A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents

Haijun Chen, Cheng Z. Wang, Chunyong Ding, Christopher Wild, Bryan Copits, Geoffrey T. Swanson, Kenneth M. Johnson, Jia Zhou

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

PAMs new in town! An effective, combined bioinformatics and chemoinformatics approach was applied to the design of novel asymmetric bivalent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor positive allosteric modulators (PAMs) with marked potency invitro and efficacy invivo for preventing neuroapoptosis. The novel chemotype could provide pharmacological probes and potential therapeutic agents for glutamatergic hypofunction and its related neurological and psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalChemMedChem
Volume8
Issue number2
DOIs
StatePublished - Feb 2013

Fingerprint

Excitatory Amino Acid Agents
AMPA Receptors
Neuroprotective Agents
Bioinformatics
Nervous System Diseases
Computational Biology
Modulators
Psychiatry
Pharmacology
Acids
Therapeutics

Keywords

  • Bioinformatics
  • Biological space
  • Chemical space
  • Chemoinformatics
  • Drug design
  • Neuroprotective agents

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry
  • Molecular Medicine

Cite this

A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents. / Chen, Haijun; Wang, Cheng Z.; Ding, Chunyong; Wild, Christopher; Copits, Bryan; Swanson, Geoffrey T.; Johnson, Kenneth M.; Zhou, Jia.

In: ChemMedChem, Vol. 8, No. 2, 02.2013, p. 226-230.

Research output: Contribution to journalArticle

Chen, Haijun ; Wang, Cheng Z. ; Ding, Chunyong ; Wild, Christopher ; Copits, Bryan ; Swanson, Geoffrey T. ; Johnson, Kenneth M. ; Zhou, Jia. / A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents. In: ChemMedChem. 2013 ; Vol. 8, No. 2. pp. 226-230.
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