TY - JOUR
T1 - A common variant associated with prostate cancer in European and African populations
AU - Amundadottir, Laufey T.
AU - Sulem, Patrick
AU - Gudmundsson, Julius
AU - Helgason, Agnar
AU - Baker, Adam
AU - Agnarsson, Bjarni A.
AU - Sigurdsson, Asgeir
AU - Benediktsdottir, Kristrun R.
AU - Cazier, Jean Baptiste
AU - Sainz, Jesus
AU - Jakobsdottir, Margret
AU - Kostic, Jelena
AU - Magnusdottir, Droplaug N.
AU - Ghosh, Shyamali
AU - Agnarsson, Kari
AU - Birgisdottir, Birgitta
AU - Le Roux, Louise
AU - Olafsdottir, Adalheidur
AU - Blondal, Thorarinn
AU - Andresdottir, Margret
AU - Gretarsdottir, Olafia Svandis
AU - Bergthorsson, Jon T.
AU - Gudbjartsson, Daniel
AU - Gylfason, Arnaldur
AU - Thorleifsson, Gudmar
AU - Manolescu, Andrei
AU - Kristjansson, Kristleifur
AU - Geirsson, Gudmundur
AU - Isaksson, Helgi
AU - Douglas, Julie
AU - Johansson, Jan Erik
AU - Bälter, Katarina
AU - Wiklund, Fredrik
AU - Montie, James E.
AU - Yu, Xiaoying
AU - Suarez, Brian K.
AU - Ober, Carole
AU - Cooney, Kathleen A.
AU - Gronberg, Henrik
AU - Catalona, William J.
AU - Einarsson, Gudmundur V.
AU - Barkardottir, Rosa B.
AU - Gulcher, Jeffrey R.
AU - Kong, Augustine
AU - Thorsteinsdottir, Unnur
AU - Stefansson, Kari
PY - 2006/6
Y1 - 2006/6
N2 - With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P ≤ 2.7 × 10-11). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of ∼8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
AB - With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P ≤ 2.7 × 10-11). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of ∼8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
UR - https://www.scopus.com/pages/publications/33745169697
UR - https://www.scopus.com/pages/publications/33745169697#tab=citedBy
U2 - 10.1038/ng1808
DO - 10.1038/ng1808
M3 - Article
C2 - 16682969
AN - SCOPUS:33745169697
SN - 1061-4036
VL - 38
SP - 652
EP - 658
JO - Nature Genetics
JF - Nature Genetics
IS - 6
ER -