A comparison of postoperative effects of bariatric surgery on medical markers of morbidity

Gwen L. Bonner, Andrew J. Nagy, Daniel C. Jupiter, Joaquin A. Rodriguez, Richard E. Symmonds, Robert O. Carpenter

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background Bariatric surgery reduces the prevalence of diabetes and improves lipid profiles. Low-density lipoprotein particle (LDL-P) is a more accurate predictor of cardiovascular events than high-density lipoprotein (HDL) and LDL cholesterol. The effects of bariatric procedures on LDL-P have not been previously reported.

Methods Two hundred thirty patients undergoing bariatric surgery, including gastric bypass, sleeve gastrectomy, and laparoscopic adjustable gastric band placement at a single institution were included. HDL, LDL, hemoglobin A1c, and LDL-P were measured preoperatively and at 3, 6, and 12 months postoperatively. Weight was recorded at baseline and after 1 year.

Results There was a decrease in serum LDL-P levels, averaging 472.58 (P <.0001) over 1 year. HDL levels increased. Hemoglobin A1c and LDL levels declined. On average, patients lost 58% of excess weight.

Conclusion LDL-P significantly decreased after bariatric surgery in relation to weight loss. It may be inferred that bariatric surgery decreases the risk of cardiovascular events.

Original languageEnglish (US)
Pages (from-to)897-902
Number of pages6
JournalAmerican Journal of Surgery
Volume208
Issue number6
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

Keywords

  • Bariatric surgery
  • Cardiovascular risk
  • Cholesterol
  • LDL particle
  • Obesity

ASJC Scopus subject areas

  • Surgery

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