Abstract
The effect of Adriamycin (doxorubicin hydrochloride) (10 mg/kg intraperitoneally) on the response of mouse gut to irradiation with 6-MVp photons or fast neutrons (67 MeV p → Be), was assessed with the six-day death endpoint. The drug reduced the LD(50/6) by the same factor (~1.25) for both types of radiation. Thus, the radiobiological effectiveness (RBE) (photons/neutrons) for gut damage is unaltered by the addition of Adriamycin. The data indicate no significant effect of drug scheduling if given within 16 hours before or after irradiation.
Original language | English (US) |
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Pages (from-to) | 833-834 |
Number of pages | 2 |
Journal | Radiology |
Volume | 137 |
Issue number | 3 |
DOIs | |
State | Published - 1980 |
Externally published | Yes |
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging