A burn center experience with toxic epidermal necrolysis

Paul Halebian, Valerie Corder, David Herndon, G. T. Shires

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Toxic epidermal necrolysis, a disease that produces skin loss, was encountered in 18 patients in a burn center. Drugs were associated in all cases, but six patients had symptoms of fever or cough before drug exposure. Liver function abnormalities were noted in all 18 patients. Corticosteroids were ineffective in preventing skin loss, and sepsis caused death in 11 patients. The unacceptably high incidence of septic deaths led to the current protocol of debridement, rapid steroid taper, topical chemotherapy, and cover age with homograft or synthetic skin substitute. Gastrointestinal ulcerations may have been a part of the disease process or a complication of high-dose corticosteroids.

Original languageEnglish (US)
Pages (from-to)176-183
Number of pages8
JournalJournal of Burn Care and Rehabilitation
Issue number3
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • General Nursing
  • Emergency Medicine
  • Rehabilitation
  • General Health Professions


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