A change in α-crystallin subunit composition in relation to cellular differentiation in adult bovine lens

Jean Delcour; John Papaconstantinou

doi:10.1016/0006-291X(70)90518-8

A change in α-crystallin subunit composition in relation to cellular differentiation in adult bovine lens

Jean Delcour
, John Papaconstantinou

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The vertebrate lens is composed of two distinct cell types, the epithelial cell and the fiber cell. α-Crystallin, a structural protein found in both cell types, is composed of four subunits (αA₁, αA₂, αB₁, and αB₂). In the epithelial cells the α-crystallin consists mainly of αA₂ and αB₂ with trace amounts of αA₁ and αB₁. In the fiber cell there is a large increase in the amount of αA₁ and αB₁ subunits. This quantitative increase in two specific subunits is related to the process of cellular growth and differentiation in the vertebrate lens.

Original language	English (US)
Pages (from-to)	401-406
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(70)90518-8
State	Published - Oct 23 1970
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(70)90518-8

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abstract = "The vertebrate lens is composed of two distinct cell types, the epithelial cell and the fiber cell. α-Crystallin, a structural protein found in both cell types, is composed of four subunits (αA1, αA2, αB1, and αB2). In the epithelial cells the α-crystallin consists mainly of αA2 and αB2 with trace amounts of αA1 and αB1. In the fiber cell there is a large increase in the amount of αA1 and αB1 subunits. This quantitative increase in two specific subunits is related to the process of cellular growth and differentiation in the vertebrate lens.",

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AU - Papaconstantinou, John

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N2 - The vertebrate lens is composed of two distinct cell types, the epithelial cell and the fiber cell. α-Crystallin, a structural protein found in both cell types, is composed of four subunits (αA1, αA2, αB1, and αB2). In the epithelial cells the α-crystallin consists mainly of αA2 and αB2 with trace amounts of αA1 and αB1. In the fiber cell there is a large increase in the amount of αA1 and αB1 subunits. This quantitative increase in two specific subunits is related to the process of cellular growth and differentiation in the vertebrate lens.

AB - The vertebrate lens is composed of two distinct cell types, the epithelial cell and the fiber cell. α-Crystallin, a structural protein found in both cell types, is composed of four subunits (αA1, αA2, αB1, and αB2). In the epithelial cells the α-crystallin consists mainly of αA2 and αB2 with trace amounts of αA1 and αB1. In the fiber cell there is a large increase in the amount of αA1 and αB1 subunits. This quantitative increase in two specific subunits is related to the process of cellular growth and differentiation in the vertebrate lens.

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

A change in α-crystallin subunit composition in relation to cellular differentiation in adult bovine lens

Abstract

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