A comparative epidemiological study of hantavirus infection in Japan and Far East Russia

Hiroaki Kariwa, Kumari Lokugamage, Nandadeva Lokugamage, Hironobu Miyamoto, Kentaro Yoshii, Mina Nakauchi, Kumiko Yoshimatsu, Jiro Arikawa, Leonid I. Ivanov, Takuya Iwasaki, Ikuo Takashima

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hantaviruses are causative agents of some severe human illnesses, including hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). The viruses are maintained by rodent hosts, and humans acquire infection by inhaling virus-contaminated excreta from infected animals. To examine the epidemiology of hantavirus infections in Japan and Far East Russia, we conducted epidemiological surveys in these regions. In Japan, anti-hantavirus antibodies were found in four rodent species, Clethrionomys rufocanus, Rattus norvegicus, R. rattus, and Apodemus speciosus. Although no new HFRS cases have been officially reported over the past 20 years in Japan, one member of the Japan Ground Self-Defense Force did test positive for hantavirus antibody. Repeated surveys in Far East Russia have revealed that two distinct hantavirus types cause severe HFRS in this region. Hantavirus sequences identified from A. peninsulae, fetal HFRS cases in Vladivostok, and Amur virus are highly similar to each other (>92% identity), but they are less similar (∼84% identity) to the prototypical Hantaan virus, which is carried by A. agrarius. Phylogenetic analysis also indicates that Amur and A. peninsulae -associated viruses are distinct from Hantaan virus, suggesting that A. peninsulae is the reservoir animal for Amur virus, which causes severe HFRS. From HFRS patients in the Khabarovsk region, we identified viruses with nucleotide sequences that are more similar to Far East virus (∼96%identity) than to the Hantaan (88-89% identity) or Amur (81-83%identity) viruses. Phylogenetic analysis also indicates that the viruses from Khabarovsk HFRS patients are closely related to the Far East virus, and distinct from Amur virus.

Original languageEnglish (US)
Pages (from-to)145-161
Number of pages17
JournalJapanese Journal of Veterinary Research
Volume54
Issue number4
StatePublished - Feb 2007

Fingerprint

Hantavirus Infections
Hantavirus
Far East
Russia
Hemorrhagic Fever with Renal Syndrome
Hantaan virus
East Asia
epidemiological studies
Epidemiologic Studies
Japan
fever
Viruses
kidneys
viruses
infection
rodents
Apodemus speciosus
Sin Nombre virus
Rodentia
Hantavirus Pulmonary Syndrome

Keywords

  • Epidemiology
  • Epizootiology
  • Hantavirus
  • Rodent
  • Zoonosis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Kariwa, H., Lokugamage, K., Lokugamage, N., Miyamoto, H., Yoshii, K., Nakauchi, M., ... Takashima, I. (2007). A comparative epidemiological study of hantavirus infection in Japan and Far East Russia. Japanese Journal of Veterinary Research, 54(4), 145-161.

A comparative epidemiological study of hantavirus infection in Japan and Far East Russia. / Kariwa, Hiroaki; Lokugamage, Kumari; Lokugamage, Nandadeva; Miyamoto, Hironobu; Yoshii, Kentaro; Nakauchi, Mina; Yoshimatsu, Kumiko; Arikawa, Jiro; Ivanov, Leonid I.; Iwasaki, Takuya; Takashima, Ikuo.

In: Japanese Journal of Veterinary Research, Vol. 54, No. 4, 02.2007, p. 145-161.

Research output: Contribution to journalArticle

Kariwa, H, Lokugamage, K, Lokugamage, N, Miyamoto, H, Yoshii, K, Nakauchi, M, Yoshimatsu, K, Arikawa, J, Ivanov, LI, Iwasaki, T & Takashima, I 2007, 'A comparative epidemiological study of hantavirus infection in Japan and Far East Russia', Japanese Journal of Veterinary Research, vol. 54, no. 4, pp. 145-161.
Kariwa H, Lokugamage K, Lokugamage N, Miyamoto H, Yoshii K, Nakauchi M et al. A comparative epidemiological study of hantavirus infection in Japan and Far East Russia. Japanese Journal of Veterinary Research. 2007 Feb;54(4):145-161.
Kariwa, Hiroaki ; Lokugamage, Kumari ; Lokugamage, Nandadeva ; Miyamoto, Hironobu ; Yoshii, Kentaro ; Nakauchi, Mina ; Yoshimatsu, Kumiko ; Arikawa, Jiro ; Ivanov, Leonid I. ; Iwasaki, Takuya ; Takashima, Ikuo. / A comparative epidemiological study of hantavirus infection in Japan and Far East Russia. In: Japanese Journal of Veterinary Research. 2007 ; Vol. 54, No. 4. pp. 145-161.
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abstract = "Hantaviruses are causative agents of some severe human illnesses, including hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). The viruses are maintained by rodent hosts, and humans acquire infection by inhaling virus-contaminated excreta from infected animals. To examine the epidemiology of hantavirus infections in Japan and Far East Russia, we conducted epidemiological surveys in these regions. In Japan, anti-hantavirus antibodies were found in four rodent species, Clethrionomys rufocanus, Rattus norvegicus, R. rattus, and Apodemus speciosus. Although no new HFRS cases have been officially reported over the past 20 years in Japan, one member of the Japan Ground Self-Defense Force did test positive for hantavirus antibody. Repeated surveys in Far East Russia have revealed that two distinct hantavirus types cause severe HFRS in this region. Hantavirus sequences identified from A. peninsulae, fetal HFRS cases in Vladivostok, and Amur virus are highly similar to each other (>92{\%} identity), but they are less similar (∼84{\%} identity) to the prototypical Hantaan virus, which is carried by A. agrarius. Phylogenetic analysis also indicates that Amur and A. peninsulae -associated viruses are distinct from Hantaan virus, suggesting that A. peninsulae is the reservoir animal for Amur virus, which causes severe HFRS. From HFRS patients in the Khabarovsk region, we identified viruses with nucleotide sequences that are more similar to Far East virus (∼96{\%}identity) than to the Hantaan (88-89{\%} identity) or Amur (81-83{\%}identity) viruses. Phylogenetic analysis also indicates that the viruses from Khabarovsk HFRS patients are closely related to the Far East virus, and distinct from Amur virus.",
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