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  • Cheng Huang
2020

Animal models of lassa fever

Sattler, R. A., Paessler, S., Ly, H. & Huang, C., Mar 2020, In : Pathogens. 9, 3, 197.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

Antiviral activities of type I interferons to SARS-CoV-2 infection

Mantlo, E., Bukreyeva, N., Maruyama, J., Paessler, S. & Huang, C., Jul 2020, In : Antiviral research. 179, 104811.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection

Ho, J. S. Y., Angel, M., Ma, Y., Sloan, E., Wang, G., Martinez-Romero, C., Alenquer, M., Roudko, V., Chung, L., Zheng, S., Chang, M., Fstkchyan, Y., Clohisey, S., Dinan, A. M., Gibbs, J., Gifford, R., Shen, R., Gu, Q., Irigoyen, N., Campisi, L. & 34 others, Huang, C., Zhao, N., Jones, J. D., van Knippenberg, I., Zhu, Z., Moshkina, N., Meyer, L., Noel, J., Peralta, Z., Rezelj, V., Kaake, R., Rosenberg, B., Wang, B., Wei, J., Paessler, S., Wise, H. M., Johnson, J., Vannini, A., Amorim, M. J., Baillie, J. K., Miraldi, E. R., Benner, C., Brierley, I., Digard, P., Łuksza, M., Firth, A. E., Krogan, N., Greenbaum, B. D., MacLeod, M. K., van Bakel, H., Garcìa-Sastre, A., Yewdell, J. W., Hutchinson, E. & Marazzi, I., Jun 25 2020, In : Cell. 181, 7, p. 1502-1517.e23

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2 Scopus citations

Monoclonal antibodies with neutralizing activity and Fc-effector functions against the Machupo virus glycoprotein

Amanat, F., Duehr, J., Huang, C., Paessler, S., Tan, G. S. & Krammer, F., Mar 1 2020, In : Journal of virology. 94, 5, e01741-19.

Research output: Contribution to journalArticle

1 Scopus citations

The Glycoprotein of the Live-Attenuated Junin Virus Vaccine Strain Induces Endoplasmic Reticulum Stress and Forms Aggregates prior to Degradation in the Lysosome

Manning, J. T., Yun, N. E., Seregin, A. V., Koma, T., Sattler, R. A., Ezeomah, C., Huang, C., de la Torre, J. C. & Paessler, S., Mar 31 2020, In : Journal of virology. 94, 8

Research output: Contribution to journalArticle

2019

Adenoviral vector-based vaccine is fully protective against lethal Lassa fever challenge in Hartley guinea pigs

Maruyama, J., Mateer, E. J., Manning, J. T., Sattler, R., Seregin, A. V., Bukreyeva, N., Jones, F. R., Balint, J. P., Gabitzsch, E. S., Huang, C. & Paessler, S., Oct 23 2019, In : Vaccine. 37, 45, p. 6824-6831 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
4 Scopus citations

Differential immune responses to hemorrhagic Fever-Causing arenaviruses

Mantlo, E., Paessler, S. & Huang, C., Dec 2019, In : Vaccines. 7, 4, 138.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

Lethal infection of Lassa virus isolated from a human clinical sample in outbred guinea pigs without adaptation

Maruyama, J., Manning, J. T., Mateer, E. J., Sattler, R., Bukreyeva, N., Huang, C. & Paessler, S., 2019, In : mSphere. 4, 5, e00428-19.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

Ibuprofen as a template molecule for drug design against Ebola virus

Paessler, S., Huang, C., Sencanski, M., Veljkovic, N., Perovic, V., Glisic, S. & Veljkovic, V., Jan 1 2018, In : Frontiers in Bioscience - Landmark. 23, 5, p. 947-953 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Impact of primer dimers and self-amplifying hairpins on reverse transcription loop-mediated isothermal amplification detection of viral RNA

Meagher, R. J., Priye, A., Light, Y. K., Huang, C. & Wang, E., Apr 21 2018, In : Analyst. 143, 8, p. 1924-1933 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Lassa fever–induced sensorineural hearing loss: A neglected public health and social burden

Mateer, E. J., Huang, C., Shehu, N. Y. & Paessler, S., Feb 22 2018, In : PLoS neglected tropical diseases. 12, 2, e0006187.

Research output: Contribution to journalReview article

31 Scopus citations
6 Scopus citations

Zika virus infection elicits auto-antibodies to C1q

Koma, T., Veljkovic, V., Anderson, D. E., Wang, L. F., Rossi, S. L., Shan, C., Shi, P. Y., Beasley, D. W., Bukreyeva, N., Smith, J. N., Hallam, S., Huang, C., Von Messling, V. & Paessler, S., Dec 1 2018, In : Scientific reports. 8, 1, 1882.

Research output: Contribution to journalArticle

9 Scopus citations
2017
10 Scopus citations

Highly pathogenic New World arenavirus infection activates the pattern recognition receptor protein kinase R without attenuating virus replication in human cells

Huang, C., Kolokoltsova, O. A., Mateer, E. J., Koma, T. & Paessler, S., Oct 1 2017, In : Journal of virology. 91, 20, e01090-17.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Machupo virus expressing GPC of the Candid#1 vaccine strain of Junin virus is highly attenuated and immunogenic

Koma, T., Patterson, M., Huang, C., Seregin, A. V., Maharaj, P. D., Miller, M., Smith, J. N., Walker, A. G., Hallam, S. & Paessler, S., 2016, In : Journal of virology. 90, 3, p. 1290-1297 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
9 Scopus citations

The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor

Koma, T., Huang, C., Aronson, J. F., Walker, A. G., Miller, M., Smith, J. N., Patterson, M. & Paessler, S., Aug 30 2016, In : PLoS neglected tropical diseases. 10, 8, e0004969.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Highly pathogenic New World and Old World human arenaviruses induce distinct interferon responses in human cells

Huang, C., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V., Ronca, S., Koma, T. & Paessler, S., 2015, In : Journal of virology. 89, 14, p. 7079-7088 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

The glycoprotein precursor gene of Junin virus determines the virulence of the romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever

Seregin, A. V., Yun, N. E., Miller, M., Aronson, J., Smith, J. K., Walker, A. G., Smith, J. N., Huang, C., Manning, J., de la Torre, J. C. & Paessler, S., 2015, In : Journal of Virology. 89, 11, p. 5949-5956 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
2014

A substitution in the transmembrane region of the glycoprotein leads to an unstable attenuation of machupo virus

Patterson, M., Koma, T., Seregin, A., Huang, C., Miller, M., Smith, J., Yun, N., Smith, J. & Paessler, S., 2014, In : Journal of virology. 88, 18, p. 10995-10999 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

A viral RNA structural element alters host recognition of nonself RNA

Hyde, J. L., Gardner, C. L., Kimura, T., White, J. P., Liu, G., Trobaugh, D. W., Huang, C., Tonelli, M., Paessler, S., Takeda, K., Klimstra, W. B., Amarasinghe, G. K. & Diamond, M. S., 2014, In : Science. 343, 6172, p. 783-787 5 p.

Research output: Contribution to journalArticle

84 Scopus citations

Potent Inhibition of Junín Virus Infection by Interferon in Murine Cells

Huang, C., Walker, A. G., Grant, A. M., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V. & Paessler, S., Jun 2014, In : PLoS neglected tropical diseases. 8, 6, e2933.

Research output: Contribution to journalArticle

11 Scopus citations

Rescue of a recombinant Machupo virus from cloned cDNAs and in vivo characterization in interferon (αβ/γ) receptor double knockout mice

Patterson, M., Seregin, A., Huang, C., Kolokoltsova, O., Smith, J., Miller, M., Smith, J., Yun, N. E., Poussard, A., Grant, A., Tigabu, B., Walker, A. & Paessler, S., Feb 2014, In : Journal of virology. 88, 4, p. 1914-1923 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

RIG-I enhanced interferon independent apoptosis upon Junin virus infection

Kolokoltsova, O. A., Grant, A. M., Huang, C., Smith, J. K., Poussard, A. L., Tian, B., Brasier, A. R., Peters, C. J., Tseng, C. T. K., De La Torre, J. C. & Paessler, S., Jun 11 2014, In : PloS one. 9, 6, e99610.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Innate immune response to arenaviral infection: A focus on the highly pathogenic new world hemorrhagic arenaviruses

Koma, T., Huang, C., Kolokoltsova, O. A., Brasier, A. R. & Paessler, S., Dec 13 2013, In : Journal of Molecular Biology. 425, 24, p. 4893-4903 11 p.

Research output: Contribution to journalReview article

19 Scopus citations
2011

Alphacoronavirus transmissible gastroenteritis virus nsp1 protein suppresses protein translation in mammalian cells and in cell-free HeLa cell extracts but not in rabbit reticulocyte lysate

Huang, C., Lokugamage, K. G., Rozovics, J. M., Narayanan, K., Semler, B. L. & Makino, S., Jan 2011, In : Journal of virology. 85, 1, p. 638-643 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: Viral mRNAs are resistant to nsp1-induced RNA cleavage

Huang, C., Lokugamage, K. G., Rozovics, J. M., Narayanan, K., Semler, B. L. & Makino, S., Dec 2011, In : PLoS pathogens. 7, 12, e1002433.

Research output: Contribution to journalArticle

91 Scopus citations