A brief survey of mRNA surveillance

Ambro Van Hoof, Eric J. Wagner

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Defective mRNAs are degraded more rapidly than normal mRNAs in a process called mRNA surveillance. Eukaryotic cells use a variety of mechanisms to detect aberrations in mRNAs and a variety of enzymes to preferentially degrade them. Recent advances in the field of RNA surveillance have provided new information regarding how cells determine which mRNA species should be subject to destruction and novel mechanisms by which a cell tags an mRNA once such a decision has been reached. In this review, we highlight recent progress in our understanding of these processes.

Original languageEnglish (US)
Pages (from-to)585-592
Number of pages8
JournalTrends in biochemical sciences
Volume36
Issue number11
DOIs
StatePublished - Nov 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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