Abstract
This study presentsd mtelinated and unmyelinated axon counts from thoracic dorsal roots of rats whose spinal cords were hemisected at birth or at 1 year of age. Axonal numbers from a root on the unoperated side are compared to numbers from the root of the same segment on the operated side of the animal. Counts were made 3 segments cranially and 3 segments caudally from the hemisection. In animals hemisected at birth and sacrified at 3-8 months, there is a statistically significant increase in unmyelinated axons in roots of the operated as compared to the normal side. We interpret this as sprouting of unmyelinated axons. In animals hemisected at 1 year of age, the statistically significant change was a drop in myelinated axons in roots of the operated side. We interpret this as a loss of myelinated axon cell bodies due to axon section in the dorsal funiculus. Thus axonal sprouting occurs in young rats in our paradigm and a loss of myelinated axons occurs in older animals. We emphasize that different axonal populations respond to hemisection in different ways at different times.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 187-197 |
| Number of pages | 11 |
| Journal | Brain Research |
| Volume | 265 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 18 1983 |
| Externally published | Yes |
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Keywords
- axonal sprouting
- dorsal root
- spinal hemisection
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
A comparison of axonal numbers in dorsal roots following spinal cord hemisection in neonate and adult rats. / Hulsebosch, Claire E.; Coggeshall, Richard E.
In: Brain Research, Vol. 265, No. 2, 18.04.1983, p. 187-197.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A comparison of axonal numbers in dorsal roots following spinal cord hemisection in neonate and adult rats
AU - Hulsebosch, Claire E.
AU - Coggeshall, Richard E.
PY - 1983/4/18
Y1 - 1983/4/18
N2 - This study presentsd mtelinated and unmyelinated axon counts from thoracic dorsal roots of rats whose spinal cords were hemisected at birth or at 1 year of age. Axonal numbers from a root on the unoperated side are compared to numbers from the root of the same segment on the operated side of the animal. Counts were made 3 segments cranially and 3 segments caudally from the hemisection. In animals hemisected at birth and sacrified at 3-8 months, there is a statistically significant increase in unmyelinated axons in roots of the operated as compared to the normal side. We interpret this as sprouting of unmyelinated axons. In animals hemisected at 1 year of age, the statistically significant change was a drop in myelinated axons in roots of the operated side. We interpret this as a loss of myelinated axon cell bodies due to axon section in the dorsal funiculus. Thus axonal sprouting occurs in young rats in our paradigm and a loss of myelinated axons occurs in older animals. We emphasize that different axonal populations respond to hemisection in different ways at different times.
AB - This study presentsd mtelinated and unmyelinated axon counts from thoracic dorsal roots of rats whose spinal cords were hemisected at birth or at 1 year of age. Axonal numbers from a root on the unoperated side are compared to numbers from the root of the same segment on the operated side of the animal. Counts were made 3 segments cranially and 3 segments caudally from the hemisection. In animals hemisected at birth and sacrified at 3-8 months, there is a statistically significant increase in unmyelinated axons in roots of the operated as compared to the normal side. We interpret this as sprouting of unmyelinated axons. In animals hemisected at 1 year of age, the statistically significant change was a drop in myelinated axons in roots of the operated side. We interpret this as a loss of myelinated axon cell bodies due to axon section in the dorsal funiculus. Thus axonal sprouting occurs in young rats in our paradigm and a loss of myelinated axons occurs in older animals. We emphasize that different axonal populations respond to hemisection in different ways at different times.
KW - axonal sprouting
KW - dorsal root
KW - spinal hemisection
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UR - http://www.scopus.com/inward/citedby.url?scp=0020534574&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(83)90332-3
DO - 10.1016/0006-8993(83)90332-3
M3 - Article
VL - 265
SP - 187
EP - 197
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -