A comparison of hemoglobin A1c in human and baboon blood

Jack B. Alperin; P. A. Dow; L. C. Stout

doi:10.1159/000207683

A comparison of hemoglobin A_1c in human and baboon blood

Jack B. Alperin
, P. A. Dow
, L. C. Stout

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Cation exchange chromatography was performed on hemolysates prepared from human and baboon (Papio anubis) blood. In humans with diabetes mellitus and in baboons with pancreatectomy induced diabetes mellitus there were significant increases in Hbs A₁,A_1c, and A_1a +A_lb. The quantity of Hb A₁, and Hb A_1c in nondiabetic baboons was approximately one-half the quantity of Hb A₁ and Hb A_1c in nondiabetic humans. These differences may be explained by the differences in survival time between human and baboon red cells.

Original language	English (US)
Pages (from-to)	334-338
Number of pages	5
Journal	Acta Haematologica
Volume	61
Issue number	6
DOIs	https://doi.org/10.1159/000207683
State	Published - 1979
Externally published	Yes

Keywords

Diabetes mellitus
Glycosylated hemoglobin
Hb A
Papio anubis

ASJC Scopus subject areas

Hematology

Access to Document

10.1159/000207683

Cite this

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title = "A comparison of hemoglobin A1c in human and baboon blood",

abstract = "Cation exchange chromatography was performed on hemolysates prepared from human and baboon (Papio anubis) blood. In humans with diabetes mellitus and in baboons with pancreatectomy induced diabetes mellitus there were significant increases in Hbs A1,A1c, and A1a +Alb. The quantity of Hb A1, and Hb A1c in nondiabetic baboons was approximately one-half the quantity of Hb A1 and Hb A1c in nondiabetic humans. These differences may be explained by the differences in survival time between human and baboon red cells.",

keywords = "Diabetes mellitus, Glycosylated hemoglobin, Hb A, Papio anubis",

author = "Alperin, \{Jack B.\} and Dow, \{P. A.\} and Stout, \{L. C.\}",

year = "1979",

doi = "10.1159/000207683",

language = "English (US)",

volume = "61",

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journal = "Acta Haematologica",

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T1 - A comparison of hemoglobin A1c in human and baboon blood

AU - Alperin, Jack B.

AU - Dow, P. A.

AU - Stout, L. C.

PY - 1979

Y1 - 1979

N2 - Cation exchange chromatography was performed on hemolysates prepared from human and baboon (Papio anubis) blood. In humans with diabetes mellitus and in baboons with pancreatectomy induced diabetes mellitus there were significant increases in Hbs A1,A1c, and A1a +Alb. The quantity of Hb A1, and Hb A1c in nondiabetic baboons was approximately one-half the quantity of Hb A1 and Hb A1c in nondiabetic humans. These differences may be explained by the differences in survival time between human and baboon red cells.

AB - Cation exchange chromatography was performed on hemolysates prepared from human and baboon (Papio anubis) blood. In humans with diabetes mellitus and in baboons with pancreatectomy induced diabetes mellitus there were significant increases in Hbs A1,A1c, and A1a +Alb. The quantity of Hb A1, and Hb A1c in nondiabetic baboons was approximately one-half the quantity of Hb A1 and Hb A1c in nondiabetic humans. These differences may be explained by the differences in survival time between human and baboon red cells.

KW - Diabetes mellitus

KW - Glycosylated hemoglobin

KW - Hb A

KW - Papio anubis

UR - https://www.scopus.com/pages/publications/0018654574

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VL - 61

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JO - Acta Haematologica

JF - Acta Haematologica

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