A change in the stoichiometry of assembly of bovine lens α-crystallin subunits in relation to cellular differentiation

Jean Delcour, John Papaconstantinou

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Incorporation of [3H] leucine into oligomeric α-crystallin via individual subunits has been measured in epithelial cells and cortex fiber cells from adult bovine lenses in vitro. Our data show that the ratio of [3H] leucine incorporation via subunits αB2 and αA2 is shifted from a value of about 1:2 in epithelial cells to a value of about 1:3 in fiber cells. Thus, in this system, cellular differentiation is accompanied by a change in the stoichiometry of assembly of individual subunits to form the oligomeric α-crystallin molecule. These results indicate possible changes in the rates of synthesis of individual α-crystallin subunits.

Original languageEnglish (US)
Pages (from-to)134-141
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume57
Issue number1
DOIs
StatePublished - Mar 15 1974
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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