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  • Robert Cross
2020

A Cross-Reactive Humanized Monoclonal Antibody Targeting Fusion Glycoprotein Function Protects Ferrets Against Lethal Nipah Virus and Hendra Virus Infection

Mire, C. E., Chan, Y. P., Borisevich, V., Cross, R. W., Yan, L., Agans, K. N., Dang, H. V., Veesler, D., Fenton, K. A., Geisbert, T. W. & Broder, C. C., May 11 2020, In : Journal of Infectious Diseases. 221, p. S471-S479

Research output: Contribution to journalArticle

Open Access

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

Gilchuk, P., Murin, C. D., Milligan, J. C., Cross, R. W., Mire, C. E., Ilinykh, P. A., Huang, K., Kuzmina, N., Altman, P. X., Hui, S., Gunn, B. M., Bryan, A. L., Davidson, E., Doranz, B. J., Turner, H. L., Alkutkar, T., Flinko, R., Orlandi, C., Carnahan, R., Nargi, R. & 13 others, Bombardi, R. G., Vodzak, M. E., Li, S., Okoli, A., Ibeawuchi, M., Ohiaeri, B., Lewis, G. K., Alter, G., Bukreyev, A., Saphire, E. O., Geisbert, T. W., Ward, A. B. & Crowe, J. E., Feb 18 2020, In : Immunity. 52, 2, p. 388-403.e12

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

An Intranasal Exposure Model of Lethal Nipah Virus Infection in African Green Monkeys

Geisbert, J. B., Borisevich, V., Prasad, A. N., Agans, K. N., Foster, S. L., Deer, D. J., Cross, R. W., Mire, C. E., Geisbert, T. W. & Fenton, K. A., May 11 2020, In : Journal of Infectious Diseases. 221, p. S414-S418

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Early transcriptional changes within liver, adrenal gland, and lymphoid tissues significantly contribute to Ebola virus pathogenesis in cynomolgus macaques

Jankeel, A., Menicucci, A. R., Woolsey, C., Fenton, K., Mendoza, N., Versteeg, K., Cross, R. W., Geisbert, T. W. & Messaoudi, I., Jun 1 2020, In : Journal of virology. 94, 11, e00250-20.

Research output: Contribution to journalArticle

Erratum: Correction for Satterfield et al., "Nipah Virus C and W Proteins Contribute to Respiratory Disease in Ferrets" (Journal of virology (2016) 90 14 (6326-6343) PII: e00059-20)

Satterfield, B. A., Cross, R. W., Fenton, K. A., Borisevich, V., Agans, K. N., Deer, D. J., Graber, J., Basler, C. F., Geisbert, T. W. & Mire, C. E., Mar 31 2020, In : Journal of virology. 94, 8

Research output: Contribution to journalComment/debate

Open Access

Immune correlates of postexposure vaccine protection against Marburg virus

Woolsey, C., Jankeel, A., Matassov, D., Geisbert, J. B., Agans, K. N., Borisevich, V., Cross, R. W., Deer, D. J., Fenton, K. A., Latham, T. E., Gerardi, C. S., Mire, C. E., Eldridge, J. H., Messaoudi, I. & Geisbert, T. W., Dec 1 2020, In : Scientific reports. 10, 1, 3071.

Research output: Contribution to journalArticle

Open Access

Quadrivalent VesiculoVax vaccine protects nonhuman primates from viral-induced hemorrhagic fever and death

Cross, R. W., Xu, R., Matassov, D., Hamm, S., Latham, T. E., Gerardi, C. S., Nowak, R. M., Geisbert, J. B., Ota-Setlik, A., Agans, K. N., Luckay, A., Witko, S. E., Soukieh, L., Deer, D. J., Mire, C. E., Feldmann, H., Happi, C., Fenton, K., Eldridge, J. H. & Geisbert, T. W., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 539-551 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Rational design of universal immunotherapy for TfR1-tropic arenaviruses

Cohen-Dvashi, H., Amon, R., Agans, K. N., Cross, R. W., Borenstein-Katz, A., Mateo, M., Baize, S., Padler-Karavani, V., Geisbert, T. W. & Diskin, R., Dec 1 2020, In : Nature communications. 11, 1, 67.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Resistance of Cynomolgus Monkeys to Nipah and Hendra Virus Disease Is Associated with Cell-Mediated and Humoral Immunity

Prasad, A. N., Woolsey, C., Geisbert, J. B., Agans, K. N., Borisevich, V., Deer, D. J., Mire, C. E., Cross, R. W., Fenton, K. A., Broder, C. C. & Geisbert, T. W., May 11 2020, In : Journal of Infectious Diseases. 221, p. S436-S447

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38

Mishra, A. K., Moyer, C. L., Abelson, D. M., Deer, D. J., El Omari, K., Duman, R., Lobel, L., Lutwama, J. J., Dye, J. M., Wagner, A., Chandran, K., Cross, R. W., Geisbert, T. W., Zeitlin, L., Bornholdt, Z. A. & McLellan, J. S., Mar 31 2020, In : Journal of virology. 94, 8

Research output: Contribution to journalArticle

Open Access
2018

Comparative Transcriptomics in Ebola Makona-Infected Ferrets, Nonhuman Primates, and Humans

Cross, R., Speranza, E., Borisevich, V., Widen, S., Wood, T., Shim, R. S., Adams, R. D., Gerhardt, D. M., Bennett, R. S., Honko, A. N., Johnson, J. C., Hensley, L. E., Geisbert, T. & Connor, J. H., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S486-S495

Research output: Contribution to journalArticle

8 Scopus citations

Efficacy of Human Monoclonal Antibody Monotherapy Against Bundibugyo Virus Infection in Nonhuman Primates

Gilchuk, P., Mire, C., Geisbert, J. B., Agans, K. N., Deer, D. J., Cross, R., Slaughter, J. C., Flyak, A. I., Mani, J., Pauly, M. H., Velasco, J., Whaley, K. J., Zeitlin, L., Geisbert, T. & Crowe, J. E., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S565-S573

Research output: Contribution to journalArticle

1 Scopus citations

Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever

Boisen, M. L., Hartnett, J. N., Shaffer, J. G., Goba, A., Momoh, M., Sandi, J. D., Fullah, M., Nelson, D. K. S., Bush, D. J., Rowland, M. M., Heinrich, M. L., Koval, A. P., Cross, R., Barnes, K. G., Lachenauer, A. E., Lin, A. E., Nekoui, M., Kotliar, D., Winnicki, S. M., Siddle, K. J. & 18 others, Gbakie, M., Fonnie, M., Koroma, V. J., Kanneh, L., Kulakosky, P. C., Hastie, K. M., Wilson, R. B., Andersen, K. G., Folarin, O. O., Happi, C. T., Sabeti, P. C., Geisbert, T., Saphire, E. O., Khan, S. H., Grant, D. S., Schieffelin, J. S., Branco, L. M. & Garry, R. F., Dec 1 2018, In : Scientific Reports. 8, 1, 5939.

Research output: Contribution to journalArticle

9 Scopus citations

Marburg and Ravn Viruses Fail to Cause Disease in the Domestic Ferret (Mustela putorius furo)

Cross, R., Mire, C., Agans, K. N., Borisevich, V., Fenton, K. A. & Geisbert, T., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S448-S452

Research output: Contribution to journalArticle

6 Scopus citations

Postexposure Efficacy of Recombinant Vesicular Stomatitis Virus Vectors Against High and Low Doses of Marburg Virus Variant Angola in Nonhuman Primates

Woolsey, C., Geisbert, J. B., Matassov, D., Agans, K. N., Borisevich, V., Cross, R., Deer, D. J., Fenton, K. A., Eldridge, J. H., Mire, C. & Geisbert, T., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S582-S587

Research output: Contribution to journalArticle

5 Scopus citations

Post-exposure treatments for Ebola and Marburg virus infections

Cross, R. W., Mire, C. E., Feldmann, H. & Geisbert, T. W., Jun 1 2018, In : Nature Reviews Drug Discovery. 17, 6, p. 413-434 22 p.

Research output: Contribution to journalReview article

47 Scopus citations

Small animal models of filovirus disease: recent advances and future directions

Cross, R., Fenton, K. A. & Geisbert, T., Nov 2 2018, In : Expert Opinion on Drug Discovery. 13, 11, p. 1027-1040 14 p.

Research output: Contribution to journalReview article

4 Scopus citations
2017

ELISA methods for the detection of ebolavirus infection

Cross, R. & Ksiazek, T., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1628. p. 363-372 10 p. (Methods in Molecular Biology; vol. 1628).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever

Mire, C. E., Cross, R. W., Geisbert, J. B., Borisevich, V., Agans, K. N., Deer, D. J., Heinrich, M. L., Rowland, M. M., Goba, A., Momoh, M., Boisen, M. L., Grant, D. S., Fullah, M., Khan, S. H., Fenton, K. A., Robinson, J. E., Branco, L. M., Garry, R. F. & Geisbert, T. W., Oct 1 2017, In : Nature Medicine. 23, 10, p. 1146-1149 4 p.

Research output: Contribution to journalArticle

35 Scopus citations

Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants

Versteeg, K., Menicucci, A. R., Woolsey, C., Mire, C., Geisbert, J. B., Cross, R., Agans, K. N., Jeske, D., Messaoudi, I. & Geisbert, T., Dec 1 2017, In : Scientific Reports. 7, 1, 9730.

Research output: Contribution to journalArticle

13 Scopus citations

Production of antigens for ELISA

Cross, R. & Ksiazek, T., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1628. p. 353-362 10 p. (Methods in Molecular Biology; vol. 1628).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

siRNA rescues nonhuman primates from advanced Marburg and Ravn virus disease

Thi, E. P., Mire, C., Lee, A. C. H., Geisbert, J. B., Ursic-Bedoya, R., Agans, K. N., Robbins, M., Deer, D. J., Cross, R., Kondratowicz, A. S., Fenton, K. A., MacLachlan, I. & Geisbert, T., Dec 1 2017, In : Journal of Clinical Investigation. 127, 12, p. 4437-4448 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Transcriptome analysis of circulating immune cell subsets highlight the role of monocytes in Zaire Ebola Virus Makona pathogenesis

Menicucci, A. R., Versteeg, K., Woolsey, C., Mire, C., Geisbert, J. B., Cross, R., Agans, K. N., Jankeel, A., Geisbert, T. & Messaoudi, I., Oct 4 2017, In : Frontiers in Immunology. 8, OCT, 1372.

Research output: Contribution to journalArticle

16 Scopus citations
2016

Analytical Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection

Cross, R. W., Boisen, M. L., Millett, M. M., Nelson, DI. S., Oottamasathien, D., Hartnett, J. N., Jones, A. B., Goba, A., Momoh, M., Fullah, M., Bornholdt, Z. A., Fusco, M. L., Abelson, D. M., Oda, S., Brown, B. L., Pham, H., Rowland, M. M., Agans, K. N., Geisbert, J. B., Heinrich, M. L. & 14 others, Kulakosky, P. C., Shaffer, J. G., Schieffelin, J. S., Kargbo, B., Gbetuwa, M., Gevao, S. M., Wilson, R. B., Saphire, E. O., Pitts, K. R., Khan, S. H., Grant, D. S., Geisbert, T. W., Branco, L. M. & Garry, R. F., Oct 15 2016, In : Journal of Infectious Diseases. 214, p. S210-S217

Research output: Contribution to journalArticle

17 Scopus citations

An Outbreak of Ebola Virus Disease in the Lassa Fever Zone

Goba, A., Khan, S. H., Fonnie, M., Fullah, M., Moigboi, A., Kovoma, A., Sinnah, V., Yoko, N., Rogers, H., Safai, S., Momoh, M., Koroma, V., Kamara, F. K., Konowu, E., Yillah, M., French, I., Mustapha, I., Kanneh, F., Foday, M., McCarthy, H. & 64 others, Kallon, T., Kallon, M., Naiebu, J., Sellu, J., Jalloh, A. A., Gbakie, M., Kanneh, L., Massaly, J. L. B., Kargbo, D., Kargbo, B., Vandi, M., Gbetuwa, M., Gevao, S. M., Sandi, J. D., Jalloh, S. C., Grant, D. S., Blyden, S. O., Crozier, I., Schieffelin, J. S., McLellan, S. L., Jacob, S. T., Boisen, M. L., Hartnett, J. N., Cross, R. W., Branco, L. M., Andersen, K. G., Yozwiak, N. L., Gire, S. K., Tariyal, R., Park, D. J., Haislip, A. M., Bishop, C. M., Melnik, L. I., Gallaher, W. R., Wimley, W. C., He, J., Shaffer, J. G., Sullivan, B. M., Grillo, S., Oman, S., Garry, C. E., Edwards, D. R., McCormick, S. J., Elliott, D. H., Rouelle, J. A., Kannadka, C. B., Reyna, A. A., Bradley, B. T., Yu, H., Yenni, R. E., Hastie, K. M., Geisbert, J. B., Kulakosky, P. C., Wilson, R. B., Oldstone, M. B. A., Pitts, K. R., Henderson, L. A., Robinson, J. E., Geisbert, T. W., Saphire, E. O., Happi, C. T., Asogun, D. A., Sabeti, P. C. & Garry, R. F., Oct 15 2016, In : Journal of Infectious Diseases. 214, p. S110-S121

Research output: Contribution to journalArticle

18 Scopus citations

Field Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection

Boisen, M. L., Cross, R. W., Hartnett, J. N., Goba, A., Momoh, M., Fullah, M., Gbakie, M., Safa, S., Fonnie, M., Baimba, F., Koroma, V. J., Geisbert, J. B., McCormick, S., Nelson, DI. K. S., Millett, M. M., Oottamasathien, D., Jones, A. B., Pham, H., Brown, B. L., Shaffer, J. G. & 11 others, Schieffelin, J. S., Kargbo, B., Gbetuwa, M., Gevao, S. M., Wilson, R. B., Pitts, K. R., Geisbert, T. W., Branco, L. M., Khan, S. H., Grant, D. S. & Garry, R. F., Oct 15 2016, In : Journal of Infectious Diseases. 214, p. S203-S209

Research output: Contribution to journalArticle

16 Scopus citations

Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits

Robinson, J. E., Hastie, K. M., Cross, R. W., Yenni, R. E., Elliott, D. H., Rouelle, J. A., Kannadka, C. B., Smira, A. A., Garry, C. E., Bradley, B. T., Yu, H., Shaffer, J. G., Boisen, M. L., Hartnett, J. N., Zandonatti, M. A., Rowland, M. M., Heinrich, M. L., Martinez-Sobrido, L., Cheng, B., De La Torre, J. C. & 30 others, Andersen, K. G., Goba, A., Momoh, M., Fullah, M., Gbakie, M., Kanneh, L., Koroma, V. J., Fonnie, R., Jalloh, S. C., Kargbo, B., Vandi, M. A., Gbetuwa, M., Ikponmwosa, O., Asogun, D. A., Okokhere, P. O., Follarin, O. A., Schieffelin, J. S., Pitts, K. R., Geisbert, J. B., Kulakoski, P. C., Wilson, R. B., Happi, C. T., Sabeti, P. C., Gevao, S. M., Khan, S. H., Grant, D. S., Geisbert, T. W., Saphire, E. O., Branco, L. M. & Garry, R. F., May 10 2016, In : Nature communications. 7, 11544.

Research output: Contribution to journalArticle

50 Scopus citations

Nipah Virus C and W Proteins Contribute to Respiratory Disease in Ferrets

Satterfield, B. A., Cross, R. W., Fenton, K. A., Borisevich, V., Agans, K. N., Deer, D. J., Graber, J., Basler, C. F., Geisbert, T. W. & Mirea, C. E., 2016, In : Journal of virology. 90, 14, p. 6326-6343 18 p.

Research output: Contribution to journalArticle

12 Scopus citations

Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates: Implications for Antibody Therapy

Mire, C., Satterfield, B. A., Geisbert, J. B., Agans, K. N., Borisevich, V., Yan, L., Chan, Y. P., Cross, R., Fenton, K. A., Broder, C. C. & Geisbert, T., Aug 3 2016, In : Scientific Reports. 6, 30916.

Research output: Contribution to journalArticle

39 Scopus citations

The domestic ferret (mustela putorius furo) as a lethal infection model for 3 species of ebolavirus

Cross, R., Mire, C., Borisevich, V., Geisbert, J. B., Fenton, K. A. & Geisbert, T., Aug 15 2016, In : Journal of Infectious Diseases. 214, 4, p. 565-569 5 p.

Research output: Contribution to journalArticle

40 Scopus citations

Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies

Cross, R., Mire, C., Branco, L. M., Geisbert, J. B., Rowland, M. M., Heinrich, M. L., Goba, A., Momoh, M., Grant, D. S., Fullah, M., Khan, S. H., Robinson, J. E., Geisbert, T. & Garry, R. F., Sep 1 2016, In : Antiviral Research. 133, p. 218-222 5 p.

Research output: Contribution to journalArticle

26 Scopus citations