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• 2020

  Acupuncture Reduces Hypertrophy and Cardiac Fibrosis, and Improves Heart Function in Mice with Diabetic Cardiomyopathy

  Ye, Y., Birnbaum, Y., Widen, S. G., Zhang, Z., Zhu, S., Bajaj, M. & Chen, H., Dec 2020, In: Cardiovascular Drugs and Therapy. 34, 6, p. 835-848 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Diabetic Cardiomyopathies
  • Acupuncture
  • Interleukin-1
  • Fibrosis
  • Somatomedin Receptors

• Dapagliflozin and Ticagrelor Have Additive Effects on the Attenuation of the Activation of the NLRP3 Inflammasome and the Progression of Diabetic Cardiomyopathy: an AMPK–mTOR Interplay

  Chen, H., Tran, D., Yang, H. C., Nylander, S., Birnbaum, Y. & Ye, Y., Aug 1 2020, In: Cardiovascular Drugs and Therapy. 34, 4, p. 443-461 19 p.

  Research output: Contribution to journal › Article › peer-review

  • 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol
  • NLR Proteins
  • Ticagrelor
  • Diabetic Cardiomyopathies
  • Inflammasomes
  4 Scopus citations

• Does Inhibition of Nuclear Factor Kappa B Explain the Protective Effect of Ticagrelor on Myocardial Ischemia-Reperfusion Injury?

  Birnbaum, Y., Ye, Y. & Perez-Polo, J. R., Feb 1 2020, In: Journal of cardiovascular pharmacology. 75, 2, p. 108-111 4 p.

  Research output: Contribution to journal › Article › peer-review
• 2017

  Aleglitazar, a dual peroxisome proliferator-activated receptor-α and -γ Agonist, protects cardiomyocytes against the adverse effects of hyperglycaemia

  Chen, Y., Chen, H., Birnbaum, Y., Nanhwan, M. K., Bajaj, M., Ye, Y. & Qian, J., Mar 1 2017, In: Diabetes and Vascular Disease Research. 14, 2, p. 152-162 11 p.

  Research output: Contribution to journal › Article › peer-review

  • aleglitazar
  • Peroxisome Proliferator-Activated Receptors
  • Cardiac Myocytes
  • Hyperglycemia
  • Small Interfering RNA
  4 Scopus citations

• SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor

  Ye, Y., Bajaj, M., Yang, H. C., Perez-Polo, J. R. & Birnbaum, Y., Apr 1 2017, In: Cardiovascular Drugs and Therapy. 31, 2, p. 119-132 14 p.

  Research output: Contribution to journal › Article › peer-review

  • saxagliptin
  • 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol
  • Diabetic Cardiomyopathies
  • Inflammasomes
  • Type 2 Diabetes Mellitus
  85 Scopus citations

• Unraveling the Interaction of Aspirin, Ticagrelor, and Rosuvastatin on the Progression of Atherosclerosis and Inflammation in Diabetic Mice

  Ye, Y., Nylander, S. & Birnbaum, Y., Dec 1 2017, In: Cardiovascular Drugs and Therapy. 31, 5-6, p. 489-500 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Ticagrelor
  • Rosuvastatin Calcium
  • Aspirin
  • Atherosclerosis
  • Inflammation
  7 Scopus citations
• 2016

  Aleglitazar, a Balanced Dual PPARα and -γ Agonist, Protects the Heart Against Ischemia-Reperfusion Injury

  Qian, J., Chen, H., Birnbaum, Y., Nanhwan, M. K., Bajaj, M. & Ye, Y., Apr 1 2016, In: Cardiovascular Drugs and Therapy. 30, 2, p. 129-141 13 p.

  Research output: Contribution to journal › Article › peer-review

  • aleglitazar
  • Peroxisome Proliferator-Activated Receptors
  • Heart
  • Cardiac Myocytes
  • Small Interfering RNA
  7 Scopus citations

• Dipeptidyl peptidase-4 inhibition by Saxagliptin prevents inflammation and renal injury by targeting the Nlrp3/ASC inflammasome

  Birnbaum, Y., Bajaj, M., Qian, J. & Ye, Y., Aug 1 2016, In: BMJ Open Diabetes Research and Care. 4, 1, e000227.

  Research output: Contribution to journal › Article › peer-review

  • saxagliptin
  • NLR Proteins
  • Dipeptidyl Peptidase 4
  • Inflammasomes
  • Inflammation
  42 Scopus citations

• Ticagrelor and Rosuvastatin Have Additive Cardioprotective Effects via Adenosine

  Birnbaum, Y., Birnbaum, G. D., Birnbaum, I., Nylander, S. & Ye, Y., Dec 1 2016, In: Cardiovascular Drugs and Therapy. 30, 6, p. 539-550 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Ticagrelor
  • Rosuvastatin Calcium
  • Adenosine
  • Prasugrel Hydrochloride
  • Reperfusion
  21 Scopus citations

• Type 2 diabetes and cardiovascular disease: A metabolic overview of recent clinical trials

  Birnbaum, Y., Ye, Y. & Bajaj, M., 2016, (Accepted/In press) In: Journal of Diabetes and its Complications.

  Research output: Contribution to journal › Article › peer-review
  1 Scopus citations
• 2015

  Statin-Induced Cardioprotection Against Ischemia-Reperfusion Injury: Potential Drug-Drug Interactions. Lesson to be Learnt by Translating Results from Animal Models to the Clinical Settings

  Birnbaum, G. D., Birnbaum, I., Ye, Y. & Birnbaum, Y., Aug 25 2015, In: Cardiovascular Drugs and Therapy. 29, 5, p. 461-467 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Drug Interactions
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Animal Models
  • Masks
  • Clinical Trials
  16 Scopus citations

• Ticagrelor protects the heart against reperfusion injury and improves remodeling after myocardial infarction

  Ye, Y., Birnbaum, G. D., Perez-Polo, J. R., Nanhwan, M. K., Nylander, S. & Birnbaum, Y., Aug 25 2015, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 8, p. 1805-1814 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ticagrelor
  • Clopidogrel
  • Myocardial Infarction
  • Heart
  • Reperfusion
  69 Scopus citations
• 2011

  Aliskiren and Valsartan reduce myocardial AT1 receptor expression and limit myocardial infarct size in diabetic mice

  Ye, Y., Qian, J., Castillo, A. C., Perez-Polo, J. R. & Birnbaum, Y., Dec 2011, In: Cardiovascular Drugs and Therapy. 25, 6, p. 505-515 11 p.

  Research output: Contribution to journal › Article › peer-review

  • aliskiren
  • Valsartan
  • Myocardial Infarction
  • Sirtuin 1
  • Type 2 Diabetes Mellitus
  23 Scopus citations

• Effect of miR-23 on Oxidant-induced injury in human retinal pigment epithelial cells

  Lin, H., Qian, J., Castillo, A. C., Long, B., Keyes, K. T., Chen, G. & Ye, Y., Aug 2011, In: Investigative Ophthalmology and Visual Science. 52, 9, p. 6308-6314 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Pigments
  • Oxidants
  • Macular Pigment
  • Epithelial Cells
  • tert-Butylhydroperoxide
  74 Scopus citations

• Impact of HMG-CoA reductase inhibition on oxidant-induced injury in human retinal pigment epithelium cells

  Qian, J., Keyes, K. T., Long, B., Chen, G. & Ye, Y., Sep 2011, In: Journal of Cellular Biochemistry. 112, 9, p. 2480-2489 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Hydroxymethylglutaryl CoA Reductases
  • Retinal Pigments
  • Retinal Pigment Epithelium
  • Oxidants
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  19 Scopus citations

• Pioglitazone limits myocardial infarct size, activates Akt, and upregulates cPLA2 and COX-2 in a PPAR-γ-independent manner

  Birnbaum, Y., Long, B., Qian, J., Perez-Polo, J. R. & Ye, Y., May 2011, In: Basic Research in Cardiology. 106, 3, p. 431-446 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Pioglitazone
  • Peroxisome Proliferator-Activated Receptors
  • Cyclooxygenase 2
  • Up-Regulation
  • Myocardial Infarction
  37 Scopus citations

• The potential effects of anti-diabetic medications on myocardial ischemia-reperfusion injury

  Ye, Y., Perez-Polo, J. R., Aguilar, D. & Birnbaum, Y., Nov 1 2011, In: Basic Research in Cardiology. 106, 6, p. 925-952 28 p.

  Research output: Contribution to journal › Review article › peer-review

  • Myocardial Reperfusion Injury
  • Myocardial Ischemia
  • Diabetes Mellitus
  • Pioglitazone
  • Lipoxins
  82 Scopus citations

• The role of microRNA in modulating myocardial ischemia-reperfusion injury

  Ye, Y., Perez-Polo, J. R., Qian, J. & Birnbaum, Y., May 2011, In: Physiological Genomics. 43, 10, p. 534-542 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Myocardial Reperfusion Injury
  • Myocardial Ischemia
  • MicroRNAs
  • Heart Diseases
  • HSP72 Heat-Shock Proteins
  169 Scopus citations