Find Research Outputs

Search in all content

Filters for Publications

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2012
  • 2011

Author

  • Alexander Freiberg
2020

Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors

Plewe, M. B., Sokolova, N. V., Gantla, V. R., Brown, E. R., Naik, S., Fetsko, A., Lorimer, D. D., Lorimer, D. D., Dranow, D. M., Dranow, D. M., Smutney, H., Smutney, H., Bullen, J., Bullen, J., Sidhu, R., Sidhu, R., Master, A., Master, A., Wang, J., Wang, J. & 6 others, Kallel, E. A., Zhang, L., Kalveram, B., Freiberg, A. N., Henkel, G. & McCormack, K., Jun 11 2020, In : ACS Medicinal Chemistry Letters. 11, 6, p. 1160-1167 8 p.

Research output: Contribution to journalArticle

Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism

Takadate, Y., Kondoh, T., Igarashi, M., Maruyama, J., Manzoor, R., Ogawa, H., Kajihara, M., Furuyama, W., Sato, M., Miyamoto, H., Yoshida, R., Hill, T. E., Freiberg, A. N., Feldmann, H., Marzi, A. & Takada, A., Jan 14 2020, In : Cell Reports. 30, 2, p. 308-319.e5

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig

Lane, T. R., Massey, C., Comer, J. E., Freiberg, A. N., Zhou, H., Dyall, J., Holbrook, M. R., Anantpadma, M., Davey, R. A., Madrid, P. B. & Ekins, S., Sep 2020, In : Antiviral research. 181, 104863.

Research output: Contribution to journalArticle

1 Scopus citations

VAMP8 contributes to the TRIM6-mediated type I interferon antiviral response during West Nile virus infection

Van Tol, S., Atkins, C., Bharaj, P., Johnson, K. N., Hage, A., Freiberg, A. N. & Rajsbaum, R., Jan 1 2020, In : Journal of virology. 94, 2, e01454-19.

Research output: Contribution to journalArticle

4 Scopus citations
2019

Filovirus virulence in interferon α/β and γ double knockout mice, and treatment with favipiravir

Comer, J. E., Escaffre, O., Neef, N., Brasel, T., Juelich, T. L., Smith, J. K., Smith, J., Kalveram, B., Perez, D. D., Massey, S., Zhang, L. & Freiberg, A. N., Feb 2019, In : Viruses. 11, 2, 137.

Research output: Contribution to journalArticle

5 Scopus citations

Henipavirus infection of the central nervous system

Dawes, B. E. & Freiberg, A. N., Mar 1 2019, In : Pathogens and disease. 77, 2, ftz023.

Research output: Contribution to journalArticle

3 Scopus citations

Peptidoglycan-associated cyclic lipopeptide disrupts viral infectivity

Johnson, B. A., Hage, A., Kalveram, B., Mears, M., Plante, J. A., Rodriguez, S. E., Ding, Z., Luo, X., Bente, D., Bradrick, S. S., Freiberg, A. N., Popov, V., Rajsbaum, R., Rossi, S., Russell, W. K. & Menachery, V. D., Nov 1 2019, In : Journal of virology. 93, 22, e01282-19.

Research output: Contribution to journalArticle

3 Scopus citations
1 Scopus citations

Repurposing quinacrine against Ebola virus infection in vivo

Lane, T. R., Comer, J. E., Freiberg, A. N., Madrid, P. B. & Ekins, S., 2019, In : Antimicrobial agents and chemotherapy. 63, 9, e01142-19.

Research output: Contribution to journalArticle

8 Scopus citations

SAR studies of 4-acyl-1,6-dialkylpiperazin-2-one arenavirus cell entry inhibitors

Plewe, M. B., Whitby, L. R., Naik, S., Brown, E. R., Sokolova, N. V., Gantla, V. R., York, J., Nunberg, J. H., Zhang, L., Kalveram, B., Freiberg, A. N., Boger, D. L., Henkel, G. & McCormack, K., Jan 1 2019, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters. 126620.

Research output: Contribution to journalArticle

2018

A single-cycle replicable Rift Valley fever phlebovirus vaccine carrying a mutated NSs confers full protection from lethal challenge in mice

Terasaki, K., Juelich, T. L., Smith, J. K., Kalveram, B., Perez, D. D., Freiberg, A. N. & Makino, S., Dec 1 2018, In : Scientific reports. 8, 1, 17097.

Research output: Contribution to journalArticle

2 Scopus citations

Efficacy of tilorone dihydrochloride against ebola virus infection

Ekins, S., Lingerfelt, M. A., Comer, J. E., Freiberg, A. N., Mirsalis, J. C., O’Loughlin, K., Harutyunyan, A., McFarlane, C., Green, C. E. & Madrid, P. B., Feb 2018, In : Antimicrobial agents and chemotherapy. 62, 2, e01711-17.

Research output: Contribution to journalArticle

20 Scopus citations

Experimental Infection of Syrian Hamsters with Aerosolized Nipah Virus

Escaffre, O., Hill, T., Ikegami, T., Juelich, T. L., Smith, J. K., Zhang, L., Perez, D. E., Atkins, C., Park, A., Lawrence, W., Sivasubramani, S. K., Peel, J. E., Peterson, J., Lee, B. & Freiberg, A., Oct 5 2018, In : Journal of Infectious Diseases. 218, 10, p. 1602-1610 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Favipiravir (T-705) protects against Nipah virus infection in the hamster model /631/326/22/1295 /631/326/596/1296 /13/106 /14/35 /38/77 /82/51 /96/63 article

Dawes, B. E., Kalveram, B., Ikegami, T., Juelich, T., Smith, J. K., Zhang, L., Park, A., Lee, B., Komeno, T., Furuta, Y. & Freiberg, A. N., Dec 1 2018, In : Scientific reports. 8, 1, 7604.

Research output: Contribution to journalArticle

28 Scopus citations
5 Scopus citations

Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing

Ochoa, L. F., Kholodnykh, A., Villarreal, P., Tian, B., Pal, R., Freiberg, A. N., Brasier, A. R., Motamedi, M. & Vargas, G., Dec 1 2018, In : Scientific reports. 8, 1, 13348.

Research output: Contribution to journalArticle

10 Scopus citations

Natural History and Pathogenesis of Wild-Type Marburg Virus Infection in STAT2 Knockout Hamsters

Atkins, C., Miao, J., Kalveram, B., Juelich, T., Smith, J. K., Perez, D., Zhang, L., Westover, J. L. B., Van Wettere, A. J., Gowen, B. B., Wang, Z. & Freiberg, A. N., Nov 22 2018, In : Journal of Infectious Diseases. 218, p. S438-S447

Research output: Contribution to journalArticle

5 Scopus citations

Phosphorylated VP30 of marburg virus is a repressor of transcription

Tigabu, B., Ramanathan, P., Ivanov, A., Lin, X., Ilinykh, P. A., Parry, C. S., Freiberg, A. N., Nekhai, S. & Bukreyev, A., Nov 1 2018, In : Journal of virology. 92, 21, e00426.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Attenuation and protective efficacy of Rift Valley fever phlebovirus rMP12-GM50 strain

Ly, H. J., Nishiyama, S., Lokugamage, N., Smith, J. K., Zhang, L., Perez, D., Juelich, T. L., Freiberg, A. N. & Ikegami, T., Dec 4 2017, In : Vaccine. 35, 48, p. 6634-6642 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Broad-Range Antiviral Activity of Hydrogen Sulfide Against Highly Pathogenic RNA Viruses

Bazhanov, N., Escaffre, O., Freiberg, A. N., Garofalo, R. P. & Casola, A., Jan 20 2017, In : Scientific reports. 7, 41029.

Research output: Contribution to journalArticle

14 Scopus citations

Contribution of human lung parenchyma and leukocyte influx to oxidative stress and immune systemmediated pathology following Nipah virus infection

Escaffre, O., Saito, T. B., Juelich, T. L., Ikegami, T., Smith, J. K., Perez, D. D., Atkins, C., Levine, C. B., Huante, M. B., Nusbaum, R. J., Endsley, J. J., Freiberg, A. N. & Rockx, B., Aug 1 2017, In : Journal of virology. 91, 15, e00275-17.

Research output: Contribution to journalArticle

5 Scopus citations

Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection

McAuley, A. J., Sawatsky, B., Ksiazek, T., Torres, M., Korva, M., Lotrič-Furlan, S., Avšič-Županc, T., Von Messling, V., Holbrook, M. R., Freiberg, A., Beasley, D. & Bente, D., Dec 1 2017, In : npj Vaccines. 2, 1, 9.

Research output: Contribution to journalArticle

9 Scopus citations

Distinct virulence of Rift Valley fever phlebovirus strains from different genetic lineages in a mouse model

Ikegami, T., Balogh, A., Nishiyama, S., Lokugamage, N., Saito, T. B., Morrill, J. C., Shivanna, V., Indran, S. V., Zhang, L., Smith, J. K., Perez, D., Juelich, T. L., Morozov, I., Wilson, W. C., Freiberg, A. N. & Richt, J. A., Dec 2017, In : PloS one. 12, 12, e0189250.

Research output: Contribution to journalArticle

6 Scopus citations

Efficient and robust Paramyxoviridae reverse genetics systems

Beaty, S. M., Park, A., Won, S. T., Hong, P., Lyons, M., Vigant, F., Freiberg, A. N., ten Oever, B. R., Paul Duprex, W. & Lee, B., Mar 1 2017, In : mSphere. 2, 2, e00376-16.

Research output: Contribution to journalArticle

14 Scopus citations

Recent advances in the development of antiviral therapeutics for Rift Valley fever virus infection

Atkins, C. & Freiberg, A., Nov 1 2017, In : Future Virology. 12, 11, p. 651-665 15 p.

Research output: Contribution to journalReview article

11 Scopus citations

The host E3-ubiquitin ligase TRIM6 ubiquitinates the Ebola virus VP35 protein and promotes virus replication

Bharaj, P., Atkins, C., Luthra, P., Giraldo, M. I., Dawes, B. E., Miorin, L., Johnson, J. R., Krogan, N. J., Basler, C. F., Freiberg, A. N. & Rajsbaum, R., Sep 1 2017, In : Journal of virology. 91, 18, e00833-17.

Research output: Contribution to journalArticle

29 Scopus citations
2016

Antiviral effect of ranpirnase against Ebola virus

Hodge, T., Draper, K., Brasel, T., Freiberg, A., Squiquera, L., Sidransky, D., Sulley, J. & Taxman, D. J., Aug 1 2016, In : Antiviral Research. 132, p. 210-218 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Attenuation of pathogenic Rift Valley fever virus strain through the chimeric S-segment encoding sandfly fever phlebovirus NSs or a dominant-negative PKR

Nishiyama, S., Slack, O. A. L., Lokugamage, N., Hill, T. E., Juelich, T. L., Zhang, L., Smith, J. K., Perez, D., Gong, B., Freiberg, A. N. & Ikegami, T., Nov 16 2016, In : Virulence. 7, 8, p. 871-881 11 p.

Research output: Contribution to journalComment/debate

11 Scopus citations

ISG15 deficiency and increased viral resistance in humans but not mice

Speer, S. D., Li, Z., Buta, S., Payelle-Brogard, B., Qian, L., Vigant, F., Rubino, E., Gardner, T. J., Wedeking, T., Hermann, M., Duehr, J., Sanal, O., Tezcan, I., Mansouri, N., Tabarsi, P., Mansouri, D., Francois-Newton, V., Daussy, C. F., Rodriguez, M. R., Lenschow, D. J. & 7 others, Freiberg, A. N., Tortorella, D., Piehler, J., Lee, B., García-Sastre, A., Pellegrini, S. & Bogunovic, D., May 19 2016, In : Nature communications. 7, 11496.

Research output: Contribution to journalArticle

71 Scopus citations

N-glycans on the rift valley fever virus envelope glycoproteins Gn and Gc redundantly support viral infection via DC-SIGN

Phoenix, I., Nishiyama, S., Lokugamage, N., Hill, T. E., Huante, M. B., Slack, O. A. L., Carpio, V. H., Freiberg, A. N. & Ikegami, T., May 23 2016, In : Viruses. 8, 5

Research output: Contribution to journalArticle

9 Scopus citations

Nipah Virus C Protein Recruits Tsg101 to Promote the Efficient Release of Virus in an ESCRT-Dependent Pathway

Park, A., Yun, T., Vigant, F., Pernet, O., Won, S. T., Dawes, B. E., Bartkowski, W., Freiberg, A. N. & Lee, B., May 2016, In : PLoS pathogens. 12, 5, e1005659.

Research output: Contribution to journalArticle

16 Scopus citations

Optimized P2A for reporter gene insertion into nipah virus results in efficient ribosomal skipping and wild-type lethality

Park, A., Yun, T., Hill, T. E., Ikegami, T., Juelich, T. L., Smith, J. K., Zhang, L., Freiberg, A. & Lee, B., Apr 1 2016, In : Journal of General Virology. 97, 4, p. 839-843 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response

Bharaj, P., Wang, Y. E., Dawes, B. E., Yun, T. E., Park, A., Yen, B., Basler, C. F., Freiberg, A. N., Lee, B. & Rajsbaum, R., Sep 2016, In : PLoS pathogens. 12, 9, e1005880.

Research output: Contribution to journalArticle

29 Scopus citations
2015

Bolstering Components of the Immune Response Compromised by Prior Exposure to Adenovirus: Guided Formulation Development for a Nasal Ebola Vaccine

Choi, J. H., Schafer, S. C., Freiberg, A. & Croyle, M. A., Aug 3 2015, In : Molecular Pharmaceutics. 12, 8, p. 2697-2711 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cytokine response in mouse bone marrow derived macrophages after infection with pathogenic and non-pathogenic Rift Valley fever virus

Roberts, K. K., Hill, T. E., Davis, M. N., Holbrook, M. R. & Freiberg, A. N., Jul 1 2015, In : Journal of General Virology. 96, 7, p. 1651-1663 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Efficient reverse genetics reveals genetic determinants of budding and fusogenic differences between Nipah and Hendra viruses and enables real-time monitoring of viral spread in small animal models of henipavirus infection

Yun, T., Park, A., Hill, T. E., Pernet, O., Beaty, S. M., Juelich, T. L., Smith, J. K., Zhang, L., Wang, Y. E., Vigant, F., Gao, J., Wu, P., Lee, B. & Freiberg, A. N., 2015, In : Journal of virology. 89, 2, p. 1242-1253 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Evidence for Ubiquitin-Regulated Nuclear and Subnuclear Trafficking among Paramyxovirinae Matrix Proteins

Pentecost, M., Vashisht, A. A., Lester, T., Voros, T., Beaty, S. M., Park, A., Wang, Y. E., Yun, T. E., Freiberg, A. N., Wohlschlegel, J. A. & Lee, B., Mar 1 2015, In : PLoS pathogens. 11, 3, p. 1-33 33 p., e1004739.

Research output: Contribution to journalArticle

29 Scopus citations

Rift Valley fever virus MP-12 vaccine is fully attenuated by a combination of partial attenuations in the S, M, and L segments

Ikegami, T., Hill, T. E., Smith, J. K., Zhang, L., Juelich, T. L., Gong, B., Slack, O. A. L., Ly, H. J., Lokugamage, N. & Freiberg, A. N., 2015, In : Journal of virology. 89, 14, p. 7262-7276 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

Timing of galectin-1 exposure differentially modulates Nipah virus entry and syncytium formation in endothelial cells

Garner, O. B., Yun, T., Pernet, O., Aguilar, H. C., Park, A., Bowden, T. A., Freiberg, A. N., Lee, B. & Baum, L. G., 2015, In : Journal of virology. 89, 5, p. 2520-2529 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
2014

Bunyaviruses: Hantavirus and others

Freiberg, A., Bente, D. & LeDuc, J., Jun 1 2014, Viral Infections of Humans: Epidemiology and Control. Springer US, Vol. 9781489974488. p. 173-197 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Evidence for henipavirus spillover into human populations in Africa

Pernet, O., Schneider, B. S., Beaty, S. M., Lebreton, M., Yun, T. E., Park, A., Zachariah, T. T., Bowden, T. A., Hitchens, P., Ramirez, C. M., Daszak, P., Mazet, J., Freiberg, A. N., Wolfe, N. D. & Lee, B., 2014, In : Nature communications. 5, 5342.

Research output: Contribution to journalArticle

71 Scopus citations

Filovirus refseq entries: Evaluation and selection of filovirus type variants, Type sequences, And names

Kuhn, J. H., Andersen, K. G., Bào, Y., Bavari, S., Becker, S., Bennett, R. S., Bergman, N. H., Blinkova, O., Bradfute, S., Rodney Brister, J., Bukreyev, A., Chandran, K., Chepurnov, A. A., Davey, R. A., Dietzgen, R. G., Doggett, N. A., Dolnik, O., Dye, J. M., Enterlein, S., Fenimore, P. W. & 56 others, Formenty, P., Freiberg, A. N., Garry, R. F., Garza, N. L., Gire, S. K., Gonzalez, J. P., Griffiths, A., Happi, C. T., Hensley, L. E., Herbert, A. S., Hevey, M. C., Hoenen, T., Honko, A. N., Ignatyev, G. M., Jahrling, P. B., Johnson, J. C., Johnson, K. M., Kindrachuk, J., Klenk, H. D., Kobinger, G., Kochel, T. J., Lackemeyer, M. G., Lackner, D. F., Leroy, E. M., Lever, M. S., Mühlberger, E., Netesov, S. V., Olinger, G. G., Omilabu, S. A., Palacios, G., Panchal, R. G., Park, D. J., Patterson, J. L., Paweska, J. T., Peters, C. J., Pettitt, J., Pitt, L., Radoshitzky, S. R., Ryabchikova, E. I., Saphire, E. O., Sabeti, P. C., Sealfon, R., Shestopalov, A. M., Smither, S. J., Sullivan, N. J., Swanepoel, R., Takada, A., Towner, J. S., Van Der Groen, G., Volchkov, V. E., Volchkova, V. A., Wahl-Jensen, V., Warren, T. K., Warfield, K. L., Weidmann, M. & Nichol, S. T., 2014, In : Viruses. 6, 9, p. 3663-3682 20 p.

Research output: Contribution to journalLetter

40 Scopus citations

Multiplexed Digital mRNA Profiling of the Inflammatory Response in the West Nile Swiss Webster Mouse Model

Peña, J., Plante, J. A., Carillo, A. C., Roberts, K. K., Smith, J. K., Juelich, T. L., Beasley, D. W. C., Freiberg, A. N., Labute, M. X. & Naraghi-Arani, P., 2014, In : PLoS neglected tropical diseases. 8, 10

Research output: Contribution to journalArticle

8 Scopus citations

Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 protein and its targeting for the inhibition of viral transcription

Ilinykh, P. A., Tigabu, B., Ivanov, A., Ammosova, T., Obukhov, Y., Garron, T., Kumari, N., Kovalskyy, D., Platonov, M. O., Naumchik, V. S., Freiberg, A. N., Nekhai, S. & Bukreyev, A., Aug 15 2014, In : Journal of Biological Chemistry. 289, 33, p. 22723-22738 16 p.

Research output: Contribution to journalArticle

50 Scopus citations

Virus nomenclature below the species level: A standardized nomenclature for filovirus strains and variants rescued from cDNA

Kuhn, J. H., Bào, Y., Bavari, S., Becker, S., Bradfute, S., Brauburger, K., Rodney Brister, J., Bukreyev, A. A., Caì, Y., Chandran, K., Davey, R. A., Dolnik, O., Dye, J. M., Enterlein, S., Gonzalez, J. P., Formenty, P., Freiberg, A. N., Hensley, L. E., Hoenen, T., Honko, A. N. & 32 others, Ignatyev, G. M., Jahrling, P. B., Johnson, K. M., Klenk, H. D., Kobinger, G., Lackemeyer, M. G., Leroy, E. M., Lever, M. S., Mühlberger, E., Netesov, S. V., Olinger, G. G., Palacios, G., Patterson, J. L., Paweska, J. T., Pitt, L., Radoshitzky, S. R., Ryabchikova, E. I., Saphire, E. O., Shestopalov, A. M., Smither, S. J., Sullivan, N. J., Swanepoel, R., Takada, A., Towner, J. S., van der Groen, G., Volchkov, V. E., Volchkova, V. A., Wahl-Jensen, V., Warren, T. K., Warfield, K. L., Weidmann, M. & Nichol, S. T., May 2014, In : Archives of virology. 159, 5, p. 1229-1237 9 p.

Research output: Contribution to journalArticle

52 Scopus citations
2012

An assembly model of Rift Valley fever virus

Rusu, M., Bonneau, R., Holbrook, M. R., Watowich, S. J., Birmanns, S., Wriggers, W. & Freiberg, A. N., 2012, In : Frontiers in Microbiology. 3, JUL

Research output: Contribution to journalArticle

25 Scopus citations

A single sublingual dose of an adenovirus-based vaccine protects against lethal ebola challenge in mice and guinea pigs

Choi, J. H., Schafer, S. C., Zhang, L., Kobinger, G. P., Juelich, T., Freiberg, A. N. & Croyle, M. A., Jan 1 2012, In : Molecular Pharmaceutics. 9, 1, p. 156-167 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Chemotactic and inflammatory responses in the liver and brain are associated with pathogenesis of rift valley fever virus infection in the mouse

Gray, K. K., Worthy, M. N., Juelich, T. L., Agar, S. L., Poussard, A., Ragland, D., Freiberg, A. N. & Holbrook, M. R., Feb 2012, In : PLoS neglected tropical diseases. 6, 2, e1529.

Research output: Contribution to journalArticle

30 Scopus citations

Detection of severe fever with thrombocytopenia syndrome virus by reverse transcription-cross-priming amplification coupled with vertical flow visualization

Cui, L., Ge, Y., Qi, X., Xu, G., Li, H., Zhao, K., Wu, B., Shi, Z., Guo, X., Hu, L., You, Q., Zhang, L. H., Freiberg, A. N., Yu, X., Wang, H., Zhou, M. & Tang, Y. W., Dec 2012, In : Journal of Clinical Microbiology. 50, 12, p. 3881-3885 5 p.

Research output: Contribution to journalArticle

54 Scopus citations

Genetic subpopulations of rift valley fever virus strains ZH548 and MP-12 and recombinant MP-12 strains

Lokugamage, N., Freiberg, A. N., Morrill, J. C. & Ikegami, T., Dec 2012, In : Journal of virology. 86, 24, p. 13566-13575 10 p.

Research output: Contribution to journalArticle

17 Scopus citations