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  • Kai-Lieh Huang
2020

Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination

Huang, K. L., Jee, D., Stein, C. B., Elrod, N. D., Henriques, T., Mascibroda, L. G., Baillat, D., Russell, W., Adelman, K. & Wagner, E. J., Oct 15 2020, In : Molecular cell. 80, 2, p. 345-358.e9

Research output: Contribution to journalArticle

Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation

Chen, C. Y. A., Strouz, K., Huang, K. L. & Shyu, A. B., Sep 2020, In : RNA. 26, 9, p. 1143-1159 17 p.

Research output: Contribution to journalArticle

2019

The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes

Elrod, N. D., Henriques, T., Huang, K. L., Tatomer, D. C., Wilusz, J. E., Wagner, E. J. & Adelman, K., Dec 5 2019, In : Molecular cell. 76, 5, p. 738-752.e7

Research output: Contribution to journalArticle

11 Scopus citations

The Integrator complex cleaves nascent mRNAs to attenuate transcription

Tatomer, D. C., Elrod, N. D., Liang, D., Xiao, M. S., Jiang, J. Z., Jonathan, M., Huang, K. L., Wagner, E. J., Cherry, S. & Wilusz, J. E., Nov 1 2019, In : Genes & development. 33, 21-22, p. 1525-1538 14 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations
2018

Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module

Albrecht, T. R., Shevtsov, S. P., Wu, Y., Mascibroda, L. G., Peart, N. J., Huang, K. L., Sawyer, I. A., Tong, L., Dundr, M. & Wagner, E. J., 2018, In : Nucleic acids research. 46, 8, p. 4241-4255 15 p.

Research output: Contribution to journalArticle

12 Scopus citations
2013

Phosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fate

Huang, K. L., Chadee, A. B., Chen, C. Y. A., Zhang, Y. & Shyu, A. B., Mar 2013, In : RNA. 19, 3, p. 295-305 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2012

Dual targeting of mTOR and Aurora-A kinase for the treatment of uterine leiomyosarcoma

Brewer Savannah, K. J., Demicco, E. G., Lusby, K., Ghadimi, M. P. H., Belousov, R., Young, E., Zhang, Y., Huang, K. L., Lazar, A. J., Hunt, K. K., Pollock, R. E., Creighton, C. J., Anderson, M. L. & Lev, D., Sep 1 2012, In : Clinical Cancer Research. 18, 17, p. 4633-4645 13 p.

Research output: Contribution to journalArticle

31 Scopus citations
2011

Expression of 'drugable' tyrosine kinase receptors in malignant peripheral nerve sheath tumour: Potential molecular therapeutic targets for a chemoresistant cancer

Torres, K. E., Liu, J., Young, E., Huang, K. L., Ghadimi, M., Lusby, K., Lazar, A. J. & Lev, D., Jul 2011, In : Histopathology. 59, 1, p. 156-159 4 p.

Research output: Contribution to journalLetter

7 Scopus citations

Vimentin is a novel AKT1 target mediating motility and invasion

Zhu, Q. S., Rosenblatt, K., Huang, K. L., Lahat, G., Brobey, R., Bolshakov, S., Nguyen, T., Ding, Z., Belousov, R., Bill, K., Luo, X., Lazar, A., Dicker, A., Mills, G. B., Hung, M. C. & Lev, D., Jan 27 2011, In : Oncogene. 30, 4, p. 457-470 14 p.

Research output: Contribution to journalArticle

116 Scopus citations