A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster

Haiping Hao, David L. Allen, Paul E. Hardin

Research output: Contribution to journalArticlepeer-review

200 Scopus citations


Genes expressed under circadian-clock control are found in organisms ranging from prokaryotes to humans. In Drosophila melanogaster, the period (per) gene, which is required for clock function, is transcribed in a circadian manner. We have identified a circadian transcriptional enhancer within a 69-bp DNA fragment upstream of the per gene. This enhancer drives high-amplitude mRNA cycling under light-dark-cycling or constant-dark conditions, and this activity is per protein (PER) dependent. An E-box sequence within this 69-bp fragment is necessary for high-level expression, but not for rhythmic expression, indicating that PER mediates circadian transcription through other sequences in this fragment.

Original languageEnglish (US)
Pages (from-to)3687-3693
Number of pages7
JournalMolecular and cellular biology
Issue number7
StatePublished - Jul 1997
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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