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• Article

  Dual targeting of mTOR and Aurora-A kinase for the treatment of uterine leiomyosarcoma

  Brewer Savannah, K. J., Demicco, E. G., Lusby, K., Ghadimi, M. P. H., Belousov, R., Young, E., Zhang, Y., Huang, K. L., Lazar, A. J., Hunt, K. K., Pollock, R. E., Creighton, C. J., Anderson, M. L. & Lev, D., Sep 1 2012, In: Clinical Cancer Research. 18, 17, p. 4633-4645 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Leiomyosarcoma
  • MLN 8237
  • Sirolimus
  • Growth
  • Cell Cycle
  31 Scopus citations

• Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination

  Huang, K. L., Jee, D., Stein, C. B., Elrod, N. D., Henriques, T., Mascibroda, L. G., Baillat, D., Russell, W. K., Adelman, K. & Wagner, E. J., Oct 15 2020, In: Molecular cell. 80, 2, p. 345-358.e9

  Research output: Contribution to journal › Article › peer-review

  • Protein Phosphatase 2
  • RNA Polymerase II
  • RNA Cleavage
  • Genes
  • Endonucleases
  2 Scopus citations

• Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module

  Albrecht, T. R., Shevtsov, S. P., Wu, Y., Mascibroda, L. G., Peart, N. J., Huang, K. L., Sawyer, I. A., Tong, L., Dundr, M. & Wagner, E. J., 2018, In: Nucleic acids research. 46, 8, p. 4241-4255 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Cleavage And Polyadenylation Specificity Factor
  • Terminal Repeat Sequences
  • RNA Polymerase II
  • Histones
  • Catalytic Domain
  16 Scopus citations

• Phosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fate

  Huang, K. L., Chadee, A. B., Chen, C. Y. A., Zhang, Y. & Shyu, A. B., Mar 2013, In: RNA. 19, 3, p. 295-305 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Amino Acid Motifs
  • Poly(A)-Binding Proteins
  • Phosphorylation
  • Messenger RNA
  • Threonine
  23 Scopus citations

• The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes

  Elrod, N. D., Henriques, T., Huang, K. L., Tatomer, D. C., Wilusz, J. E., Wagner, E. J. & Adelman, K., Dec 5 2019, In: Molecular cell. 76, 5, p. 738-752.e7

  Research output: Contribution to journal › Article › peer-review

  • RNA
  • RNA Polymerase II
  • Genes
  • Proteins
  • Peptide Elongation Factors
  20 Scopus citations

• The Integrator complex cleaves nascent mRNAs to attenuate transcription

  Tatomer, D. C., Elrod, N. D., Liang, D., Xiao, M. S., Jiang, J. Z., Jonathan, M., Huang, K. L., Wagner, E. J., Cherry, S. & Wilusz, J. E., Nov 1 2019, In: Genes & development. 33, 21-22, p. 1525-1538 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Metallothionein
  • Small Nuclear RNA
  • Messenger RNA
  • Exosome Multienzyme Ribonuclease Complex
  • Drosophila Proteins
  22 Scopus citations

• Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation

  Chen, C. Y. A., Strouz, K., Huang, K. L. & Shyu, A. B., Sep 2020, In: RNA. 26, 9, p. 1143-1159 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Poly(A)-Binding Proteins
  • Transcriptome
  • Phosphorylation
  • Cell Proliferation
  • Messenger RNA

• Vimentin is a novel AKT1 target mediating motility and invasion

  Zhu, Q. S., Rosenblatt, K., Huang, K. L., Lahat, G., Brobey, R., Bolshakov, S., Nguyen, T., Ding, Z., Belousov, R., Bill, K., Luo, X., Lazar, A., Dicker, A., Mills, G. B., Hung, M. C. & Lev, D., Jan 27 2011, In: Oncogene. 30, 4, p. 457-470 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Vimentin
  • Sarcoma
  • Neoplasms
  • Cell Movement
  • Phosphorylation
  119 Scopus citations
• Letter

  Expression of 'drugable' tyrosine kinase receptors in malignant peripheral nerve sheath tumour: Potential molecular therapeutic targets for a chemoresistant cancer

  Torres, K. E., Liu, J., Young, E., Huang, K. L., Ghadimi, M., Lusby, K., Lazar, A. J. & Lev, D., Jul 2011, In: Histopathology. 59, 1, p. 156-159 4 p.

  Research output: Contribution to journal › Letter › peer-review
  7 Scopus citations