun, N. E., Poussard, A. L., Walker, A. G., De La Torre, J. C. & Paessler, S., Feb 2011, In : Journal of virology. 85, 4, p. 1473-1483 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

Vγ4+ T cells regulate host immune response to West Nile virus infection

Welte, T., Aronson, J., Gong, B., Rachamallu, A., Mendell, N., Tesh, R., Paessler, S., Born, W. K., O'Brien, R. L. & Wang, T., Nov 2011, In : FEMS Immunology and Medical Microbiology. 63, 2, p. 183-192 10 p.

Research output: Contribution to journalArticle

24 Scopus citations