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  • Robert Cross

A Cross-Reactive Humanized Monoclonal Antibody Targeting Fusion Glycoprotein Function Protects Ferrets Against Lethal Nipah Virus and Hendra Virus Infection

Mire, C. E., Chan, Y. P., Borisevich, V., Cross, R. W., Yan, L., Agans, K. N., Dang, H. V., Veesler, D., Fenton, K. A., Geisbert, T. W. & Broder, C. C., May 11 2020, In : Journal of Infectious Diseases. 221, p. S471-S479

Research output: Contribution to journalArticle

Open Access

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

Gilchuk, P., Murin, C. D., Milligan, J. C., Cross, R. W., Mire, C. E., Ilinykh, P. A., Huang, K., Kuzmina, N., Altman, P. X., Hui, S., Gunn, B. M., Bryan, A. L., Davidson, E., Doranz, B. J., Turner, H. L., Alkutkar, T., Flinko, R., Orlandi, C., Carnahan, R., Nargi, R. & 13 others, Bombardi, R. G., Vodzak, M. E., Li, S., Okoli, A., Ibeawuchi, M., Ohiaeri, B., Lewis, G. K., Alter, G., Bukreyev, A., Saphire, E. O., Geisbert, T. W., Ward, A. B. & Crowe, J. E., Feb 18 2020, In : Immunity. 52, 2, p. 388-403.e12

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Analytical Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection

Cross, R. W., Boisen, M. L., Millett, M. M., Nelson, DI. S., Oottamasathien, D., Hartnett, J. N., Jones, A. B., Goba, A., Momoh, M., Fullah, M., Bornholdt, Z. A., Fusco, M. L., Abelson, D. M., Oda, S., Brown, B. L., Pham, H., Rowland, M. M., Agans, K. N., Geisbert, J. B., Heinrich, M. L. & 14 others, Kulakosky, P. C., Shaffer, J. G., Schieffelin, J. S., Kargbo, B., Gbetuwa, M., Gevao, S. M., Wilson, R. B., Saphire, E. O., Pitts, K. R., Khan, S. H., Grant, D. S., Geisbert, T. W., Branco, L. M. & Garry, R. F., Oct 15 2016, In : Journal of Infectious Diseases. 214, p. S210-S217

Research output: Contribution to journalArticle

17 Scopus citations

An Intranasal Exposure Model of Lethal Nipah Virus Infection in African Green Monkeys

Geisbert, J. B., Borisevich, V., Prasad, A. N., Agans, K. N., Foster, S. L., Deer, D. J., Cross, R. W., Mire, C. E., Geisbert, T. W. & Fenton, K. A., May 11 2020, In : Journal of Infectious Diseases. 221, p. S414-S418

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

An Outbreak of Ebola Virus Disease in the Lassa Fever Zone

Goba, A., Khan, S. H., Fonnie, M., Fullah, M., Moigboi, A., Kovoma, A., Sinnah, V., Yoko, N., Rogers, H., Safai, S., Momoh, M., Koroma, V., Kamara, F. K., Konowu, E., Yillah, M., French, I., Mustapha, I., Kanneh, F., Foday, M., McCarthy, H. & 64 others, Kallon, T., Kallon, M., Naiebu, J., Sellu, J., Jalloh, A. A., Gbakie, M., Kanneh, L., Massaly, J. L. B., Kargbo, D., Kargbo, B., Vandi, M., Gbetuwa, M., Gevao, S. M., Sandi, J. D., Jalloh, S. C., Grant, D. S., Blyden, S. O., Crozier, I., Schieffelin, J. S., McLellan, S. L., Jacob, S. T., Boisen, M. L., Hartnett, J. N., Cross, R. W., Branco, L. M., Andersen, K. G., Yozwiak, N. L., Gire, S. K., Tariyal, R., Park, D. J., Haislip, A. M., Bishop, C. M., Melnik, L. I., Gallaher, W. R., Wimley, W. C., He, J., Shaffer, J. G., Sullivan, B. M., Grillo, S., Oman, S., Garry, C. E., Edwards, D. R., McCormick, S. J., Elliott, D. H., Rouelle, J. A., Kannadka, C. B., Reyna, A. A., Bradley, B. T., Yu, H., Yenni, R. E., Hastie, K. M., Geisbert, J. B., Kulakosky, P. C., Wilson, R. B., Oldstone, M. B. A., Pitts, K. R., Henderson, L. A., Robinson, J. E., Geisbert, T. W., Saphire, E. O., Happi, C. T., Asogun, D. A., Sabeti, P. C. & Garry, R. F., Oct 15 2016, In : Journal of Infectious Diseases. 214, p. S110-S121

Research output: Contribution to journalArticle

20 Scopus citations

Comparative Transcriptomics in Ebola Makona-Infected Ferrets, Nonhuman Primates, and Humans

Cross, R. W., Speranza, E., Borisevich, V., Widen, S. G., Wood, T. G., Shim, R. S., Adams, R. D., Gerhardt, D. M., Bennett, R. S., Honko, A. N., Johnson, J. C., Hensley, L. E., Geisbert, T. W. & Connor, J. H., Nov 22 2018, In : Journal of Infectious Diseases. 218, p. S486-S495

Research output: Contribution to journalArticle

8 Scopus citations

Crimean-congo hemorrhagic fever virus strains hoti and afghanistan cause viremia and mild clinical disease in cynomolgus monkeys

Cross, R. W., Prasadid, A. N., Borisevich, V., Geisbert, J. B., Agans, K. N., Deer, D. J., Fenton, K. A. & Geisbert, T. W., Aug 2020, In : PLoS neglected tropical diseases. 14, 8, p. 1-19 19 p., e0008637.

Research output: Contribution to journalArticle

Open Access

Early transcriptional changes within liver, adrenal gland, and lymphoid tissues significantly contribute to Ebola virus pathogenesis in cynomolgus macaques

Jankeel, A., Menicucci, A. R., Woolsey, C., Fenton, K., Mendoza, N., Versteeg, K., Cross, R. W., Geisbert, T. W. & Messaoudi, I., Jun 1 2020, In : Journal of virology. 94, 11, e00250-20.

Research output: Contribution to journalArticle

Efficacy of Human Monoclonal Antibody Monotherapy Against Bundibugyo Virus Infection in Nonhuman Primates

Gilchuk, P., Mire, C. E., Geisbert, J. B., Agans, K. N., Deer, D. J., Cross, R. W., Slaughter, J. C., Flyak, A. I., Mani, J., Pauly, M. H., Velasco, J., Whaley, K. J., Zeitlin, L., Geisbert, T. W. & Crowe, J. E., Nov 22 2018, In : Journal of Infectious Diseases. 218, p. S565-S573

Research output: Contribution to journalArticle

1 Scopus citations

Erratum: Correction for Satterfield et al., "Nipah Virus C and W Proteins Contribute to Respiratory Disease in Ferrets" (Journal of virology (2016) 90 14 (6326-6343) PII: e00059-20)

Satterfield, B. A., Cross, R. W., Fenton, K. A., Borisevich, V., Agans, K. N., Deer, D. J., Graber, J., Basler, C. F., Geisbert, T. W. & Mire, C. E., Mar 31 2020, In : Journal of virology. 94, 8

Research output: Contribution to journalComment/debate

Open Access

Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever

Boisen, M. L., Hartnett, J. N., Shaffer, J. G., Goba, A., Momoh, M., Sandi, J. D., Fullah, M., Nelson, D. K. S., Bush, D. J., Rowland, M. M., Heinrich, M. L., Koval, A. P., Cross, R. W., Barnes, K. G., Lachenauer, A. E., Lin, A. E., Nekoui, M., Kotliar, D., Winnicki, S. M., Siddle, K. J. & 18 others, Gbakie, M., Fonnie, M., Koroma, V. J., Kanneh, L., Kulakosky, P. C., Hastie, K. M., Wilson, R. B., Andersen, K. G., Folarin, O. O., Happi, C. T., Sabeti, P. C., Geisbert, T. W., Saphire, E. O., Khan, S. H., Grant, D. S., Schieffelin, J. S., Branco, L. M. & Garry, R. F., Dec 1 2018, In : Scientific reports. 8, 1, 5939.

Research output: Contribution to journalArticle

11 Scopus citations

Field Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection

Boisen, M. L., Cross, R. W., Hartnett, J. N., Goba, A., Momoh, M., Fullah, M., Gbakie, M., Safa, S., Fonnie, M., Baimba, F., Koroma, V. J., Geisbert, J. B., McCormick, S., Nelson, DI. K. S., Millett, M. M., Oottamasathien, D., Jones, A. B., Pham, H., Brown, B. L., Shaffer, J. G. & 11 others, Schieffelin, J. S., Kargbo, B., Gbetuwa, M., Gevao, S. M., Wilson, R. B., Pitts, K. R., Geisbert, T. W., Branco, L. M., Khan, S. H., Grant, D. S. & Garry, R. F., Oct 15 2016, In : Journal of Infectious Diseases. 214, p. S203-S209

Research output: Contribution to journalArticle

17 Scopus citations

Immune correlates of postexposure vaccine protection against Marburg virus

Woolsey, C., Jankeel, A., Matassov, D., Geisbert, J. B., Agans, K. N., Borisevich, V., Cross, R. W., Deer, D. J., Fenton, K. A., Latham, T. E., Gerardi, C. S., Mire, C. E., Eldridge, J. H., Messaoudi, I. & Geisbert, T. W., Dec 1 2020, In : Scientific reports. 10, 1, 3071.

Research output: Contribution to journalArticle

Open Access

Intranasal exposure of African green monkeys to SARS-CoV-2 results in acute phase pneumonia with shedding and lung injury still present in the early convalescence phase

Cross, R. W., Agans, K. N., Prasad, A. N., Borisevich, V., Woolsey, C., Deer, D. J., Dobias, N. S., Geisbert, J. B., Fenton, K. A. & Geisbert, T. W., Aug 18 2020, In : Virology journal. 17, 1, 125.

Research output: Contribution to journalArticle

Open Access

Marburg and Ravn Viruses Fail to Cause Disease in the Domestic Ferret (Mustela putorius furo)

Cross, R. W., Mire, C. E., Agans, K. N., Borisevich, V., Fenton, K. A. & Geisbert, T. W., Nov 22 2018, In : Journal of Infectious Diseases. 218, p. S448-S452

Research output: Contribution to journalArticle

6 Scopus citations

Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits

Robinson, J. E., Hastie, K. M., Cross, R. W., Yenni, R. E., Elliott, D. H., Rouelle, J. A., Kannadka, C. B., Smira, A. A., Garry, C. E., Bradley, B. T., Yu, H., Shaffer, J. G., Boisen, M. L., Hartnett, J. N., Zandonatti, M. A., Rowland, M. M., Heinrich, M. L., Martinez-Sobrido, L., Cheng, B., De La Torre, J. C. & 30 others, Andersen, K. G., Goba, A., Momoh, M., Fullah, M., Gbakie, M., Kanneh, L., Koroma, V. J., Fonnie, R., Jalloh, S. C., Kargbo, B., Vandi, M. A., Gbetuwa, M., Ikponmwosa, O., Asogun, D. A., Okokhere, P. O., Follarin, O. A., Schieffelin, J. S., Pitts, K. R., Geisbert, J. B., Kulakoski, P. C., Wilson, R. B., Happi, C. T., Sabeti, P. C., Gevao, S. M., Khan, S. H., Grant, D. S., Geisbert, T. W., Saphire, E. O., Branco, L. M. & Garry, R. F., May 10 2016, In : Nature communications. 7, 11544.

Research output: Contribution to journalArticle

53 Scopus citations

Nipah Virus C and W Proteins Contribute to Respiratory Disease in Ferrets

Satterfield, B. A., Cross, R. W., Fenton, K. A., Borisevich, V., Agans, K. N., Deer, D. J., Graber, J., Basler, C. F., Geisbert, T. W. & Mirea, C. E., 2016, In : Journal of virology. 90, 14, p. 6326-6343 18 p.

Research output: Contribution to journalArticle

13 Scopus citations

Pathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates: Implications for Antibody Therapy

Mire, C. E., Satterfield, B. A., Geisbert, J. B., Agans, K. N., Borisevich, V., Yan, L., Chan, Y. P., Cross, R. W., Fenton, K. A., Broder, C. C. & Geisbert, T. W., Aug 3 2016, In : Scientific reports. 6, 30916.

Research output: Contribution to journalArticle

42 Scopus citations

Postexposure Efficacy of Recombinant Vesicular Stomatitis Virus Vectors Against High and Low Doses of Marburg Virus Variant Angola in Nonhuman Primates

Woolsey, C., Geisbert, J. B., Matassov, D., Agans, K. N., Borisevich, V., Cross, R. W., Deer, D. J., Fenton, K. A., Eldridge, J. H., Mire, C. E. & Geisbert, T. W., Nov 22 2018, In : Journal of Infectious Diseases. 218, p. S582-S587

Research output: Contribution to journalArticle

7 Scopus citations

Post-exposure treatments for Ebola and Marburg virus infections

Cross, R. W., Mire, C. E., Feldmann, H. & Geisbert, T. W., Jun 1 2018, In : Nature Reviews Drug Discovery. 17, 6, p. 413-434 22 p.

Research output: Contribution to journalReview article

48 Scopus citations

Prior vaccination with rVSV-ZEBOV does not interfere with but improves efficacy of postexposure antibody treatment

Cross, R. W., Bornholdt, Z. A., Prasad, A. N., Geisbert, J. B., Borisevich, V., Agans, K. N., Deer, D. J., Melody, K., Fenton, K. A., Feldmann, H., Sprecher, A., Zeitlin, L. & Geisbert, T. W., Dec 1 2020, In : Nature communications. 11, 1, 3736.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Quadrivalent VesiculoVax vaccine protects nonhuman primates from viral-induced hemorrhagic fever and death

Cross, R. W., Xu, R., Matassov, D., Hamm, S., Latham, T. E., Gerardi, C. S., Nowak, R. M., Geisbert, J. B., Ota-Setlik, A., Agans, K. N., Luckay, A., Witko, S. E., Soukieh, L., Deer, D. J., Mire, C. E., Feldmann, H., Happi, C., Fenton, K. A., Eldridge, J. H. & Geisbert, T. W., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 539-551 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Rational design of universal immunotherapy for TfR1-tropic arenaviruses

Cohen-Dvashi, H., Amon, R., Agans, K. N., Cross, R. W., Borenstein-Katz, A., Mateo, M., Baize, S., Padler-Karavani, V., Geisbert, T. W. & Diskin, R., Dec 1 2020, In : Nature communications. 11, 1, 67.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Resistance of Cynomolgus Monkeys to Nipah and Hendra Virus Disease Is Associated with Cell-Mediated and Humoral Immunity

Prasad, A. N., Woolsey, C., Geisbert, J. B., Agans, K. N., Borisevich, V., Deer, D. J., Mire, C. E., Cross, R. W., Fenton, K. A., Broder, C. C. & Geisbert, T. W., May 11 2020, In : Journal of Infectious Diseases. 221, p. S436-S447

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Small animal models of filovirus disease: recent advances and future directions

Cross, R. W., Fenton, K. & Geisbert, T. W., Nov 2 2018, In : Expert Opinion on Drug Discovery. 13, 11, p. 1027-1040 14 p.

Research output: Contribution to journalReview article

4 Scopus citations

Structure and characterization of crimean-congo hemorrhagic fever virus GP38

Mishra, A. K., Moyer, C. L., Abelson, D. M., Deer, D. J., El Omari, K., Duman, R., Lobel, L., Lutwama, J. J., Dye, J. M., Wagner, A., Chandran, K., Cross, R. W., Geisbert, T. W., Zeitlin, L., Bornholdt, Z. A. & McLellan, J. S., Mar 1 2020, In : Journal of virology. 94, 8, e02005-19.

Research output: Contribution to journalArticle

Open Access

The domestic ferret (mustela putorius furo) as a lethal infection model for 3 species of ebolavirus

Cross, R. W., Mire, C. E., Borisevich, V., Geisbert, J. B., Fenton, K. A. & Geisbert, T. W., Aug 15 2016, In : Journal of Infectious Diseases. 214, 4, p. 565-569 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies

Cross, R. W., Mire, C. E., Branco, L. M., Geisbert, J. B., Rowland, M. M., Heinrich, M. L., Goba, A., Momoh, M., Grant, D. S., Fullah, M., Khan, S. H., Robinson, J. E., Geisbert, T. W. & Garry, R. F., Sep 1 2016, In : Antiviral research. 133, p. 218-222 5 p.

Research output: Contribution to journalArticle

29 Scopus citations