A comparative study of the effect of adriamycin on the sensitivity of mice to whole-body irradiation with 6-MVp photons or fast neutrons (67 MeV p → Be)

M. Colman, E. Zabilansky, J. L. Redpath

Research output: Contribution to journalArticle

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Abstract

The effect of Adriamycin (doxorubicin hydrochloride) (10 mg/kg intraperitoneally) on the response of mouse gut to irradiation with 6-MVp photons or fast neutrons (67 MeV p → Be), was assessed with the six-day death endpoint. The drug reduced the LD(50/6) by the same factor (~1.25) for both types of radiation. Thus, the radiobiological effectiveness (RBE) (photons/neutrons) for gut damage is unaltered by the addition of Adriamycin. The data indicate no significant effect of drug scheduling if given within 16 hours before or after irradiation.

Original languageEnglish (US)
Pages (from-to)833-834
Number of pages2
JournalRadiology
Volume137
Issue number3
StatePublished - 1980
Externally publishedYes

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Fast Neutrons
Whole-Body Irradiation
Photons
Doxorubicin
Neutrons
Pharmaceutical Preparations
Radiation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

A comparative study of the effect of adriamycin on the sensitivity of mice to whole-body irradiation with 6-MVp photons or fast neutrons (67 MeV p → Be). / Colman, M.; Zabilansky, E.; Redpath, J. L.

In: Radiology, Vol. 137, No. 3, 1980, p. 833-834.

Research output: Contribution to journalArticle

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