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• 2019

  DPP-4 inhibition by linagliptin prevents cardiac dysfunction and inflammation by targeting the Nlrp3/ASC inflammasome

  Birnbaum, Y., Tran, D., Bajaj, M. & Ye, Y., Sep 1 2019, In: Basic Research in Cardiology. 114, 5, 35.

  Research output: Contribution to journal › Article › peer-review

  • Linagliptin
  • Inflammasomes
  • Flax
  • Inflammation
  • Infarction
  11 Scopus citations

• The Role of Non-coding RNAs in Ischemic Myocardial Reperfusion Injury

  Siebert, V., Allencherril, J., Ye, Y., Wehrens, X. H. T. & Birnbaum, Y., Aug 15 2019, In: Cardiovascular Drugs and Therapy. 33, 4, p. 489-498 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Myocardial Reperfusion Injury
  • Untranslated RNA
  • MicroRNAs
  • Ischemia
  • Reperfusion
  7 Scopus citations

• Ticagrelor Improves Remodeling, Reduces Apoptosis, Inflammation and Fibrosis and Increases the Number of Progenitor Stem Cells After Myocardial Infarction in a Rat Model of Ischemia Reperfusion

  Birnbaum, Y., Tran, D., Chen, H., Nylander, S., Sampaio, L. C. & Ye, Y., Jan 1 2019, In: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 53, 6, p. 961-981 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ticagrelor
  • Reperfusion
  • Ischemia
  • Fibrosis
  • Stem Cells
  6 Scopus citations
• 2017

  Aleglitazar, a dual peroxisome proliferator-activated receptor-α and -γ Agonist, protects cardiomyocytes against the adverse effects of hyperglycaemia

  Chen, Y., Chen, H., Birnbaum, Y., Nanhwan, M. K., Bajaj, M., Ye, Y. & Qian, J., Mar 1 2017, In: Diabetes and Vascular Disease Research. 14, 2, p. 152-162 11 p.

  Research output: Contribution to journal › Article › peer-review

  • aleglitazar
  • Peroxisome Proliferator-Activated Receptors
  • Cardiac Myocytes
  • Hyperglycemia
  • Small Interfering RNA
  4 Scopus citations

• SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor

  Ye, Y., Bajaj, M., Yang, H. C., Perez-Polo, J. R. & Birnbaum, Y., Apr 1 2017, In: Cardiovascular Drugs and Therapy. 31, 2, p. 119-132 14 p.

  Research output: Contribution to journal › Article › peer-review

  • saxagliptin
  • 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol
  • Diabetic Cardiomyopathies
  • Inflammasomes
  • Type 2 Diabetes Mellitus
  82 Scopus citations

• Unraveling the Interaction of Aspirin, Ticagrelor, and Rosuvastatin on the Progression of Atherosclerosis and Inflammation in Diabetic Mice

  Ye, Y., Nylander, S. & Birnbaum, Y., Nov 28 2017, (Accepted/In press) In: Cardiovascular Drugs and Therapy. p. 1-12 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Ticagrelor
  • Rosuvastatin Calcium
  • Aspirin
  • Atherosclerosis
  • Inflammation
  7 Scopus citations
• 2016

  Aleglitazar, a Balanced Dual PPARα and -γ Agonist, Protects the Heart Against Ischemia-Reperfusion Injury

  Qian, J., Chen, H., Birnbaum, Y., Nanhwan, M. K., Bajaj, M. & Ye, Y., Feb 10 2016, (Accepted/In press) In: Cardiovascular Drugs and Therapy. p. 1-13 13 p.

  Research output: Contribution to journal › Article › peer-review

  • aleglitazar
  • Peroxisome Proliferator-Activated Receptors
  • Heart
  • Cardiac Myocytes
  • Small Interfering RNA
  7 Scopus citations

• Dipeptidyl peptidase-4 inhibition by Saxagliptin prevents inflammation and renal injury by targeting the Nlrp3/ASC inflammasome

  Birnbaum, Y., Bajaj, M., Qian, J. & Ye, Y., Aug 1 2016, In: BMJ Open Diabetes Research and Care. 4, 1, e000227.

  Research output: Contribution to journal › Article › peer-review

  • saxagliptin
  • NLR Proteins
  • Dipeptidyl Peptidase 4
  • Inflammasomes
  • Inflammation
  41 Scopus citations

• Ticagrelor and Rosuvastatin Have Additive Cardioprotective Effects via Adenosine

  Birnbaum, Y., Birnbaum, G. D., Birnbaum, I., Nylander, S. & Ye, Y., Dec 1 2016, In: Cardiovascular Drugs and Therapy. 30, 6, p. 539-550 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Ticagrelor
  • Rosuvastatin Calcium
  • Adenosine
  • Prasugrel Hydrochloride
  • Reperfusion
  21 Scopus citations

• Type 2 diabetes and cardiovascular disease: A metabolic overview of recent clinical trials

  Birnbaum, Y., Ye, Y. & Bajaj, M., 2016, (Accepted/In press) In: Journal of Diabetes and its Complications.

  Research output: Contribution to journal › Article › peer-review
  1 Scopus citations
• 2015

  Statin-Induced Cardioprotection Against Ischemia-Reperfusion Injury: Potential Drug-Drug Interactions. Lesson to be Learnt by Translating Results from Animal Models to the Clinical Settings

  Birnbaum, G. D., Birnbaum, I., Ye, Y. & Birnbaum, Y., Aug 25 2015, In: Cardiovascular Drugs and Therapy. 29, 5, p. 461-467 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Drug Interactions
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Animal Models
  • Masks
  • Clinical Trials
  16 Scopus citations

• Ticagrelor protects the heart against reperfusion injury and improves remodeling after myocardial infarction

  Ye, Y., Birnbaum, G. D., Perez-Polo, J. R., Nanhwan, M. K., Nylander, S. & Birnbaum, Y., Aug 25 2015, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 8, p. 1805-1814 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ticagrelor
  • Clopidogrel
  • Myocardial Infarction
  • Heart
  • Reperfusion
  69 Scopus citations
• 2014

  Chronic treatment with ticagrelor limits myocardial infarct size: An adenosine and cyclooxygenase-2-dependent effect

  Nanhwan, M. K., Ling, S., Kodakandla, M., Nylander, S., Ye, Y. & Birnbaum, Y., Sep 2014, In: Arteriosclerosis, thrombosis, and vascular biology. 34, 9, p. 2078-2085 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Ticagrelor
  • Cyclooxygenase 2
  • Adenosine
  • Clopidogrel
  • Myocardial Infarction
  95 Scopus citations

• Dipeptidyl peptidase IV inhibitors and ischemic myocardial injury

  Yoon, A. H., Ye, Y. & Birnbaum, Y., Sep 2014, In: Journal of Cardiovascular Pharmacology and Therapeutics. 19, 5, p. 417-425 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Dipeptidyl-Peptidase IV Inhibitors
  • Wounds and Injuries
  • Glucagon-Like Peptide 1
  • Clinical Trials
  • Hypoglycemic Agents
  7 Scopus citations

• PTEN Upregulation May Explain the Development of Insulin Resistance and Type 2 Diabetes with High Dose Statins

  Birnbaum, Y., Nanhwan, M. K., Ling, S., Perez-Polo, J. R., Ye, Y. & Bajaj, M., Oct 2014, In: Cardiovascular Drugs and Therapy. 28, 5, p. 447-457 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Rosuvastatin Calcium
  • Western Diet
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Insulin Resistance
  • Type 2 Diabetes Mellitus
  23 Scopus citations
• 2012

  Myocardial protection against Ischemia-Reperfusion Injury by GLP-1: Molecular mechanisms

  Birnbaum, Y., Ye, Y. & Bajaj, M., Dec 1 2012, In: Metabolic Syndrome and Related Disorders. 10, 6, p. 387-390 4 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  13 Scopus citations

• Phosphodiesterase III Inhibition Increases cAMP levels and augments the infarct size limiting effect of a dpp-4 inhibitor in mice with type-2 diabetes mellitus

  Birnbaum, Y., Castillo, A. C., Qian, J., Ling, S., Ye, H., Perez-Polo, J. R., Bajaj, M. & Ye, Y., Dec 1 2012, In: Cardiovascular Drugs and Therapy. 26, 6, p. 445-456 12 p.

  Research output: Contribution to journal › Article › peer-review

  • MK0626
  • Type 3 Cyclic Nucleotide Phosphodiesterases
  • Cilostazol
  • Type 2 Diabetes Mellitus
  • Arachidonate 5-Lipoxygenase
  22 Scopus citations

• Pleiotropic effects of statins: The role of eicosanoid production

  Birnbaum, Y. & Ye, Y., Apr 1 2012, In: Current Atherosclerosis Reports. 14, 2, p. 135-139 5 p.

  Research output: Contribution to journal › Review article › peer-review

  • Eicosanoids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • 3-hydroxy-3-methylglutaryl-coenzyme A
  • Anti-Inflammatory Agents
  • Oxidoreductases
  13 Scopus citations

• Regulation of phosphatase and tensin homolog on chromosome 10 in response to Hypoxia

  Qian, J., Ling, S., Castillo, A. C., Long, B., Birnbaum, Y. & Ye, Y., May 1 2012, In: American Journal of Physiology - Heart and Circulatory Physiology. 302, 9, p. H1806-H1817

  Research output: Contribution to journal › Article › peer-review

  • Activating Transcription Factor 2
  • Tensins
  • Chromosomes, Human, Pair 10
  • Phosphoric Monoester Hydrolases
  • Cardiac Myocytes
  19 Scopus citations

• The effect of pioglitazone treatment on 15-epi-lipoxin A ₄ levels in patients with type 2 diabetes

  Gutierrez, A. D., Sathyanarayana, P., Konduru, S., Ye, Y., Birnbaum, Y. & Bajaj, M., Jul 2012, In: Atherosclerosis. 223, 1, p. 204-208 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Lipoxins
  • Pioglitazone
  • Type 2 Diabetes Mellitus
  • Adiponectin
  • Nonesterified Fatty Acids
  17 Scopus citations