A comparative study of the effect of adriamycin on the sensitivity of mice to whole-body irradiation with 6-MVp photons or fast neutrons (67 MeV p → Be)

M. Colman, E. Zabilansky, J. L. Redpath

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Abstract

The effect of Adriamycin (doxorubicin hydrochloride) (10 mg/kg intraperitoneally) on the response of mouse gut to irradiation with 6-MVp photons or fast neutrons (67 MeV p → Be), was assessed with the six-day death endpoint. The drug reduced the LD(50/6) by the same factor (~1.25) for both types of radiation. Thus, the radiobiological effectiveness (RBE) (photons/neutrons) for gut damage is unaltered by the addition of Adriamycin. The data indicate no significant effect of drug scheduling if given within 16 hours before or after irradiation.

Original languageEnglish (US)
Pages (from-to)833-834
Number of pages2
JournalRadiology
Volume137
Issue number3
DOIs
StatePublished - Jan 1 1980

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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