A case of peripheral T-cell lymphoma, not otherwise specified in a HCV and HTLV-II-positive patient, diagnosed by abdominal fluid cytology

Maryam Dadfarnia Ameri, Trisha M. Parekh, You-Wen Qian, M. Tarek Elghetany, Vicki Schnadig, Ranjana Nawgiri

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a rare neoplasm that typically presents as generalized lymphadenopathy. PTCL, NOS presenting as malignant ascites is rare. Methods: A 61-year-old African-American man with past medical history of HCV, cryoglobulinemia, and cryptococcal pneumonia was admitted for dyspnea on exertion over a period of 1 month and new onset of abdominal distension. Results: Ascites, splenomegaly, hepatomegaly and extensive lymphadenopathy were found by imaging. Paracentesis obtained 1.3 liter of abdominal fluid, the cytologic evaluation showed a monomorphic population of intermediate-sized lymphoid cells with irregular to convoluted nuclear contours. Fluid sent for flow cytometry showed an abnormal T-lymphocyte population expressing CD4, weak surface CD3 and absence of CD7. PCR studies of ascitic fluid detected a clonal T-lymphocyte population with T-cell receptor gamma gene rearrangement. Serologic testing for human T lymphotropic virus (HTLV) was positive for HTLV-II. Subsequent bone marrow biopsy revealed lymphomatous involvement. CD30 and ALK-1 immunostaining were negative. This case was classified as PTCL, NOS. Conclusions: PTCL, NOS can have unusual clinical presentation such as ascites and pleural effusion, and may also occur as a complication of immunodeficiency state. Further studies are needed to determine if HCV or HTLV-II viral infection is associated with PTCL.

Original languageEnglish (US)
Pages (from-to)S96-S99
JournalJournal of Gastrointestinal Oncology
Volume7
DOIs
StatePublished - Apr 1 2016

Fingerprint

Human T-lymphotropic virus 2
Peripheral T-Cell Lymphoma
Cell Biology
Ascites
T-Cell Receptor gamma Genes
Population
T-Lymphocytes
Paracentesis
Cryoglobulinemia
Hepatomegaly
Gene Rearrangement
Ascitic Fluid
Splenomegaly
Virus Diseases
Pleural Effusion
African Americans
Dyspnea
Pneumonia
Flow Cytometry
Bone Marrow

Keywords

  • Ascites
  • Human T lymphotropic virus II (HTLV-II)
  • Not otherwise specified (PTCL, NOS)
  • Peripheral T-cell lymphoma

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

A case of peripheral T-cell lymphoma, not otherwise specified in a HCV and HTLV-II-positive patient, diagnosed by abdominal fluid cytology. / Ameri, Maryam Dadfarnia; Parekh, Trisha M.; Qian, You-Wen; Elghetany, M. Tarek; Schnadig, Vicki; Nawgiri, Ranjana.

In: Journal of Gastrointestinal Oncology, Vol. 7, 01.04.2016, p. S96-S99.

Research output: Contribution to journalArticle

@article{3df33cd83056437f8a3abe6eddc4f3d2,
title = "A case of peripheral T-cell lymphoma, not otherwise specified in a HCV and HTLV-II-positive patient, diagnosed by abdominal fluid cytology",
abstract = "Background: Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a rare neoplasm that typically presents as generalized lymphadenopathy. PTCL, NOS presenting as malignant ascites is rare. Methods: A 61-year-old African-American man with past medical history of HCV, cryoglobulinemia, and cryptococcal pneumonia was admitted for dyspnea on exertion over a period of 1 month and new onset of abdominal distension. Results: Ascites, splenomegaly, hepatomegaly and extensive lymphadenopathy were found by imaging. Paracentesis obtained 1.3 liter of abdominal fluid, the cytologic evaluation showed a monomorphic population of intermediate-sized lymphoid cells with irregular to convoluted nuclear contours. Fluid sent for flow cytometry showed an abnormal T-lymphocyte population expressing CD4, weak surface CD3 and absence of CD7. PCR studies of ascitic fluid detected a clonal T-lymphocyte population with T-cell receptor gamma gene rearrangement. Serologic testing for human T lymphotropic virus (HTLV) was positive for HTLV-II. Subsequent bone marrow biopsy revealed lymphomatous involvement. CD30 and ALK-1 immunostaining were negative. This case was classified as PTCL, NOS. Conclusions: PTCL, NOS can have unusual clinical presentation such as ascites and pleural effusion, and may also occur as a complication of immunodeficiency state. Further studies are needed to determine if HCV or HTLV-II viral infection is associated with PTCL.",
keywords = "Ascites, Human T lymphotropic virus II (HTLV-II), Not otherwise specified (PTCL, NOS), Peripheral T-cell lymphoma",
author = "Ameri, {Maryam Dadfarnia} and Parekh, {Trisha M.} and You-Wen Qian and Elghetany, {M. Tarek} and Vicki Schnadig and Ranjana Nawgiri",
year = "2016",
month = "4",
day = "1",
doi = "10.3978/j.issn.2078-6891.2015.054",
language = "English (US)",
volume = "7",
pages = "S96--S99",
journal = "Journal of Gastrointestinal Oncology",
issn = "2078-6891",
publisher = "Pioneer Bioscience Publishing Company (PBPC)",

}

TY - JOUR

T1 - A case of peripheral T-cell lymphoma, not otherwise specified in a HCV and HTLV-II-positive patient, diagnosed by abdominal fluid cytology

AU - Ameri, Maryam Dadfarnia

AU - Parekh, Trisha M.

AU - Qian, You-Wen

AU - Elghetany, M. Tarek

AU - Schnadig, Vicki

AU - Nawgiri, Ranjana

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background: Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a rare neoplasm that typically presents as generalized lymphadenopathy. PTCL, NOS presenting as malignant ascites is rare. Methods: A 61-year-old African-American man with past medical history of HCV, cryoglobulinemia, and cryptococcal pneumonia was admitted for dyspnea on exertion over a period of 1 month and new onset of abdominal distension. Results: Ascites, splenomegaly, hepatomegaly and extensive lymphadenopathy were found by imaging. Paracentesis obtained 1.3 liter of abdominal fluid, the cytologic evaluation showed a monomorphic population of intermediate-sized lymphoid cells with irregular to convoluted nuclear contours. Fluid sent for flow cytometry showed an abnormal T-lymphocyte population expressing CD4, weak surface CD3 and absence of CD7. PCR studies of ascitic fluid detected a clonal T-lymphocyte population with T-cell receptor gamma gene rearrangement. Serologic testing for human T lymphotropic virus (HTLV) was positive for HTLV-II. Subsequent bone marrow biopsy revealed lymphomatous involvement. CD30 and ALK-1 immunostaining were negative. This case was classified as PTCL, NOS. Conclusions: PTCL, NOS can have unusual clinical presentation such as ascites and pleural effusion, and may also occur as a complication of immunodeficiency state. Further studies are needed to determine if HCV or HTLV-II viral infection is associated with PTCL.

AB - Background: Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a rare neoplasm that typically presents as generalized lymphadenopathy. PTCL, NOS presenting as malignant ascites is rare. Methods: A 61-year-old African-American man with past medical history of HCV, cryoglobulinemia, and cryptococcal pneumonia was admitted for dyspnea on exertion over a period of 1 month and new onset of abdominal distension. Results: Ascites, splenomegaly, hepatomegaly and extensive lymphadenopathy were found by imaging. Paracentesis obtained 1.3 liter of abdominal fluid, the cytologic evaluation showed a monomorphic population of intermediate-sized lymphoid cells with irregular to convoluted nuclear contours. Fluid sent for flow cytometry showed an abnormal T-lymphocyte population expressing CD4, weak surface CD3 and absence of CD7. PCR studies of ascitic fluid detected a clonal T-lymphocyte population with T-cell receptor gamma gene rearrangement. Serologic testing for human T lymphotropic virus (HTLV) was positive for HTLV-II. Subsequent bone marrow biopsy revealed lymphomatous involvement. CD30 and ALK-1 immunostaining were negative. This case was classified as PTCL, NOS. Conclusions: PTCL, NOS can have unusual clinical presentation such as ascites and pleural effusion, and may also occur as a complication of immunodeficiency state. Further studies are needed to determine if HCV or HTLV-II viral infection is associated with PTCL.

KW - Ascites

KW - Human T lymphotropic virus II (HTLV-II)

KW - Not otherwise specified (PTCL, NOS)

KW - Peripheral T-cell lymphoma

UR - http://www.scopus.com/inward/record.url?scp=84995757637&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84995757637&partnerID=8YFLogxK

U2 - 10.3978/j.issn.2078-6891.2015.054

DO - 10.3978/j.issn.2078-6891.2015.054

M3 - Article

AN - SCOPUS:84995757637

VL - 7

SP - S96-S99

JO - Journal of Gastrointestinal Oncology

JF - Journal of Gastrointestinal Oncology

SN - 2078-6891

ER -