A change in α-crystallin subunit composition in relation to cellular differentiation in adult bovine lens

Jean Delcour, John Papaconstantinou

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The vertebrate lens is composed of two distinct cell types, the epithelial cell and the fiber cell. α-Crystallin, a structural protein found in both cell types, is composed of four subunits (αA1, αA2, αB1, and αB2). In the epithelial cells the α-crystallin consists mainly of αA2 and αB2 with trace amounts of αA1 and αB1. In the fiber cell there is a large increase in the amount of αA1 and αB1 subunits. This quantitative increase in two specific subunits is related to the process of cellular growth and differentiation in the vertebrate lens.

Original languageEnglish (US)
Pages (from-to)401-406
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume41
Issue number2
DOIs
StatePublished - Oct 23 1970
Externally publishedYes

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Crystallins
Lenses
Fibers
Chemical analysis
varespladib methyl
Vertebrates
Epithelial Cells
Proteins
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

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abstract = "The vertebrate lens is composed of two distinct cell types, the epithelial cell and the fiber cell. α-Crystallin, a structural protein found in both cell types, is composed of four subunits (αA1, αA2, αB1, and αB2). In the epithelial cells the α-crystallin consists mainly of αA2 and αB2 with trace amounts of αA1 and αB1. In the fiber cell there is a large increase in the amount of αA1 and αB1 subunits. This quantitative increase in two specific subunits is related to the process of cellular growth and differentiation in the vertebrate lens.",
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