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• 2020

  Bisphenol A Activates an Innate Viral Immune Response Pathway

  Sowers, M. L., Tang, H., Tian, B., Goldblum, R., Midoro-Horiuti, T. & Zhang, K., Feb 7 2020, In: Journal of Proteome Research. 19, 2, p. 644-654 11 p.

  Research output: Contribution to journal › Article › peer-review

  • bisphenol A
  • Innate Immunity
  • Proteomics
  • Chemical activation
  • Epigenomics
• 2019

  Analysis of glucose-derived amino acids involved in one-carbon and cancer metabolism by stable-isotope tracing gas chromatography mass spectrometry

  Sowers, M. L., Herring, J., Zhang, W., Tang, H., Ou, Y., Gu, W. & Zhang, K., Feb 1 2019, In: Analytical Biochemistry. 566, p. 1-9 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Mass spectrometry
  • Metabolism
  • Gas chromatography
  • Gas Chromatography-Mass Spectrometry
  • Isotopes
  6 Scopus citations

• A unique role of carboxylesterase 3 (CES3) in b-adrenergic signaling–stimulated thermogenesis

  Yang, L., Li, X., Tang, H., Gao, Z., Zhang, K. & Sun, K., Jun 1 2019, In: Diabetes. 68, 6, p. 1178-1196 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Carboxylesterase
  • Thermogenesis
  • Adrenergic Agents
  • Adipose Tissue
  • Isoproterenol
  7 Scopus citations

• Sex-specific proteomic changes induced by genetic deletion of fibroblast growth factor 14 (FGF14), a regulator of neuronal ion channels

  Sowers, M. L., Di Re, J., Wadsworth, P. A., Shavkunov, A. S., Lichti, C., Zhang, K. & Laezza, F., Mar 1 2019, In: Proteomes. 7, 1, 5.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • fibroblast growth factor 14
  • Proteomics
  • Ion Channels
  • Schizophrenia
  • Proteome
  5 Scopus citations
• 2018

  Development of a stretch-induced neurotrauma model for medium-throughput screening in vitro: identification of rifampicin as a neuroprotectant

  López-García, I., Gerő, D., Szczesny, B., Szoleczky, P., Olah, G., Módis, K., Zhang, K., Gao, J., Wu, P., Sowers, L. C., DeWitt, D., Prough, D. S. & Szabo, C., 2018, In: British Journal of Pharmacology. 175, 2, p. 284-300 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Rifampin
  • Neuroprotective Agents
  • Wounds and Injuries
  • In Vitro Techniques
  • Neurons
  9 Scopus citations

• Proteomic changes in traumatic brain injury: Experimental approaches

  Sowers, J. L., Wu, P., Zhang, K., DeWitt, D. S. & Prough, D. S., 2018, In: Current opinion in neurology. 31, 6, p. 709-717 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Traumatic Brain Injury
  • Proteomics
  • Theoretical Models
  • Proteome
  • Mass Spectrometry
  4 Scopus citations

• Role of acetyltransferase PG1842 in gingipain biogenesis in Porphyromonas gingivalis

  Mishra, A., Roy, F., Dou, Y., Zhang, K., Tang, H. & Fletcher, H. M., Dec 1 2018, In: Journal of bacteriology. 200, 24, e00385.

  Research output: Contribution to journal › Article › peer-review

  • Porphyromonas gingivalis argingipain
  • Acetyltransferases
  • Porphyromonas gingivalis
  • Peptide Hydrolases
  • Chronic Periodontitis
  5 Scopus citations
• 2017

  Detection of nuclear protein profile changes by human metapneumovirus M2-2 protein using quantitative differential proteomics

  Ren, Y., Choi, E., Zhang, K., Chen, Y., Ye, S., Deng, X., Zhang, K. & Bao, X., Dec 2017, In: Vaccines. 5, 4, 45.

  Research output: Contribution to journal › Article › peer-review

  • Metapneumovirus
  • Nuclear Proteins
  • Proteomics
  • PDZ Domains
  • Proteome
  3 Scopus citations

• Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β

  Nicholas, D. A., Zhang, K., Hung, C., Glasgow, S., Aruni, A. W., Unternaehrer, J., Payne, K. J., Langridge, W. H. R. & De Leon, M., May 2017, In: PloS one. 12, 5, e0176793.

  Research output: Contribution to journal › Article › peer-review

  • Dendritic Cells
  • Toll-like receptor 4
  • dendritic cells
  • Palmitic Acid
  • interleukin-1
  31 Scopus citations

• Probes and targets of DNA methylation and demethylation in drug development

  Mirfattah, B., Herring, J., Tang, H. & Zhang, K., Jun 1 2017, In: Current Topics in Medicinal Chemistry. 17, 15, p. 1727-1740 14 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Demethylation
  • DNA Methylation
  • Drug Development
  • Mass Spectrometry
  • Epigenomics
  3 Scopus citations

• Proteome analysis of hypoxic glioblastoma cells reveals sequential metabolic adaptation of one-carbon metabolic pathways

  Zhang, K., Xu, P., Sowers, J. L., Machuca, D. F., Mirfattah, B., Herring, J., Tang, H., Chen, Y., Tian, B., Brasier, A. R. & Sowers, L. C., Nov 2017, In: Molecular and Cellular Proteomics. 16, 11, p. 1906-1921 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Metabolic Networks and Pathways
  • Stem cells
  • Proteome
  • Glioblastoma
  • Carbon
  7 Scopus citations

• Retinoic acid regulates immune responses by promoting IL-22 and modulating S100 proteins in viral hepatitis

  Jie, Z., Liang, Y., Yi, P., Tang, H., Soong, L., Cong, Y., Zhang, K. & Sun, J., May 1 2017, In: Journal of Immunology. 198, 9, p. 3448-3460 13 p.

  Research output: Contribution to journal › Article › peer-review

  • interleukin-22
  • S100 Proteins
  • Tretinoin
  • Hepatitis
  • T-Lymphocytes
  15 Scopus citations
• 2015

  Acetylome analysis identifies SIRT1 targets in mRNA-processing and chromatin-remodeling in mouse liver

  Kim, S. Y., Sim, C. K., Tang, H., Han, W., Zhang, K. & Xu, F., Oct 15 2015, In: PloS one. 10, 10, e0140619.

  Research output: Contribution to journal › Article › peer-review

  • Sirtuin 1
  • Liver
  • Chromatin Assembly and Disassembly
  • chromatin
  • Chromatin
  8 Scopus citations

• Induction of indoleamine 2, 3-dioxygenase in human dendritic cells by a cholera toxin B subunit- Proinsulin vaccine

  Mbongue, J. C., Nicholas, D. A., Zhang, K., Kim, N. S., Hamilton, B. N., Larios, M., Zhang, G., Umezawa, K., Firek, A. F. & Langridge, W. H. R., Feb 25 2015, In: PloS one. 10, 2, e0118562.

  Research output: Contribution to journal › Article › peer-review

  • indoleamine 2,3-dioxygenase
  • Dendritic Cells
  • proinsulin
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Proinsulin
  19 Scopus citations

• Measurement of Postreplicative DNA Metabolism and Damage in the Rodent Brain

  Patel, J. P., Sowers, M. L., Herring, J. L., Theruvathu, J. A., Emmett, M., Hawkins, B., Zhang, K., Dewitt, D., Prough, D. & Sowers, L., Dec 21 2015, In: Chemical Research in Toxicology. 28, 12, p. 2352-2363 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Metabolism
  • DNA Damage
  • Brain
  • Rodentia
  • DNA
  5 Scopus citations

• Quantification of Histone Modifications by Parallel-Reaction Monitoring: A Method Validation

  Sowers, J. L., Mirfattah, B., Xu, P., Tang, H., Park, I. Y., Walker, C., Wu, P., Laezza, F., Sowers, L. C. & Zhang, K., Oct 6 2015, In: Analytical Chemistry. 87, 19, p. 10006-10014 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Histones
  • Monitoring
  • Acetylation
  • Methylation
  • Ascorbic Acid
  18 Scopus citations

• Quantitative proteomics reveals a role for epigenetic reprogramming during human monocyte differentiation

  Nicholas, D., Tang, H., Zhang, Q., Rudra, J., Xu, F., Langridge, W. & Zhang, K., Jan 1 2015, In: Molecular and Cellular Proteomics. 14, 1, p. 15-29 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Proteomics
  • Macrophages
  • Dendritic Cells
  • Histones
  • Epigenomics
  19 Scopus citations
• 2014

  Cellular levels of oxidative stress affect the response of cervical cancer cells to chemotherapeutic agents

  Filippova, M., Filippov, V., Williams, V. M., Zhang, K., Kokoza, A., Bashkirova, S. & Duerksen-Hughes, P., 2014, In: BioMed Research International. 2014, 574659.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • Cells
  • Uterine Cervical Neoplasms
  • Oxidative Stress
  • Doxorubicin
  32 Scopus citations

• Down-regulation of LXR/RXR activation and negative acute phase response pathways in colon adenocarcinoma revealed by proteomics and bioinformatics analysis

  Tang, H., Mirshahidi, S., Senthil, M., Kazanjian, K., Chen, C. S. & Zhang, K., 2014, In: Cancer Biomarkers. 14, 5, p. 313-324 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute-Phase Reaction
  • Computational Biology
  • Proteomics
  • Colon
  • Adenocarcinoma
  13 Scopus citations

• Inhibition of DNA methylation reverses norepinephrine-induced cardiac hypertrophy in rats

  Xiao, D., Dasgupta, C., Chen, M., Zhang, K., Buchholz, J., Xu, Z. & Zhang, L., Mar 1 2014, In: Cardiovascular research. 101, 3, p. 373-382 10 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Methylation
  • Norepinephrine
  • Decitabine
  • Heart
  • Demethylation
  62 Scopus citations

• Multiplexed parallel reaction monitoring targeting histone modifications on the QExactive mass spectrometer

  Tang, H., Fang, H., Yin, E., Brasier, A. R., Sowers, L. C. & Zhang, K., Jun 3 2014, In: Analytical Chemistry. 86, 11, p. 5526-5534 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Mass spectrometers
  • Acetylation
  • Histones
  • Methylation
  • Monitoring
  44 Scopus citations

• Proteome analysis of coinfection of epithelial cells with Filifactor alocis and Porphyromonas gingivalis shows modulation of pathogen and host regulatory pathways

  Aruni, A. W., Zhang, K., Dou, Y. & Fletcher, H., 2014, In: Infection and immunity. 82, 8, p. 3261-3274 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Porphyromonas gingivalis
  • Proteome
  • Coinfection
  • Epithelial Cells
  • Proteins
  18 Scopus citations
• 2012

  A histone acetyltransferase regulates active DNA demethylation in Arabidopsis

  Qian, W., Miki, D., Zhang, H., Liu, Y., Zhang, X., Tang, K., Kan, Y., La, H., Li, X., Li, S., Zhu, X., Shi, X., Zhang, K., Pontes, O., Chen, X., Liu, R., Gong, Z. & Zhu, J. K., Jun 15 2012, In: Science. 336, 6087, p. 1445-1448 4 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Demethylation
  • Histone Acetyltransferases
  • Arabidopsis
  • 5-methylcytosine-DNA glycosylase
  • Epigenomics
  131 Scopus citations

• DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells

  Haynes, T. A. S., Filippov, V., Filippova, M., Yang, J., Zhang, K. & Duerksen-Hughes, P. J., Jul 2012, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1821, 7, p. 943-953 11 p.

  Research output: Contribution to journal › Article › peer-review

  • ceramide glucosyltransferase
  • Ceramides
  • DNA Damage
  • Down-Regulation
  • Apoptosis
  13 Scopus citations

• Increased ceramide in brains with alzheimer's and other neurodegenerative diseases

  Filippov, V., Song, M. A., Zhang, K., Vinters, H. V., Tung, S., Kirsch, W. M., Yang, J. & Duerksen-Hughes, P. J., 2012, In: Journal of Alzheimer's Disease. 29, 3, p. 537-547 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Ceramides
  • Neurodegenerative Diseases
  • Brain
  • Alzheimer Disease
  • Gene Expression
  102 Scopus citations

• Targeted proteomics for quantification of histone acetylation in Alzheimer's disease

  Zhang, K., Schrag, M., Crofton, A., Trivedi, R., Vinters, H. & Kirsch, W., Apr 2012, In: Proteomics. 12, 8, p. 1261-1268 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Acetylation
  • Proteomics
  • Histones
  • Alzheimer Disease
  • Biomarkers
  115 Scopus citations
• 2011

  Differential histone modification and protein expression associated with cell wall removal and regeneration in rice (Oryza sativa)

  Tan, F., Zhang, K., Mujahid, H., Verma, D. P. S. & Peng, Z., Feb 4 2011, In: Journal of Proteome Research. 10, 2, p. 551-563 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Oryza
  • Histone Code
  • Cell Wall
  • Cells
  • Histones
  20 Scopus citations

• Mass spectrometric studies on epigenetic interaction networks in cell differentiation

  Xiong, L., Darwanto, A., Sharma, S., Herring, J., Hu, S., Filippova, M., Filippov, V., Wang, Y., Chen, C. S., Duerksen-Hughes, P. J., Sowers, L. C. & Zhang, K., Apr 15 2011, In: Journal of Biological Chemistry. 286, 15, p. 13657-13668 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Histones
  • Epigenomics
  • Cell Differentiation
  • RNA Polymerase II
  • Ubiquitination
  21 Scopus citations

• Quantification of ceramide levels in mammalian cells by high performance liquid chromatography coupled to tandem mass spectrometry with multiple-reaction-monitoring mode (HPLC-MS/MS-MRM)

  Zhang, K., Haynes, T. A. S., Filippova, M., Filippov, V. & Duerksen-Hughes, P. J., May 1 2011, In: Analytical Methods. 3, 5, p. 1193-1197 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Ceramides
  • High performance liquid chromatography
  • Mass spectrometry
  • Cells
  • Monitoring
  10 Scopus citations

• Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

  He, Y. F., Li, B. Z., Li, Z., Liu, P., Wang, Y., Tang, Q., Ding, J., Jia, Y., Chen, Z., Li, N., Sun, Y., Li, X., Dai, Q., Song, C. X., Zhang, K., He, C. & Xu, G. L., Sep 2 2011, In: Science. 333, 6047, p. 1303-1307 5 p.

  Research output: Contribution to journal › Article › peer-review

  • 5-carboxylcytosine
  • Thymine DNA Glycosylase
  • 5-Methylcytosine
  • 5-hydroxymethylcytosine
  • Dioxygenases
  1661 Scopus citations