A comparison of epidemiologic and immunologic features of bronchiolitis caused by influenza virus and respiratory syncytial virus

Roberto Garofalo, Karen H. Hintz, Vanessa Hill, John Patti, Pearay L. Ogra, Robert C. Welliver

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We studied epidemiologic and immunologic factors in infants with bronchiolitis caused by influenza virus. The proportion of these infants who were male and who had an immediate family member with a history of asthma was similar to that of a control group of infants with respiratory syncytial virus (RSV) bronchiolitis. In subjects with influenza virus infection, concentrations of the beta chemokine macrophage inflammatory protein-1alpha (MIP-1α), but not other beta chemokines, in nasopharyngeal secretions (NPS) were greater among infants with more severe, hypoxic bronchiolitis than in subjects with mild, nonhypoxic bronchiolitis, or upper respiratory tract infection alone. Quantities of MIP-1α were also correlated with lower values of oxygen saturation. These findings point out epidemiologic and immunologic similarities between bronchiolitis caused by influenza and RSV, and suggest that hostfactors are more important than the nature of the infecting virus in the development of severe forms of bronchiolitis caused by influenza and RSV.

Original languageEnglish (US)
Pages (from-to)282-289
Number of pages8
JournalJournal of Medical Virology
Volume75
Issue number2
DOIs
StatePublished - Feb 2005

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Bronchiolitis
Respiratory Syncytial Viruses
Orthomyxoviridae
Macrophage Inflammatory Proteins
CC Chemokines
Human Influenza
Epidemiologic Factors
Immunologic Factors
Virus Diseases
Respiratory Tract Infections
Asthma
Oxygen
Viruses
Control Groups

Keywords

  • Chemokines
  • Macrophage inflammatory protein-1alpha
  • Monocyte chemotactic protein
  • Normal T-cell expressed and secreted
  • Regulated on activation

ASJC Scopus subject areas

  • Virology

Cite this

A comparison of epidemiologic and immunologic features of bronchiolitis caused by influenza virus and respiratory syncytial virus. / Garofalo, Roberto; Hintz, Karen H.; Hill, Vanessa; Patti, John; Ogra, Pearay L.; Welliver, Robert C.

In: Journal of Medical Virology, Vol. 75, No. 2, 02.2005, p. 282-289.

Research output: Contribution to journalArticle

Garofalo, Roberto ; Hintz, Karen H. ; Hill, Vanessa ; Patti, John ; Ogra, Pearay L. ; Welliver, Robert C. / A comparison of epidemiologic and immunologic features of bronchiolitis caused by influenza virus and respiratory syncytial virus. In: Journal of Medical Virology. 2005 ; Vol. 75, No. 2. pp. 282-289.
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