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  • Kathryn Cunningham
2020

Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats

Ezeomah, C., Cunningham, K. A., Stutz, S. J., Fox, R. G., Bukreyeva, N., Dineley, K. T., Paessler, S. & Cisneros, I. E., Jan 1 2020, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

1 Scopus citations

Inherent Motor Impulsivity Associates with Specific Gene Targets in the Rat Medial Prefrontal Cortex

Sholler, D. J., Merritt, C. R., Davis-Reyes, B. D., Golovko, G., Anastasio, N. C. & Cunningham, K. A., May 21 2020, In : Neuroscience. 435, p. 161-173 13 p.

Research output: Contribution to journalArticle

Serotonin neurobiology in cocaine use disorder

Cunningham, K. A., Howell, L. L. & Anastasio, N. C., 2020, Handbook of Behavioral Neuroscience. Elsevier B.V., p. 745-802 58 p. (Handbook of Behavioral Neuroscience; vol. 31).

Research output: Chapter in Book/Report/Conference proceedingChapter

Suppression of cocaine relapse-like behaviors upon pimavanserin and lorcaserin co-administration

Anastasio, N. C., Sholler, D. J., Fox, R. G., Stutz, S. J., Merritt, C. R., Bjork, J. M., Moeller, F. G. & Cunningham, K. A., May 15 2020, In : Neuropharmacology. 168, 108009.

Research output: Contribution to journalArticle

2019

Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts

Wold, E. A., Chen, J., Cunningham, K. & Zhou, J., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 88-127 40 p.

Research output: Contribution to journalArticle

14 Scopus citations

Anterior insula activity regulates the associated behaviors of high fat food binge intake and cue reactivity in male rats

Price, A. E., Stutz, S. J., Hommel, J. D., Anastasio, N. C. & Cunningham, K. A., Feb 1 2019, In : Appetite. 133, p. 231-239 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Chronic poly-drug administration damages adult mouse brain neural stem cells

McGrath, E. L., Schlagal, C. R., Cortez, I., Dunn, T. J., Gao, J., Fox, R. G., Stutz, S. J., Kuo, Y. F., Hommel, J., Dineley, K., Cunningham, K., Kaphalia, B. & Wu, P., Nov 15 2019, In : Brain Research. 1723, 146425.

Research output: Contribution to journalArticle

Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder

Ma, L., Steinberg, J. L., Bjork, J. M., Taylor, B. A., Arias, A. J., Terplan, M., Anastasio, N. C., Zuniga, E. A., Lennon, M., Cunningham, K. A. & Moeller, F. G., Dec 30 2019, In : Psychiatry Research - Neuroimaging. 294, 110977.

Research output: Contribution to journalArticle

1 Scopus citations

Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats

Anastasio, N., Stutz, S. J., Price, A. E., Davis-Reyes, B. D., Sholler, D. J., Ferguson, S. M., Neumaier, J. F., Moeller, F. G., Hommel, J. & Cunningham, K., Jan 1 2019, In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

3 Scopus citations

Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor

Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M., Anastasio, N., Cunningham, K. & Zhou, J., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 288-305 18 p.

Research output: Contribution to journalArticle

9 Scopus citations

Endogenous Serotonin 5-HT 2A and 5-HT 2C Receptors Associate in the Medial Prefrontal Cortex

Price, A. E., Sholler, D. J., Stutz, S. J., Anastasio, N. & Cunningham, K., Jan 1 2019, In : ACS Chemical Neuroscience.

Research output: Contribution to journalArticle

3 Scopus citations

In vivo and in vitro analyses of novel peptidomimetic disruptors for the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog (PTEN)

Soto, C., Du, H. C., Fox, R., Yang, T., Hooson, J., Anastasio, N. C., Gilbertson, S. R., Cunningham, K. A., Cunningham, K. A. & Gilbertson, S. R., Jan 1 2019, In : Frontiers in Pharmacology. 10, JULY, 907.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Leave the Ordinary Elsewhere: Novel Serotonin Mechanisms to Address 21st Century Public Health Challenges

Sholler, D. J. & Cunningham, K., Jul 17 2019, In : ACS chemical neuroscience. 10, 7, p. 3045-3046 2 p.

Research output: Contribution to journalArticle

Serotonin 5-HT2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro

Land, M. A., Chapman, H. L., Davis-Reyes, B. D., Felsing, D. E., Allen, J. A., Moeller, F. G., Elferink, L. A., Cunningham, K. A. & Anastasio, N. C., Dec 1 2019, In : Scientific reports. 9, 1, 16737.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development

Wold, E. A., Wild, C. T., Cunningham, K. A. & Zhou, J., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 16, p. 1381-1398 18 p.

Research output: Contribution to journalReview article

5 Scopus citations

The 5-HT2A receptor (5-HT2AR) regulates impulsive action and cocaine cue reactivity in Male Sprague-Dawley rats

Sholler, D. J., Stutz, S. J., Fox, R. G., Boone, E. L., Wang, Q., Rice, K. C., Gerard Moeller, F., Anastasio, N. & Cunningham, K., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 368, 1, p. 41-49 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Translating pharmacology into therapeutics to fight the opioid crisis

Marek, G. J., Cunningham, K. A. & Rasmussen, K., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 371, 2, p. 394-395 2 p.

Research output: Contribution to journalEditorial

Open Access
2018

A protocol for measuring cue reactivity in a rat model of cocaine use disorder

Dimet, A. L., Cisneros, I. E., Fox, R. G., Stutz, S. J., Anastasio, N. C., Cunningham, K. A. & Dineley, K. T., Jun 20 2018, In : Journal of Visualized Experiments. 2018, 136, e55864.

Research output: Contribution to journalArticle

3 Scopus citations

Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction

Felsing, D., Anastasio, N., Miszkiel, J. M., Gilbertson, S. R., Allen, J. & Cunningham, K., Aug 1 2018, In : PLoS One. 13, 8, e0203137.

Research output: Contribution to journalArticle

9 Scopus citations

Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes

Cisneros, I., Erdenizmenli, M., Cunningham, K., Paessler, S. & Dineley, K., Jun 1 2018, In : Neuropharmacology. 135, p. 431-443 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Editors' Favorites of 2017

Lindsley, C. W., Cunningham, K. A., Hooker, J. M. & Andrews, A. M., Jan 17 2018, In : ACS Chemical Neuroscience. 9, 1, p. 1-4 4 p.

Research output: Contribution to journalReview article

1 Scopus citations

Innovative Therapeutic Intervention for Opioid Use Disorder

Moeller, F. G. & Cunningham, K., Jan 1 2018, In : Neuropsychopharmacology. 43, 1, p. 220-221 2 p.

Research output: Contribution to journalShort survey

3 Scopus citations

Novel Bivalent 5-HT2A Receptor Antagonists Exhibit High Affinity and Potency in Vitro and Efficacy in Vivo

Soto, C. A., Shashack, M. J., Fox, R. G., Bubar, M. J., Rice, K. C., Watson, C. S., Cunningham, K., Gilbertson, S. R. & Anastasio, N., Mar 21 2018, In : ACS Chemical Neuroscience. 9, 3, p. 514-521 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
9 Scopus citations

Special Issue on Precision Medicine for Brain Cancer in ACS Chemical Neuroscience

Nilsson, C. L. & Cunningham, K., Jan 17 2018, In : ACS Chemical Neuroscience. 9, 1, 1 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT2A receptor (5-HT2AR) antagonist M100907

Gilbertson, S. R., Chen, Y. C., Soto, C. A., Yang, Y., Rice, K. C., Cunningham, K. & Anastasio, N., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Aged dominant negative p38α MAPK mice are resistant to age-dependent decline in adult-neurogenesis and context discrimination fear conditioning

Cortez, I. D., Bulavin, D. V., Wu, P., McGrath, E. L., Cunningham, K. A., Wakamiya, M., Papaconstantinou, J. & Dineley, K. T., Mar 30 2017, In : Behavioural Brain Research. 322, p. 212-222 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder

Ma, L., Steinberg, J. L., Cunningham, K., Bjork, J. M., Lane, S. D., Schmitz, J. M., Burroughs, T., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., 2017, (Accepted/In press) In : Psychiatry Research - Neuroimaging.

Research output: Contribution to journalArticle

3 Scopus citations

Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine

Simmler, L. D., Anacker, A. M. J., Levin, M. H., Vaswani, N. M., Gresch, P. J., Nackenoff, A. G., Anastasio, N. C., Stutz, S. J., Cunningham, K. A., Wang, J., Zhang, B., Henry, L. K., Stewart, A., Veenstra-VanderWeele, J. & Blakely, R. D., Aug 1 2017, In : British Journal of Pharmacology. 174, 16, p. 2716-2738 23 p.

Research output: Contribution to journalArticle

7 Scopus citations

Editors’ Favorites of 2016

Lindsley, C. W., Hooker, J. M., Cunningham, K. A. & Andrews, A. M., Jan 18 2017, In : ACS Chemical Neuroscience. 8, 1, p. 1-3 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Lorcaserin Suppresses Oxycodone Self-Administration and Relapse Vulnerability in Rats

Neelakantan, H., Holliday, E. D., Fox, R. G., Stutz, S. J., Comer, S. D., Haney, M., Anastasio, N. C., Moeller, F. G. & Cunningham, K. A., May 17 2017, In : ACS Chemical Neuroscience. 8, 5, p. 1065-1073 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

PPAR-gamma agonist pioglitazone modifies craving intensity and brain white matter integrity in patients with primary cocaine use disorder: A double-blind randomized controlled pilot trial

Schmitz, J. M., Green, C. E., Hasan, K. M., Vincent, J., Suchting, R., Weaver, M. F., Moeller, F. G., Narayana, P. A., Cunningham, K., Dineley, K. & Lane, S. D., 2017, (Accepted/In press) In : Addiction.

Research output: Contribution to journalArticle

25 Scopus citations

Synthesis and Structure-Activity Relationships of Tool Compounds Based on WAY163909, a 5-HT2C Receptor Agonist

Chen, Y. C., Hartley, R. M., Anastasio, N. C., Cunningham, K. A. & Gilbertson, S. R., May 17 2017, In : ACS Chemical Neuroscience. 8, 5, p. 1004-1010 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons

Gao, Y., Yao, T., Deng, Z., Sohn, J. W., Sun, J., Huang, Y., Kong, X., Yu, K. J., Wang, R. T., Chen, H., Guo, H., Yan, J., Cunningham, K. A., Chang, Y., Liu, T. & Williams, K. W., Jan 17 2017, In : Cell Reports. 18, 3, p. 583-592 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
2016

Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT2C receptor (5-HT2CR) system

Swinford-Jackson, S. E., Anastasio, N. C., Fox, R. G., Stutz, S. J. & Cunningham, K. A., Jun 2 2016, In : Neuroscience. 324, p. 50-61 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Is There a causal relation between maternal acetaminophen administration and ADHD?

Saad, A., Hegde, S., Kechichian, T., Gamble, P., Rahman, M., Stutz, S. J., Anastasio, N. C., Alshehri, W., Lei, J., Mori, S., Kajs, B., Cunningham, K. A., Saade, G., Burd, I. & Costantine, M., Jun 1 2016, In : PLoS One. 11, 6, e0157380.

Research output: Contribution to journalArticle

3 Scopus citations

PPARγ agonism attenuates cocaine cue reactivity

Miller, W. R., Fox, R. G., Stutz, S. J., Lane, S. D., Denner, L., Cunningham, K. & Dineley, K., 2016, (Accepted/In press) In : Addiction Biology.

Research output: Contribution to journalArticle

9 Scopus citations

Spatial and Sex-Dependent Responses of Adult Endogenous Neural Stem Cells to Alcohol Consumption

McGrath, E. L., Gao, J., Kuo, Y. F., Dunn, T. J., Ray, M. J., Dineley, K. T., Cunningham, K. A., Kaphalia, B. S. & Wu, P., Aug 7 2016, (Accepted/In press) In : Stem Cell Reports.

Research output: Contribution to journalArticle

4 Scopus citations

Suppression of Cocaine-Evoked Hyperactivity by Self-Adjuvanting and Multivalent Peptide Nanofiber Vaccines

Rudra, J. S., Ding, Y., Neelakantan, H., Ding, C., Appavu, R., Stutz, S., Snook, J. D., Chen, H., Cunningham, K. A. & Zhou, J., May 18 2016, In : ACS Chemical Neuroscience. 7, 5, p. 546-552 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2015

5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: From behavioral to cellular evidence

Martin, C. B. P., Martin, V. S., Trigo, J. M., Chevarin, C., Maldonado, R., Fink, L. H., Cunningham, K. A., Hamon, M., Lanfumey, L. & Mongeau, R., Jan 1 2015, In : International Journal of Neuropsychopharmacology. 18, 3

Research output: Contribution to journalArticle

7 Scopus citations

Evaluation of the dopamine β-hydroxylase (DβH) inhibitor nepicastat in participants who meet criteria for cocaine use disorder

De La Garza, R., Bubar, M. J., Carbone, C. L., Moeller, F. G., Newton, T. F., Anastasio, N. C., Harper, T. A., Ware, D. L., Fuller, M. A., Holstein, G. J., Jayroe, J. B., Bandak, S. I., Reiman, K. Z., Neale, A. C., Pickford, L. B. & Cunningham, K. A., Jun 3 2015, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 59, p. 40-48 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U

Kasper, J., McCue, D. L., Milton, A. J., Szwed, A., Sampson, C. M., Huang, M., Carlton, S., Meltzer, H. Y., Cunningham, K. & Hommel, J., Dec 18 2015, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

7 Scopus citations

Individual differences in impulsive action reflect variation in the cortical serotonin 5-HT <inf>2A</inf> receptor system

Fink, L. H., Anastasio, N., Fox, R. G., Rice, K. C., Moeller, F. G. & Cunningham, K., Jul 13 2015, In : Neuropsychopharmacology. 40, 8, p. 1957-1968 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Inhibitory behavioral control: A stochastic dynamic causal modeling study comparing cocaine dependent subjects and controls

Ma, L., Steinberg, J. L., Cunningham, K. A., Lane, S. D., Bjork, J. M., Neelakantan, H., Price, A. E., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., Jan 1 2015, In : NeuroImage: Clinical. 7, p. 837-847 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Inhibitory behavioral control: a stochastic dynamic causal modeling study using network discovery analysis

Ma, L., Steinberg, J. L., Cunningham, K., Lane, S. D., Kramer, L. A., Narayana, P. A., Kosten, T. R., Bechara, A. & Moeller, F. G., Apr 1 2015, In : Brain Connectivity. 5, 3, p. 177-186 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Prevalence of Food Addiction among Low-Income Reproductive-Aged Women

Berenson, A., Laz, T. H., Pohlmeier, A. M., Rahman, M. & Cunningham, K., Sep 1 2015, In : Journal of Women's Health. 24, 9, p. 740-744 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Rapid-response impulsivity: Definitions, measurement issues, and clinical implications

Hamilton, K. R., Littlefield, A. K., Anastasio, N. C., Cunningham, K. A., Fink, L. H. L., Wing, V. C., Mathias, C. W., Lane, S. D., Schütz, C. G., Swann, A. C., Lejuez, C. W., Clark, L., Moeller, F. G. & Potenza, M. N., Apr 1 2015, In : Personality Disorders: Theory, Research, and Treatment. 6, 2, p. 168-181 14 p.

Research output: Contribution to journalArticle

53 Scopus citations

Serotonin (5-HT) 5-HT<inf>2A</inf> Receptor (5-HT<inf>2A</inf>R): 5-HT<inf>2C</inf>R Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity

Anastasio, N., Stutz, S. J., Fink, L. H. L., Swinford-Jackson, S. E., Sears, R. M., Dileone, R. J., Rice, K. C., Moeller, F. G. & Cunningham, K., Jul 15 2015, In : ACS Chemical Neuroscience. 6, 7, p. 1248-1258 11 p.

Research output: Contribution to journalArticle

40 Scopus citations