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  • Roberto P. Garofalo
2020

A polymorphism in the catalase gene promoter confers protection against severe RSV bronchiolitis

Chambliss, J. M., Ansar, M., Kelley, J. P., Spratt, H., Garofalo, R. P. & Casola, A., Jan 3 2020, In : Viruses. 12, 1, , 57.

Research output: Contribution to journalArticle

Open Access

HIF-1α modulates core metabolism and virus replication in primary airway epithelial cells infected with respiratory syncytial virus

Morris, D. R., Qu, Y., Agrawal, A., Garofalo, R. P. & Casola, A., Oct 2020, In : Viruses. 12, 10, 1088.

Research output: Contribution to journalArticle

Open Access

Increased Lung Catalase Activity Confers Protection Against Experimental RSV Infection

Ansar, M., Ivanciuc, T., Garofalo, R. P. & Casola, A., Dec 1 2020, In : Scientific reports. 10, 1, 3653.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions

Sawant, K. V., Sepuru, K. M., Lowry, E., Penaranda, B., Frevert, C. W., Garofalo, R. P. & Rajarathnam, K., 2020, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

Respiratory syncytial virus infection induces chromatin remodeling to activate growth factor and extracellular matrix secretion pathways

Xu, X., Qiao, D., Mann, M., Garofalo, R. P. & Brasier, A. R., Aug 2020, In : Viruses. 12, 8, 804.

Research output: Contribution to journalArticle

Open Access
2019

Antiviral and immunomodulatory activity of silver nanoparticles in experimental rsv infection

Morris, D., Ansar, M., Speshock, J., Ivanciuc, T., Qu, Y., Casola, A. & Garofalo, R., Aug 2019, In : Viruses. 11, 8, 732.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
Open Access

Cystathionine γ-lyase deficiency enhances airway reactivity and viral-induced disease in mice exposed to side-stream tobacco smoke

Ivanciuc, T., Sbrana, E., Casola, A. & Garofalo, R. P., Jul 1 2019, In : Pediatric Research. 86, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

BRD4 couples NF-κB/RelA with airway inflammation and the IRF-RIG-I amplification loop in respiratory syncytial virus infection

Tian, B., Yang, J., Zhao, Y., Ivanciuc, T., Sun, H., Garofalo, R. P. & Brasier, A. R., 2017, In : Journal of virology. 91, 6, e00007-17.

Research output: Contribution to journalArticle

25 Scopus citations

Broad-Range Antiviral Activity of Hydrogen Sulfide Against Highly Pathogenic RNA Viruses

Bazhanov, N., Escaffre, O., Freiberg, A. N., Garofalo, R. P. & Casola, A., Jan 20 2017, In : Scientific reports. 7, 41029.

Research output: Contribution to journalArticle

14 Scopus citations
13 Scopus citations

Hydrogen sulfide: A novel player in airway development, pathophysiology of respiratory diseases, and antiviral defenses

Bazhanov, N., Ansar, M., Ivanciuc, T., Garofalo, R. P. & Casola, A., Oct 2017, In : American journal of respiratory cell and molecular biology. 57, 4, p. 403-410 8 p.

Research output: Contribution to journalReview article

26 Scopus citations
12 Scopus citations

Systematic analysis of cell-type differences in the epithelial secretome reveals insights into the pathogenesis of respiratory syncytial virus-induced lower respiratory tract infections

Zhao, Y., Jamaluddin, M., Zhang, Y., Sun, H., Ivanciuc, T., Garofalo, R. P. & Brasier, A. R., Apr 15 2017, In : Journal of Immunology. 198, 8, p. 3345-3364 20 p.

Research output: Contribution to journalArticle

24 Scopus citations

The interdependencies of viral load, the innate immune response, and clinical outcome in children presenting to the emergency department with respiratory syncytial virus-Associated bronchiolitis

Piedra, F. A., Mei, M., Avadhanula, V., Mehta, R., Aideyan, L., Garofalo, R. P. & Piedra, P. A., Mar 2017, In : PloS one. 12, 3, e0172953.

Research output: Contribution to journalArticle

19 Scopus citations
2016

Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions

Sawant, K. V., Poluri, K. M., Dutta, A. K., Sepuru, K. M., Troshkina, A., Garofalo, R. P. & Rajarathnam, K., Sep 14 2016, In : Scientific reports. 6, 33123.

Research output: Contribution to journalArticle

70 Scopus citations

Hydrogen sulfide is an antiviral and Antiinflammatory endogenous Gasotransmitter in the airways role in respiratory Syncytial virus infection

Ivanciuc, T., Sbrana, E., Ansar, M., Bazhanov, N., Szabo, C., Casola, A. & Garofalo, R. P., Nov 2016, In : American journal of respiratory cell and molecular biology. 55, 5, p. 684-696 13 p.

Research output: Contribution to journalArticle

24 Scopus citations
31 Scopus citations

Robust cytokine and chemokine response in nasopharyngeal secretions: Association with decreased severity in children with physician diagnosed bronchiolitis

Nicholson, E. G., Schlegel, C., Garofalo, R. P., Mehta, R., Scheffler, M., Mei, M. & Piedra, P. A., Aug 15 2016, In : Journal of Infectious Diseases. 214, 4, p. 649-655 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

The calcium-sensing receptor as a mediator of inflammation

Klein, G. L., Castro, S. M. & Garofalo, R. P., Jan 1 2016, In : Seminars in Cell and Developmental Biology. 49, p. 52-56 5 p.

Research output: Contribution to journalReview article

14 Scopus citations
2015

Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection

Fang, L., Choudhary, S., Tian, B., Boldogh, I., Yang, C., Ivanciuc, T., Ma, Y., Garofalo, R. P. & Brasier, A. R., Jan 1 2015, In : Journal of virology. 89, 5, p. 2628-2642 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Chemokine CXCL1-Mediated Neutrophil Trafficking in the Lung: Role of CXCR2 Activation

Sawant, K. V., Xu, R., Cox, R., Hawkins, H., Sbrana, E., Kolli, D., Garofalo, R. P. & Rajarathnam, K., Oct 16 2015, In : Journal of Innate Immunity. 7, 6, p. 647-658 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Mitochondrial antiviral-signalling protein plays an essential role in host immunity against human metapneumovirus

Deng, J., Chen, Y., Liu, G., Ren, J., Go, C., Ivanciuc, T., Deepthi, K., Casola, A., Garofalo, R. P. & Bao, X., Aug 1 2015, In : Journal of General Virology. 96, 8, p. 2104-2113 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2

Komaravelli, N., Tian, B., Ivanciuc, T., Mautemps, N., Brasier, A. R., Garofalo, R. P. & Casola, A., 2015, In : Free Radical Biology and Medicine. 88, Part B, p. 391-403 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Role of hydrogen sulfide in paramyxovirus infections

Li, H., Ma, Y., Escaffre, O., Ivanciuc, T., Komaravelli, N., Kelley, J. P., Coletta, C., Szabo, C., Rockx, B., Garofalo, R. P. & Casola, A., 2015, In : Journal of virology. 89, 10, p. 5557-5568 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
2014

Alveolar macrophages contribute to the pathogenesis of human metapneumovirus infection while protecting against respiratory syncytial virus infection

Kolli, D., Gupta, M. R., Sbrana, E., Velayutham, T. S., Chao, H., Casola, A. & Garofalo, R. P., Oct 1 2014, In : American journal of respiratory cell and molecular biology. 51, 4, p. 502-515 14 p.

Research output: Contribution to journalArticle

46 Scopus citations

Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity

Mehta, R., Scheffler, M., Tapia, L., Aideyan, L., Patel, K. D., Jewell, A. M., Avadhanula, V., Mei, M., Garofalo, R. P. & Piedra, P. A., Nov 1 2014, In : Influenza and other respiratory viruses. 8, 6, p. 617-625 9 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Paramyxovirus infection regulates T cell responses by BDCA-1+and BDCA-3+ myeloid dendritic cells

Gupta, M. R., Kolli, D., Molteni, C., Casola, A. & Garofalo, R. P., Jun 11 2014, In : PloS one. 9, 6, e99227.

Research output: Contribution to journalArticle

5 Scopus citations
2013

CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells

Tian, B., Zhao, Y., Kalita, M., Edeh, C. B., Paessler, S., Casola, A., Teng, M. N., Garofalo, R. P. & Brasier, A. R., Jun 2013, In : Journal of virology. 87, 12, p. 7075-7092 18 p.

Research output: Contribution to journalArticle

41 Scopus citations

Critical role of TLR4 in human metapneumovirus mediated innate immune responses and disease pathogenesis.

Velayutham, T. S., Kolli, D., Ivanciuc, T., Garofalo, R. P. & Casola, A., 2013, In : PloS one. 8, 10

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Differential response of BDCA-1+ and BDCA-3+ myeloid dendritic cells to respiratory syncytial virus infection

Gupta, M. R., Kolli, D. & Garofalo, R. P., Jul 5 2013, In : Respiratory Research. 14, 1, 71.

Research output: Contribution to journalArticle

15 Scopus citations

Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

Joseph, P. R. B., Sawant, K. V., Isley, A., Pedroza, M., Garofalo, R. P., Richardson, R. M. & Rajarathnam, K., Dec 1 2013, In : Biochemical Journal. 456, 2, p. 241-251 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Human Metapneumovirus Glycoprotein G Disrupts Mitochondrial Signaling in Airway Epithelial Cells

Bao, X., Kolli, D., Ren, J., Liu, T., Garofalo, R. P. & Casola, A., Apr 23 2013, In : PloS one. 8, 4, e62568.

Research output: Contribution to journalArticle

21 Scopus citations

Pancreatitis activates pancreatic apelin-APJ axis in mice

Han, S., Englander, E. W., Gomez, G. A., Aronson, J. F., Rastellini, C., Garofalo, R. P., Kolli, D., Quertermous, T., Kundu, R. & Greeley, G. H., Jul 15 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 2, p. G139-G150

Research output: Contribution to journalArticle

11 Scopus citations

Proline substitution of dimer interface β-strand residues as a strategy for the design of functional monomeric proteins

Joseph, P. R. B., Poluri, K. M., Gangavarapu, P., Rajagopalan, L., Raghuwanshi, S., Richardson, R. M., Garofalo, R. P. & Rajarathnam, K., Sep 17 2013, In : Biophysical journal. 105, 6, p. 1491-1501 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Respiratory syncytial virus infection: Mechanisms of redox control and novel therapeutic opportunities

Garofalo, R. P., Kolli, D. & Casola, A., Jan 10 2013, In : Antioxidants and Redox Signaling. 18, 2, p. 186-217 32 p.

Research output: Contribution to journalReview article

45 Scopus citations
2012
35 Scopus citations

The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

Gangavarapu, P., Rajagopalan, L., Kolli, D., Guerrero-Plata, A., Garofalo, R. P. & Rajarathnam, K., Feb 2012, In : Journal of Leukocyte Biology. 91, 2, p. 259-265 7 p.

Research output: Contribution to journalArticle

59 Scopus citations
2011
54 Scopus citations

Human metapneumovirus glycoprotein G inhibits TLR4-dependent signaling in monocyte-derived dendritic cells

Kolli, D., Bao, X., Liu, T., Hong, C., Wang, T., Garofalo, R. P. & Casola, A., Jul 1 2011, In : Journal of Immunology. 187, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Human metapneumovirus inhibits IFN-β signaling by downregulating Jak1 and Tyk2 cellular levels

Ren, J., Kolli, D., Liu, T., Xu, R., Garofalo, R. P., Casola, A. & Bao, X., Sep 19 2011, In : PloS one. 6, 9, e24496.

Research output: Contribution to journalArticle

34 Scopus citations

RelA Ser276 phosphorylation-coupled Lys310 acetylation controls transcriptional elongation of inflammatory cytokines in respiratory syncytial virus infection

Brasier, A. R., Tian, B., Jamaluddin, M., Kalita, M. K., Garofalo, R. P. & Lu, M., Nov 2011, In : Journal of virology. 85, 22, p. 11752-11769 18 p.

Research output: Contribution to journalArticle

63 Scopus citations

TAK1 regulates NF-ΚB and AP-1 activation in airway epithelial cells following RSV infection

Dey, N., Liu, T., Garofalo, R. P. & Casola, A., Sep 30 2011, In : Virology. 418, 2, p. 93-101 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
78 Scopus citations